2022
2214. National Testing Assessment of Select Bacterial STIs During the COVID-19 Pandemic
Fonseca G, Maier M, Keddem S, Borgerding J, Lowy E, McFarland L, Comstock E, Van Epps P, Ohl M, Hauser R, Ross D, Beste L. 2214. National Testing Assessment of Select Bacterial STIs During the COVID-19 Pandemic. Open Forum Infectious Diseases 2022, 9: ofac492.1833. DOI: 10.1093/ofid/ofac492.1833.Peer-Reviewed Original ResearchTesting ratesSyphilis testsCOVID-19 pandemicGC testingVeterans Health Administration healthcare systemCT/GCNumber of ChlamydiaOverall testing rateElectronic health record dataAge 25 yearsHealth record dataSTI testing ratesNear-baseline levelsSelf-reported raceBackground ChlamydiaSTI diagnosisSyphilis infectionBacterial STIsSTI testingHIV statusInfection testingPatient groupRetrospective studySyphilis testingPre-pandemic levels
2021
Lower Gastrointestinal Syphilis: Case Series and Literature Review
Ferzacca E, Barbieri A, Barakat L, Olave MC, Dunne D. Lower Gastrointestinal Syphilis: Case Series and Literature Review. Open Forum Infectious Diseases 2021, 8: ofab157. PMID: 34631920, PMCID: PMC8494075, DOI: 10.1093/ofid/ofab157.Peer-Reviewed Original ResearchHuman immunodeficiency virusAdditional casesCommon physical examination findingsAnal sexual contactLower gastrointestinal symptomsChronic inflammatory infiltrateInflammatory bowel diseasePhysical examination findingsPercent of specimensAnal painAnorectal massAnorectal ulcersNontreponemal titersGastrointestinal symptomsRectal massSyphilis infectionBowel diseaseRare manifestationCase seriesInflammatory infiltrateEarly syphilisExamination findingsImmunodeficiency virusMucosal abnormalitiesMedical recordsClinical and laboratory impact of concomitant syphilis infection during acute HIV
Chan P, Colby D, Kroon E, Sacdalan C, Pinyakorn S, Paul R, Robb M, Valcour V, Ananworanich J, Marra C, Spudich S. Clinical and laboratory impact of concomitant syphilis infection during acute HIV. HIV Medicine 2021, 22: 502-511. PMID: 33728759, DOI: 10.1111/hiv.13079.Peer-Reviewed Original ResearchConceptsAcute HIV-1T lymphocyte levelsVenereal Disease Research LaboratoryUntreated syphilisHistory of syphilisHIV-1Higher plasma HIV-1 RNACD4 T-lymphocyte levelsPlasma HIV-1 RNAHIV-1 RNA levelsCognitive performanceCD4 T lymphocytesHIV-1 infectionHIV-1 RNAImpaired cognitive performanceAcute HIVAHI participantsFiebig stagesIncident syphilisPrior syphilisSerum TreponemaSyphilis infectionChronic infectionDisease measuresSyphilis status
2020
1546. Update in Syphilis Proctitis: Insights from a Case Series and Literature Review
Ferzacca E, Dunne D, Barbieri A, Aoun-Barakat L. 1546. Update in Syphilis Proctitis: Insights from a Case Series and Literature Review. Open Forum Infectious Diseases 2020, 7: s772-s773. PMCID: PMC7777609, DOI: 10.1093/ofid/ofaa439.1726.Peer-Reviewed Original ResearchCases of proctitisLower gastrointestinal symptomsLymphoplasmacytic inflammatory infiltrateProminent plasma cellsInflammatory bowel diseasePhysical exam findingsMale sex assignmentPublic health consequencesAnal painAnorectal massAnorectal ulcersSyphilitic proctitisGastrointestinal symptomsChart reviewRectal massSyphilis infectionBowel diseaseRare manifestationCase seriesInflammatory infiltrateEarly syphilisExam findingsBiopsy specimensMedical recordsMisdiagnosis results
2019
Screening for HBV, HCV, HIV and syphilis infections among bacteriologically confirmed tuberculosis prisoners: An urgent action required
Puga M, Bandeira L, Pompilio M, de Rezende G, Soares L, de Castro V, Tanaka T, Cesar G, de Oliveira S, Teles S, Yassuda R, dos Santos Weis-Torres S, Basílio S, Croda J, Motta-Castro A. Screening for HBV, HCV, HIV and syphilis infections among bacteriologically confirmed tuberculosis prisoners: An urgent action required. PLOS ONE 2019, 14: e0221265. PMID: 31437184, PMCID: PMC6705821, DOI: 10.1371/journal.pone.0221265.Peer-Reviewed Original ResearchConceptsHepatitis B virusSyphilis infectionViral hepatitisHIV infectionB virusAnti-HCV positive samplesChronic hepatitis B virusFirst-line anti-tuberculosis drugsLifetime syphilis infectionCases of tuberculosisAnti-TB drugsCross-sectional studyPublic health problemAnti-tuberculosis drugsCurrent HCVHCV exposureHCV RNAHepatitis testingTuberculosis infectionActive syphilisSerological markersEpidemiological featuresFrequent causeSide effectsHCVSyphilis associated with recreational drug use, depression and high-risk sexual behaviour in men who have sex with men: a case–control study in China
Wu H, Xiu C, Fu X, Li M, Wang Z, Li X, Wu J, Vermund SH, Hu Y. Syphilis associated with recreational drug use, depression and high-risk sexual behaviour in men who have sex with men: a case–control study in China. Sexually Transmitted Infections 2019, 95: 267-272. PMID: 30842346, PMCID: PMC11093516, DOI: 10.1136/sextrans-2018-053878.Peer-Reviewed Original ResearchConceptsRecreational drug useHigh-risk sexual behaviorCase-control studyDrug useSyphilis infectionToluidine red unheated serum testUnmatched case-control studyRed unheated serum testMultivariable logistic regressionPotential risk factorsMultiple drug useSexual behaviorPrior STIFrequent methamphetamine useSyphilis prevalenceSyphilis testingRisk factorsSerum testHealth workersDepression scoresSelf-administrated questionnaireRecreational drugsLogistic regressionSyphilisMethamphetamine use
2018
Risk Prediction Score for HIV Infection: Development and Internal Validation with Cross-Sectional Data from Men Who Have Sex with Men in China
Yin L, Zhao Y, Peratikos MB, Song L, Zhang X, Xin R, Sun Z, Xu Y, Zhang L, Hu Y, Hao C, Ruan Y, Shao Y, Vermund SH, Qian HZ. Risk Prediction Score for HIV Infection: Development and Internal Validation with Cross-Sectional Data from Men Who Have Sex with Men in China. AIDS And Behavior 2018, 22: 2267-2276. PMID: 29786768, PMCID: PMC7024582, DOI: 10.1007/s10461-018-2129-y.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAlcohol DrinkingChinaCondomsCross-Sectional StudiesHIV InfectionsHomosexuality, MaleHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisPrevalenceRisk AssessmentRisk FactorsRisk-TakingSafe SexSexual and Gender MinoritiesSexual BehaviorSexual PartnersSurveys and QuestionnairesSyphilisUnsafe SexYoung AdultConceptsHIV infectionRisk scoreHuman immunodeficiency virus (HIV) riskMultivariable logistic regression modelingBootstrap-corrected C-indexMultiple male sexual partnersValid risk scoreVaccine clinical trialsHigh-risk MSMHigh-risk personsRisk prediction scoreReceptive anal intercourseReceptive anal sexInconsistent condom useMale sexual partnersHIV prevention programmingLogistic regression modelingDrug/alcohol addictionHIV acquisitionRisk reduction programsSyphilis infectionHIV prevalenceClinical trialsC-indexIllegal drug use
2017
HIV testing and sexual risks among migrant men who have sex with men: findings from a large cross-sectional study in Beijing, China
Liu Y, Vermund SH, Ruan Y, Liu H, Zhang C, Yin L, Shao Y, Qian HZ. HIV testing and sexual risks among migrant men who have sex with men: findings from a large cross-sectional study in Beijing, China. AIDS Care 2017, 30: 86-94. PMID: 28944685, PMCID: PMC6088860, DOI: 10.1080/09540121.2017.1381331.Peer-Reviewed Original ResearchConceptsLifetime male sexual partnersCondomless receptive anal sexHIV testingMigrant MSMHIV perceptionAnal sexHIV/syphilis infectionOlder ageLarge cross-sectional studyHIV/STI riskLikelihood of syphilisHIV/syphilisInsertive anal sexReceptive anal sexCross-sectional studyMale sexual partnersSyphilis infectionHIV transmissionLocal MSMSTI riskChinese MSMLower oddsEpidemiological studiesSexual partnersRisk profileActive syphilis and its association with HIV and sexual risk behaviours in a multicity sample of men who have sex with men and transgender women in Peru
Pizzicato LN, Vagenas P, Gonzales P, Lama JR, Pun M, Sanchez J, Altice FL. Active syphilis and its association with HIV and sexual risk behaviours in a multicity sample of men who have sex with men and transgender women in Peru. Sexual Health 2017, 14: 304-312. PMID: 28514994, DOI: 10.1071/sh16149.Peer-Reviewed Original ResearchConceptsActive syphilis infectionActive syphilisIndependent correlatesSyphilis infectionTransgender womenRisk factorsRecent sexRecent sex workSignificant independent correlatesReceptive anal intercourseFemale partnersRecent drug useSexual risk behaviorsTreatment of syphilisBackground SyphilisTGW populationPresent studySyphilis testingSyphilis screeningTransmissible infectionsSyphilis diagnosisHigh prevalenceStratified analysisSyphilis epidemicAge 35
2016
Alcohol misuse, risky sexual behaviors, and HIV or syphilis infections among Chinese men who have sex with men
Liu Y, Ruan Y, Strauss SM, Yin L, Liu H, Amico KR, Zhang C, Shao Y, Qian HZ, Vermund SH. Alcohol misuse, risky sexual behaviors, and HIV or syphilis infections among Chinese men who have sex with men. Drug And Alcohol Dependence 2016, 168: 239-246. PMID: 27723554, PMCID: PMC5523945, DOI: 10.1016/j.drugalcdep.2016.09.020.Peer-Reviewed Original ResearchConceptsAlcohol Use Disorders Identification Test-ConsumptionSyphilis infectionBinge drinkersChinese menAlcohol misuseCondomless insertive anal intercourseHIV/syphilis infectionRecent alcohol misuseAlcohol risk reduction programCross-sectional studyInsertive anal intercourseAUDIT-C scoresCurrent alcohol dependenceInterviewer-administered surveyHigh-risk behaviorsRisk reduction programsRisky sexual behaviorMisuse MeasureHIV riskChinese MSMAnal intercourseHigh riskSyphilis riskBinge drinkingHazardous drinkersSexual Behaviors Linked to Drug and Alcohol Use Among Men Who Have Sex With Men in China
Zhang C, Qian HZ, Yin L, Liu Y, Strauss SM, Ruan Y, Shao Y, Lu H, Vermund SH. Sexual Behaviors Linked to Drug and Alcohol Use Among Men Who Have Sex With Men in China. Substance Use & Misuse 2016, 51: 1821-1830. PMID: 27608264, PMCID: PMC5423713, DOI: 10.1080/10826084.2016.1197264.Peer-Reviewed Original ResearchConceptsAlcohol useHigher oddsAlcohol consumptionSexual behaviorDrug useHigh-risk sexual behaviorFemale partnersHistory of alcoholSexual risk behaviorsHigh-risk behaviorsEffects of drugsSelf-administered questionnaireSyphilis infectionHIV infectionSyphilis prevalenceMean ageSyphilis testingClinical trialsHIV epidemicHIV interventionsBlood samplesHIVHan ethnicityRisk behaviorsMSMIntersecting epidemics of HIV, HCV, and syphilis among soon-to-be released prisoners in Kyrgyzstan: Implications for prevention and treatment
Azbel L, Polonsky M, Wegman M, Shumskaya N, Kurmanalieva A, Asanov A, Wickersham JA, Dvoriak S, Altice FL. Intersecting epidemics of HIV, HCV, and syphilis among soon-to-be released prisoners in Kyrgyzstan: Implications for prevention and treatment. International Journal Of Drug Policy 2016, 37: 9-20. PMID: 27455177, PMCID: PMC5124506, DOI: 10.1016/j.drugpo.2016.06.007.Peer-Reviewed Original ResearchConceptsDrug injectionHIV infectionLifetime drug injectionPrison drug injectionHIV care continuumAntiretroviral therapy coverageConfidence intervalsMean numberEpidemic of HIVHealth assessment surveyUndiagnosed syphilisSyphilis infectionConsented participantsHIV incidenceHIV transmissionIndependent correlatesWeighted prevalenceEvidence-based responsesHIV epidemicCare continuumDuration of imprisonmentHIV preventionHealth SurveyAIDS mortalityHIV
2015
Bridging the Epidemic: A Comprehensive Analysis of Prevalence and Correlates of HIV, Hepatitis C, and Syphilis, and Infection among Female Sex Workers in Guangxi Province, China
Chen Y, Shen Z, Morano JP, Khoshnood K, Wu Z, Lan G, Zhu Q, Zhou Y, Tang S, Liu W, Chen J, Tang Z. Bridging the Epidemic: A Comprehensive Analysis of Prevalence and Correlates of HIV, Hepatitis C, and Syphilis, and Infection among Female Sex Workers in Guangxi Province, China. PLOS ONE 2015, 10: e0115311. PMID: 25723548, PMCID: PMC4344209, DOI: 10.1371/journal.pone.0115311.Peer-Reviewed Original ResearchConceptsLow-tier female sex workersFemale sex workersSentinel surveillance dataHepatitis CSurveillance dataCorrelates of HIVIntravenous drug useHeterosexual HIV epidemicPrevalence of HIVSex workersHarm reduction campaignsLogistic regression analysisLow formal education levelLow-tier venuesSafer sex practicesHCV prevalencePrior STIHCV infectionSyphilis infectionSyphilis prevalenceRisk factorsHIV epidemicCondom distributionHCVHigh risk
2014
A-101 New Evidence that Circumcision Might Protect MSM from HIV
Vermund S, Qian H, Ruan Y, Shao Y, Liu Y, Milam D, Spiegel H, Li D, Yin L. A-101 New Evidence that Circumcision Might Protect MSM from HIV. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2014, 67: 37. DOI: 10.1097/01.qai.0000456053.93927.60.Peer-Reviewed Original ResearchInsertive anal sexAnal sexUncircumcised menCircumcision statusMale circumcisionMultivariate logistic regression analysisOdds of HIVUnknown HIV statusHIV prevention strategiesCross-sectional studyInsertive anal intercourseLogistic regression analysisAnal sex rolesAdjusted riskHIV clinicSyphilis infectionHIV statusClinical trialsCircumcision ratesGenital examinationAnal intercourseLower oddsGenital examHIVPrevention strategiesHIV and syphilis prevalence trends among men who have sex with men in Guangxi, China: yearly cross-sectional surveys, 2008–2012
Wang X, Lan G, Shen Z, Vermund SH, Zhu Q, Chen Y, Khoshnood K, Wu Z, Tang Z. HIV and syphilis prevalence trends among men who have sex with men in Guangxi, China: yearly cross-sectional surveys, 2008–2012. BMC Infectious Diseases 2014, 14: 367. PMID: 24993252, PMCID: PMC4091643, DOI: 10.1186/1471-2334-14-367.Peer-Reviewed Original ResearchConceptsYears of ageSyphilis prevalenceCross-sectional surveyCurrent syphilisHIV prevalencePrevalence trendsSexual intercourseIncident HIV casesAnnual cross-sectional surveyRisk factor dataSignificant predictorsRisk of HIVNational sentinel surveillanceYearly cross-sectional surveysHIV/AIDSSyphilis infectionHIV infectionHIV casesSentinel surveillanceRisk factorsBlood samplesHIVKey populationsMSMPrevalence
2013
Effectiveness of HIV Risk Reduction Interventions among Men who have Sex with Men in China: A Systematic Review and Meta-Analysis
Lu H, Liu Y, Dahiya K, Qian HZ, Fan W, Zhang L, Ma J, Ruan Y, Shao Y, Vermund SH, Yin L. Effectiveness of HIV Risk Reduction Interventions among Men who have Sex with Men in China: A Systematic Review and Meta-Analysis. PLOS ONE 2013, 8: e72747. PMID: 24137497, PMCID: PMC3796948, DOI: 10.1371/journal.pone.0072747.Peer-Reviewed Original ResearchConceptsRisk reduction interventionsHIV risk reduction interventionsPrevalence of HIVRandomized clinical trialsStandardized mean differenceReduction interventionsIntervention studiesSexual partnersChinese MSMSystematic reviewHIV/AIDS-related knowledgeCross-sectional intervention studyEffect sizeRegular sexual partnersPost-intervention studyMale sexual partnersConsistent condom useRandom-effects modelPost-intervention assessmentCasual sexual partnersSyphilis infectionHIV testingStudy armsHIV knowledgeClinical trialsSex with Women Among Men Who Have Sex with Men in China: Prevalence and Sexual Practices
Tao J, Ruan Y, Yin L, Vermund SH, Shepherd BE, Shao Y, Qian HZ. Sex with Women Among Men Who Have Sex with Men in China: Prevalence and Sexual Practices. AIDS Patient Care And STDs 2013, 27: 524-528. PMID: 23931683, PMCID: PMC3760059, DOI: 10.1089/apc.2013.0161.Peer-Reviewed Original ResearchConceptsPotential bridge populationPrevalence of HIVSubgroup of menPrevention intervention programsHIV prevention intervention programsSyphilis infectionEligible MSMHIV transmissionAlcohol drinkingAnal sexOlder ageLower educationInsertive roleWomenIntervention programsSexMenBisexual behaviorHIVSignificant differencesStrongest predictorBisexual orientationSexual practicesBridge populationInfection
2012
Prevention, Detection, and Treatment of Coinfections: A Priority in Human Immunodeficiency Virus–Infected Persons to Reduce Viral Load and Consequent Disease Progression and Transmission : Comment on “Effect of Early Syphilis Infection on Plasma Viral Load and CD4 Cell Count in Human Immunodeficiency Virus–Infected Men”
Vermund SH. Prevention, Detection, and Treatment of Coinfections: A Priority in Human Immunodeficiency Virus–Infected Persons to Reduce Viral Load and Consequent Disease Progression and Transmission : Comment on “Effect of Early Syphilis Infection on Plasma Viral Load and CD4 Cell Count in Human Immunodeficiency Virus–Infected Men”. JAMA Internal Medicine 2012, 172: 1243-1244. PMID: 22824925, DOI: 10.1001/archinternmed.2012.3770.Peer-Reviewed Original ResearchPredictors of HIV and Syphilis among Men Who Have Sex with Men in a Chinese Metropolitan City: Comparison of Risks among Students and Non-Students
Zhang L, Ding X, Lu R, Feng L, Li X, Xiao Y, Ruan Y, Vermund SH, Shao Y, Qian HZ. Predictors of HIV and Syphilis among Men Who Have Sex with Men in a Chinese Metropolitan City: Comparison of Risks among Students and Non-Students. PLOS ONE 2012, 7: e37211. PMID: 22623994, PMCID: PMC3356386, DOI: 10.1371/journal.pone.0037211.Peer-Reviewed Original ResearchConceptsSyphilis infectionRisky sexual behaviorHIV prevalenceStudent MSMMultivariable logistic regression analysisSexual behaviorPredictors of HIVLow HIV prevalencePrevalence of syphilisRisk of HIVLogistic regression analysisRisk sexual behaviourLow HIVHIV infectionSyphilis prevalenceComparison of risksSyphilis testingAdjusted prevalenceHigh prevalenceHIV riskBlood specimensHIVMSM participantsMultivariate analysisSexual partners
2011
O4-S2.05 Myd-88 deficient mice show evidence of productive T pallidum infection"
Dunne D, Silver A, Fieber J, Zeiss C, Fikrig E. O4-S2.05 Myd-88 deficient mice show evidence of productive T pallidum infection". Sexually Transmitted Infections 2011, 87: a87. DOI: 10.1136/sextrans-2011-050109.149.Peer-Reviewed Original ResearchMyD-88C57BL/6 miceDeficient miceImmunohistochemical stainsImmune responseMurine modelT pallidumDay 10Intact innate immune responseOnly natural reservoirNew Zealand male rabbitsB6 control miceInnate immune cellsUseful murine modelAged C57BL/6 miceWild-type miceInnate immune responseInnate immune systemPattern recognition receptorsImmune response mechanismsDownstream cytokine responsesSyphilis infectionSystemic illnessLymph nodesCytokine responses
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