2023
Adoption of Emergency Department–Initiated Buprenorphine for Patients With Opioid Use Disorder
Gao E, Melnick E, Paek H, Nath B, Taylor R, Loza A. Adoption of Emergency Department–Initiated Buprenorphine for Patients With Opioid Use Disorder. JAMA Network Open 2023, 6: e2342786. PMID: 37948075, PMCID: PMC10638655, DOI: 10.1001/jamanetworkopen.2023.42786.Peer-Reviewed Original ResearchConceptsHealth care systemED initiationOpioid use disorderBuprenorphine initiationCare systemUse disordersEmergency department-initiated buprenorphineSecondary analysisClinician's roleEmergency department initiationClinical decision support interventionClinical decision support toolProportional hazard modelingCare of patientsNetwork of cliniciansDecision support interventionsAdvanced practice practitionersDose-dependent mannerUnique cliniciansTime-dependent covariatesTrial interventionNonintervention groupED clustersMore effective interventionsNumber of exposuresCyberKnife Stereotactic Radiosurgery for Growing Vestibular Schwannoma: Longitudinal Tumor Control, Hearing Outcomes, and Predicting Post‐Treatment Hearing Status
Hildrew D, Perez P, Mady L, Li J, Nilsen M, Hirsch B. CyberKnife Stereotactic Radiosurgery for Growing Vestibular Schwannoma: Longitudinal Tumor Control, Hearing Outcomes, and Predicting Post‐Treatment Hearing Status. The Laryngoscope 2023, 134: s1-s12. PMID: 37178050, DOI: 10.1002/lary.30731.Peer-Reviewed Original ResearchConceptsTumor control rateCyberKnife stereotactic radiosurgeryHearing outcomesVestibular schwannomaControl rateStereotactic radiosurgeryRetrospective case series reviewCase series reviewThird of patientsProportional hazard modelingMaximum radiation doseSeries reviewTumor controlAvailable audiogramsOtolaryngology-HeadTumor volumeEffective treatmentClass APatientsHearing statusAmerican AcademyHazard modelingVolumetric analysisRadiation doseOutcomes
2022
Residual stroke risk despite oral anticoagulation in patients with atrial fibrillation
Carlisle M, Shrader P, Fudim M, Pieper K, Blanco R, Fonarow G, Naccarelli G, Gersh B, Reiffel J, Kowey P, Steinberg B, Freeman J, Ezekowitz M, Singer D, Allen L, Chan P, Pokorney S, Peterson E, Piccini J, Patients and Investigators O. Residual stroke risk despite oral anticoagulation in patients with atrial fibrillation. Heart Rhythm O2 2022, 3: 621-628. PMID: 36589908, PMCID: PMC9795305, DOI: 10.1016/j.hroo.2022.09.018.Peer-Reviewed Original ResearchTransient ischemic attackPermanent atrial fibrillationOral anticoagulationAtrial fibrillationVASc scoreIschemic attackThromboembolic eventsFemale sexPrevious stroke/transient ischemic attackStroke/transient ischemic attackTransient ischemic attack eventsCox proportional hazard modelingResidual riskResidual stroke riskBetter Informed TreatmentRisk of thromboembolismProportional hazard modelingSystemic embolismPrevious strokeStroke riskOutcomes RegistryMean ageRisk markersOutcome eventsThromboembolismLong-term Opioid Therapy and Overdose in Patients with and without Cancer
Merlin J, Black A, Midboe A, Troszak L, Asch S, Bohnert A, Fenton B, Giannitrapani K, Glassman P, Kerns R, Silveira M, Lorenz K, Becker W. Long-term Opioid Therapy and Overdose in Patients with and without Cancer. Journal Of Pain 2022, 23: 60. DOI: 10.1016/j.jpain.2022.03.225.Peer-Reviewed Original ResearchLong-term opioid therapyOpioid therapyCox proportional hazard modelingElectronic health record databaseCancer pain managementRetrospective cohort studyProportional hazard modelingOpioid overdose riskHealth record databasePresence of cancerRole of cancerOpioid receiptCohort entryCohort studyHazard ratioMost patientsPain managementOpioid risksDose/Inclusion criteriaOpioid overdoseOverdose riskLatent growth mixture modelingLower riskPatients
2020
Prevalence of and characteristics associated with in-hospital mortality in a Ugandan neurology ward
Diaz MM, Hu X, Fenton BT, Kimuli I, Lee A, Lindsey H, Bigelow JK, Maiser S, Altalib HH, Sico JJ. Prevalence of and characteristics associated with in-hospital mortality in a Ugandan neurology ward. BMC Neurology 2020, 20: 42. PMID: 32005185, PMCID: PMC6995141, DOI: 10.1186/s12883-020-1627-5.Peer-Reviewed Original ResearchConceptsNeurology wardHead traumaHospital mortalityWorse survivalCommon diagnosisMultivariate Cox proportional hazard modelingSub-Saharan African hospitalsCox proportional hazard modelingKaplan-Meier survival curvesConclusionsIn-hospital mortalityPatient-level predictorsHigh-risk groupProportional hazard modelingDiagnosis of infectionTime of deathIndex hospitalizationHospital admissionMulago HospitalNeurologic illnessAfrican hospitalsNeurologic diseaseSurvival curvesPatientsHazard modelingMortality
2019
Patterns of amiodarone use and outcomes in clinical practice for atrial fibrillation
Pokorney SD, Holmes DN, Shrader P, Thomas L, Fonarow GC, Mahaffey KW, Gersh BJ, Kowey PR, Naccarelli GV, Freeman JV, Singer DE, Washam JB, Peterson ED, Piccini JP, Reiffel JA. Patterns of amiodarone use and outcomes in clinical practice for atrial fibrillation. American Heart Journal 2019, 220: 145-154. PMID: 31812756, DOI: 10.1016/j.ahj.2019.09.017.Peer-Reviewed Original ResearchConceptsUse of amiodaroneAmiodarone useAntiarrhythmic drugsAtrial fibrillationAF patientsDifferent antiarrhythmic drugsGuideline-based indicationsPropensity-matched cohortEffective antiarrhythmic drugProportional hazard modelingORBIT-AF registryLogistic regression modelsHierarchical logistic regressionCause mortalityAF RegistryCardiovascular hospitalizationAmiodaroneHigh incidencePatientsClinical practiceHazard modelingLogistic regressionAdverse effectsRandom interceptFibrillationO1-8-4 [Encore] Dose justification for [fam-] trastuzumab deruxtecan (DS-8201a) in HER2-positive breast cancer
Takahashi S, Modi S, Tsurutani J, Krop I, Iwata H, Wada R, Yin O, Garimella T, Sugihara M, Zhang L, Lee C, Saito K, Kawasaki Y, Yver A, Tamura K. O1-8-4 [Encore] Dose justification for [fam-] trastuzumab deruxtecan (DS-8201a) in HER2-positive breast cancer. Annals Of Oncology 2019, 30: vi84. DOI: 10.1093/annonc/mdz339.009.Peer-Reviewed Original ResearchObjective response rateInterstitial lung diseaseTrastuzumab deruxtecanOngoing phase 1 studiesImproved progression-free survivalCox proportional hazard modelingHER2-positive breast cancerBenefit/risk profileLogistic regressionProgression-free survivalPhase 1 studyProportional hazard modelingPopulation PK modelDose-finding stageIndividual PK parametersAvailable PK dataILD riskSafety endpointLung diseasePPK modelBC subjectsBreast cancerDose justificationPK parametersPK dataDigital Inference of Immune Microenvironment Reveals Low-Risk Subtype of Early Lung Adenocarcinoma
Kurbatov V, Balayev A, Saffarzadeh A, Heller DR, Boffa DJ, Blasberg JD, Lu J, Khan SA. Digital Inference of Immune Microenvironment Reveals Low-Risk Subtype of Early Lung Adenocarcinoma. The Annals Of Thoracic Surgery 2019, 109: 343-349. PMID: 31568747, DOI: 10.1016/j.athoracsur.2019.08.050.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma of LungAdultAgedCohort StudiesDatabases, FactualDisease-Free SurvivalFemaleHumansImmunotherapyKaplan-Meier EstimateLung NeoplasmsMaleMiddle AgedNeoplasm InvasivenessNeoplasm StagingPneumonectomyPrognosisProportional Hazards ModelsRetrospective StudiesRisk AssessmentSurvival AnalysisTumor MicroenvironmentConceptsTumor immune microenvironmentImmune microenvironmentLung adenocarcinomaOverall survivalRisk groupsMast cellsCox proportional hazard modelingEarly-stage lung adenocarcinomaLow-risk subtypesKaplan-Meier analysisPathological staging systemProportional hazard modelingImproved clinical outcomesCancer immune microenvironmentImmune cell typesEarly lung adenocarcinomaActivation stateClinical outcomesValidation cohortMacrophage contentStaging systemMultivariable modelCIBERSORT analysisPatientsClinical decision
2018
The effect of socioeconomic factors on the outcome of intrahepatic cholangiocarcinoma.
Sellers C, Ludwig J, Uhlig J, Stein S, Lacy J, Kim H. The effect of socioeconomic factors on the outcome of intrahepatic cholangiocarcinoma. Journal Of Clinical Oncology 2018, 36: 465-465. DOI: 10.1200/jco.2018.36.4_suppl.465.Peer-Reviewed Original ResearchMedian overall survivalOverall survivalIntrahepatic cholangiocarcinomaPrimary insurancePrivate insuranceLocoregional therapyInner-city tertiary care hospitalDecreased median overall survivalCox proportional hazard modelingCancer-directed treatmentOS of patientsTertiary care hospitalKaplan-Meier curvesProportional hazard modelingPrivate insurance patientsSocioeconomic factorsConsecutive patientsCare hospitalCancer RegistryMean ageTreatment coursePreventive careEarly treatmentMedicaid patientsInsurance patientsThe effect of socioeconomic factors on the outcome of hepatocellular carcinoma.
Sellers C, Ludwig J, Uhlig J, Stein S, Taddei T, Kim H. The effect of socioeconomic factors on the outcome of hepatocellular carcinoma. Journal Of Clinical Oncology 2018, 36: 466-466. DOI: 10.1200/jco.2018.36.4_suppl.466.Peer-Reviewed Original ResearchMedian overall survivalCancer-directed treatmentOverall survivalHepatocellular carcinomaPrivate insurancePrimary insuranceInner-city tertiary care hospitalDecreased median overall survivalCox proportional hazard modelingMultivariate Cox proportional analysisCox proportional analysisTertiary care hospitalOS of patientsKaplan-Meier curvesProportional hazard modelingSocioeconomic factorsMedian OSSurvival benefitCare hospitalConsecutive patientsAJCC stageCancer RegistryMean ageTreatment courseSurvival advantage
2017
Value of a flow cytometry cross‐match in the setting of a negative complement‐dependent cytotoxicity cross‐match in heart transplant recipients
Keeshan BC, O'Connor MJ, Lin KY, Monos D, Lind C, Mascio CE, Rame JE, Spray TL, Shaddy RE, Rossano JW. Value of a flow cytometry cross‐match in the setting of a negative complement‐dependent cytotoxicity cross‐match in heart transplant recipients. Clinical Transplantation 2017, 31 PMID: 28766759, DOI: 10.1111/ctr.13064.Peer-Reviewed Original ResearchConceptsHeart transplant recipientsGraft survivalPositive FCXMHeart transplantationTransplant recipientsT cellsB cellsNegative complement-dependent cytotoxicityCox proportional hazard modelingDecreased graft survivalOrgan Sharing databaseHLA-specific antibodiesKaplan-Meier analysisCross-match resultsProportional hazard modelingDifferent patient cohortsComplement-dependent cytotoxicityXM patientsGraft failureSharing databaseUnited NetworkPatient cohortInclusion criteriaCross matchClinical relevancePhysical inactivity and cardiac events: An analysis of the Detection of Ischemia in Asymptomatic Diabetics (DIAD) study
McCarthy M, Wackers F, Davey J, Chyun D. Physical inactivity and cardiac events: An analysis of the Detection of Ischemia in Asymptomatic Diabetics (DIAD) study. Journal Of Clinical & Translational Endocrinology 2017, 9: 8-14. PMID: 29067262, PMCID: PMC5651289, DOI: 10.1016/j.jcte.2017.05.005.Peer-Reviewed Original ResearchCoronary artery diseaseHigher pulse pressurePremature coronary artery diseaseCAD eventsPhysical inactivityPulse pressureDetection of ischemiaPeripheral numbnessDiabetes durationIndependent predictorsHip ratioFamily historyOlder adultsAsymptomatic Diabetics (DIAD) studyCAD event ratesProportional hazard modelingImportant risk factorType 2 diabetesCause of deathAsymptomatic diabeticsInsulin useBaseline characteristicsCardiac eventsArtery diseaseHemoglobin A1c
2016
Adjuvant chemotherapy and overall survival in adult medulloblastoma
Kann BH, Lester-Coll NH, Park HS, Yeboa DN, Kelly JR, Baehring JM, Becker KP, Yu JB, Bindra RS, Roberts KB. Adjuvant chemotherapy and overall survival in adult medulloblastoma. Neuro-Oncology 2016, 19: 259-269. PMID: 27540083, PMCID: PMC5464064, DOI: 10.1093/neuonc/now150.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsCerebellar NeoplasmsChemoradiotherapy, AdjuvantChemotherapy, AdjuvantCraniospinal IrradiationFemaleFollow-Up StudiesHumansMaleMedulloblastomaMiddle AgedNeoplasm StagingPrognosisRadiotherapy, AdjuvantSurvival RateYoung AdultConceptsGy craniospinal irradiationCraniospinal irradiationOverall survivalM0 patientsAdjuvant chemotherapyAdult MBMultivariable Cox proportional hazard modelingHigh-dose craniospinal irradiationNational Cancer Data BaseCox proportional hazard modelingSuperior overall survivalPlanned subgroup analysisMultivariable logistic regressionNational database analysisLog-rank testProportional hazard modelingPediatric medulloblastoma patientsCSI dosesPostoperative chemotherapySurgical resectionSurvival impactYear OSMultivariable analysisSubgroup analysisRisk factors
2012
Validation of IHC4 algorithms for prediction of risk of recurrence in early breast cancer using both conventional and quantitative IHC approaches.
Christiansen J, Bartlett J, Gustavson M, Rimm D, Robson T, Van De Velde C, Hasenburg A, Kieback D, Putter H, Markopoulos C, Dirix L, Seynaeve C, Rea D. Validation of IHC4 algorithms for prediction of risk of recurrence in early breast cancer using both conventional and quantitative IHC approaches. Journal Of Clinical Oncology 2012, 30: 517-517. DOI: 10.1200/jco.2012.30.15_suppl.517.Peer-Reviewed Original ResearchEarly breast cancerBreast cancerDAB IHCHazard ratioDisease recurrenceCox proportional hazard modelingKaplan-Meier survival analysisCox proportional hazards modelC-index calculationClinical prognostic factorsProportional hazard modelingProportional hazards modelResidual riskHormone therapyIndependent predictorsPrognostic factorsPrediction of riskRisk markersClinical utilityHazards modelRecurrence riskRecurrencePathology studiesSurvival analysisMultivariate analysis
2007
Mortality risk associated with ejection fraction differs across resting nuclear perfusion findings
Bourque JM, Velazquez EJ, Tuttle RH, Shaw LK, O’Connor C, Borges-Neto S. Mortality risk associated with ejection fraction differs across resting nuclear perfusion findings. Journal Of Nuclear Cardiology 2007, 14: 165-173. PMID: 17386378, DOI: 10.1016/j.nuclcard.2006.11.011.Peer-Reviewed Original ResearchConceptsMortality riskEjection fractionPrognostic informationHigher long-term mortality ratesLong-term mortality ratesPerfusion single-photon emissionVentricular ejection fractionIschemic heart diseaseLong-term outcomesProportional hazard modelingLong-term survivalSingle photon emissionCardiac catheterizationNormal LVEFRisk stratificationPerfusion findingsPatient prognosticationHeart diseaseRest scoreLVEFMyocardial perfusionMortality ratePerfusion studiesHazard modelingSignificant predictors
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