Advanced Cell Therapy (ACT) Laboratory
The Yale Advanced Cell Therapy (ACT) laboratory is a GMP (Good Manufacturing Practices) laboratory designed for the production of high quality, safe, cell products for clinical treatment. The ACT is dedicated to and responsible for the production of cellular products to be used in phase I/II clinical trials conducted by investigators at Yale and in multicenter trials. Our laboratory has significant experience with IND-enabling studies using GMP. Cell product safety and quality are the top priorities for our GMP laboratory. By executing and documenting Good Manufacturing Practices (GMPs), the ACT practices assure that all government regulations are met, and that all products meet defined release criteria and are safe for administration to human subjects.
Manufacturing Tumor Infiltrating Lymphocytes
Chemistry, Manufacturing and Controls (CMC)
To support clinical investigation in the field of cellular therapy the ACT Laboratory is located directly adjacent to the Transfusion Medicine Division and the Clinical Blood Bank for Yale New Haven Hospital.
Advanced Cell Therapy Laboratory
Advanced Cell Therapy Faculty
Assistant Professor of Clinical Laboratory Medicine
Anthony N. Brady Professor of Laboratory Medicine and Professor of Pathology; Vice Chair for Research Affairs, Laboratory Medicine; Assoc. Director, Yale Stem Cell Center; Assoc. Director, Transfusion Medicine Service; Medical Director, Clinical Cell Processing Laboratory; Medical Director, Advanced Cell Therapy LaboratoryDiane Krause MD, PhD is Professor of Laboratory Medicine, Pathology and Cell Biology at Yale University; Associate Director of the Yale Stem Cell Center; and Director of the Clinical Cell Processing Laboratory. She received an Sc.B. degree in Biology from Brown University, and an MD and PhD degree from the University of Pennsylvania. After completing a residency in Clinical Pathology at the University of Pennsylvania, she performed post-doctoral studies at Johns Hopkins University. She runs a well-funded research laboratory focused on leukemogenesis, hematopoietic stem and progenitor cell fate specification clinical cell therapy and pluripotent stem cell differentiation down the parathyroid lineage. Watch a video with Dr. Diane Krause >>