2024
Adding Insult to Injury Sleep Deficiency in Hospitalized Patients
Mansour W, Knauert M. Adding Insult to Injury Sleep Deficiency in Hospitalized Patients. Sleep Medicine Clinics 2024, 19: 607-623. PMID: 39455181, DOI: 10.1016/j.jsmc.2024.07.008.Peer-Reviewed Original ResearchConceptsHospital settingSleep promotion protocolsSleep deficiencyHospitalized patientsNegative health effectsObjective sleep measuresSleep measurement techniquesHospital outcomesMedical conditionsEffects of sleep deficiencyStudy protocolIllness severitySleep promotionHospital environmentImpact multiple organ systemsMultiple organ systemsHospitalTreatment-related effectsSleep measuresContributing factorsPromotion protocolOrgan systemsOutcomesPatientsSleepUnderstanding the significance of oxygen tension on the biology of Plasmodium falciparum blood stages: From the human body to the laboratory
Nahid D, Coffey K, Bei A, Cordy R. Understanding the significance of oxygen tension on the biology of Plasmodium falciparum blood stages: From the human body to the laboratory. PLOS Pathogens 2024, 20: e1012514. PMID: 39298535, PMCID: PMC11412506, DOI: 10.1371/journal.ppat.1012514.Peer-Reviewed Original ResearchConceptsRed blood cellsIntraerythrocytic developmentReactive oxygen speciesPlasmodium falciparum blood stagesMultiple organ systemsP. falciparum mitochondrionStatus of hemoglobinBlood stagesPlasmodium falciparumReactive oxygen species productionO2-sensing mechanismIn vitro experimentsPlasmodiumBlood cellsOxygenation statusOrgan systemsFunctional changesParasite growthOxidative stressOxygen tensionMosquito hostCulture systemDeep tissuesOxygen species
2023
Kidney Damage in Long COVID: Studies in Experimental Mice
Ramamoorthy R, Hussain H, Ravelo N, Sriramajayam K, Di Gregorio D, Paulrasu K, Chen P, Young K, Masciarella A, Jayakumar A, Paidas M. Kidney Damage in Long COVID: Studies in Experimental Mice. Biology 2023, 12: 1070. PMID: 37626956, PMCID: PMC10452084, DOI: 10.3390/biology12081070.Peer-Reviewed Original ResearchNeutrophil Gelatinase-Associated LipocalinSARS-CoV-2 infectionAcute infectionTubular necrosisLong COVIDTGF-β1Severe acute tubular necrosisInitial SARS-CoV-2 infectionAcute tubular necrosisGelatinase-Associated LipocalinCoV-2 infectionProtein levelsInfiltration of macrophagesDevelopment of edemaMultiple organ systemsMMP-7 protein levelsCommon complicationKidney complicationsTLR-2IL-18Kidney damageKIM-1Renal fibrosisYKL-40NGAL mRNA“Long Haulers”
Lutchmansingh D, Sevilla J, Possick J, Gulati M. “Long Haulers”. Seminars In Respiratory And Critical Care Medicine 2023, 44: 130-142. PMID: 36646091, DOI: 10.1055/s-0042-1759568.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPost-COVID conditionsAcute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionSyndrome coronavirus 2 infectionSARS-CoV-2 infectionChronic COVID-19Long-haul COVIDOngoing interventional trialsLong-term morbidityCoronavirus disease 2019Multiple organ systemsInterventional trialsLong COVIDTreatment algorithmNeuropsychiatric sequelaePostacute sequelaeRisk factorsObservational studyDisease 2019Long-term effectsSurvivors' qualityClinical protocolsLong haulersOrgan systemsPerioperative Complications in Patients with Systemic Sclerosis: A Comparative Cohort Analysis
Carr Z, Yan L, Yanez N, Schonberger R, Bohorquez M, He Z, Li F, Hines R, Treggiari M. Perioperative Complications in Patients with Systemic Sclerosis: A Comparative Cohort Analysis. Medical Research Archives 2023, 11: 10.18103/mra.v11i10.4606. PMID: 38037571, PMCID: PMC10688569, DOI: 10.18103/mra.v11i10.4606.Peer-Reviewed Original ResearchMajor adverse cardiac eventsSystemic sclerosisLength of stayPerioperative complicationsSSc patientsComparative cohort analysisSSc cohortPerioperative outcomesControl cohortCohort analysisCormack-Lehane grade 3Limited cervical rangeAdverse cardiac eventsRare autoimmune disorderComparative cohort studySurgical site infectionBetween-group differencesQuaternary care institutionMultiple organ systemsHigh rateAirway complicationsComposite infectionHospital complicationsCardiac eventsCohort study
2022
Severe extra-glandular involvement and pleural effusions complicating primary Sjogren’s syndrome: a case report
Abou Ziki M, Taoutel R, Hong J, Podell D. Severe extra-glandular involvement and pleural effusions complicating primary Sjogren’s syndrome: a case report. Journal Of Medical Case Reports 2022, 16: 374. PMID: 36253840, PMCID: PMC9578189, DOI: 10.1186/s13256-022-03557-7.Peer-Reviewed Original ResearchConceptsPrimary Sjogren's syndromeSjogren's syndromePleural effusionKeratoconjunctivitis siccaMonoclonal gammopathyDisease severityB-cell non-Hodgkin lymphomaExtra-glandular involvementBilateral pleural effusionLymphocytic interstitial pneumoniaEvidence of malignancyMulti-organ diseaseSevere multi-organ diseaseAnti-Ro antibodiesNon-Hodgkin lymphomaMultiple organ systemsSevere bronchiectasisRare complicationInterstitial pneumoniaBenign diseaseAutoimmune diseasesDental cariesCase reportCaucasian womenSkin ulcersGenetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells
Lynall ME, Soskic B, Hayhurst J, Schwartzentruber J, Levey DF, Pathak GA, Polimanti R, Gelernter J, Stein MB, Trynka G, Clatworthy MR, Bullmore E. Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells. Nature Communications 2022, 13: 6102. PMID: 36243721, PMCID: PMC9569335, DOI: 10.1038/s41467-022-33885-7.Peer-Reviewed Original ResearchConceptsMultiple psychiatric disordersPsychiatric disordersPsychiatric risk variantT cellsLymphoid cellsRisk variantsImmune cell subsetsMental health disordersMultiple organ systemsAdaptive immune systemCell subsetsImmune cellsHealth disordersMyeloid cellsImmune systemBrain tissueOrgan systemsSpecific disordersDisordersPathogenesisAbnormalitiesGenetic variantsCellsCD4VariantsA Retinol Derivative Inhibits SARS-CoV-2 Infection by Interrupting Spike-Mediated Cellular Entry
Tong L, Wang L, Liao S, Xiao X, Qu J, Wu C, Zhu Y, Tai W, Huang Y, Wang P, Li L, Zhang R, Xiang Y, Cheng G. A Retinol Derivative Inhibits SARS-CoV-2 Infection by Interrupting Spike-Mediated Cellular Entry. MBio 2022, 13: e01485-22. PMID: 35862773, PMCID: PMC9426596, DOI: 10.1128/mbio.01485-22.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 variantsSARS-CoV-2 infectionPotent antiviral activitySevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Inhibits SARS-CoV-2 infectionAntiviral activityRespiratory syndrome coronavirus 2Retinoic acidLower respiratory tractSyndrome coronavirus 2Coronavirus disease 2019Multiple organ systemsVitamin A derivativesCOVID-19 diseaseSpike protein trimerS trimerCoronavirus 2Respiratory tractDisease 2019Vitamin AActive metaboliteOrgan systemsEtiological agentTherapeutic antibodiesAdding Insult to Injury Sleep Deficiency in Hospitalized Patients
Mansour W, Knauert M. Adding Insult to Injury Sleep Deficiency in Hospitalized Patients. Clinics In Chest Medicine 2022, 43: 287-303. PMID: 35659026, PMCID: PMC9177053, DOI: 10.1016/j.ccm.2022.02.009.Peer-Reviewed Original ResearchConceptsSleep deficiencyHospital settingTreatment-related effectsMultiple organ systemsObjective sleep measurementsHospital outcomesHospitalized patientsIllness severityNegative health effectsSleep promotionStudy protocolPromotion protocolMedical conditionsSleep measurementsKey next stepOrgan systemsHealth effectsHospital environmentPatientsContributing factorDeficiencyOutcomesCommon problemInsultSettingThe genetics and diagnosis of pediatric neurocutaneous disorders: Neurofibromatosis and tuberous sclerosis complex
Tolliver S, Smith Z, Silverberg N. The genetics and diagnosis of pediatric neurocutaneous disorders: Neurofibromatosis and tuberous sclerosis complex. Clinics In Dermatology 2022, 40: 374-382. PMID: 35248688, DOI: 10.1016/j.clindermatol.2022.02.010.Peer-Reviewed Original ResearchConceptsTuberous sclerosis complexMultiple organ systemsNeurocutaneous disorderTarget of rapamycin signaling pathwayClinical featuresGenetic sequencing technologiesSeizure controlLoss of tumor suppressionMitogen-activated protein kinaseCausative genetic mutationsRapamycin signaling pathwayAt-risk family membersSequencing technologiesMammalian target of rapamycin signaling pathwayBenign fibrous growthsCases of NFCafe-au-lait patchesOrgan systemsDisease-specific surveillanceAsh leaf spotsLeaf spotProtein kinaseMosaic conditionSignaling pathwayInstitution of interventions
2021
Patients With Ehlers-Danlos Syndromes Experience Higher Rates of Prosthetic Dislocation After Total Hip Arthroplasty and Worse Implant Survival at 5 Years
Moore HG, Burroughs PJ, Rubin LE, Frumberg DB, Sculco PK, Grauer JN. Patients With Ehlers-Danlos Syndromes Experience Higher Rates of Prosthetic Dislocation After Total Hip Arthroplasty and Worse Implant Survival at 5 Years. Journal Of The American Academy Of Orthopaedic Surgeons 2021, 30: 177-183. PMID: 34967762, DOI: 10.5435/jaaos-d-21-00347.Peer-Reviewed Original ResearchConceptsEhlers-Danlos syndromeTotal hip arthroplastyImplant survivalHip arthroplastyAdverse eventsDiagnosis of EDSGenetic connective tissue disorderNinety-day incidenceWorse implant survivalHigh rateDay of surgeryLong-term outcomesLog-rank testMultivariate logistic regressionConnective tissue disordersMultiple organ systemsConnective tissue laxityPerioperative dislocationPeriprosthetic dislocationPostoperative complicationsPostoperative periodProsthetic dislocationHospital readmissionControl subjectsAdministrative databasesIsolated Encephalopathy Without Severe Disease in a COVID-19 Patient: Case Presentation and Workup Strategies
McAlpine LS, Barden M, Zubair AS, Sanamandra S. Isolated Encephalopathy Without Severe Disease in a COVID-19 Patient: Case Presentation and Workup Strategies. Cureus 2021, 13: e13277. PMID: 33728212, PMCID: PMC7955529, DOI: 10.7759/cureus.13277.Peer-Reviewed Case Reports and Technical NotesSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2COVID-19 patientsSyndrome coronavirus 2Common COVID-19 symptomsCOVID-19 symptomsHuman coronavirus disease 2019Coronavirus disease 2019Multiple organ systemsCOVID-19Neurologic examinationRespiratory dysfunctionCoronavirus 2Disease 2019Respiratory diseaseSevere diseaseSensory examinationWorkup strategiesCase presentationCognitive declineOrgan systemsIntact motorDiseasePatientsNeuroinvasion of SARS-CoV-2 in human and mouse brain
Song E, Zhang C, Israelow B, Lu-Culligan A, Prado AV, Skriabine S, Lu P, Weizman OE, Liu F, Dai Y, Szigeti-Buck K, Yasumoto Y, Wang G, Castaldi C, Heltke J, Ng E, Wheeler J, Alfajaro MM, Levavasseur E, Fontes B, Ravindra NG, Van Dijk D, Mane S, Gunel M, Ring A, Kazmi SAJ, Zhang K, Wilen CB, Horvath TL, Plu I, Haik S, Thomas JL, Louvi A, Farhadian SF, Huttner A, Seilhean D, Renier N, Bilguvar K, Iwasaki A. Neuroinvasion of SARS-CoV-2 in human and mouse brain. Journal Of Experimental Medicine 2021, 218: e20202135. PMID: 33433624, PMCID: PMC7808299, DOI: 10.1084/jem.20202135.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Central nervous systemSARS-CoV-2 neuroinvasionImmune cell infiltratesCOVID-19 patientsType I interferon responseMultiple organ systemsCOVID-19I interferon responseHuman brain organoidsNeuroinvasive capacityCNS infectionsCell infiltrateNeuronal infectionPathological featuresCortical neuronsRespiratory diseaseDirect infectionCerebrospinal fluidNervous systemMouse brainInterferon responseOrgan systemsHuman ACE2Infection
2020
Altered Hemodynamics and End-Organ Damage in Heart Failure
Verbrugge FH, Guazzi M, Testani JM, Borlaug BA. Altered Hemodynamics and End-Organ Damage in Heart Failure. Circulation 2020, 142: 998-1012. PMID: 32897746, PMCID: PMC7482031, DOI: 10.1161/circulationaha.119.045409.Peer-Reviewed Original ResearchConceptsHeart failureHemodynamic derangementsHemodynamic perturbationsElevated cardiac filling pressuresReduced cardiac outputCardiac filling pressuresEnd-organ damagePulmonary vascular diseaseHeart failure phenotypeMultiple organ systemsCapillary stress failureDevelopment of abnormalitiesCardiogenic shockHemodynamic abnormalitiesRenal functionEjection fractionClinical outcomesPulmonary congestionVenous capacityCardiac outputPericardial constraintVascular diseaseChronic diseasesFilling pressureVentilatory controlDLG5 variants are associated with multiple congenital anomalies including ciliopathy phenotypes
Marquez J, Mann N, Arana K, Deniz E, Ji W, Konstantino M, Mis EK, Deshpande C, Jeffries L, McGlynn J, Hugo H, Widmeier E, Konrad M, Tasic V, Morotti R, Baptista J, Ellard S, Lakhani SA, Hildebrandt F, Khokha MK. DLG5 variants are associated with multiple congenital anomalies including ciliopathy phenotypes. Journal Of Medical Genetics 2020, 58: 453-464. PMID: 32631816, PMCID: PMC7785698, DOI: 10.1136/jmedgenet-2019-106805.Peer-Reviewed Original ResearchConceptsLoss of ciliaPatient tissuesPatient variantsCongenital heart diseaseMultiple organ systemsMultiple congenital anomaliesDLG5 variantsVariety of pathologiesNephrotic syndromeHeart diseaseCongenital anomaliesRespiratory tractKidney tissueOrgan systemsCystic kidneysPatient phenotypesKidneyDiseaseLimb abnormalitiesUnrelated familiesRescue experimentsCraniofacial malformationsCilia dysfunctionTissue-specific manifestationsTissueImaging in the Evaluation of Chest Pain in the Primary Care Setting, Part 2: Sources of Noncardiac Chest Pain
Bader AS, Rubinowitz AN, Gange CP, Bader EM, Cortopassi IO. Imaging in the Evaluation of Chest Pain in the Primary Care Setting, Part 2: Sources of Noncardiac Chest Pain. The American Journal Of Medicine 2020, 133: 1135-1142. PMID: 32442508, DOI: 10.1016/j.amjmed.2020.04.013.Peer-Reviewed Educational MaterialsMeSH KeywordsChest PainEsophageal Motility DisordersFractures, CompressionGastroesophageal RefluxHernia, HiatalHumansMagnetic Resonance ImagingMusculoskeletal DiseasesPleural EffusionPneumoniaPneumothoraxPrimary Health CareRadiography, ThoracicRespiratory Tract DiseasesRib FracturesSpinal FracturesThoracic WallTietze's SyndromeTomography, X-Ray ComputedConceptsChest painPrimary care settingCare settingsNoncardiac chest painCommon presenting complaintPrimary care physiciansMultiple organ systemsNoncardiac sourcesPresenting complaintCare physiciansMusculoskeletal etiologyRadiologic appearancePainNumerous imaging modalitiesOrgan systemsImaging modalitiesAppropriate testsEtiologyCliniciansFindingsPhysiciansSettingComplaintsImaging in the Evaluation of Chest Pain in the Primary Care Setting, Part 1: Cardiovascular Etiologies
Bader AS, Rubinowitz AN, Gange CP, Bader EM, Cortopassi IO. Imaging in the Evaluation of Chest Pain in the Primary Care Setting, Part 1: Cardiovascular Etiologies. The American Journal Of Medicine 2020, 133: 1033-1038. PMID: 32442507, DOI: 10.1016/j.amjmed.2020.04.024.Peer-Reviewed Educational MaterialsConceptsChest painPrimary care settingCardiovascular etiologyCare settingsCommon presenting complaintPrimary care physiciansMultiple organ systemsPresenting complaintCare physiciansPainNumerous imaging modalitiesOrgan systemsImaging modalitiesEtiologyAppropriate testsCliniciansFindingsPhysiciansSettingComplaintsJoint American Academy of Dermatology–National Psoriasis Foundation guidelines of care for the management of psoriasis with systemic nonbiologic therapies
Menter A, Gelfand JM, Connor C, Armstrong AW, Cordoro KM, Davis DMR, Elewski BE, Gordon KB, Gottlieb AB, Kaplan DH, Kavanaugh A, Kiselica M, Kivelevitch D, Korman NJ, Kroshinsky D, Lebwohl M, Leonardi CL, Lichten J, Lim HW, Mehta NN, Paller AS, Parra SL, Pathy AL, Prater EF, Rahimi RS, Rupani RN, Siegel M, Stoff B, Strober BE, Tapper EB, Wong EB, Wu JJ, Hariharan V, Elmets CA. Joint American Academy of Dermatology–National Psoriasis Foundation guidelines of care for the management of psoriasis with systemic nonbiologic therapies. Journal Of The American Academy Of Dermatology 2020, 82: 1445-1486. PMID: 32119894, DOI: 10.1016/j.jaad.2020.02.044.Peer-Reviewed Original ResearchConceptsDermatology–National Psoriasis Foundation guidelinesManagement of psoriasisTreatment of psoriasisChronic inflammatory diseaseFumaric acid estersMultiple organ systemsJoint American AcademyNonbiologic medicationsNonbiologic therapiesInflammatory diseasesFoundation guidelinesNew therapiesAmerican AcademyOrgan systemsMedicationsPsoriasisTherapyTreatmentDiseaseGuidelinesTofacitinibAcitretinPatientsApremilastPrescribers
2019
Joint American Academy of Dermatology–National Psoriasis Foundation guidelines of care for the management and treatment of psoriasis with phototherapy
Elmets CA, Lim HW, Stoff B, Connor C, Cordoro KM, Lebwohl M, Armstrong AW, Davis DMR, Elewski BE, Gelfand JM, Gordon KB, Gottlieb AB, Kaplan DH, Kavanaugh A, Kiselica M, Kivelevitch D, Korman NJ, Kroshinsky D, Leonardi CL, Lichten J, Mehta NN, Paller AS, Parra SL, Pathy AL, Farley Prater E, Rupani RN, Siegel M, Strober BE, Wong EB, Wu JJ, Hariharan V, Menter A. Joint American Academy of Dermatology–National Psoriasis Foundation guidelines of care for the management and treatment of psoriasis with phototherapy. Journal Of The American Academy Of Dermatology 2019, 81: 775-804. PMID: 31351884, DOI: 10.1016/j.jaad.2019.04.042.Peer-Reviewed Original ResearchConceptsDermatology–National Psoriasis Foundation guidelinesSystemic psoriasis treatmentsGuidelines of careTreatment of psoriasisChronic inflammatory diseaseMultiple organ systemsJoint American AcademyLight-based therapiesEvidence-based discussionPsoriasis treatmentTreatment modalitiesFoundation guidelinesInflammatory diseasesAmerican AcademyUVB treatmentOrgan systemsPsoriasisIntense pulse lightTherapyTreatmentPhototherapyCareModalitiesGuidelinesWorld population
2018
Is Posthospital Syndrome a Result of Hospitalization-Induced Allostatic Overload?
Goldwater DS, Dharmarajan K, McEwan BS, Krumholz HM. Is Posthospital Syndrome a Result of Hospitalization-Induced Allostatic Overload? Journal Of Hospital Medicine 2018, 13 PMID: 29813141, DOI: 10.12788/jhm.2986.Peer-Reviewed Original ResearchConceptsPosthospital syndromeAllostatic overloadAutonomic nervous systemMultiple organ systemsHospital dischargeInflammatory markersAdverse eventsHospital readmissionAdrenal axisAdverse outcomesPlausible etiologyPathophysiologic consequencesElevated riskNervous systemNarrative reviewOrgan systemsEnhanced vulnerabilityElevated levelsHospital environmentTraditional hospital environmentSyndromeMaladaptive statesOverloadOutcomesPossible mechanism
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