2023
The β1-adrenergic receptor links sympathetic nerves to T cell exhaustion
Globig A, Zhao S, Roginsky J, Maltez V, Guiza J, Avina-Ochoa N, Heeg M, Araujo Hoffmann F, Chaudhary O, Wang J, Senturk G, Chen D, O’Connor C, Pfaff S, Germain R, Schalper K, Emu B, Kaech S. The β1-adrenergic receptor links sympathetic nerves to T cell exhaustion. Nature 2023, 622: 383-392. PMID: 37731001, PMCID: PMC10871066, DOI: 10.1038/s41586-023-06568-6.Peer-Reviewed Original ResearchConceptsImmune checkpoint blockadeCell exhaustionExhausted CD8Sympathetic nervesT cell exhaustionSympathetic stress responsePancreatic cancer modelAnti-tumor functionCheckpoint blockadeCatecholamine levelsTissue innervationCytokine productionChronic antigenMalignant diseaseChronic infectionCD8Immune responseAdrenergic signalingEffector functionsΒ-blockersViral infectionCancer modelExhausted stateCell responsesCell functionCatecholamine induces Kupffer cell apoptosis via growth differentiation factor 15 in alcohol-associated liver disease
Kim H, Shim Y, Choi S, Kim M, Lee G, You H, Choi W, Yang K, Ryu T, Kim K, Kim M, Woo C, Chung K, Hong S, Eun H, Kim S, Ko G, Park J, Gao B, Kim W, Jeong W. Catecholamine induces Kupffer cell apoptosis via growth differentiation factor 15 in alcohol-associated liver disease. Experimental & Molecular Medicine 2023, 55: 158-170. PMID: 36631664, PMCID: PMC9898237, DOI: 10.1038/s12276-022-00921-x.Peer-Reviewed Original ResearchConceptsAlcohol-associated liver diseaseApoptotic Kupffer cellsKupffer cellsSingle-cell RNA sequencingCatecholamine levelsLiver diseaseKupffer cell apoptosisPortal bloodGrowth differentiation factor 15Chronic ethanol intakePathogen challengeChronic alcohol exposureApoptotic genesChronic alcohol consumptionB2 adrenergic receptorDifferentiation factor 15Effects of catecholaminesEthanol-fed miceExpression of ADRB2KC apoptosisChronic ethanol-fed miceGrowth differentiation factorRegulatory roleCell apoptosisGenetic ablation
2020
No modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men
Vosseler A, Zhao D, Fritsche L, Lehmann R, Kantartzis K, Small DM, Peter A, Häring HU, Birkenfeld AL, Fritsche A, Wagner R, Preißl H, Kullmann S, Heni M. No modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men. Scientific Reports 2020, 10: 20466. PMID: 33235256, PMCID: PMC7686306, DOI: 10.1038/s41598-020-77430-2.Peer-Reviewed Original ResearchConceptsTranscutaneous auricular vagus nerve stimulationOral glucose tolerance testAuricular vagus nerve stimulationVagus nerve stimulationGlucose tolerance testAutonomic nervous systemNerve stimulationCatecholamine levelsTolerance testNervous systemHealthy lean menCross-over studyHeart rate variability parametersCross-over designWhole-body metabolismHeart rate variabilityMajor regulatory effectsLean menAutonomic innervationAutonomic toneHealthy menPlasma glucoseInsulin sensitivityPeripheral organsInsulin secretion
2016
Beneficial effect of antidepressants against rotenone induced Parkinsonism like symptoms in rats
Sharma N, Jamwal S, Kumar P. Beneficial effect of antidepressants against rotenone induced Parkinsonism like symptoms in rats. Pathophysiology 2016, 23: 123-134. PMID: 26996500, DOI: 10.1016/j.pathophys.2016.03.002.Peer-Reviewed Original ResearchRotenone administrationCommon age-related neurodegenerative disorderDay one hourPro-inflammatory mediatorsAge-related neurodegenerative disordersLevels of catecholaminesTreatment of PDPathogenesis of PDLevodopa combinationAdjuvant therapyDA neuronsNeuroprotective roleCatecholamine levelsDifferent antidepressantsNeurotransmitter dysfunctionCNS disordersParkinson's diseaseMotor coordinationBody weightAntidepressantsSNpc regionNeurodegenerative disordersParkinsonismBeneficial effectsSertraline
2015
Protective Effect of Spermidine Against Excitotoxic Neuronal Death Induced by Quinolinic Acid in Rats: Possible Neurotransmitters and Neuroinflammatory Mechanism
Jamwal S, Singh S, Kaur N, Kumar P. Protective Effect of Spermidine Against Excitotoxic Neuronal Death Induced by Quinolinic Acid in Rats: Possible Neurotransmitters and Neuroinflammatory Mechanism. Neurotoxicity Research 2015, 28: 171-184. PMID: 26078029, DOI: 10.1007/s12640-015-9535-y.Peer-Reviewed Original ResearchConceptsQuinolinic acidBody weightQA treatmentGABAergic medium spiny neuronsN-methyl-D-aspartate receptorsOxidative stressGABAergic neuronal lossPro-inflammatory levelsHyperkinetic movement disordersExcitotoxic cell deathAnti-inflammatory propertiesExcitotoxic neuronal deathMedium spiny neuronsReceptor antagonistic propertiesNeuroinflammatory mechanismsPossible neurotransmittersNeuroinflammatory markersNeuronal lossNeuroprotective effectsNeurotransmitter alterationsCatecholamine levelsCascade of eventsNeuronal deathSpiny neuronsMovement disorders
2014
Renalase regulates peripheral and central dopaminergic activities
Quelhas-Santos J, Serrão MP, Soares-Silva I, Fernandes-Cerqueira C, Simões-Silva L, Pinho MJ, Remião F, Sampaio-Maia B, Desir GV, Pestana M. Renalase regulates peripheral and central dopaminergic activities. American Journal Of Physiology. Renal Physiology 2014, 308: f84-f91. PMID: 25411385, PMCID: PMC4338928, DOI: 10.1152/ajprenal.00274.2014.Peer-Reviewed Original ResearchConceptsKO miceUrinary excretionPlasma levelsDopaminergic activityIncreased Plasma LevelsPeripheral dopaminergic activityUrine catecholamine levelsRenal dopaminergic systemCentral dopaminergic activityL-type amino acid transporterWild-type miceAmino acid decarboxylase activityKnockout mouse modelRenalase deficiencyCatecholamine levelsDA outputUrinary dopamineAADC activityDopaminergic systemRenal cortexMouse modelDOPA ratioVivo administrationOverexpression of LAT1Amino acid transportersHuman iPSC Neurons Display Activity-Dependent Neurotransmitter Secretion: Aberrant Catecholamine Levels in Schizophrenia Neurons
Hook V, Brennand K, Kim Y, Toneff T, Funkelstein L, Lee K, Ziegler M, Gage F. Human iPSC Neurons Display Activity-Dependent Neurotransmitter Secretion: Aberrant Catecholamine Levels in Schizophrenia Neurons. Stem Cell Reports 2014, 3: 531-538. PMID: 25358781, PMCID: PMC4223699, DOI: 10.1016/j.stemcr.2014.08.001.Peer-Reviewed Original ResearchConceptsHiPSC neuronsHuman-induced pluripotent stem cell-derived neuronsPluripotent stem cell-derived neuronsActivity-dependent secretionStem cell-derived neuronsCell-derived neuronsPositive neuronsCatecholamine levelsActivity-dependent mannerTyrosine hydroxylasePeptide neurotransmittersNeuronal culturesBrain disordersNeurotransmitter releaseChemical neurotransmissionKCl stimulationNeuronsNorepinephrineCatecholaminesElevated levelsNeurotransmitter secretionCatecholamine biosynthesisSchizophreniaDopamineNeurotransmittersRenalase Prevents AKI Independent of Amine Oxidase Activity
Wang L, Velazquez H, Moeckel G, Chang J, Ham A, Lee HT, Safirstein R, Desir GV. Renalase Prevents AKI Independent of Amine Oxidase Activity. Journal Of The American Society Of Nephrology 2014, 25: 1226-1235. PMID: 24511138, PMCID: PMC4033373, DOI: 10.1681/asn.2013060665.Peer-Reviewed Original ResearchConceptsIschemic injuryCatecholamine levelsRecombinant renalaseAmine oxidase activityHuman proximal tubular cellsCisplatin-induced AKITreatment of AKIWild-type miceHK-2 cellsProximal tubular cellsOxidase activityKidney injuryRenal injuryC-Jun N-terminal kinaseExtracellular signal-regulated kinaseP38 mitogen-activated protein kinaseToxic injuryRenalase proteinTubular cellsSignal-regulated kinaseIntracellular signaling cascadesRenalaseInjuryMitogen-activated protein kinaseN-terminal kinaseThe granin VGF promotes genesis of secretory vesicles, and regulates circulating catecholamine levels and blood pressure
Fargali S, Garcia AL, Sadahiro M, Jiang C, Janssen WG, Lin W, Cogliani V, Elste A, Mortillo S, Cero C, Veitenheimer B, Graiani G, Pasinetti GM, Mahata SK, Osborn JW, Huntley GW, Phillips GR, Benson DL, Bartolomucci A, Salton SR. The granin VGF promotes genesis of secretory vesicles, and regulates circulating catecholamine levels and blood pressure. The FASEB Journal 2014, 28: 2120-2133. PMID: 24497580, PMCID: PMC3986843, DOI: 10.1096/fj.13-239509.Peer-Reviewed Original ResearchConceptsBlood pressureCatecholamine levelsLarge dense-core vesiclesTLQP-21Peptide TLQP-21VGF knockout miceSystolic blood pressureNoradrenergic chromaffin cellsMouse adrenal medullaDense-core vesiclesChronic administrationPlasma epinephrineNeurochemical changesAdrenal norepinephrineEpinephrine contentAdrenal medullaChromaffin cellsCore vesiclesGranin proteinsVGFSignificant increaseMiceSecretionSecretion of proteinsHypertension
2013
Renalase Protects against Ischemic AKI
Lee HT, Kim JY, Kim M, Wang P, Tang L, Baroni S, D’Agati V, Desir GV. Renalase Protects against Ischemic AKI. Journal Of The American Society Of Nephrology 2013, 24: 445-455. PMID: 23393318, PMCID: PMC3582209, DOI: 10.1681/asn.2012090943.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdrenergic alpha-AntagonistsAnimalsApoptosisGene ExpressionHumansInflammation MediatorsIschemiaKidney Tubular Necrosis, AcuteMacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutMonoamine OxidaseNeutrophil InfiltrationNorepinephrinePhentolamineRecombinant ProteinsReperfusion InjuryRNA, MessengerConceptsRenal ischemia-reperfusion injuryIschemia-reperfusion injuryIschemic AKIWild-type miceReperfusion injuryCatecholamine levelsRenal tubular inflammationTreatment of AKIRenal ischemia reperfusionSham-operated micePlasma catecholamine levelsRenal tubular necrosisRecombinant human renalasePlasma renalaseTubular inflammationTubular necrosisIschemia reperfusionNE levelsPlasma catecholaminesMyocardial necrosisInflammatory responseProximal tubulesAKIRenalaseMice
2011
Novel insights into the physiology of renalase and its role in hypertension and heart disease
Desir G. Novel insights into the physiology of renalase and its role in hypertension and heart disease. Pediatric Nephrology 2011, 27: 719-725. PMID: 21424526, DOI: 10.1007/s00467-011-1828-7.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseKidney diseaseResistant hypertensionSympathetic toneBlood pressureRecombinant renalaseSpontaneously Hypertensive Stroke-PronePlasma renalase levelsRenalase knockout mouseSystolic blood pressureModel of hypertensionPotent antihypertensive agentSevere cardiac hypertrophyRenalase deficiencyRenalase levelsRenal functionUrine catecholaminesEssential hypertensionSalt intakeStroke proneAntihypertensive agentsCatecholamine levelsRenal sodiumSingle dosePlasma levels
2010
Renalase deficiency aggravates ischemic myocardial damage
Wu Y, Xu J, Velazquez H, Wang P, Li G, Liu D, Sampaio-Maia B, Quelhas-Santos J, Russell K, Russell R, Flavell RA, Pestana M, Giordano F, Desir GV. Renalase deficiency aggravates ischemic myocardial damage. Kidney International 2010, 79: 853-860. PMID: 21178975, DOI: 10.1038/ki.2010.488.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseWild-type miceRenalase deficiencyKnockout micePlasma blood urea nitrogenLevels of renalaseMild ventricular hypertrophyRenalase knockout mouseNormal systolic functionTraditional risk factorsPlasma catecholamine levelsIschemic myocardial damageBlood urea nitrogenCardiac complicationsCardiovascular complicationsSystolic functionVentricular hypertrophyCardioprotective effectsCatecholamine levelsKidney diseaseMyocardial damageMyocardial necrosisRecombinant renalaseRisk factorsCardiac ischemiaBiochemical and clinical responses after treatment of a catecholamine‐secreting glomus jugulare tumor with gamma knife radiosurgery
Castrucci WA, Chiang VL, Hulinsky I, Knisely JP. Biochemical and clinical responses after treatment of a catecholamine‐secreting glomus jugulare tumor with gamma knife radiosurgery. Head & Neck 2010, 32: 1720-1727. PMID: 19787788, DOI: 10.1002/hed.21242.Peer-Reviewed Original ResearchConceptsGlomus jugulare tumorsGamma knife radiosurgeryJugulare tumorsKnife radiosurgeryFunctional capacitySingle-fraction gamma knife radiosurgeryTumor growthMinimal treatment-related morbidityPrimary radiation therapyTreatment-related morbiditySignificant symptomatic improvementLocal tumor growthCatecholamine blockadeHypertensive crisisSymptomatic improvementClinical responseCatecholamine levelsPharmacologic blockadeRadiation therapyDurable controlRadiosurgeryBlockadeTumorsTreatmentMorbidity
2008
Catecholamines Regulate the Activity, Secretion, and Synthesis of Renalase
Li G, Xu J, Wang P, Velazquez H, Li Y, Wu Y, Desir GV. Catecholamines Regulate the Activity, Secretion, and Synthesis of Renalase. Circulation 2008, 117: 1277-1282. PMID: 18299506, DOI: 10.1161/circulationaha.107.732032.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseKidney diseaseExcess catecholaminesPlasma renalase concentrationSystolic pressure increaseSympathetic nervous systemRenalase gene expressionRegulation of catecholaminesAttractive therapeutic modalityRenalase concentrationCatecholamine surgeBlood pressureNormotensive ratsCatecholamine levelsHemodynamic changesPlasma levelsRecombinant renalaseSystemic abnormalitiesRenalase activityCardiac contractilityTherapeutic modalitiesCardiac hypertrophyCatecholamine metabolismHeart rateParenteral administration
2007
Renalase is a novel renal hormone that regulates cardiovascular function
Desir GV. Renalase is a novel renal hormone that regulates cardiovascular function. International Journal Of Cardiology Cardiovascular Risk And Prevention 2007, 1: 99-103. PMID: 20409839, DOI: 10.1016/j.jash.2006.12.001.Peer-Reviewed Original ResearchChronic kidney diseaseRenal hormoneBlood pressureKidney diseaseBlood levelsFlavin adenine dinucleotide-dependent amine oxidaseEnd-stage renal diseaseRenal replacement therapySystemic blood pressurePeripheral vascular toneCardiovascular morbidityCardiovascular outcomesSympathetic toneRenal diseaseCatecholamine levelsReplacement therapyVascular tonePatient populationCardiac functionDiseased kidneysCardiovascular functionCardiac contractilityHealthy subjectsHeart rateCompensatory increase
1991
A pharmacodynamic interaction between caffeine and phenylpropanolamine
Brown N, Ryder D, Branch R. A pharmacodynamic interaction between caffeine and phenylpropanolamine. Clinical Pharmacology & Therapeutics 1991, 50: 363-371. PMID: 1914371, DOI: 10.1038/clpt.1991.152.Peer-Reviewed Original ResearchConceptsBlood pressurePharmacodynamic interactionsPlasma renin activityRenin-angiotensin systemDrug-free subjectsCoadministration of caffeineRenin responseRenin activityPharmacokinetic interactionsCatecholamine levelsSupine positionNormal subjectsLatin square design studyDrug AdministrationRandom orderPhenylpropanolamineMetabolite levelsPlaceboCaffeineSubjectsAdditive increaseHoursCoadministrationEpinephrineAdministration
1988
Advances in the Diagnosis and Treatment of Pheochromocytoma
Havlik R, Cahow C, Kinder B. Advances in the Diagnosis and Treatment of Pheochromocytoma. JAMA Surgery 1988, 123: 626-630. PMID: 3282495, DOI: 10.1001/archsurg.1988.01400290112020.Peer-Reviewed Original ResearchConceptsPerioperative fluid requirementsTotal catecholamine levelsAlpha-adrenergic blockadeIntraoperative hemodynamic stabilityTreatment of pheochromocytomaManagement of pheochromocytomaDiagnosis of pheochromocytomaHemodynamic stabilityCatecholamine levelsCatecholamine excretionSelective blockadeFluid requirementsComputed tomographyPheochromocytomaPatientsPhenoxybenzamine hydrochlorideBiochemical diagnosisPrazosin hydrochlorideDiagnosisBlockadePhenoxybenzaminePrazosinSurgeryYearsExcretion
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