2017
Protective Efficacy of Broadly Neutralizing Antibodies with Incomplete Neutralization Activity against Simian-Human Immunodeficiency Virus in Rhesus Monkeys
Julg B, Sok D, Schmidt S, Abbink P, Newman R, Broge T, Linde C, Nkolola J, Le K, Su D, Torabi J, Pack M, Pegu A, Allen T, Mascola J, Burton D, Barouch D. Protective Efficacy of Broadly Neutralizing Antibodies with Incomplete Neutralization Activity against Simian-Human Immunodeficiency Virus in Rhesus Monkeys. Journal Of Virology 2017, 91: 10.1128/jvi.01187-17. PMID: 28768869, PMCID: PMC5625479, DOI: 10.1128/jvi.01187-17.Peer-Reviewed Original ResearchConceptsImmunodeficiency virusProtective effects <i>inNeutralizing antibodiesSimian-human immunodeficiency virusCirculating HIV strainsResistant to antibody neutralizationRhesus macaquesBroadly Neutralizing AntibodiesPlasma viremiaIncreased levelsSterile protectionHIV strainsBnAbsPGT121Neutralizing activityAntibody neutralizationVirus-antibody combinationsIncomplete neutralizationControl animalsMultiple antibodiesRhesus monkeysPrevent infectionProtective efficacySterilizing activityInput virus
2015
Adenovirus-Vectored Broadly Neutralizing Antibodies Directed Against gp120 Prevent Human Immunodeficiency Virus Type 1 Acquisition in Humanized Mice
Liu S, Jackson A, Beloor J, Kumar P, Sutton RE. Adenovirus-Vectored Broadly Neutralizing Antibodies Directed Against gp120 Prevent Human Immunodeficiency Virus Type 1 Acquisition in Humanized Mice. Human Gene Therapy 2015, 26: 622-634. PMID: 25953321, PMCID: PMC4575530, DOI: 10.1089/hum.2014.146.Peer-Reviewed Original ResearchConceptsHumanized miceHuman immunodeficiency virus type 1 (HIV-1) acquisitionHuman immunodeficiency virus type 1Immunodeficiency virus type 1Plasma viral loadHigher serum levelsSingle intramuscular injectionBroadly Neutralizing AntibodiesVirus type 1First-generation adenoviral vectorsSerum levelsViral loadNeutralizing antibodiesIntramuscular injectionEffective vaccineT cellsHIV-1Therapeutic approachesHigh doseTherapeutic useType 1Adenoviral vectorAdV vectorsMiceAntibodies
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