2013
MRP4 and MRP5 in the ciliary epithelium of the eye and their potential role in regulating extracellular cAMP levels
Hotchkiss A, Pasumarthi K, Coca‐Prados M, Pelis R. MRP4 and MRP5 in the ciliary epithelium of the eye and their potential role in regulating extracellular cAMP levels. The FASEB Journal 2013, 27: 732.3-732.3. DOI: 10.1096/fasebj.27.1_supplement.732.3.Peer-Reviewed Original ResearchMultidrug resistance-associated proteinCAMP levelsExtracellular cAMP levelsCiliary epitheliumAqueous humor dynamicsResistance-associated proteinCiliary epithelial cell lineHuman ciliary bodyCE cellsEpithelial cell lineMRP inhibitorsCiliary bodyAdrenergic stimulationIntracellular cAMPIntracellular accumulationPotential roleCell linesIndomethacinFurosemideMRP4Cyclic nucleotidesMRP5EpitheliumIbuprofenCells
2001
Ibuprofen as a Chemesthetic Stimulus: Evidence of a Novel Mechanism of Throat Irritation
Breslin P, Gingrich T, Green B. Ibuprofen as a Chemesthetic Stimulus: Evidence of a Novel Mechanism of Throat Irritation. Chemical Senses 2001, 26: 55-65. PMID: 11124216, DOI: 10.1093/chemse/26.1.55.Peer-Reviewed Original ResearchConceptsCapsaicin-sensitive receptorsThroat irritationRatings of irritationReceptor mechanismsSensory irritationNon-steroidal anti-inflammatory drug ibuprofenIrritationAnti-inflammatory drug ibuprofenOral irritantsThroatReceptorsNovel mechanismStimulationIbuprofenChemesthetic propertiesChemesthetic stimuliBuffering agentDrug ibuprofenPrickAgentsChemesthetic effects
2000
Comparison of the effect of rofecoxib (a cyclooxygenase 2 inhibitor), ibuprofen, and placebo on the gastroduodenal mucosa of patients with osteoarthritis: A randomized, double‐blind, placebo‐controlled trial
Hawkey C, Laine L, Simon T, Beaulieu A, Maldonado‐Cocco J, Acevedo E, Shahane A, Quan H, Bolognese J, Mortensen E. Comparison of the effect of rofecoxib (a cyclooxygenase 2 inhibitor), ibuprofen, and placebo on the gastroduodenal mucosa of patients with osteoarthritis: A randomized, double‐blind, placebo‐controlled trial. Arthritis & Rheumatism 2000, 43: 370-377. PMID: 10693877, DOI: 10.1002/1529-0131(200002)43:2<370::aid-anr17>3.0.co;2-d.Peer-Reviewed Original ResearchConceptsGastroduodenal ulcersPrespecified criteriaEffect of rofecoxibPlacebo-controlled trialSecondary end pointsDouble-blind studyGastroduodenal ulcerationGastroduodenal mucosaUlcer incidenceCyclooxygenase-2Side effectsUlcersEnd pointEffective doseRofecoxibWeeksPlaceboPatientsOsteoarthritisIncidenceDoseIbuprofenUlcerationMucosaEndoscopy
1991
Can Ibuprofen Cause Acute Renal Failure in a Normal Individual? A Case of Acute Overdose
Perazella M, Buller G. Can Ibuprofen Cause Acute Renal Failure in a Normal Individual? A Case of Acute Overdose. American Journal Of Kidney Diseases 1991, 18: 600-602. PMID: 1951342, DOI: 10.1016/s0272-6386(12)80657-3.Peer-Reviewed Original ResearchConceptsNonsteroidal antiinflammatory drugsAcute renal failureRenal blood flowRenal failureAcute renal insufficiencyCase of AcuteRenal insufficiencyTubular necrosisAntiinflammatory drugsBlood flowRenal syndromeClinical situationsNormal individualsIbuprofenFailureAcutePatientsSyndromeInsufficiencyNecrosisThe influence of ibuprofen on fracture repair: Biomechanical, biochemical, histologic, and histomorphometric parameters in rats
Huo M, Troiano N, Pelker R, Gundberg C, Friedlaender G. The influence of ibuprofen on fracture repair: Biomechanical, biochemical, histologic, and histomorphometric parameters in rats. Journal Of Orthopaedic Research® 1991, 9: 383-390. PMID: 2010842, DOI: 10.1002/jor.1100090310.Peer-Reviewed Original ResearchConceptsControl animalsHistomorphometric parametersFracture repairUnilateral femur fracturesMature Sprague-Dawley ratsSerum osteocalcin levelsCyclo-oxygenase inhibitorSprague-Dawley ratsBone formation rateInfluence of ibuprofenOral doseFemur fracturesOsteocalcin levelsClinical practiceBone volumeBone remodelingInhibitory effectSignificant alterationsFracture biomechanicsRatsAnimalsTail vertebraePresent studyIbuprofenRepair
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