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A Radiologist and an Artist: Boustani Provides High Quality Medical Illustrations for Her Peers
- August 22, 2019
Yale Radiologists Advance Prostate Cancer Imaging
- August 22, 2019
Yale Radiology Medical Student Thesis Program Annual Update
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2019 Honors & Achievements
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Imaging Agent Shows Promise for Better Prostate Cancer Detection
- July 16, 2018
Yale-developed test for Alzheimer’s disease directly measures synaptic loss
Nuclear Medicine
General Information
PO Box 208042
New Haven, CT 06520-8042 Admin Assistant, Nel Rodríguez |
Phone:
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203-785-2168
|
The Nuclear Medicine section in the Department of Radiology and Biomedical Imaging is comprised of subspecialty trained physicians. The section provides comprehensive nuclear medicine imaging and therapy.
Clinical
Nuclear medicine uses organ function to image and treat many diseases. Small amounts of radioactive substances are administered to patients to map organ function and create functional or molecular images.
Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT) are nuclear medicine techniques used to generate highly sensitive, measurable images of disease.
Examples of nuclear medicine studies include imaging for pulmonary embolism, infection, gastrointestinal bleeding, renal function, bone tumors, fractures, gallbladder diseases, Parkinson's disease, hyperparathyroidism, thyroid diseases, neuroendocrine diseases, dementia, epilepsy and many forms of cancer.
We have an active nuclear medicine therapy service, treating thyroid cancer and hyperthyroidism, as well as metastatic disease. The Nuclear Medicine Section was the first site in Connecticut to use Ra-223 therapy for bone pain palliation in patients with metastatic prostate cancer. Patients receiving treatment doses are seen by physicians in our nuclear medicine consultation clinic, where we discuss treatment effects and radiation safety precautions.
New additions to the Nuclear Medicine division include state-of-the-art PET/CT scanners for evaluation of cancer and neurologic diseases. We have 3 dedicated PET/CT scanners which provide the highest quality molecular imaging for tumor diagnosis, staging and treatment response.
The Nuclear Medicine section is at the forefront of the field of theranostics. Theranostics is the term used to describe the combination of using one radioactive agent to diagnose disease and a second radioactive drug to deliver therapy to treat tumors. We were the first site in Connecticut to utilize this technology in the imaging and treatment of neuroendocrine tumors.
Research
The section of Nuclear Medicine is actively involved in performing clinical and translational research. Some recent examples include novel PET agents for imaging and treating prostate and neuroendocrine cancers and the imaging of brain tumors. The Molecular Imaging Clinical and Translational Research Laboratory (MICTRL) was created to support the rapid growth of our involvement in this arena.
The research mission of the section is realized through collaboration with the Yale Positron Emission Tomography Center (PET Center). The PET Center provides the highest quality nuclear imaging research to aid in the diagnosis of disease and advance drug development.
Education
The Nuclear Medicine section is committed to the strong education mission embraced by the Department of Radiology and Biomedical Imaging. This includes daily clinical rotation teaching, multidisciplinary conferences and didactic lectures for medical students, radiology residents and nuclear radiology fellows.
The section has an ACGME accredited Nuclear Radiology Fellowship, as well as the Nuclear Radiology Pathway. Through the American Board of Radiology, the Nuclear Radiology Pathway enables diagnostic radiology residents to qualify for dual board certification in Radiology and Nuclear Medicine.
Recent Publications
2024
- Reactive axillary lymph nodes after COVID-19 mRNA vaccination: comparison of mRNA vs. attenuated whole-virus vaccines.Adin ME, Isufi E, Wu J, Pang Y, Nguyen D, Simsek Has D, Caner C, Aboueldaha N, Mossa-Basha M, Pucar D. Nucl Med Commun. 2024 Mar 11; 2024 Mar 11. PMID: 38465449.
- Comparison of Volumetric and 2D Measurements and Longitudinal Trajectories in the Response Assessment of BRAF V600E-Mutant Pediatric Gliomas in the Pacific Pediatric Neuro-Oncology Consortium Clinical Trial.Ramakrishnan D, Brüningk SC, von Reppert M, Memon F, Maleki N, Aneja S, Kazerooni AF, Nabavizadeh A, Lin M, Bousabarah K, Molinaro A, Nicolaides T, Prados M, Mueller S, Aboian MS. AJNR Am J Neuroradiol. 2024 Mar 7; 2024 Mar 7. PMID: 38453411.
- The regional pattern of age-related synaptic loss in the human brain differs from gray matter volume loss: in vivo PET measurement with [(11)C]UCB-J.Toyonaga T, Khattar N, Wu Y, Lu Y, Naganawa M, Gallezot JD, Matuskey D, Mecca AP, Pittman B, Dias M, Nabulsi NB, Finnema SJ, Chen MK, Arnsten A, Radhakrishnan R, Skosnik PD, D'Souza DC, Esterlis I, Huang Y, van Dyck CH, Carson RE. Eur J Nucl Med Mol Imaging. 2024 Mar; 2023 Nov 13. PMID: 37955791.
- A large open access dataset of brain metastasis 3D segmentations on MRI with clinical and imaging information.Ramakrishnan D, Jekel L, Chadha S, Janas A, Moy H, Maleki N, Sala M, Kaur M, Petersen GC, Merkaj S, von Reppert M, Baid U, Bakas S, Kirsch C, Davis M, Bousabarah K, Holler W, Lin M, Westerhoff M, Aneja S, Memon F, Aboian MS. Sci Data. 2024 Feb 29; 2024 Feb 29. PMID: 38424079.
- The Brain Tumor Segmentation (BraTS) Challenge 2023: Focus on Pediatrics (CBTN-CONNECT-DIPGR-ASNR-MICCAI BraTS-PEDs).Kazerooni AF, Khalili N, Liu X, Haldar D, Jiang Z, Anwar SM, Albrecht J, Adewole M, Anazodo U, Anderson H, Bagheri S, Baid U, Bergquist T, Borja AJ, Calabrese E, Chung V, Conte GM, Dako F, Eddy J, Ezhov I, Familiar A, Farahani K, Haldar S, Iglesias JE, Janas A, Johansen E, Jones BV, Kofler F, LaBella D, Lai HA, Van Leemput K, Li HB, Maleki N, McAllister AS, Meier Z, Menze B, Moawad AW, Nandolia KK, Pavaine J, Piraud M, Poussaint T, Prabhu SP, Reitman Z, Rodriguez A, Rudie JD, Sanchez-Montano M, Shaikh IS, Shah LM, Sheth N, Shinohara RT, Tu W, Viswanathan K, Wang C, Ware JB, Wiestler B, Wiggins W, Zapaishchykova A, Aboian M, Bornhorst M, de Blank P, Deutsch M, Fouladi M, Hoffman L, Kann B, Lazow M, Mikael L, Nabavizadeh A, Packer R, Resnick A, Rood B, Vossough A, Bakas S, Linguraru MG. ArXiv. 2024 Feb 14; 2024 Feb 14. PMID: 37292481.
- Everolimus for Children With Recurrent or Progressive Low-Grade Glioma: Results From the Phase II PNOC001 Trial.Haas-Kogan DA, Aboian MS, Minturn JE, Leary SES, Abdelbaki MS, Goldman S, Elster JD, Kraya A, Lueder MR, Ramakrishnan D, von Reppert M, Liu KX, Rokita JL, Resnick AC, Solomon DA, Phillips JJ, Prados M, Molinaro AM, Waszak SM, Mueller S. J Clin Oncol. 2024 Feb 1; 2023 Nov 17. PMID: 37978951.
- Comparison of volumetric and 2D-based response methods in the PNOC-001 pediatric low-grade glioma clinical trial.von Reppert M, Ramakrishnan D, Brüningk SC, Memon F, Abi Fadel S, Maleki N, Bahar R, Avesta AE, Jekel L, Sala M, Lost J, Tillmanns N, Kaur M, Aneja S, Fathi Kazerooni A, Nabavizadeh A, Lin M, Hoffmann KT, Bousabarah K, Swanson KR, Haas-Kogan D, Mueller S, Aboian MS. Neurooncol Adv. 2024 Jan-Dec; 2023 Dec 27. PMID: 38221978.
- Assessment of Gray Matter Microstructure and Synaptic Density in Alzheimer's Disease: A Multimodal Imaging Study With DTI and SV2A PET.Silva-Rudberg JA, Salardini E, O'Dell RS, Chen MK, Ra J, Georgelos JK, Morehouse MR, Melino KP, Varma P, Toyonaga T, Nabulsi NB, Huang Y, Carson RE, van Dyck CH, Mecca AP. Am J Geriatr Psychiatry. 2024 Jan; 2023 Aug 11. PMID: 37673749.
2023
- Application of novel PACS-based informatics platform to identify imaging based predictors of CDKN2A allelic status in glioblastomas.Tillmanns N, Lost J, Tabor J, Vasandani S, Vetsa S, Marianayagam N, Yalcin K, Erson-Omay EZ, von Reppert M, Jekel L, Merkaj S, Ramakrishnan D, Avesta A, de Oliveira Santo ID, Jin L, Huttner A, Bousabarah K, Ikuta I, Lin M, Aneja S, Turowski B, Aboian M, Moliterno J. Sci Rep. 2023 Dec 22; 2023 Dec 22. PMID: 38135704.
- Clinical implications of Peri-hematomal edema microperfusion fraction in intracerebral hemorrhage intravoxel incoherent motion imaging - A pilot study.Abou Karam G, Tharmaseelan H, Aboian MS, Malhotra A, Gilmore EJ, Falcone GJ, de Havenon A, Sheth KN, Payabvash S. J Stroke Cerebrovasc Dis. 2023 Nov; 2023 Sep 20. PMID: 37738914.
- Systematic Literature Review of Machine Learning Algorithms Using Pretherapy Radiologic Imaging for Glioma Molecular Subtype Prediction.Lost J, Verma T, Jekel L, von Reppert M, Tillmanns N, Merkaj S, Petersen GC, Bahar R, Gordem A, Haider MA, Subramanian H, Brim W, Ikuta I, Omuro A, Conte GM, Marquez-Nostra BV, Avesta A, Bousabarah K, Nabavizadeh A, Kazerooni AF, Aneja S, Bakas S, Lin M, Sabel M, Aboian M. AJNR Am J Neuroradiol. 2023 Oct. PMID: 37770204.
- Local Economic Considerations in Selecting Artificial Intelligence Tools for Implementation.Davis MA, Ramakrishnan D, Sala M, Aboian M. J Am Coll Radiol. 2023 Oct; 2023 Aug 19. PMID: 37604325.
- PACS-Integrated Tools for Peritumoral Edema Volumetrics Provide Additional Information to RANO-BM-Based Assessment of Lung Cancer Brain Metastases after Stereotactic Radiotherapy: A Pilot Study.Kaur M, Cassinelli Petersen G, Jekel L, von Reppert M, Varghese S, Dixe de Oliveira Santo I, Avesta A, Aneja S, Omuro A, Chiang V, Aboian M. Cancers (Basel). 2023 Sep 30; 2023 Sep 30. PMID: 37835516.
- Evolution and implementation of radiographic response criteria in neuro-oncology.Ramakrishnan D, von Reppert M, Krycia M, Sala M, Mueller S, Aneja S, Nabavizadeh A, Galldiks N, Lohmann P, Raji C, Ikuta I, Memon F, Weinberg BD, Aboian MS. Neurooncol Adv. 2023 Jan-Dec; 2023 Sep 13. PMID: 37860269.
- A Large Open Access Dataset of Brain Metastasis 3D Segmentations with Clinical and Imaging Feature Information.Ramakrishnan D, Jekel L, Chadha S, Janas A, Moy H, Maleki N, Sala M, Kaur M, Petersen GC, Merkaj S, von Reppert M, Baid U, Bakas S, Kirsch C, Davis M, Bousabarah K, Holler W, Lin M, Westerhoff M, Aneja S, Memon F, Aboian MS. ArXiv. 2023 Sep 12; 2023 Sep 12. PMID: 37744461.
- The Brain Tumor Segmentation (BraTS) Challenge 2023: Brain MR Image Synthesis for Tumor Segmentation (BraSyn).Li HB, Conte GM, Anwar SM, Kofler F, Ezhov I, van Leemput K, Piraud M, Diaz M, Cole B, Calabrese E, Rudie J, Meissen F, Adewole M, Janas A, Kazerooni AF, LaBella D, Moawad AW, Farahani K, Eddy J, Bergquist T, Chung V, Shinohara RT, Dako F, Wiggins W, Reitman Z, Wang C, Liu X, Jiang Z, Familiar A, Johanson E, Meier Z, Davatzikos C, Freymann J, Kirby J, Bilello M, Fathallah-Shaykh HM, Wiest R, Kirschke J, Colen RR, Kotrotsou A, Lamontagne P, Marcus D, Milchenko M, Nazeri A, Weber MA, Mahajan A, Mohan S, Mongan J, Hess C, Cha S, Villanueva-Meyer J, Colak E, Crivellaro P, Jakab A, Albrecht J, Anazodo U, Aboian M, Yu T, Chung V, Bergquist T, Eddy J, Albrecht J, Baid U, Bakas S, Linguraru MG, Menze B, Iglesias JE, Wiestler B. ArXiv. 2023 Jun 28; 2023 Jun 28. PMID: 37608932.
- The Brain Tumor Segmentation (BraTS-METS) Challenge 2023: Brain Metastasis Segmentation on Pre-treatment MRI.Moawad AW, Janas A, Baid U, Ramakrishnan D, Jekel L, Krantchev K, Moy H, Saluja R, Osenberg K, Wilms K, Kaur M, Avesta A, Pedersen GC, Maleki N, Salimi M, Merkaj S, von Reppert M, Tillmans N, Lost J, Bousabarah K, Holler W, Lin M, Westerhoff M, Maresca R, Link KE, Tahon NH, Marcus D, Sotiras A, LaMontagne P, Chakrabarty S, Teytelboym O, Youssef A, Nada A, Velichko YS, Gennaro N, Cramer J, Johnson DR, Kwan BYM, Petrovic B, Patro SN, Wu L, So T, Thompson G, Kam A, Perez-Carrillo GG, Lall N, Albrecht J, Anazodo U, Lingaru MG, Menze BH, Wiestler B, Adewole M, Anwar SM, Labella D, Li HB, Iglesias JE, Farahani K, Eddy J, Bergquist T, Chung V, Shinohara RT, Dako F, Wiggins W, Reitman Z, Wang C, Liu X, Jiang Z, Van Leemput K, Piraud M, Ezhov I, Johanson E, Meier Z, Familiar A, Kazerooni AF, Kofler F, Calabrese E, Aneja S, Chiang V, Ikuta I, Shafique U, Memon F, Conte GM, Bakas S, Rudie J, Aboian M. ArXiv. 2023 Jun 1; 2023 Jun 1. PMID: 37396600.
- PET/MRI Applications in Pediatric Epilepsy.Pedersen C, Aboian M, Messina SA, Daldrup-Link H, Franceschi AM. World J Nucl Med. 2023 Jun; 2023 Apr 28. PMID: 37223623.
- The Brain Tumor Segmentation (BraTS) Challenge 2023: Glioma Segmentation in Sub-Saharan Africa Patient Population (BraTS-Africa).Adewole M, Rudie JD, Gbdamosi A, Toyobo O, Raymond C, Zhang D, Omidiji O, Akinola R, Suwaid MA, Emegoakor A, Ojo N, Aguh K, Kalaiwo C, Babatunde G, Ogunleye A, Gbadamosi Y, Iorpagher K, Calabrese E, Aboian M, Linguraru M, Albrecht J, Wiestler B, Kofler F, Janas A, LaBella D, Kzerooni AF, Li HB, Iglesias JE, Farahani K, Eddy J, Bergquist T, Chung V, Shinohara RT, Wiggins W, Reitman Z, Wang C, Liu X, Jiang Z, Familiar A, Van Leemput K, Bukas C, Piraud M, Conte GM, Johansson E, Meier Z, Menze BH, Baid U, Bakas S, Dako F, Fatade A, Anazodo UC. ArXiv. 2023 May 30; 2023 May 30. PMID: 37396608.
- The role of imaging and sentinel lymph node biopsy in patients with T3b-T4b melanoma with clinically negative disease.Papageorge MV, Maina RM, King ALO, Lee V, Baumann R, Pucar D, Ariyan S, Khan SA, Weiss SA, Clune J, Olino K. Front Oncol. 2023; 2023 May 8. PMID: 37223678.