2024
Efficacy of GABA aminotransferase inactivator OV329 in models of neuropathic and inflammatory pain without tolerance or addiction
Wirt J, Ferreira L, Jesus C, Woodward T, Oliva I, Xu Z, Crystal J, Pepin R, Silverman R, Hohmann A. Efficacy of GABA aminotransferase inactivator OV329 in models of neuropathic and inflammatory pain without tolerance or addiction. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 122: e2318833121. PMID: 39793055, PMCID: PMC11725897, DOI: 10.1073/pnas.2318833121.Peer-Reviewed Original ResearchConceptsComplete Freund's adjuvantInflammatory painMechanical hypersensitivityAntinociceptive efficacyGlutamate levelsInjection of complete Freund's adjuvantConditioned place preference assayPaclitaxel-induced mechanical hypersensitivitySpinal site of actionSide effectsEnhancement of GABAergic transmissionChemotherapeutic agent paclitaxelPaclitaxel-induced increaseCompared to morphineLumbar spinal cordIncreased endogenous GABA levelsReduced glutamate levelsNeuropathic nociceptionSite of actionGABAergic transmissionAnalgesic strategiesPathological painGABAergic inhibitionSpinal sitesAbuse liability
2023
Developing non-opioid therapeutics to alleviate pain among persons with opioid use disorder: a review of the human evidence
Oliveira D, Fontenele R, Weleff J, Sofuoglu M, De Aquino J. Developing non-opioid therapeutics to alleviate pain among persons with opioid use disorder: a review of the human evidence. International Review Of Psychiatry 2023, 35: 377-396. PMID: 38299655, PMCID: PMC10835074, DOI: 10.1080/09540261.2023.2229430.Peer-Reviewed Original ResearchOpioid agonist therapyOpioid use disorderNon-opioid analgesicsUse disordersNon-opioid analgesic therapyAlpha-2 adrenergic agonistsMajor public health concernGlial activation inhibitorNon-opioid therapeuticsNovel analgesic strategiesPotential of cannabinoidsPrior opioid exposureOpioid-dependent individualsOpioid-dependent populationsAbuse liability assessmentPublic health concernAnalgesic strategiesAgonist therapyAnalgesic therapyOpioid exposureOUD treatmentPharmacokinetic interactionsGABAergic drugsSignificant morbidityPain typesPractice Advisory for Preoperative and Intraoperative Pain Management of Cardiac Surgical Patients: Part 2
Makkad B, Heinke T, Sheriffdeen R, Khatib D, Brodt J, Meng M, Grant M, Kachulis B, Popescu W, Wu C, Bollen B. Practice Advisory for Preoperative and Intraoperative Pain Management of Cardiac Surgical Patients: Part 2. Anesthesia & Analgesia 2023, 137: 26-47. PMID: 37326862, DOI: 10.1213/ane.0000000000006506.Peer-Reviewed Original ResearchConceptsIntraoperative pain managementCardiac surgical patientsCardiac surgeryPain managementPractice advisorySurgical patientsEffective postoperative pain controlMultimodal analgesic strategyPostoperative pain controlPain management strategiesCardiac surgical proceduresPreoperative patient evaluationMeaningful patient outcomesHealth care costsAnalgesic strategiesMultimodal analgesicsOpioid exposurePain controlPerioperative usePostoperative distressFunctional recoveryPatient evaluationPatient outcomesRegional techniquesSurgical proceduresPractice Advisory for Preoperative and Intraoperative Pain Management of Thoracic Surgical Patients: Part 1
Makkad B, Heinke T, Sheriffdeen R, Khatib D, Brodt J, Meng M, Grant M, Kachulis B, Popescu W, Wu C, Bollen B. Practice Advisory for Preoperative and Intraoperative Pain Management of Thoracic Surgical Patients: Part 1. Anesthesia & Analgesia 2023, 137: 2-25. PMID: 37079466, DOI: 10.1213/ane.0000000000006441.Peer-Reviewed Original ResearchConceptsIntraoperative pain managementThoracic surgical patientsPain managementThoracic surgerySurgical patientsPractice advisoryEffective postoperative pain controlMultimodal analgesic strategyPostoperative pain controlPersistent postoperative painPain management strategiesPreoperative patient evaluationRelevant patient outcomesThoracic surgical proceduresAnalgesic strategiesMultimodal analgesicsOpioid exposurePain controlPostoperative painPerioperative usePostoperative distressFunctional recoveryPatient evaluationPatient outcomesRegional techniques
2022
Perioperative Buprenorphine Management A Multidisciplinary Approach
Hickey T, Abelleira A, Acampora G, Becker WC, Falker CG, Nazario M, Weimer MB. Perioperative Buprenorphine Management A Multidisciplinary Approach. 2022, 106: 169-185. PMID: 34823729, DOI: 10.1016/j.mcna.2021.09.001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAcetaminophenAgedAnalgesics, Non-NarcoticAnalgesics, OpioidAnti-Inflammatory Agents, Non-SteroidalArthroplasty, Replacement, HipBuprenorphineCombined Modality TherapyDrug CompoundingFemaleHumansInterdisciplinary CommunicationMaleOpiate Substitution TreatmentOpioid-Related DisordersPainPain ManagementPain, PostoperativePerioperative CareReceptors, Opioid, muConceptsOpioid use disorderBuprenorphine treatmentMu-opioid receptor availabilityAgonist opioid treatmentMultimodal analgesic strategyAnti-inflammatory drugsLong-term buprenorphine treatmentAnalgesic strategiesNonopioid adjunctsOpioid treatmentPerioperative strategiesHospital dischargePerioperative managementBuprenorphine formulationsSimultaneous administrationRegional anesthesiaEffective treatmentUse disordersReceptor availabilityMultidisciplinary approachBuprenorphinePatientsTreatmentPainAnesthesia
2021
Methadone maintenance patients lack analgesic response to a cumulative intravenous dose of 32 mg of hydromorphone
Agin-Liebes G, Huhn A, Strain E, Bigelow G, Smith M, Edwards R, Gruber V, Tompkins D. Methadone maintenance patients lack analgesic response to a cumulative intravenous dose of 32 mg of hydromorphone. Drug And Alcohol Dependence 2021, 226: 108869. PMID: 34216862, PMCID: PMC9559787, DOI: 10.1016/j.drugalcdep.2021.108869.Peer-Reviewed Original ResearchConceptsQuantitative sensory testingDoses of hydromorphoneAcute intravenous (IVLevel of opioid toleranceAbuse liability effectsAbuse liability measuresExperimental pain paradigmDoses of opioidsMethadone-maintained individualsAcute pain managementCumulative intravenous dosesIntravenous (IVOpioid use disorderRandomized Controlled StudyMethadone maintenance patientsPlacebo-controlled conditionsAnalgesic indexEfficacy opioidsQST outcomesEscalating dosesOpioid tolerancePlacebo doseOral methadoneAnalgesic strategiesAnalgesic response
2019
Anesthesia for Spine Surgery
Zorrilla-Vaca A, Grant M, Mirski M. Anesthesia for Spine Surgery. 2019, 189-200. DOI: 10.1007/978-981-13-3387-3_14.Peer-Reviewed Original ResearchSpine surgeryMultimodal analgesic strategyIntraoperative blood lossLumbar spine surgeryLength of stayManagement of anesthesiaPatient-focused approachAnalgesic strategiesHospital stayPostoperative complicationsPostoperative nauseaPostoperative painPostoperative outcomesAnesthetic managementBlood lossAnesthetic techniqueGeneral anesthesiaIntraoperative stabilityPerioperative assessmentOptimal anesthesiaRegional anesthesiaRegional techniquesSurgery programSurgeryAnesthesia
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