2023
The Biological Basis of Sex Differences in Athletic Performance: Consensus Statement for the American College of Sports Medicine
Hunter S, Angadi S, Bhargava A, Harper J, Hirschberg A, Levine B, Moreau K, Nokoff N, Stachenfeld N, Bermon S. The Biological Basis of Sex Differences in Athletic Performance: Consensus Statement for the American College of Sports Medicine. Translational Journal Of The American College Of Sports Medicine 2023, 8: 1-33. DOI: 10.1249/tjx.0000000000000236.Peer-Reviewed Original ResearchSex steroid hormonesConsensus statementAthletic performanceEndogenous sex steroid hormonesSex differencesSteroid hormonesOnset of pubertyExercise trainingMuscle strengthAcute boutFundamental sex differencesSex hormonesAmerican CollegeParticular testosteroneAdult menSports medicineTraining statusHigh-impact studiesHormoneSimilar ageNonphysiological factorsPrimary determinantMalesBiological basisWomenThe Biological Basis of Sex Differences in Athletic Performance: Consensus Statement for the American College of Sports Medicine
HUNTER S, ANGADI S, BHARGAVA A, HARPER J, HIRSCHBERG A, LEVINE B, MOREAU K, NOKOFF N, STACHENFELD N, BERMON S. The Biological Basis of Sex Differences in Athletic Performance: Consensus Statement for the American College of Sports Medicine. Medicine & Science In Sports & Exercise 2023, 55: 2328-2360. PMID: 37772882, DOI: 10.1249/mss.0000000000003300.Peer-Reviewed Original ResearchConceptsSex steroid hormonesConsensus statementAthletic performanceEndogenous sex steroid hormonesSex differencesSteroid hormonesOnset of pubertyExercise trainingMuscle strengthAcute boutFundamental sex differencesSex hormonesAmerican CollegeParticular testosteroneAdult menSports medicineTraining statusHigh-impact studiesHormoneSimilar ageNonphysiological factorsPrimary determinantMalesBiological basisWomen
2022
Course of Tic Severity in Tourette Syndrome: The First Two Decades
Leckman J, Zhang H, Vitale A, Lahnin F, Lynch K, Bondi C, Kim Y, Peterson B. Course of Tic Severity in Tourette Syndrome: The First Two Decades. 2022, 80-85. DOI: 10.4324/9780203822937-8.Peer-Reviewed Original ResearchYears of ageDecades of lifeTic severityTourette syndromeTS patientsTic onsetClinical evaluationPrevalence studySeverity of ticsInitial clinical evaluationConsistent time courseTime courseHigh rateOnset of pubertyInitial followPatient's coursePrognostic valueYale Child Study CenterBirth-year cohortsPatientsNatural historySyndromeCurve analysisSeverityStudy centers
2018
Mitogenic Insulin Receptor A Increases in the Rodent Pituitary at the Onset of Puberty
SALEH F, TAYLOR H, FLANNERY C. Mitogenic Insulin Receptor A Increases in the Rodent Pituitary at the Onset of Puberty. Diabetes 2018, 67 DOI: 10.2337/db18-245-lb.Peer-Reviewed Original ResearchOnset of pubertyIGF-1RFVB/NJ miceIGF-1R levelsPhysiological insulin resistanceWeek old micePeri-pubertal girlsPituitary hormone productionT-testInitiation of pubertyStudent's t-testSteroid hormone synthesisActive folliculogenesisHPO axisOvarian axisInsulin resistanceRisk factorsReceptor expressionIGF-1Normal insulinOld miceVaginal openingPuberty developmentHormone productionSplice variant isoforms
2012
Pubertal stage and brain anatomy in girls
Blanton R, Cooney R, Joormann J, Eugène F, Glover G, Gotlib I. Pubertal stage and brain anatomy in girls. Neuroscience 2012, 217: 105-112. PMID: 22569152, PMCID: PMC4584426, DOI: 10.1016/j.neuroscience.2012.04.059.Peer-Reviewed Original ResearchConceptsAmygdala volumeMagnetic resonance imagingIntracranial volumePubertal statusPubertal stageHigh-resolution magnetic resonance imagingIncidence of depressionStudy of pubertyBrain anatomyBrain morphometric analysisTotal intracranial volumeOnset of pubertyRight hippocampusTanner stagingMRI scansResonance imagingSignificant associationBrain physiologyHippocampusSubcortical structuresStepwise regression analysisOutcome variablesPubertyRegression analysisCognitive functioning
2008
Excitatory Effects of the Puberty-Initiating Peptide Kisspeptin and Group I Metabotropic Glutamate Receptor Agonists Differentiate Two Distinct Subpopulations of Gonadotropin-Releasing Hormone Neurons
Dumalska I, Wu M, Morozova E, Liu R, van den Pol A, Alreja M. Excitatory Effects of the Puberty-Initiating Peptide Kisspeptin and Group I Metabotropic Glutamate Receptor Agonists Differentiate Two Distinct Subpopulations of Gonadotropin-Releasing Hormone Neurons. Journal Of Neuroscience 2008, 28: 8003-8013. PMID: 18685025, PMCID: PMC2597556, DOI: 10.1523/jneurosci.1225-08.2008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBarium CompoundsCapillariesChloridesDiagonal Band of BrocaDrug ResistanceElectrophysiologyFemaleGonadotropin-Releasing HormoneGreen Fluorescent ProteinsIn Vitro TechniquesMaleMedian EminenceMethoxyhydroxyphenylglycolMiceMice, TransgenicNeuronsPotassium ChannelsRatsRats, Sprague-DawleyReceptors, Metabotropic GlutamateRNA, MessengerSynapsesTumor Suppressor ProteinsVesicular Glutamate Transport Protein 2ConceptsMetabotropic glutamate receptor agonistGlutamate receptor agonistsGroup I metabotropic glutamate receptor agonistReceptor agonistGnRH neuronsGonadotropin-Releasing Hormone NeuronsG protein-coupled receptor GPR54Vesicular glutamate transporter 2GnRH-GFP miceRetrograde labeling techniqueGlutamate transporter 2Gonadotropin-releasing hormoneDistinct subpopulationsOnset of pubertyPostpubertal miceHormone neuronsGnRH cellsExcitatory effectsCentral releaseHypogonadotropic hypogonadismPeptide kisspeptinReceptor GPR54Brain slicesNormal pubertyKisspeptin
1998
Course of Tic Severity in Tourette Syndrome: The First Two Decades
Leckman J, Zhang H, Vitale A, Lahnin F, Lynch K, Bondi C, Kim Y, Peterson B. Course of Tic Severity in Tourette Syndrome: The First Two Decades. 1998, 102: 14-19. PMID: 9651407, DOI: 10.1542/peds.102.1.14.Peer-Reviewed Original ResearchConceptsYears of ageTic severityTS patientsTourette syndromeSeverity of ticsInitial clinical evaluationDecades of lifeConsistent time courseOnset of pubertyPatient's coursePrognostic valueTic onsetYale Child Study CenterClinical evaluationBirth-year cohortsPrevalence studyPatientsSeverityStudy centersChild Study CenterIdentification of factorsSevere levelsAgeProgressive patternSyndrome
1996
Co-existence of severe insulin resistance and hyperinsulinaemia in pre-adolescent obese children
Caprio S, Bronson M, Sherwin RS, Rife F, Tamborlane WV. Co-existence of severe insulin resistance and hyperinsulinaemia in pre-adolescent obese children. Diabetologia 1996, 39: 1489-1497. PMID: 8960831, DOI: 10.1007/s001250050603.Peer-Reviewed Original ResearchConceptsObese groupHyperglycaemic clampInsulin resistanceObese preadolescentsInsulin actionGlucose-stimulated insulin levelsHigher insulin infusion ratesNon-oxidative glucose metabolismGlucose uptakeDuration of obesityGroup of obeseNon-obese subjectsBeta-cell functionDevelopment of obesityEuglycaemic hyperinsulinaemic clampSevere insulin resistanceInsulin infusion rateCross-sectional analysisOnset of pubertyAbility of insulinSevere obesityObese adultsObese childrenObese subjectsInsulin levels
1990
Current concepts of β-endorphin physiology in female reproductive dysfunction
Wallach E, Seifer D, Collins R. Current concepts of β-endorphin physiology in female reproductive dysfunction. Fertility And Sterility 1990, 54: 757-771. PMID: 2226908, DOI: 10.1016/s0015-0282(16)53928-4.Peer-Reviewed Original ResearchConceptsEndogenous opioid peptidesBeta-endorphinReproductive dysfunctionOpioid peptidesPulsatile GnRH releasePolycystic ovarian syndromeBeta-endorphin levelsFemale reproductive dysfunctionExercise-associated amenorrheaNormal menstrual cycleOnset of pubertyGnRH releaseOvarian syndromeMenstrual cyclePeripheral levelsDopaminergic pathwaysPathophysiological processesPulsatile releaseSpecific disordersDysfunctionParticular disorderCurrent conceptsPrecise mechanismAmenorrheaClinical application
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