2020
Lysis of cold-storage-induced microvascular obstructions for ex vivo revitalization of marginal human kidneys
DiRito JR, Hosgood SA, Reschke M, Albert C, Bracaglia LG, Ferdinand JR, Stewart BJ, Edwards CM, Vaish AG, Thiru S, Mulligan DC, Haakinson DJ, Clatworthy MR, Saltzman WM, Pober JS, Nicholson ML, Tietjen GT. Lysis of cold-storage-induced microvascular obstructions for ex vivo revitalization of marginal human kidneys. American Journal Of Transplantation 2020, 21: 161-173. PMID: 32627324, PMCID: PMC7775334, DOI: 10.1111/ajt.16148.Peer-Reviewed Original ResearchConceptsNormothermic machine perfusionHuman kidneyMicrovascular obstructionMarginal organsHigh-risk donorsSevere organ shortageLikelihood of complicationsMicrovascular blood flowAccumulation of fibrinogenCold storage injuryTissue plasminogen activatorImmediate translational potentialMicrovascular pluggingRenal functionRenal injuryMachine perfusionTubular epitheliumBlood flowIntravascular releaseOrgan shortagePhysiologic impactKidneyTranslational potentialPlasminogen activatorVivo assessment
2009
Renal FcRn Reclaims Albumin but Facilitates Elimination of IgG
Sarav M, Wang Y, Hack B, Chang A, Jensen M, Bao L, Quigg R. Renal FcRn Reclaims Albumin but Facilitates Elimination of IgG. Journal Of The American Society Of Nephrology 2009, 20: 1941-1952. PMID: 19661163, PMCID: PMC2736763, DOI: 10.1681/asn.2008090976.Peer-Reviewed Original ResearchConceptsElimination of IgGFcRn(-/-Renal lossFcRn(-/-) miceMinimal urinary excretionSerum albumin levelWild-type miceWild-type kidneysSerum concentrations of albuminProximal tubular epitheliumWild-type controlsDevelopment of hypoalbuminemiaNeonatal Fc receptorLoss of IgGLoss of albuminSerum levelsAlbumin levelsIncreased to wild-type levelsUrinary excretionSerum concentrationsFc receptorsTubular epitheliumConcentrations of albuminPlasma protein poolKidney
2008
The Collecting Duct Is the Major Source of Prorenin in Diabetes
Kang J, Toma I, Sipos A, Meer E, Vargas S, Peti-Peterdi J. The Collecting Duct Is the Major Source of Prorenin in Diabetes. Hypertension 2008, 51: 1597-1604. PMID: 18413493, PMCID: PMC2398652, DOI: 10.1161/hypertensionaha.107.107268.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin IIAngiotensin II Type 1 Receptor BlockersAnimalsCell DivisionCells, CulturedDiabetes Mellitus, ExperimentalDiabetic NephropathiesDisease Models, AnimalHypertension, RenalImidazolesImmunohistochemistryJuxtaglomerular ApparatusKidney Tubules, CollectingMicroscopy, FluorescenceQuinacrineRatsRats, WistarReninTetrazolesTrypsinVasoconstrictor AgentsConceptsCD reninRenin activityJuxtaglomerular apparatusAng II type 1 receptor blockadeType 1 receptor blockadeRenin-Ang systemAng II activityAng II treatmentCD cell lineRenal tubular epitheliumMunich-Wistar ratsHigh prorenin levelsVivo multiphoton microscopyJuxtaglomerular reninProrenin contentReceptor blockadeDiabetes mellitusAng IIProrenin levelsAngiotensin IIRenin contentRat modelRenin assaysII treatmentTubular epithelium
2003
Proteolytic processing of laminin‐5 by MT1‐MMP in tissues and its effects on epithelial cell morphology
Koshikawa N, Schenk S, Moeckel G, Sharabi A, Miyazaki K, Gardner H, Zent R, Quaranta V. Proteolytic processing of laminin‐5 by MT1‐MMP in tissues and its effects on epithelial cell morphology. The FASEB Journal 2003, 18: 1-22. PMID: 14688206, DOI: 10.1096/fj.03-0584fje.Peer-Reviewed Original ResearchBone marrow stem cells contribute to repair of the ischemically injured renal tubule
Kale S, Karihaloo A, Clark PR, Kashgarian M, Krause DS, Cantley LG. Bone marrow stem cells contribute to repair of the ischemically injured renal tubule. Journal Of Clinical Investigation 2003, 112: 42-49. PMID: 12824456, PMCID: PMC162291, DOI: 10.1172/jci17856.Peer-Reviewed Original ResearchConceptsAcute tubular necrosisBone marrow stem cellsRenal tubulesMarrow stem cellsTubular necrosisRenal ischemiaTransient renal ischemiaAcute renal failureRenal tubular epithelial cellsStem cell infusionBlood urea nitrogenStem cellsTubular epithelial cellsMouse bone marrowRenal failureCell infusionHuman trialsTubular epitheliumBone marrowUrea nitrogenLin-Sca-1Adult mouse bone marrowNecrotic tubulesGreater riseEpithelial cells
1986
Postischemic hemodynamics and recovery of renal adenosine triphosphate
Gaudio K, Stromski M, Thulin G, Ardito T, Kashgarian M, Siegel N. Postischemic hemodynamics and recovery of renal adenosine triphosphate. American Journal Of Physiology 1986, 251: f603-f609. PMID: 3490185, DOI: 10.1152/ajprenal.1986.251.4.f603.Peer-Reviewed Original ResearchConceptsRenal blood flowIschemic acute renal injuryImportant pathophysiological componentRenal ATP levelsAcute renal injuryInfusion of dopamineSaline-treated ratsPostischemic enhancementRenal adenosineRenal vasoconstrictionRenal injuryTubular functionPathophysiological componentPostischemic infusionInulin clearanceATP-MgCl2Vasoactive compoundsTubular epitheliumBlood flowPharmacological agentsPostischemic hemodynamicsTubular cellsSaline ratsEnhances recoveryRats
1982
Kinetics, competition, and selectivity of tubular absorption of proteins
Sumpio BE, Maack T. Kinetics, competition, and selectivity of tubular absorption of proteins. American Journal Of Physiology 1982, 243: f379-f392. PMID: 7124951, DOI: 10.1152/ajprenal.1982.243.4.f379.Peer-Reviewed Original ResearchConceptsBeta 2MTubular absorptionHuman growth hormoneLow perfusate calcium concentrationsPerfusate calcium concentrationMorphologic damageTubular epitheliumProximal tubulesGrowth hormoneRat kidneyCationic proteinCalcium concentrationSaturable processSaturating loadSelective effectLuminal wallLow apparent affinityTubulesImportant determinantReversible mannerApparent affinityMicrovilliProteinKidney
1978
Electrophysiological Measurements on the Renal Tubule
Boulpaep E, Giebisch G. Electrophysiological Measurements on the Renal Tubule. 1978, 165-193. DOI: 10.1007/978-1-4615-8894-8_7.Peer-Reviewed Original Research
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