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Nuclear Medicine
General Information
PO Box 208042 New Haven, CT 06520-8042 Admin Assistant, Nel Rodríguez |
The Nuclear Medicine section in the Department of Radiology and Biomedical Imaging is comprised of subspecialty trained physicians. The section provides comprehensive nuclear medicine imaging and therapy.
Clinical
Nuclear medicine uses organ function to image and treat many diseases. Small amounts of radioactive substances are administered to patients to map organ function and create functional or molecular images.
Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT) are nuclear medicine techniques used to generate highly sensitive, measurable images of disease.
Examples of nuclear medicine studies include imaging for pulmonary embolism, infection, gastrointestinal bleeding, renal function, bone tumors, fractures, gallbladder diseases, Parkinson's disease, hyperparathyroidism, thyroid diseases, neuroendocrine diseases, dementia, epilepsy and many forms of cancer.
We have an active nuclear medicine therapy service, treating thyroid cancer and hyperthyroidism, as well as metastatic disease. The Nuclear Medicine Section was the first site in Connecticut to use Ra-223 therapy for bone pain palliation in patients with metastatic prostate cancer. Patients receiving treatment doses are seen by physicians in our nuclear medicine consultation clinic, where we discuss treatment effects and radiation safety precautions.
New additions to the Nuclear Medicine division include state-of-the-art PET/CT scanners for evaluation of cancer and neurologic diseases. We have 3 dedicated PET/CT scanners which provide the highest quality molecular imaging for tumor diagnosis, staging and treatment response.
The Nuclear Medicine section is at the forefront of the field of theranostics. Theranostics is the term used to describe the combination of using one radioactive agent to diagnose disease and a second radioactive drug to deliver therapy to treat tumors. We were the first site in Connecticut to utilize this technology in the imaging and treatment of neuroendocrine tumors.
Research
The section of Nuclear Medicine is actively involved in performing clinical and translational research. Some recent examples include novel PET agents for imaging and treating prostate and neuroendocrine cancers and the imaging of brain tumors. The Molecular Imaging Clinical and Translational Research Laboratory (MICTRL) was created to support the rapid growth of our involvement in this arena.
The research mission of the section is realized through collaboration with the Yale Positron Emission Tomography Center (PET Center). The PET Center provides the highest quality nuclear imaging research to aid in the diagnosis of disease and advance drug development.
Education
The Nuclear Medicine section is committed to the strong education mission embraced by the Department of Radiology and Biomedical Imaging. This includes daily clinical rotation teaching, multidisciplinary conferences and didactic lectures for medical students, radiology residents and nuclear radiology fellows.
The section has an ACGME accredited Nuclear Radiology Fellowship, as well as the Nuclear Radiology Pathway. Through the American Board of Radiology, the Nuclear Radiology Pathway enables diagnostic radiology residents to qualify for dual board certification in Radiology and Nuclear Medicine.
Recent Publications
- The Brain Tumor Segmentation (BraTS) Challenge 2023: Brain MR Image Synthesis for Tumor Segmentation (BraSyn).Li HB, Conte GM, Hu Q, Anwar SM, Kofler F, Ezhov I, van Leemput K, Piraud M, Diaz M, Cole B, Calabrese E, Rudie J, Meissen F, Adewole M, Janas A, Kazerooni AF, LaBella D, Moawad AW, Farahani K, Eddy J, Bergquist T, Chung V, Shinohara RT, Dako F, Wiggins W, Reitman Z, Wang C, Liu X, Jiang Z, Familiar A, Johanson E, Meier Z, Davatzikos C, Freymann J, Kirby J, Bilello M, Fathallah-Shaykh HM, Wiest R, Kirschke J, Colen RR, Kotrotsou A, Lamontagne P, Marcus D, Milchenko M, Nazeri A, Weber MA, Mahajan A, Mohan S, Mongan J, Hess C, Cha S, Villanueva-Meyer J, Colak E, Crivellaro P, Jakab A, Albrecht J, Anazodo U, Aboian M, Yu T, Chung V, Bergquist T, Eddy J, Albrecht J, Baid U, Bakas S, Linguraru MG, Menze B, Iglesias JE, Wiestler B. ArXiv. 2024 Nov 24; 2024 Nov 24. PMID: 37608932.
- Validation of a Simplified Tissue-to-Reference Ratio Measurement Using SUVR to Assess Synaptic Density Alterations in Alzheimer Disease with [(11)C]UCB-J PET.Young JJ, O'Dell RS, Naganawa M, Toyonaga T, Chen MK, Nabulsi NB, Huang Y, Cooper E, Miller A, Lam J, Bates K, Ruan A, Nelsen K, Salardini E, Carson RE, van Dyck CH, Mecca AP. J Nucl Med. 2024 Nov 1; 2024 Nov 1. PMID: 39299782.
- AI-Generated Annotations Dataset for Diverse Cancer Radiology Collections in NCI Image Data Commons.Murugesan GK, McCrumb D, Aboian M, Verma T, Soni R, Memon F, Farahani K, Pei L, Wagner U, Fedorov AY, Clunie D, Moore S, Van Oss J. Sci Data. 2024 Oct 23; 2024 Oct 23. PMID: 39443503.
- Enhancing clinical decision-making: An externally validated machine learning model for predicting isocitrate dehydrogenase mutation in gliomas using radiomics from presurgical magnetic resonance imaging.Lost J, Ashraf N, Jekel L, von Reppert M, Tillmanns N, Willms K, Merkaj S, Petersen GC, Avesta A, Ramakrishnan D, Omuro A, Nabavizadeh A, Bakas S, Bousabarah K, Lin M, Aneja S, Sabel M, Aboian M. Neurooncol Adv. 2024 Jan-Dec; 2024 Oct 3. PMID: 39659829.
- Long-Term Outcomes of Prostate-Specific Membrane Antigen-PET Imaging of Recurrent Prostate Cancer.Kunst N, Long JB, Westvold S, Sprenkle PC, Kim IY, Saperstein L, Rabil M, Ghaffar U, Karnes RJ, Ma X, Gross CP, Wang SY, Leapman MS. JAMA Netw Open. 2024 Oct 1; 2024 Oct 1. PMID: 39441595.
- Patterns of brain metastases response to immunotherapy with pembrolizumab.Mahajan A, Goldberg SL, Weiss SA, Tran T, Singh K, Joshi K, Aboian MS, Kluger HM, Chiang VL. J Neurooncol. 2024 Sep; 2024 Jul 4. PMID: 38963658.
- Population-based deep image prior for dynamic PET denoising: A data-driven approach to improve parametric quantification.Liu Q, Tsai YJ, Gallezot JD, Guo X, Chen MK, Pucar D, Young C, Panin V, Casey M, Miao T, Xie H, Chen X, Zhou B, Carson R, Liu C. Med Image Anal. 2024 Jul; 2024 Apr 17. PMID: 38657423.
- Reactive axillary lymph nodes after COVID-19 mRNA vaccination: comparison of mRNA vs. attenuated whole-virus vaccines.Adin ME, Isufi E, Wu J, Pang Y, Nguyen D, Simsek Has D, Caner C, Aboueldaha N, Mossa-Basha M, Pucar D. Nucl Med Commun. 2024 Jun 1; 2024 Mar 11. PMID: 38465449.
- The Brain Tumor Segmentation (BraTS) Challenge 2023: Focus on Pediatrics (CBTN-CONNECT-DIPGR-ASNR-MICCAI BraTS-PEDs).Kazerooni AF, Khalili N, Liu X, Haldar D, Jiang Z, Anwar SM, Albrecht J, Adewole M, Anazodo U, Anderson H, Bagheri S, Baid U, Bergquist T, Borja AJ, Calabrese E, Chung V, Conte GM, Dako F, Eddy J, Ezhov I, Familiar A, Farahani K, Haldar S, Iglesias JE, Janas A, Johansen E, Jones BV, Kofler F, LaBella D, Lai HA, Van Leemput K, Li HB, Maleki N, McAllister AS, Meier Z, Menze B, Moawad AW, Nandolia KK, Pavaine J, Piraud M, Poussaint T, Prabhu SP, Reitman Z, Rodriguez A, Rudie JD, Shaikh IS, Shah LM, Sheth N, Shinohara RT, Tu W, Viswanathan K, Wang C, Ware JB, Wiestler B, Wiggins W, Zapaishchykova A, Aboian M, Bornhorst M, de Blank P, Deutsch M, Fouladi M, Hoffman L, Kann B, Lazow M, Mikael L, Nabavizadeh A, Packer R, Resnick A, Rood B, Vossough A, Bakas S, Linguraru MG. ArXiv. 2024 May 23; 2024 May 23. PMID: 37292481.
- A multi-institutional meningioma MRI dataset for automated multi-sequence image segmentation.LaBella D, Khanna O, McBurney-Lin S, Mclean R, Nedelec P, Rashid AS, Tahon NH, Altes T, Baid U, Bhalerao R, Dhemesh Y, Floyd S, Godfrey D, Hilal F, Janas A, Kazerooni A, Kent C, Kirkpatrick J, Kofler F, Leu K, Maleki N, Menze B, Pajot M, Reitman ZJ, Rudie JD, Saluja R, Velichko Y, Wang C, Warman PI, Sollmann N, Diffley D, Nandolia KK, Warren DI, Hussain A, Fehringer JP, Bronstein Y, Deptula L, Stein EG, Taherzadeh M, Portela de Oliveira E, Haughey A, Kontzialis M, Saba L, Turner B, Brüßeler MMT, Ansari S, Gkampenis A, Weiss DM, Mansour A, Shawali IH, Yordanov N, Stein JM, Hourani R, Moshebah MY, Abouelatta AM, Rizvi T, Willms K, Martin DC, Okar A, D'Anna G, Taha A, Sharifi Y, Faghani S, Kite D, Pinho M, Haider MA, Alonso-Basanta M, Villanueva-Meyer J, Rauschecker AM, Nada A, Aboian M, Flanders A, Bakas S, Calabrese E. Sci Data. 2024 May 15; 2024 May 15. PMID: 38750041.
- Impact of (18)F-FDG PET Intensity Normalization on Radiomic Features of Oropharyngeal Squamous Cell Carcinomas and Machine Learning-Generated Biomarkers.Haider SP, Zeevi T, Sharaf K, Gross M, Mahajan A, Kann BH, Judson BL, Prasad ML, Burtness B, Aboian M, Canis M, Reichel CA, Baumeister P, Payabvash S. J Nucl Med. 2024 May 1; 2024 May 1. PMID: 38514087.
- Comparison of Volumetric and 2D Measurements and Longitudinal Trajectories in the Response Assessment of BRAF V600E-Mutant Pediatric Gliomas in the Pacific Pediatric Neuro-Oncology Consortium Clinical Trial.Ramakrishnan D, Brüningk SC, von Reppert M, Memon F, Maleki N, Aneja S, Kazerooni AF, Nabavizadeh A, Lin M, Bousabarah K, Molinaro A, Nicolaides T, Prados M, Mueller S, Aboian MS. AJNR Am J Neuroradiol. 2024 Apr 8; 2024 Apr 8. PMID: 38453411.
- Synaptic density patterns in early Alzheimer's disease assessed by independent component analysis.Fang XT, Raval NR, O'Dell RS, Naganawa M, Mecca AP, Chen MK, van Dyck CH, Carson RE. Brain Commun. 2024; 2024 Mar 26. PMID: 38601916.
- The regional pattern of age-related synaptic loss in the human brain differs from gray matter volume loss: in vivo PET measurement with [(11)C]UCB-J.Toyonaga T, Khattar N, Wu Y, Lu Y, Naganawa M, Gallezot JD, Matuskey D, Mecca AP, Pittman B, Dias M, Nabulsi NB, Finnema SJ, Chen MK, Arnsten A, Radhakrishnan R, Skosnik PD, D'Souza DC, Esterlis I, Huang Y, van Dyck CH, Carson RE. Eur J Nucl Med Mol Imaging. 2024 Mar; 2023 Nov 13. PMID: 37955791.
- A large open access dataset of brain metastasis 3D segmentations on MRI with clinical and imaging information.Ramakrishnan D, Jekel L, Chadha S, Janas A, Moy H, Maleki N, Sala M, Kaur M, Petersen GC, Merkaj S, von Reppert M, Baid U, Bakas S, Kirsch C, Davis M, Bousabarah K, Holler W, Lin M, Westerhoff M, Aneja S, Memon F, Aboian MS. Sci Data. 2024 Feb 29; 2024 Feb 29. PMID: 38424079.
- Everolimus for Children With Recurrent or Progressive Low-Grade Glioma: Results From the Phase II PNOC001 Trial.Haas-Kogan DA, Aboian MS, Minturn JE, Leary SES, Abdelbaki MS, Goldman S, Elster JD, Kraya A, Lueder MR, Ramakrishnan D, von Reppert M, Liu KX, Rokita JL, Resnick AC, Solomon DA, Phillips JJ, Prados M, Molinaro AM, Waszak SM, Mueller S. J Clin Oncol. 2024 Feb 1; 2023 Nov 17. PMID: 37978951.
- Comparison of volumetric and 2D-based response methods in the PNOC-001 pediatric low-grade glioma clinical trial.von Reppert M, Ramakrishnan D, Brüningk SC, Memon F, Abi Fadel S, Maleki N, Bahar R, Avesta AE, Jekel L, Sala M, Lost J, Tillmanns N, Kaur M, Aneja S, Fathi Kazerooni A, Nabavizadeh A, Lin M, Hoffmann KT, Bousabarah K, Swanson KR, Haas-Kogan D, Mueller S, Aboian MS. Neurooncol Adv. 2024 Jan-Dec; 2023 Dec 27. PMID: 38221978.
- Assessment of Gray Matter Microstructure and Synaptic Density in Alzheimer's Disease: A Multimodal Imaging Study With DTI and SV2A PET.Silva-Rudberg JA, Salardini E, O'Dell RS, Chen MK, Ra J, Georgelos JK, Morehouse MR, Melino KP, Varma P, Toyonaga T, Nabulsi NB, Huang Y, Carson RE, van Dyck CH, Mecca AP. Am J Geriatr Psychiatry. 2024 Jan; 2023 Aug 11. PMID: 37673749.
- Application of novel PACS-based informatics platform to identify imaging based predictors of CDKN2A allelic status in glioblastomas.Tillmanns N, Lost J, Tabor J, Vasandani S, Vetsa S, Marianayagam N, Yalcin K, Erson-Omay EZ, von Reppert M, Jekel L, Merkaj S, Ramakrishnan D, Avesta A, de Oliveira Santo ID, Jin L, Huttner A, Bousabarah K, Ikuta I, Lin M, Aneja S, Turowski B, Aboian M, Moliterno J. Sci Rep. 2023 Dec 22; 2023 Dec 22. PMID: 38135704.
- Clinical implications of Peri-hematomal edema microperfusion fraction in intracerebral hemorrhage intravoxel incoherent motion imaging - A pilot study.Abou Karam G, Tharmaseelan H, Aboian MS, Malhotra A, Gilmore EJ, Falcone GJ, de Havenon A, Sheth KN, Payabvash S. J Stroke Cerebrovasc Dis. 2023 Nov; 2023 Sep 20. PMID: 37738914.
- Systematic Literature Review of Machine Learning Algorithms Using Pretherapy Radiologic Imaging for Glioma Molecular Subtype Prediction.Lost J, Verma T, Jekel L, von Reppert M, Tillmanns N, Merkaj S, Petersen GC, Bahar R, Gordem A, Haider MA, Subramanian H, Brim W, Ikuta I, Omuro A, Conte GM, Marquez-Nostra BV, Avesta A, Bousabarah K, Nabavizadeh A, Kazerooni AF, Aneja S, Bakas S, Lin M, Sabel M, Aboian M. AJNR Am J Neuroradiol. 2023 Oct. PMID: 37770204.
- Local Economic Considerations in Selecting Artificial Intelligence Tools for Implementation.Davis MA, Ramakrishnan D, Sala M, Aboian M. J Am Coll Radiol. 2023 Oct; 2023 Aug 19. PMID: 37604325.
- PACS-Integrated Tools for Peritumoral Edema Volumetrics Provide Additional Information to RANO-BM-Based Assessment of Lung Cancer Brain Metastases after Stereotactic Radiotherapy: A Pilot Study.Kaur M, Cassinelli Petersen G, Jekel L, von Reppert M, Varghese S, Dixe de Oliveira Santo I, Avesta A, Aneja S, Omuro A, Chiang V, Aboian M. Cancers (Basel). 2023 Sep 30; 2023 Sep 30. PMID: 37835516.
- Evolution and implementation of radiographic response criteria in neuro-oncology.Ramakrishnan D, von Reppert M, Krycia M, Sala M, Mueller S, Aneja S, Nabavizadeh A, Galldiks N, Lohmann P, Raji C, Ikuta I, Memon F, Weinberg BD, Aboian MS. Neurooncol Adv. 2023 Jan-Dec; 2023 Sep 13. PMID: 37860269.
- A Large Open Access Dataset of Brain Metastasis 3D Segmentations with Clinical and Imaging Feature Information.Ramakrishnan D, Jekel L, Chadha S, Janas A, Moy H, Maleki N, Sala M, Kaur M, Petersen GC, Merkaj S, von Reppert M, Baid U, Bakas S, Kirsch C, Davis M, Bousabarah K, Holler W, Lin M, Westerhoff M, Aneja S, Memon F, Aboian MS. ArXiv. 2023 Sep 12; 2023 Sep 12. PMID: 37744461.
- PET/MRI Applications in Pediatric Epilepsy.Pedersen C, Aboian M, Messina SA, Daldrup-Link H, Franceschi AM. World J Nucl Med. 2023 Jun; 2023 Apr 28. PMID: 37223623.
- The Brain Tumor Segmentation (BraTS) Challenge 2023: Glioma Segmentation in Sub-Saharan Africa Patient Population (BraTS-Africa).Adewole M, Rudie JD, Gbdamosi A, Toyobo O, Raymond C, Zhang D, Omidiji O, Akinola R, Suwaid MA, Emegoakor A, Ojo N, Aguh K, Kalaiwo C, Babatunde G, Ogunleye A, Gbadamosi Y, Iorpagher K, Calabrese E, Aboian M, Linguraru M, Albrecht J, Wiestler B, Kofler F, Janas A, LaBella D, Kzerooni AF, Li HB, Iglesias JE, Farahani K, Eddy J, Bergquist T, Chung V, Shinohara RT, Wiggins W, Reitman Z, Wang C, Liu X, Jiang Z, Familiar A, Van Leemput K, Bukas C, Piraud M, Conte GM, Johansson E, Meier Z, Menze BH, Baid U, Bakas S, Dako F, Fatade A, Anazodo UC. ArXiv. 2023 May 30; 2023 May 30. PMID: 37396608.
- The role of imaging and sentinel lymph node biopsy in patients with T3b-T4b melanoma with clinically negative disease.Papageorge MV, Maina RM, King ALO, Lee V, Baumann R, Pucar D, Ariyan S, Khan SA, Weiss SA, Clune J, Olino K. Front Oncol. 2023; 2023 May 8. PMID: 37223678.
- Generation of Whole-Body FDG Parametric K(i) Images from Static PET Images Using Deep Learning.Miao T, Zhou B, Liu J, Guo X, Liu Q, Xie H, Chen X, Chen MK, Wu J, Carson RE, Liu C. IEEE Trans Radiat Plasma Med Sci. 2023 May; 2023 Feb 22. PMID: 37997577.
- Comparison of whole-body DW-MRI with 2-[(18)F]FDG PET for staging and treatment monitoring of children with Langerhans cell histiocytosis.Baratto L, Nyalakonda R, Theruvath AJ, Sarrami AH, Hawk KE, Rashidi A, Shen S, States L, Aboian M, Jeng M, Daldrup-Link HE. Eur J Nucl Med Mol Imaging. 2023 May; 2023 Jan 31. PMID: 36717409.
- Inter-pass motion correction for whole-body dynamic PET and parametric imaging.Guo X, Wu J, Chen MK, Liu Q, Onofrey JA, Pucar D, Pang Y, Pigg D, Casey ME, Dvornek NC, Liu C. IEEE Trans Radiat Plasma Med Sci. 2023 Apr; 2022 Dec 8. PMID: 37842204.
- Artificial Intelligence for Neuroimaging and Musculoskeletal Radiology: Overview of Current Commercial Algorithms.Berson ER, Aboian MS, Malhotra A, Payabvash S. Semin Roentgenol. 2023 Apr; 2023 Mar 31. PMID: 37087138.
- Automated tumor segmentation and brain tissue extraction from multiparametric MRI of pediatric brain tumors: A multi-institutional study.Fathi Kazerooni A, Arif S, Madhogarhia R, Khalili N, Haldar D, Bagheri S, Familiar AM, Anderson H, Haldar S, Tu W, Chul Kim M, Viswanathan K, Muller S, Prados M, Kline C, Vidal L, Aboian M, Storm PB, Resnick AC, Ware JB, Vossough A, Davatzikos C, Nabavizadeh A. Neurooncol Adv. 2023 Jan-Dec; 2023 Mar 16. PMID: 37051331.
- ImmunoPET Imaging Identifies the Optimal Timepoint for Combination Therapy in Xenograft Models of Triple-Negative Breast Cancer.Li Z, Belitzky E, Blaha O, Cavaliere A, Katz SR, Aboian M, Melegari L, Rajabimoghadam K, Kurpiewski S, Zhu X, Marquez-Nostra B. Cancers (Basel). 2023 Mar 3; 2023 Mar 3. PMID: 36900378.
- Comparing 3D, 2.5D, and 2D Approaches to Brain Image Auto-Segmentation.Avesta A, Hossain S, Lin M, Aboian M, Krumholz HM, Aneja S. Bioengineering (Basel). 2023 Feb 1; 2023 Feb 1. PMID: 36829675.
- Principal component analysis of synaptic density measured with [(11)C]UCB-J PET in early Alzheimer's disease.O'Dell RS, Higgins-Chen A, Gupta D, Chen MK, Naganawa M, Toyonaga T, Lu Y, Ni G, Chupak A, Zhao W, Salardini E, Nabulsi NB, Huang Y, Arnsten AFT, Carson RE, van Dyck CH, Mecca AP. Neuroimage Clin. 2023; 2023 Jun 22. PMID: 37422964.
- Brain PET Imaging: Approach to Cognitive Impairment and Dementia.Spano M, Roytman M, Aboian M, Saboury B, Franceschi A, Chiang GC. PET Clin. 2023 Jan. PMID: 36442959.
- Spectrum of qualitative and quantitative imaging of pilomyxoid, intermediate pilomyxoid and pilocytic astrocytomas in relation to their genetic alterations.Fadel SA, von Reppert M, Kazarian E, Omay EZE, Marks A, Linder N, Hoffmann KT, Darbinyan A, Huttner A, Aboian MS. Neuroradiology. 2023 Jan; 2022 Aug 19. PMID: 35984480.
- Synaptic density and cognitive performance in Alzheimer's disease: A PET imaging study with [(11) C]UCB-J.Mecca AP, O'Dell RS, Sharp ES, Banks ER, Bartlett HH, Zhao W, Lipior S, Diepenbrock NG, Chen MK, Naganawa M, Toyonaga T, Nabulsi NB, Vander Wyk BC, Arnsten AFT, Huang Y, Carson RE, van Dyck CH. Alzheimers Dement. 2022 Dec; 2022 Feb 17. PMID: 35174954.
- FDG PET vascular imaging in IgG4-RD: Potential and challenges.Pucar D, Hinchcliff M. J Nucl Cardiol. 2022 Dec; 2021 Dec 28. PMID: 34964084.
- Real-world assessment of the clinical utility of whole body 18F-FDG PET/CT in the diagnosis of infection.Medvedeva N, Radcliffe C, Malinis M, Chen MK, Azar MM. PLoS One. 2022; 2022 Nov 14. PMID: 36374789.
- Drug characteristics derived from kinetic modeling: combined (11)C-UCB-J human PET imaging with levetiracetam and brivaracetam occupancy of SV2A.Naganawa M, Gallezot JD, Finnema SJ, Maguire RP, Mercier J, Nabulsi NB, Kervyn S, Henry S, Nicolas JM, Huang Y, Chen MK, Hannestad J, Klitgaard H, Stockis A, Carson RE. EJNMMI Res. 2022 Nov 8; 2022 Nov 8. PMID: 36346513.
- Systemic inflammation enhances stimulant-induced striatal dopamine elevation in tobacco smokers.Zakiniaeiz Y, Hoye J, Ryan Petrulli J, LeVasseur B, Stanley G, Gao H, Najafzadeh S, Ropchan J, Nabulsi N, Huang Y, Chen MK, Matuskey D, Barron DS, Kelmendi B, Fulbright RK, Hampson M, Cosgrove KP, Morris ED. Brain Behav Immun. 2022 Nov; 2022 Sep 1. PMID: 36058419.
- Nicotine Patch Alters Patterns of Cigarette Smoking-Induced Dopamine Release: Patterns Relate to Biomarkers Associated With Treatment Response.Zakiniaeiz Y, Liu H, Gao H, Najafzadeh S, Ropchan J, Nabulsi N, Huang Y, Matuskey D, Chen MK, Cosgrove KP, Morris ED. Nicotine Tob Res. 2022 Oct 17. PMID: 35100429.
- Clinical implementation of artificial intelligence in neuroradiology with development of a novel workflow-efficient picture archiving and communication system-based automated brain tumor segmentation and radiomic feature extraction.Aboian M, Bousabarah K, Kazarian E, Zeevi T, Holler W, Merkaj S, Cassinelli Petersen G, Bahar R, Subramanian H, Sunku P, Schrickel E, Bhawnani J, Zawalich M, Mahajan A, Malhotra A, Payabvash S, Tocino I, Lin M, Westerhoff M. Front Neurosci. 2022; 2022 Oct 13. PMID: 36312024.
- PET Image Denoising using a Deep-Learning Method for Extremely Obese Patients.Liu H, Yousefi H, Mirian N, Lin M, Menard D, Gregory M, Aboian M, Boustani A, Chen MK, Saperstein L, Pucar D, Kulon M, Liu C. IEEE Trans Radiat Plasma Med Sci. 2022 Sep; 2021 Dec 2. PMID: 37284026.
- Virtual high-count PET image generation using a deep learning method.Liu J, Ren S, Wang R, Mirian N, Tsai YJ, Kulon M, Pucar D, Chen MK, Liu C. Med Phys. 2022 Sep; 2022 Aug 13. PMID: 35880541.
- Real-time PACS-integrated longitudinal brain metastasis tracking tool provides comprehensive assessment of treatment response to radiosurgery.Cassinelli Petersen G, Bousabarah K, Verma T, von Reppert M, Jekel L, Gordem A, Jang B, Merkaj S, Abi Fadel S, Owens R, Omuro A, Chiang V, Ikuta I, Lin M, Aboian MS. Neurooncol Adv. 2022 Jan-Dec; 2022 Jul 26. PMID: 36043121.
- Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 2: Inflammation, Fibrosis, Thrombosis, Calcification, and Amyloidosis Imaging.Stendahl JC, Kwan JM, Pucar D, Sadeghi MM. J Nucl Med. 2022 Jul. PMID: 35772956.
- Deep learning-based attenuation correction for whole-body PET - a multi-tracer study with (18)F-FDG, (68) Ga-DOTATATE, and (18)F-Fluciclovine.Toyonaga T, Shao D, Shi L, Zhang J, Revilla EM, Menard D, Ankrah J, Hirata K, Chen MK, Onofrey JA, Lu Y. Eur J Nucl Med Mol Imaging. 2022 Jul; 2022 Mar 12. PMID: 35277742.
- Identifying clinically applicable machine learning algorithms for glioma segmentation: recent advances and discoveries.Tillmanns N, Lum AE, Cassinelli G, Merkaj S, Verma T, Zeevi T, Staib L, Subramanian H, Bahar RC, Brim W, Lost J, Jekel L, Brackett A, Payabvash S, Ikuta I, Lin M, Bousabarah K, Johnson MH, Cui J, Malhotra A, Omuro A, Turowski B, Aboian MS. Neurooncol Adv. 2022 Jan-Dec; 2022 Jun 14. PMID: 36071926.
- Inhibition of type 1 immunity with tofacitinib is associated with marked improvement in longstanding sarcoidosis.Damsky W, Wang A, Kim DJ, Young BD, Singh K, Murphy MJ, Daccache J, Clark A, Ayasun R, Ryu C, McGeary MK, Odell ID, Fazzone-Chettiar R, Pucar D, Homer R, Gulati M, Miller EJ, Bosenberg M, Flavell RA, King B. Nat Commun. 2022 Jun 6; 2022 Jun 6. PMID: 35668129.
- Imaging of Synaptic Density in Neurodegenerative Disorders.Carson RE, Naganawa M, Toyonaga T, Koohsari S, Yang Y, Chen MK, Matuskey D, Finnema SJ. J Nucl Med. 2022 Jun. PMID: 35649655.
- Machine Learning Tools for Image-Based Glioma Grading and the Quality of Their Reporting: Challenges and Opportunities.Merkaj S, Bahar RC, Zeevi T, Lin M, Ikuta I, Bousabarah K, Cassinelli Petersen GI, Staib L, Payabvash S, Mongan JT, Cha S, Aboian MS. Cancers (Basel). 2022 May 25; 2022 May 25. PMID: 35681603.
- Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 1: Technical Considerations and Perfusion and Neuronal Imaging.Stendahl JC, Kwan JM, Pucar D, Sadeghi MM. J Nucl Med. 2022 May. PMID: 35487563.
- Molecular testing of isolated myeloid sarcoma allows successful FLT3-targeted therapy.Shallis RM, Pucar D, Perincheri S, Gore SD, Seropian SE, Podoltsev NA, Zeidan AM. Ann Hematol. 2022 May; 2021 Oct 22. PMID: 34686913.
- Clinical Evaluation of Nuclear Imaging Agents in Breast Cancer.Li Z, Aboian MS, Zhu X, Marquez-Nostra B. Cancers (Basel). 2022 Apr 23; 2022 Apr 23. PMID: 35565232.
- Machine Learning Models for Classifying High- and Low-Grade Gliomas: A Systematic Review and Quality of Reporting Analysis.Bahar RC, Merkaj S, Cassinelli Petersen GI, Tillmanns N, Subramanian H, Brim WR, Zeevi T, Staib L, Kazarian E, Lin M, Bousabarah K, Huttner AJ, Pala A, Payabvash S, Ivanidze J, Cui J, Malhotra A, Aboian MS. Front Oncol. 2022; 2022 Apr 22. PMID: 35530302.
- Ipsilateral Malignant Axillary Lymphadenopathy and Contralateral Reactive Lymph Nodes in a COVID-19 Vaccine Recipient With Breast Cancer.Adin ME, Wu J, Isufi E, Tsui E, Pucar D. J Breast Cancer. 2022 Apr; 2021 Mar 15. PMID: 35380021.
- Brain Tumor Imaging: Applications of Artificial Intelligence.Afridi M, Jain A, Aboian M, Payabvash S. Semin Ultrasound CT MR. 2022 Apr; 2022 Feb 11. PMID: 35339256.
- Radiomics: A Primer on Processing Workflow and Analysis.Avery E, Sanelli PC, Aboian M, Payabvash S. Semin Ultrasound CT MR. 2022 Apr; 2022 Feb 12. PMID: 35339254.
- Infective Endocarditis White Blood Cell Imaging: Is There an Added Value to the First-Line Imaging?Pucar D, William Strauss H. J Nucl Cardiol. 2022 Apr; 2021 Jul 6. PMID: 34228332.
- Neuropathology of Chiari Malformation II with Chromosome X Alterations: An Autopsy Study in a 17-Month-Old and Review of Literature.Wang X, Habet V, Aboian M, Leelatian N, McGuone D, Morotti R, Kandil S, Darbinyan A. J Neuropathol Exp Neurol. 2022 Mar 29. PMID: 35139536.
- Machine Learning Applications for Differentiation of Glioma from Brain Metastasis-A Systematic Review.Jekel L, Brim WR, von Reppert M, Staib L, Cassinelli Petersen G, Merkaj S, Subramanian H, Zeevi T, Payabvash S, Bousabarah K, Lin M, Cui J, Brackett A, Mahajan A, Omuro A, Johnson MH, Chiang VL, Malhotra A, Scheffler B, Aboian MS. Cancers (Basel). 2022 Mar 8; 2022 Mar 8. PMID: 35326526.
- Association of entorhinal cortical tau deposition and hippocampal synaptic density in older individuals with normal cognition and early Alzheimer's disease.Mecca AP, Chen MK, O'Dell RS, Naganawa M, Toyonaga T, Godek TA, Harris JE, Bartlett HH, Zhao W, Banks ER, Ni GS, Rogers K, Gallezot JD, Ropchan J, Emery PR, Nabulsi NB, Vander Wyk BC, Arnsten AFT, Huang Y, Carson RE, van Dyck CH. Neurobiol Aging. 2022 Mar; 2021 Nov 20. PMID: 34963063.
- Radiation Necrosis with Proton Therapy in a Patient with Aarskog-Scott Syndrome and Medulloblastoma.Puthenpura V, DeNunzio NJ, Zeng X, Giantsoudi D, Aboian M, Ebb D, Kahle KT, Yock TI, Marks AM. Int J Part Ther. 2022 Winter; 2021 Jul 29. PMID: 35127977.
- Trends in Development of Novel Machine Learning Methods for the Identification of Gliomas in Datasets That Include Non-Glioma Images: A Systematic Review.Subramanian H, Dey R, Brim WR, Tillmanns N, Cassinelli Petersen G, Brackett A, Mahajan A, Johnson M, Malhotra A, Aboian M. Front Oncol. 2021; 2021 Dec 23. PMID: 35004312.
- Methods of Sentinel Lymph Node Identification in Auricular Melanoma.Noorbakhsh S, Papageorge M, Maina RM, Baumann R, Moores C, Weiss SA, Pucar D, Ariyan S, Olino K, Clune J. Plast Reconstr Surg Glob Open. 2021 Dec; 2021 Dec 20. PMID: 34938645.
- Determining the minimal ultra-low dose CT for reliable attenuation correction of (18)F-FDG PET-CT: a phantom study.Cheng D, Ghita M, Menard D, Chen MK. J Nucl Med Technol. 2021 Nov 8; 2021 Nov 8. PMID: 34750234.
- Clinical PET/CT utilization during the COVID-19 pandemic: initial experience at Yale University.Adin ME, Uezono H, Isufi E, Pang Y, Zucconi W, Saperstein L, Pucar D. Nucl Med Commun. 2021 Nov 1. PMID: 34049340.
- Correction to: Incidence and characteristics of metastatic intracranial lesions in stage III and IV melanoma: a single institute retrospective analysis.Sandhu MRS, Chiang VL, Tran T, Yu JB, Weiss SA, Goldberg SB, Aboian MS, Kluger HM, Mahajan A. J Neurooncol. 2021 Sep. PMID: 34403041.
- Incidence and characteristics of metastatic intracranial lesions in stage III and IV melanoma: a single institute retrospective analysis.Sandhu MRS, Chiang VL, Tran T, Yu JB, Weiss SA, Goldberg SB, Aboian MS, Kluger HM, Mahajan A. J Neurooncol. 2021 Sep; 2021 Aug 5. PMID: 34351544.
- Type of bony involvement predicts genomic subgroup in sphenoid wing meningiomas.Jin L, Youngblood MW, Gupte TP, Vetsa S, Nadar A, Barak T, Yalcin K, Aguilera SM, Mishra-Gorur K, Blondin NA, Gorelick E, Omay SB, Pointdujour-Lim R, Judson BL, Alperovich M, Aboian MS, McGuone D, Gunel M, Erson-Omay Z, Fulbright RK, Moliterno J. J Neurooncol. 2021 Sep; 2021 Aug 4. PMID: 34350560.
- Generation of parametric K(i) images for FDG PET using two 5-min scans.Wu J, Liu H, Ye Q, Gallezot JD, Naganawa M, Miao T, Lu Y, Chen MK, Esserman DA, Kyriakides TC, Carson RE, Liu C. Med Phys. 2021 Sep; 2021 Aug 13. PMID: 34287939.
- Generation of synthetic PET images of synaptic density and amyloid from (18) F-FDG images using deep learning.Wang R, Liu H, Toyonaga T, Shi L, Wu J, Onofrey JA, Tsai YJ, Naganawa M, Ma T, Liu Y, Chen MK, Mecca AP, O'Dell RS, van Dyck CH, Carson RE, Liu C. Med Phys. 2021 Sep; 2021 Jul 27. PMID: 34224153.
- Partial volume correction analysis for (11)C-UCB-J PET studies of Alzheimer's disease.Lu Y, Toyonaga T, Naganawa M, Gallezot JD, Chen MK, Mecca AP, van Dyck CH, Carson RE. Neuroimage. 2021 Sep; 2021 Jun 11. PMID: 34119639.
- Comparison of [(11)C]UCB-J and [(18)F]FDG PET in Alzheimer's disease: A tracer kinetic modeling study.Chen MK, Mecca AP, Naganawa M, Gallezot JD, Toyonaga T, Mondal J, Finnema SJ, Lin SF, O'Dell RS, McDonald JW, Michalak HR, Vander Wyk B, Nabulsi NB, Huang Y, Arnsten AF, van Dyck CH, Carson RE. J Cereb Blood Flow Metab. 2021 Sep; 2021 Mar 24. PMID: 33757318.
- Author Correction: Topographic correlates of driver mutations and endogenous gene expression in pediatric diffuse midline gliomas and hemispheric high-grade gliomas.Kazarian E, Marks A, Cui J, Darbinyan A, Tong E, Mueller S, Cha S, Aboian MS. Sci Rep. 2021 Aug 11; 2021 Aug 11. PMID: 34381151.
- Letter regarding "Contribution of PET imaging to radiotherapy planning and monitoring in glioma patients-a report of the PET/RANO group": 18F-fluciclovine and target volume delineation.Kotecha R, Aboian M, Nabavizadeh SA, Parent EE, Trifiletti DM, Chao ST. Neuro Oncol. 2021 Aug 2. PMID: 34081125.
- Association of COVID-19 mRNA Vaccine With Ipsilateral Axillary Lymph Node Reactivity on Imaging.Adin ME, Isufi E, Kulon M, Pucar D. JAMA Oncol. 2021 Aug 1. PMID: 34110378.
- Standardization and quantification is a key to the future of atherosclerosis FDG PET/CT imaging.Pucar D, Liu C. J Nucl Cardiol. 2021 Aug; 2019 Oct 7. PMID: 31591696.
- Topographic correlates of driver mutations and endogenous gene expression in pediatric diffuse midline gliomas and hemispheric high-grade gliomas.Kazarian E, Marks A, Cui J, Darbinyan A, Tong E, Mueller S, Cha S, Aboian MS. Sci Rep. 2021 Jul 13; 2021 Jul 13. PMID: 34257334.
- Cocaine-induced pulmonary complications: A diagnosis of waiting and watching.Munagala R, Chiruvella V, Pucar D, Keshavamurthy J. Lung India. 2021 Jul-Aug. PMID: 34259176.
- Theranostics in Brain Tumors.Shooli H, Nemati R, Ahmadzadehfar H, Aboian M, Jafari E, Jokar N, Nabipour I, Dadgar H, Gholamrezanezhad A, Larvie M, Assadi M. PET Clin. 2021 Jul. PMID: 34053584.
- Reply by Authors.Pienta KJ, Gorin MA, Rowe SP, Carroll PR, Pouliot F, Probst S, Saperstein L, Preston MA, Alva AS, Patnaik A, Durack JC, Stambler N, Lin T, Jensen J, Wong V, Siegel BA, Morris MJ. J Urol. 2021 Jul; 2021 Apr 15. PMID: 33853358.
- A Phase 2/3 Prospective Multicenter Study of the Diagnostic Accuracy of Prostate Specific Membrane Antigen PET/CT with (18)F-DCFPyL in Prostate Cancer Patients (OSPREY).Pienta KJ, Gorin MA, Rowe SP, Carroll PR, Pouliot F, Probst S, Saperstein L, Preston MA, Alva AS, Patnaik A, Durack JC, Stambler N, Lin T, Jensen J, Wong V, Siegel BA, Morris MJ. J Urol. 2021 Jul; 2021 Feb 26. PMID: 33634707.
- Diagnostic Performance of (18)F-DCFPyL-PET/CT in Men with Biochemically Recurrent Prostate Cancer: Results from the CONDOR Phase III, Multicenter Study.Morris MJ, Rowe SP, Gorin MA, Saperstein L, Pouliot F, Josephson D, Wong JYC, Pantel AR, Cho SY, Gage KL, Piert M, Iagaru A, Pollard JH, Wong V, Jensen J, Lin T, Stambler N, Carroll PR, Siegel BA. Clin Cancer Res. 2021 Jul 1; 2021 Feb 23. PMID: 33622706.
- Intracystic Papillary Neoplasm of Gallbladder Mimicking Metastatic Malignancy on PET/CT.Ismail R, Saeed Bamashmos A, Cohen PJ, Pucar D. Clin Nucl Med. 2021 Jul 1. PMID: 33234941.
- (18)F-Fluorodeoxyglucose PET imaging in aortic graft infection: many more questions than answers.Pucar D, Sadeghi MM. J Nucl Cardiol. 2021 Jun; 2020 Jun 30. PMID: 32607838.
- Binding of the synaptic vesicle radiotracer [(11)C]UCB-J is unchanged during functional brain activation using a visual stimulation task.Smart K, Liu H, Matuskey D, Chen MK, Torres K, Nabulsi N, Labaree D, Ropchan J, Hillmer AT, Huang Y, Carson RE. J Cereb Blood Flow Metab. 2021 May; 2020 Aug 5. PMID: 32757741.
- Altered FDG Biodistribution in Subcutaneous White Fat on PET/CT Following l-Asparaginase Chemotherapy.Young CR, Kulon ME, Boustani AM, Pucar D. Clin Nucl Med. 2021 Mar 1. PMID: 33086270.
- Maximizing the use of batch production of (18)F-FDOPA for imaging of brain tumors to increase availability of hybrid PET/MR imaging in clinical setting.Aboian M, Barajas R, Shatalov J, Ravanfar V, Bahroos E, Tong E, Taylor JW, Bush NO, Sneed P, Seo Y, Cha S, Hernandez-Pampaloni M. Neurooncol Pract. 2021 Feb; 2020 Oct 14. PMID: 33664973.
- Gallbladder Perforation Into the Peritoneal Cavity.Wang BF, Yi S, Keshavamurthy J, Williams H, Pucar D. Clin Nucl Med. 2021 Feb 1. PMID: 33031242.
- Changes in Population-Level and Institutional-Level Prescribing Habits of Radioiodine Therapy for Papillary Thyroid Cancer.Jacobs D, Breen CT, Pucar D, Holt EH, Judson BL, Mehra S. Thyroid. 2021 Feb; 2020 Sep 22. PMID: 32811347.
- Association of Aβ deposition and regional synaptic density in early Alzheimer's disease: a PET imaging study with [(11)C]UCB-J.O'Dell RS, Mecca AP, Chen MK, Naganawa M, Toyonaga T, Lu Y, Godek TA, Harris JE, Bartlett HH, Banks ER, Kominek VL, Zhao W, Nabulsi NB, Ropchan J, Ye Y, Vander Wyk BC, Huang Y, Arnsten AFT, Carson RE, van Dyck CH. Alzheimers Res Ther. 2021 Jan 5; 2021 Jan 5. PMID: 33402201.
- (124)I-MIBG PET/CT to Monitor Metastatic Disease in Children with Relapsed Neuroblastoma.Aboian MS, Huang SY, Hernandez-Pampaloni M, Hawkins RA, VanBrocklin HF, Huh Y, Vo KT, Gustafson WC, Matthay KK, Seo Y. J Nucl Med. 2021 Jan; 2020 May 15. PMID: 32414950.
- Assessment of population-based input functions for Patlak imaging of whole body dynamic (18)F-FDG PET.Naganawa M, Gallezot JD, Shah V, Mulnix T, Young C, Dias M, Chen MK, Smith AM, Carson RE. EJNMMI Phys. 2020 Nov 23; 2020 Nov 23. PMID: 33226522.
- Reduced synaptic vesicle protein 2A binding in temporal lobe epilepsy: A [(11) C]UCB-J positron emission tomography study.Finnema SJ, Toyonaga T, Detyniecki K, Chen MK, Dias M, Wang Q, Lin SF, Naganawa M, Gallezot JD, Lu Y, Nabulsi NB, Huang Y, Spencer DD, Carson RE. Epilepsia. 2020 Oct; 2020 Sep 18. PMID: 32944949.
- Nuclear Medicine Advanced Associates: Physician Extenders in Nuclear Medicine-Now Is the Time.Owen MA, Sinotte KN, Bolus N, Siska R, Jacob J, LaRue V, Norton B, Pucar D. J Nucl Med Technol. 2020 Sep; 2020 Apr 20. PMID: 32312850.
- Inferior vena cava syndrome on skeletal scintigraphy secondary to metastatic prostate cancer.Makusha LP, Kulon M, Pucar D, Young CR. World J Nucl Med. 2020 Jul-Sep; 2020 Jul 2. PMID: 33354201.