2022
Vancomycin Should Be Considered a Nephrotoxic Antimicrobial Agent: COMMENTARY
Perazella MA. Vancomycin Should Be Considered a Nephrotoxic Antimicrobial Agent: COMMENTARY. Kidney360 2022, 3: 1491-1493. PMID: 36250736, PMCID: PMC9528384, DOI: 10.34067/kid.0008112021.Peer-Reviewed Original Research
2021
Urinary NGAL as a Diagnostic and Prognostic Marker for Acute Kidney Injury in Cirrhosis: A Prospective Study
Allegretti AS, Parada XV, Endres P, Zhao S, Krinsky S, St. Hillien SA, Kalim S, Nigwekar SU, Flood JG, Nixon A, Simonetto DA, Juncos LA, Karakala N, Wadei HM, Regner KR, Belcher JM, Nadim MK, Garcia-Tsao G, Velez JCQ, Parikh SM, Chung RT. Urinary NGAL as a Diagnostic and Prognostic Marker for Acute Kidney Injury in Cirrhosis: A Prospective Study. Clinical And Translational Gastroenterology 2021, 12: e00359. PMID: 33979307, PMCID: PMC8116001, DOI: 10.14309/ctg.0000000000000359.Peer-Reviewed Original ResearchConceptsNeutrophil Gelatinase-Associated LipocalinUrinary neutrophil gelatinase-associated lipocalinAcute kidney injuryAcute tubular necrosisPrerenal acute kidney injuryHepatorenal syndromeKidney injuryC-statisticManagement of AKITypes of AKIEnd-stage liver disease (MELD) scoreTransplant-free survivalLiver Disease scoreMedian serum creatinineGelatinase-Associated LipocalinPrediction of mortalityNet reclassification indexDiscrimination incrementProspective cohortSerum creatinineTubular necrosisProspective studyReclassification indexUnadjusted analysesPrognostic marker
2016
Urine Interleukin 18 and Lipocalin 2 Are Biomarkers of Acute Tubular Necrosis in Patients With Cirrhosis: A Systematic Review and Meta-analysis
Puthumana J, Ariza X, Belcher JM, Graupera I, Ginès P, Parikh CR. Urine Interleukin 18 and Lipocalin 2 Are Biomarkers of Acute Tubular Necrosis in Patients With Cirrhosis: A Systematic Review and Meta-analysis. Clinical Gastroenterology And Hepatology 2016, 15: 1003-1013.e3. PMID: 28013112, PMCID: PMC5474196, DOI: 10.1016/j.cgh.2016.11.035.Peer-Reviewed Original ResearchConceptsNeutrophil Gelatinase-Associated LipocalinAcute tubular necrosisUrine levelsUrine biomarkersSystematic reviewKidney impairmentKidney injuryTubular necrosisLipocalin-2Development of ATNAUC valuesEtiology of AKIUrine interleukin-18Acute kidney injuryGelatinase-Associated LipocalinShort-term mortalityLogistic mixed-effects modelsHepatorenal syndromeCause mortalityPrerenal azotemiaCommon complicationInterleukin-18Prospective studyPatient outcomesCommon causeApplication of new acute kidney injury biomarkers in human randomized controlled trials
Parikh CR, Moledina DG, Coca SG, Thiessen-Philbrook HR, Garg AX. Application of new acute kidney injury biomarkers in human randomized controlled trials. Kidney International 2016, 89: 1372-1379. PMID: 27165835, PMCID: PMC4869991, DOI: 10.1016/j.kint.2016.02.027.Peer-Reviewed Original ResearchConceptsAcute kidney injuryAKI biomarkersKidney injuryClinical trialsNew biomarkersEarly acute kidney injuryObserved relative risk reductionPostoperative acute kidney injuryAcute kidney injury biomarkersHypothetical trialKidney injury progressionMulti-country trialAcute tubular necrosisCardiopulmonary bypass timeClinical risk factorsKidney injury biomarkersProportion of patientsProspective cohort studyKidney injury markersRelative risk reductionAKI progressionAKI trialsBypass timeCohort studyInjury markers
2013
Renalase Protects against Ischemic AKI
Lee HT, Kim JY, Kim M, Wang P, Tang L, Baroni S, D’Agati V, Desir GV. Renalase Protects against Ischemic AKI. Journal Of The American Society Of Nephrology 2013, 24: 445-455. PMID: 23393318, PMCID: PMC3582209, DOI: 10.1681/asn.2012090943.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdrenergic alpha-AntagonistsAnimalsApoptosisGene ExpressionHumansInflammation MediatorsIschemiaKidney Tubular Necrosis, AcuteMacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutMonoamine OxidaseNeutrophil InfiltrationNorepinephrinePhentolamineRecombinant ProteinsReperfusion InjuryRNA, MessengerConceptsRenal ischemia-reperfusion injuryIschemia-reperfusion injuryIschemic AKIWild-type miceReperfusion injuryCatecholamine levelsRenal tubular inflammationTreatment of AKIRenal ischemia reperfusionSham-operated micePlasma catecholamine levelsRenal tubular necrosisRecombinant human renalasePlasma renalaseTubular inflammationTubular necrosisIschemia reperfusionNE levelsPlasma catecholaminesMyocardial necrosisInflammatory responseProximal tubulesAKIRenalaseMice
2012
A Dysfunctional Peritoneal Dialysis Catheter: Imaging the Problem
Luciano RL, Brewster UC. A Dysfunctional Peritoneal Dialysis Catheter: Imaging the Problem. Seminars In Dialysis 2012, 25: 560-561. PMID: 22780865, DOI: 10.1111/j.1525-139x.2012.01108.x.Peer-Reviewed Case Reports and Technical NotesLow Cefepime Concentrations during High Blood and Dialysate Flow Continuous Venovenous Hemodialysis
Wilson FP, Bachhuber MA, Caroff D, Adler R, Fish D, Berns J. Low Cefepime Concentrations during High Blood and Dialysate Flow Continuous Venovenous Hemodialysis. Antimicrobial Agents And Chemotherapy 2012, 56: 2178-2180. PMID: 22290968, PMCID: PMC3318326, DOI: 10.1128/aac.05987-11.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Bacterial AgentsCefepimeCephalosporinsChromatography, High Pressure LiquidFemaleHalf-LifeHemofiltrationHumansKidney Failure, ChronicKidney Tubular Necrosis, AcuteMaleMicrobial Sensitivity TestsMiddle AgedPseudomonas aeruginosaShock, CardiogenicSpectrophotometry, UltravioletYoung Adult
2011
Is It Time to Evolve Past the Prerenal Azotemia versus Acute Tubular Necrosis Classification?
Belcher JM, Parikh CR. Is It Time to Evolve Past the Prerenal Azotemia versus Acute Tubular Necrosis Classification? Clinical Journal Of The American Society Of Nephrology 2011, 6: 2332-2334. PMID: 21921150, PMCID: PMC3186449, DOI: 10.2215/cjn.08570811.Commentaries, Editorials and LettersEpithelial CellsFemaleFluid TherapyHospitalizationHumansInpatientsKidney DiseasesKidney Tubular Necrosis, AcuteMaleMicroscopyUrinalysisUrine
2003
Bone marrow stem cells contribute to repair of the ischemically injured renal tubule
Kale S, Karihaloo A, Clark PR, Kashgarian M, Krause DS, Cantley LG. Bone marrow stem cells contribute to repair of the ischemically injured renal tubule. Journal Of Clinical Investigation 2003, 112: 42-49. PMID: 12824456, PMCID: PMC162291, DOI: 10.1172/jci17856.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Marrow CellsBone Marrow TransplantationIschemiaKidney Tubular Necrosis, AcuteKidney TubulesMiceMice, Inbred C57BLStem CellsConceptsAcute tubular necrosisBone marrow stem cellsRenal tubulesMarrow stem cellsTubular necrosisRenal ischemiaTransient renal ischemiaAcute renal failureRenal tubular epithelial cellsStem cell infusionBlood urea nitrogenStem cellsTubular epithelial cellsMouse bone marrowRenal failureCell infusionHuman trialsTubular epitheliumBone marrowUrea nitrogenLin-Sca-1Adult mouse bone marrowNecrotic tubulesGreater riseEpithelial cells
1992
Expression of vascular cell adhesion molecule-1 in human renal allografts.
Briscoe DM, Pober JS, Harmon WE, Cotran RS. Expression of vascular cell adhesion molecule-1 in human renal allografts. Journal Of The American Society Of Nephrology 1992, 3: 1180-5. PMID: 1282831, DOI: 10.1681/asn.v351180.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAntigens, CDAntigens, Differentiation, MyelomonocyticCD3 ComplexCell Adhesion MoleculesE-SelectinEndothelium, VascularGraft RejectionHumansIntercellular Adhesion Molecule-1Kidney TransplantationKidney Tubular Necrosis, AcuteKidney TubulesMacrophagesMonocytesPostoperative ComplicationsT-Lymphocyte SubsetsTransplantation, HomologousVascular Cell Adhesion Molecule-1ConceptsVascular cell adhesion molecule-1Cell adhesion molecule-1VCAM-1 expressionAdhesion molecule-1Renal allograftsNormal biopsiesMolecule-1Human renal allograft biopsiesMonocyte/macrophage infiltrateEndothelial VCAM-1 expressionAcute tubular necrosisRenal allograft biopsiesT-cell infiltratesT cell infiltrationHuman renal allograftsEndothelial VCAM-1Normal kidney specimensArea of infiltratesMean scoreVascular endothelial cellsAcute rejectionAllograft biopsiesTubular necrosisCell infiltrateClinicopathologic diagnosis
1991
Can Ibuprofen Cause Acute Renal Failure in a Normal Individual? A Case of Acute Overdose
Perazella M, Buller G. Can Ibuprofen Cause Acute Renal Failure in a Normal Individual? A Case of Acute Overdose. American Journal Of Kidney Diseases 1991, 18: 600-602. PMID: 1951342, DOI: 10.1016/s0272-6386(12)80657-3.Peer-Reviewed Original ResearchConceptsNonsteroidal antiinflammatory drugsAcute renal failureRenal blood flowRenal failureAcute renal insufficiencyCase of AcuteRenal insufficiencyTubular necrosisAntiinflammatory drugsBlood flowRenal syndromeClinical situationsNormal individualsIbuprofenFailureAcutePatientsSyndromeInsufficiencyNecrosis
1977
Renal disease.
Kashgarian M, Hayslett J, Spargo B. Renal disease. American Journal Of Pathology 1977, 89: 183-272. PMID: 143893, PMCID: PMC2032191.Peer-Reviewed Original Research
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