2021
Autonomic Arousal Tracks Outcome Salience Not Valence in Monkeys Making Social Decisions
Basile BM, Joiner JA, Dal Monte O, Fagan NA, Karaskiewicz CL, Lucas DR, Chang SWC, Murray EA. Autonomic Arousal Tracks Outcome Salience Not Valence in Monkeys Making Social Decisions. Behavioral Neuroscience 2021, 135: 443-452. PMID: 34264694, PMCID: PMC8489567, DOI: 10.1037/bne0000424.Peer-Reviewed Original ResearchRadiochemical Synthesis and Evaluation in Non-Human Primates of 3‑[11C]methoxy-4-aminopyridine: A Novel PET Tracer for Imaging Potassium Channels in the CNS
Guehl N, Neelamegam R, Zhou Y, Moon S, Dhaynaut M, Fakhri G, Normandin M, Brugarolas P. Radiochemical Synthesis and Evaluation in Non-Human Primates of 3‑[11C]methoxy-4-aminopyridine: A Novel PET Tracer for Imaging Potassium Channels in the CNS. ACS Chemical Neuroscience 2021, 12: 756-765. PMID: 33539063, PMCID: PMC8060895, DOI: 10.1021/acschemneuro.0c00791.Peer-Reviewed Original ResearchMeSH Keywords4-AminopyridineAnimalsBrainHaplorhiniPositron-Emission TomographyPotassium ChannelsRadiochemistry
2019
Data-driven voluntary body motion detection and non-rigid event-by-event correction for static and dynamic PET
Lu Y, Gallezot JD, Naganawa M, Ren S, Fontaine K, Wu J, Onofrey JA, Toyonaga T, Boutagy N, Mulnix T, Panin VY, Casey ME, Carson RE, Liu C. Data-driven voluntary body motion detection and non-rigid event-by-event correction for static and dynamic PET. Physics In Medicine And Biology 2019, 64: 065002. PMID: 30695768, DOI: 10.1088/1361-6560/ab02c2.Peer-Reviewed Original Research
2018
Human–Monkey Chimeras for Modeling Human Disease: Opportunities and Challenges
De Los Angeles A, Hyun I, Latham S, Elsworth J, Redmond D. Human–Monkey Chimeras for Modeling Human Disease: Opportunities and Challenges. Stem Cells And Development 2018, 27: 1599-1604. PMID: 30319057, PMCID: PMC7366261, DOI: 10.1089/scd.2018.0162.Peer-Reviewed Original ResearchConceptsImportant ethical considerationsModeling Human DiseaseHuman PS cellsInterspecies chimerasUse of monkeysChimera researchEthical considerationsEthical concernsInvasive researchCell researchPolitical issuesScientific valueBiomedical researchLight of advancesHuman stem cellsJurisdictionsPS cellsHoly grailQuestionsModeling autism in non‐human primates: Opportunities and challenges
Zhao H, Jiang Y, Zhang YQ. Modeling autism in non‐human primates: Opportunities and challenges. Autism Research 2018, 11: 686-694. PMID: 29573234, PMCID: PMC6188783, DOI: 10.1002/aur.1945.Peer-Reviewed Original Research
2017
Cryopreservation Maintains Functionality of Human iPSC Dopamine Neurons and Rescues Parkinsonian Phenotypes In Vivo
Wakeman D, Hiller B, Marmion D, McMahon C, Corbett G, Mangan K, Ma J, Little L, Xie Z, Perez-Rosello T, Guzman J, Surmeier D, Kordower J. Cryopreservation Maintains Functionality of Human iPSC Dopamine Neurons and Rescues Parkinsonian Phenotypes In Vivo. Stem Cell Reports 2017, 9: 149-161. PMID: 28579395, PMCID: PMC5511045, DOI: 10.1016/j.stemcr.2017.04.033.Peer-Reviewed Original ResearchConceptsParkinson's diseaseDopamine neuronsMidbrain dopamine neuronsStem cell therapyGrafted neuronsHost striatumCell-based therapiesPluripotent stem cell therapyFunctional deficitsPrimate modelFiber innervationParkinsonian phenotypeTherapeutic efficacyTransplantation studiesCell therapyNeuronsSignificant reversalTranslational developmentBehavioral assessmentClinical applicationTherapyElectrophysiological signaturesRatsDiseaseMinimal manipulation
2016
Biotransformation and Rearrangement of Laromustine
Nassar AE, Wisnewski AV, King I. Biotransformation and Rearrangement of Laromustine. Drug Metabolism And Disposition 2016, 44: 1349-1363. PMID: 27278961, DOI: 10.1124/dmd.116.069823.Peer-Reviewed Original ResearchConceptsNuclear magnetic resonance spectroscopyCollision-induced dissociationFourier transform ion cyclotron resonance mass spectrometerIon cyclotron resonance mass spectrometerAccurate mass measurementsMass spectrometry studiesHydrogen-deuterium exchangeMagnetic resonance spectroscopyMass spectral rearrangementsExact massSpectrometry studiesEnzyme catalysisReactive intermediatesMass spectrometerDecomposition productsResonance spectroscopyConjugation reactionsElemental compositionPossibility of rearrangementMass measurementsSpectral rearrangementsDissociationRadioactive componentsLoss of nitrogenMetabolite products
2015
A Promising PET Tracer for Imaging of α7 Nicotinic Acetylcholine Receptors in the Brain: Design, Synthesis, and in Vivo Evaluation of a Dibenzothiophene-Based Radioligand
Teodoro R, Scheunemann M, Deuther-Conrad W, Wenzel B, Fasoli FM, Gotti C, Kranz M, Donat CK, Patt M, Hillmer A, Zheng MQ, Peters D, Steinbach J, Sabri O, Huang Y, Brust P. A Promising PET Tracer for Imaging of α7 Nicotinic Acetylcholine Receptors in the Brain: Design, Synthesis, and in Vivo Evaluation of a Dibenzothiophene-Based Radioligand. Molecules 2015, 20: 18387-18421. PMID: 26473809, PMCID: PMC6332508, DOI: 10.3390/molecules201018387.Peer-Reviewed Original ResearchMeSH Keywordsalpha7 Nicotinic Acetylcholine ReceptorAnimalsAza CompoundsBrainBrain MappingFluorine RadioisotopesHaplorhiniHumansHydrogen BondingKineticsLigandsOxidesPiperazinesPositron-Emission TomographyProtein BindingRadiopharmaceuticalsRatsReceptors, Serotonin, 5-HT3Structure-Activity RelationshipSwineThiophenesTissue DistributionConceptsStructure-activity relationshipsCationic centerPositron emission tomographyHydrogen bond acceptor functionalitiesNicotinic acetylcholine receptorsAcceptor functionalitiesAcetylcholine receptorsNew ligandsDibenzothiophene dioxideΑ7 nicotinic acetylcholine receptorCompound 7Promising PET tracerNew basic structureRadioligand displacement studiesTwo-tissue compartment modelLigandsEmission tomographyPET radioligandKinetic analysisFurther evaluationDynamic positron emission tomographyPET tracersInitial evaluationVivo evaluationBrain
2010
Clinical Experiences With Anti-CD137 and Anti-PD1 Therapeutic Antibodies
Ascierto PA, Simeone E, Sznol M, Fu YX, Melero I. Clinical Experiences With Anti-CD137 and Anti-PD1 Therapeutic Antibodies. Seminars In Oncology 2010, 37: 508-516. PMID: 21074066, DOI: 10.1053/j.seminoncol.2010.09.008.Peer-Reviewed Original ResearchConceptsDurable objective responsesPotent cellular immunityAnti-CD137 antibodyCellular immune responsesLigand PD-L1Reasonable safety profileSevere liver toxicityTumor response criteriaTransplantable murine tumorsDose-dependent effectSurface of antigenImmunostimulatory mAbsAntitumor immunityObjective responseDeath-1PD-L1Tumor immunityCellular immunitySafety profileLiver toxicityClinical activityT lymphocytesImmune responseTumor antigensAgonist antibodyRapid Chemical Antagonism of Neuromuscular Blockade by l-Cysteine Adduction to and Inactivation of the Olefinic (Double-bonded) Isoquinolinium Diester Compounds Gantacurium (AV430A), CW 002, and CW 011
Savarese JJ, McGilvra JD, Sunaga H, Belmont MR, Van Ornum SG, Savard PM, Heerdt PM. Rapid Chemical Antagonism of Neuromuscular Blockade by l-Cysteine Adduction to and Inactivation of the Olefinic (Double-bonded) Isoquinolinium Diester Compounds Gantacurium (AV430A), CW 002, and CW 011. Anesthesiology 2010, 113: 58-73. PMID: 20526187, DOI: 10.1097/aln.0b013e3181dc1b5b.Peer-Reviewed Original ResearchMeSH KeywordsAlkenesAnimalsAtracuriumChemical PhenomenaCholinesterase InhibitorsChromatography, High Pressure LiquidCysteineDose-Response Relationship, DrugDrug InteractionsEdrophoniumHaplorhiniIsoquinolinesMacaca mulattaMaleMaleatesNeostigmineNeuromuscular BlockadeNeuromuscular Blocking AgentsStructure-Activity RelationshipConceptsDuration of blockED95 dosesNeuromuscular blockadeNeuromuscular blockersNovel agentsTwitch inhibitionCysteine adductionGantacuriumExogenous L-cysteineIntermediate durationAdductionL-cysteineED95Preliminary dataBlockadeAntagonismChemical antagonismHigh-performance liquid chromatographyDurationMinRapid adductionAdduction productsCisatracuriumLiquid chromatographyBlockers
2009
Dopamine D3 receptor antagonists: The quest for a potentially selective PET ligand. Part 3: Radiosynthesis and in vivo studies
Bennacef I, Salinas CA, Bonasera TA, Gunn RN, Audrain H, Jakobsen S, Nabulsi N, Weinzimmer D, Carson RE, Huang Y, Holmes I, Micheli F, Heidbreder C, Gentile G, Rossi T, Laruelle M. Dopamine D3 receptor antagonists: The quest for a potentially selective PET ligand. Part 3: Radiosynthesis and in vivo studies. Bioorganic & Medicinal Chemistry Letters 2009, 19: 5056-5059. PMID: 19635669, DOI: 10.1016/j.bmcl.2009.07.055.Peer-Reviewed Original ResearchAn in Vitro Evaluation of the Victim and Perpetrator Potential of the Anticancer Agent Laromustine (VNP40101M), Based on Reaction Phenotyping and Inhibition and Induction of Cytochrome P450 Enzymes
Nassar A, King I, Paris B, Haupt L, Ndikum-Moffor F, Campbell R, Usuki E, Skibbe J, Brobst D, Ogilvie B, Parkinson A. An in Vitro Evaluation of the Victim and Perpetrator Potential of the Anticancer Agent Laromustine (VNP40101M), Based on Reaction Phenotyping and Inhibition and Induction of Cytochrome P450 Enzymes. Drug Metabolism And Disposition 2009, 37: 1922-1930. PMID: 19520774, DOI: 10.1124/dmd.109.027516.Peer-Reviewed Original ResearchConceptsInhibition of CYP2B6Cytochrome P450 enzymesInhibition of CYP1A2Induction of cytochrome P450 enzymesPrimary cultures of human hepatocytesCultures of human hepatocytesPlasma C(maxHuman liver microsomesInduce CYP1A2Intravenous administrationClinical effectsCYP2C19P450 enzymesCYP3A4/5CYP2B6Human hepatocytesMetabolite profilesAnticancer drugsHydroxylated metabolitesIn vitro evaluationLaromustineLiver microsomesCYP3A4Reactive intermediatesCYP1A2
2008
Group A Human Rotavirus Genomics: Evidence that Gene Constellations Are Influenced by Viral Protein Interactions
Heiman E, McDonald S, Barro M, Taraporewala Z, Bar-Magen T, Patton J. Group A Human Rotavirus Genomics: Evidence that Gene Constellations Are Influenced by Viral Protein Interactions. Journal Of Virology 2008, 82: 11106-11116. PMID: 18786998, PMCID: PMC2573243, DOI: 10.1128/jvi.01402-08.Peer-Reviewed Original ResearchConceptsAmino acid sequence alignmentGene constellationViral proteinsProtein-protein interactionsViral protein interactionsViral capsid proteinsGenome sequenceProtein interactionsGenetic variationIndividual proteinsSequence alignmentDistinguish proteinsCapsid proteinSequencing resultsDS-1ProteinHuman rotavirusStrain DSerotype referenceSevere viral gastroenteritisGenotypesStrainsGenotype 1VP7 serotypesResiduesActin disassembly by cofilin, coronin, and Aip1 occurs in bursts and is inhibited by barbed-end cappers
Kueh H, Charras G, Mitchison T, Brieher W. Actin disassembly by cofilin, coronin, and Aip1 occurs in bursts and is inhibited by barbed-end cappers. Journal Of Cell Biology 2008, 182: 341-353. PMID: 18663144, PMCID: PMC2483518, DOI: 10.1083/jcb.200801027.Peer-Reviewed Original ResearchMeSH Keywords4-ButyrolactoneActin CytoskeletonActinsAdaptor Proteins, Signal TransducingAnimalsBridged Bicyclo Compounds, HeterocyclicCapZ Actin Capping ProteinCarrier ProteinsCell LineChlorocebus aethiopsCofilin 1Cytochalasin DCytoskeletonGuanylate KinasesHaplorhiniHeLa CellsHumansMicrofilament ProteinsNucleic Acid Synthesis InhibitorsProteinsRabbitsSignal TransductionThiazolidinesConceptsActin disassemblyBarbed-endActin filamentsActin-interacting protein 1Turnover of actin filamentsSingle actin filamentsBarbed endsLatrunculin BMammalian cellsCytoplasmic environmentCytochalasin DDisassembly pathwayActinLowered affinityCoroninCofilinPhysiological relevanceCapZDisassemblyProtein 1Protein systemsFilamentsCytoDFilamentous strandsCells
2006
Large animal models are critical for rationally advancing regenerative therapies
Wakeman D, Crain A, Snyder E. Large animal models are critical for rationally advancing regenerative therapies. Regenerative Medicine 2006, 1: 405-413. PMID: 17465832, PMCID: PMC2905042, DOI: 10.2217/17460751.1.4.405.Peer-Reviewed Original ResearchGeneralized five‐dimensional dynamic and spectral factor analysis
Fakhri G, Sitek A, Zimmerman R, Ouyang J. Generalized five‐dimensional dynamic and spectral factor analysis. Medical Physics 2006, 33: 1016-1024. PMID: 16696478, DOI: 10.1118/1.2179168.Peer-Reviewed Original Research
2002
The dark side of visual attention
Chun M, Marois R. The dark side of visual attention. Current Opinion In Neurobiology 2002, 12: 184-189. PMID: 12015235, DOI: 10.1016/s0959-4388(02)00309-4.Peer-Reviewed Original ResearchConceptsVisual attentionNon-visual factorsDark sideAttentional deploymentEmotional salienceNeural correlatesVisual eventsNeural processingVisual processingUnattended eventsNeural mechanismsFocal processingNumber of objectsBehavioral setsBright sidePast experienceFunctional blindnessProcessingAttentionSalienceLimited capacityRecent workCorrelatesExperienceObjects
2000
Application of DNA Topoisomerase-Activated Adapters to Riboprobe Synthesis
Yarovinsky T. Application of DNA Topoisomerase-Activated Adapters to Riboprobe Synthesis. BioTechniques 2000, 28: 1160-1165. PMID: 10868281, DOI: 10.2144/00286st06.Peer-Reviewed Original ResearchRole for dopamine in the behavioral functions of the prefrontal corticostriatal system: implications for mental disorders and psychotropic drug action
Jentsch J, Roth R, Taylor J. Role for dopamine in the behavioral functions of the prefrontal corticostriatal system: implications for mental disorders and psychotropic drug action. Progress In Brain Research 2000, 126: 433-453. PMID: 11105661, DOI: 10.1016/s0079-6123(00)26028-7.Peer-Reviewed Original ResearchMeSH KeywordsAmphetaminesAmygdalaAnimalsBehaviorBrain MappingCentral Nervous System StimulantsCognitionCorpus StriatumDepressionDopamineDopamine AgonistsEmotionsHaplorhiniHumansLearningLimbic SystemMammalsMemoryMental DisordersNeural PathwaysNeurotransmitter AgentsNucleus AccumbensPhencyclidinePrefrontal CortexPsychotropic DrugsReceptors, NeurotransmitterRewardSchizophreniaSubstance-Related DisordersConceptsForebrain sitesPsychotropic drug actionPrecise anatomical sitesRole of dopamineDopaminergic dysfunctionDopaminergic transmissionDopaminergic functionDopamine neuronsDopaminergic responseReward-related stimuliCorticolimbic circuitsChronic activationDopaminergic activationStriatal regionsAfferent controlAnatomical sitesCorticostriatal systemMental disordersNeuropsychiatric disordersNeuromodulatory systemsPersistent neuroadaptationsDrug actionBehavioral functionsCellular mechanismsDopamineStress impairs prefrontal cortical function in rats and monkeys: role of dopamine D1 and norepinephrine α-1 receptor mechanisms
Arnsten A. Stress impairs prefrontal cortical function in rats and monkeys: role of dopamine D1 and norepinephrine α-1 receptor mechanisms. Progress In Brain Research 2000, 126: 183-192. PMID: 11105647, DOI: 10.1016/s0079-6123(00)26014-7.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAmygdalaAnimalsAttentionCalcium SignalingCyclic AMPCyclic AMP-Dependent Protein KinasesDopamineHaplorhiniHelplessness, LearnedHumansMemory DisordersModels, NeurologicalModels, PsychologicalNerve Tissue ProteinsNoiseNorepinephrinePhosphatidylinositol Diacylglycerol-LyasePrefrontal CortexRatsReceptors, Adrenergic, alpha-1Receptors, Dopamine D1Second Messenger SystemsStress, PhysiologicalType C PhospholipasesConceptsMemory functionSensory cortexLong-term memory consolidationLong-term memoryPrefrontal cortical functionAssociative memory functionStress-induced deficitsAttentional regulationFocus of attentionAversive eventsMemory consolidationSalient signalsCortical functionProminent stimulusNorepinephrine αHigh levelsAmygdalaCortexCatecholamine releaseAttentionMemoryStimuliDeficitsΒ-receptor stimulationD1 receptors
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