2018
Multicenter Phase IB Trial of Carboxyamidotriazole Orotate and Temozolomide for Recurrent and Newly Diagnosed Glioblastoma and Other Anaplastic Gliomas.
Omuro A, Beal K, McNeill K, Young RJ, Thomas A, Lin X, Terziev R, Kaley TJ, DeAngelis LM, Daras M, Gavrilovic IT, Mellinghoff I, Diamond EL, McKeown A, Manne M, Caterfino A, Patel K, Bavisotto L, Gorman G, Lamson M, Gutin P, Tabar V, Chakravarty D, Chan TA, Brennan CW, Garrett-Mayer E, Karmali RA, Pentsova E. Multicenter Phase IB Trial of Carboxyamidotriazole Orotate and Temozolomide for Recurrent and Newly Diagnosed Glioblastoma and Other Anaplastic Gliomas. Journal Of Clinical Oncology 2018, 36: 1702-1709. PMID: 29683790, PMCID: PMC5993168, DOI: 10.1200/jco.2017.76.9992.Peer-Reviewed Original ResearchConceptsAnaplastic gliomasCohort 2Cohort 1Median progression-free survivalFavorable brain penetrationMedian overall survivalPhase Ib studyPhase Ib trialPhase II doseProgression-free survivalRecurrent anaplastic gliomasDependent calcium channelsNovel oral inhibitorSignal of activityMismatch repair genesIb trialTreat populationMethylguanine-DNA methyltransferaseOverall survivalComplete responseFlat doseOral inhibitorBrain penetrationResults FortyTherapeutic concentrations
2012
Low Cefepime Concentrations during High Blood and Dialysate Flow Continuous Venovenous Hemodialysis
Wilson FP, Bachhuber MA, Caroff D, Adler R, Fish D, Berns J. Low Cefepime Concentrations during High Blood and Dialysate Flow Continuous Venovenous Hemodialysis. Antimicrobial Agents And Chemotherapy 2012, 56: 2178-2180. PMID: 22290968, PMCID: PMC3318326, DOI: 10.1128/aac.05987-11.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Bacterial AgentsCefepimeCephalosporinsChromatography, High Pressure LiquidFemaleHalf-LifeHemofiltrationHumansKidney Failure, ChronicKidney Tubular Necrosis, AcuteMaleMicrobial Sensitivity TestsMiddle AgedPseudomonas aeruginosaShock, CardiogenicSpectrophotometry, UltravioletYoung AdultRapid Evaluation in Whole Blood Culture of Regimens for XDR-TB Containing PNU-100480 (Sutezolid), TMC207, PA-824, SQ109, and Pyrazinamide
Wallis RS, Jakubiec W, Mitton-Fry M, Ladutko L, Campbell S, Paige D, Silvia A, Miller PF. Rapid Evaluation in Whole Blood Culture of Regimens for XDR-TB Containing PNU-100480 (Sutezolid), TMC207, PA-824, SQ109, and Pyrazinamide. PLOS ONE 2012, 7: e30479. PMID: 22279595, PMCID: PMC3261206, DOI: 10.1371/journal.pone.0030479.Peer-Reviewed Original ResearchMeSH KeywordsAdamantaneAntitubercular AgentsDiarylquinolinesDrug MonitoringDrug Therapy, CombinationEthylenediaminesExtensively Drug-Resistant TuberculosisHumansMicrobial Sensitivity TestsMycobacterium tuberculosisNitroimidazolesOxazolidinonesPyrazinamideQuinolinesReproducibility of ResultsTime FactorsConceptsPNU-100480Whole blood culturesPA-824Blood culturesWhole-blood bactericidal activityBactericidal activityStandard TB therapyDihydroxy vitamin DIntracellular M. tuberculosisBlood bactericidal activityCumulative activityPZA-resistant strainsHigh therapeutic concentrationsActive regimensTB regimensNew regimensTB therapyVitamin DOral dosingTherapeutic concentrationsDrug combinationsPharmacokinetic dataRegimensIndividual drugsTMC207
1985
1094 THE EFFECT OF BETAMETHASONE ON THE CHEMOTACTIC RESPONSE OF NEONATAL NEUTROPHILS
Fuenfer M, Ingardia C, Raye J, Block C, Krause P. 1094 THE EFFECT OF BETAMETHASONE ON THE CHEMOTACTIC RESPONSE OF NEONATAL NEUTROPHILS. Pediatric Research 1985, 19: 293-293. DOI: 10.1203/00006450-198504000-01124.Peer-Reviewed Original ResearchEffect of betamethasoneMaternal steroid administrationPerinatal bacterial infectionHealthy term neonatesFetal lung maturationRisk of infectionSteroid administrationTerm neonatesHost defense systemNeonatal neutrophilsLung maturationNeutrophil functionCord bloodPMN functionNeonatal PMNTherapeutic concentrationsPMN chemokinesisBacterial infectionsBetamethasoneNeonatesPMN motilitySignificant inhibitionRandom migrationMicropore filtersFurther compromise
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