2020
P37 Convergent somatic mutations in effectors of insulin signalling in chronic liver disease
Ng S, Brunner S, Brzozowska N, Aitken S, Abascal F, Moore L, Leongamornlert D, Ivovic A, Robinson P, Butler T, Sanders M, Williams N, Coorens T, Teague J, Raine K, Butler A, Hooks Y, Wilson B, Birtchnell N, Naylor H, Davies S, Stratton M, Martincorena I, Hoare M, Campbell P. P37 Convergent somatic mutations in effectors of insulin signalling in chronic liver disease. Gut 2020, 69: a25-a25. DOI: 10.1136/gutjnl-2020-basl.47.Peer-Reviewed Original ResearchChronic liver diseaseLiver diseaseSomatic mutationsAssociated with metabolic dysregulationSystemic metabolic dysfunctionNon-alcoholic fatty liver diseaseFatty liver diseaseInsulin signalingEffectors of insulin signalingLiver failureHepatocellular carcinomaMultiple independent acquisitionsGram of tissueDownstream of insulin signalingMetabolic dysfunctionMetabolic dysregulationNormal controlsPatient samplesLiver samplesExcess of mutationsNormal liverDietary caloriesLiverAlcohol-relatedDisease
2019
Expression of the type 3 InsP3 receptor is a final common event in the development of hepatocellular carcinoma
Guerra MT, Florentino RM, Franca A, Lima Filho AC, Dos Santos ML, Fonseca RC, Lemos FO, Fonseca MC, Kruglov E, Mennone A, Njei B, Gibson J, Guan F, Cheng YC, Ananthanarayanan M, Gu J, Jiang J, Zhao H, Lima CX, Vidigal PT, Oliveira AG, Nathanson MH, Leite MF. Expression of the type 3 InsP3 receptor is a final common event in the development of hepatocellular carcinoma. Gut 2019, 68: 1676-1687. PMID: 31315892, PMCID: PMC7087395, DOI: 10.1136/gutjnl-2018-317811.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsApoptosisCalcium SignalingCarcinogenesisCarcinoma, HepatocellularCell ProliferationCells, CulturedDNA MethylationFemaleGene Expression Regulation, NeoplasticHepatocytesHumansInositol 1,4,5-Trisphosphate ReceptorsLiverLiver NeoplasmsLiver RegenerationMaleMice, KnockoutMiddle AgedSurvival AnalysisConceptsChronic liver diseaseITPR3 expressionLiver cancer cellsLiver diseaseMouse modelFinal common eventCancer cellsSpecimens of patientsIndependent patient cohortsControl liver specimensHuman HCC cellsType 3 InsP3 receptorHuman liver samplesIncreased expression levelCancer deathPatient cohortCommon molecular eventPoor survivalHepatocellular carcinomaLiver specimensNormal liverHCC cellsAbstractTextHCCType 3 isoform
2018
Characterization of hepatocellular adenoma and carcinoma using microRNA profiling and targeted gene sequencing
Zheng J, Sadot E, Vigidal J, Klimstra D, Balachandran V, Kingham T, Allen P, D’Angelica M, DeMatteo R, Jarnagin W, Ventura A. Characterization of hepatocellular adenoma and carcinoma using microRNA profiling and targeted gene sequencing. PLOS ONE 2018, 13: e0200776. PMID: 30052636, PMCID: PMC6063411, DOI: 10.1371/journal.pone.0200776.Peer-Reviewed Original ResearchMeSH KeywordsAdenoma, Liver CellAdultAgedAged, 80 and overbeta CateninBiomarkers, TumorCarcinoma, HepatocellularCluster AnalysisDNA Mutational AnalysisFemaleGene Expression Regulation, NeoplasticHumansImmunohistochemistryInflammationLiver NeoplasmsMaleMicroRNAsMiddle AgedPilot ProjectsSequence Analysis, DNASequence Analysis, RNAConceptsMiR-490-3pMiR-520c-3pMiR-515-5pMicroRNA profilesMiR-490MiR-515MiR-1180MiR-766MiR-429MiR-518bMiR-200aMiR-452MiR-517aDrivers of hepatocarcinogenesisMiRNA clusterMicroRNAsMicroRNA expressionHepatocellular adenomaHepatocellular carcinomaMiRNAsNon-neoplastic liverTargeted gene sequencingNormal liverBenign liver tumorsNon-tumor liver tissues
2016
Imaging Biomarkers of Tumor Response in Neuroendocrine Liver Metastases Treated with Transarterial Chemoembolization: Can Enhancing Tumor Burden of the Whole Liver Help Predict Patient Survival?
Sahu S, Schernthaner R, Ardon R, Chapiro J, Zhao Y, Sohn JH, Fleckenstein F, Lin M, Geschwind JF, Duran R. Imaging Biomarkers of Tumor Response in Neuroendocrine Liver Metastases Treated with Transarterial Chemoembolization: Can Enhancing Tumor Burden of the Whole Liver Help Predict Patient Survival? Radiology 2016, 283: 160838. PMID: 27831830, PMCID: PMC5425309, DOI: 10.1148/radiol.2016160838.Peer-Reviewed Original ResearchConceptsNeuroendocrine liver metastasesWorld Health OrganizationContrast material-enhanced magnetic resonance (MR) imagesFirst TACE procedureResponse Evaluation CriteriaKaplan-Meier curvesTreatment response biomarkersTransarterial chemoembolization proceduresInstitutional review boardFirst TACELiver methodLiver metastasesIndependent predictorsTumor burdenRetrospective studyTACE proceduresCox regressionOnly biomarkerSurvival differencesChemoembolization proceduresTreatment responseResponse biomarkersPatientsSolid tumorsNormal liver
2013
Vascular endothelial growth factors in progenitor cells mediated liver repair
Spirli C, Strazzabosco M. Vascular endothelial growth factors in progenitor cells mediated liver repair. HepatoBiliary Surgery And Nutrition 2013, 2: 657-667. PMID: 24570918, PMCID: PMC3924655, DOI: 10.3978/j.issn.2304-3881.2012.12.05.Peer-Reviewed Original Research
2008
c-Met gene amplification is associated with advanced stage colorectal cancer and liver metastases
Zeng ZS, Weiser MR, Kuntz E, Chen CT, Khan SA, Forslund A, Nash GM, Gimbel M, Yamaguchi Y, Culliford AT, D’Alessio M, Barany F, Paty PB. c-Met gene amplification is associated with advanced stage colorectal cancer and liver metastases. Cancer Letters 2008, 265: 258-269. PMID: 18395971, PMCID: PMC4367187, DOI: 10.1016/j.canlet.2008.02.049.Peer-Reviewed Original ResearchConceptsC-MET gene amplificationC-Met gene copy numberLiver metastasesPrimary colorectal cancerColorectal cancerGene amplificationC-MetAdvanced stage colorectal cancerAdvanced colorectal cancerStage colorectal cancerNormal colonic mucosaLiver resectionTyrosine kinaseGene copy numberDistant metastasisPrimary cancerLung cancerColonic mucosaGastric cancerNormal mucosaMetastasisNormal liverTumor growthMetastatic progressionLiver tissue
2007
Decreased intrahepatic response to α1‐adrenergic agonists in lipopolysaccharide‐treated rats is located in the sinusoidal area and depends on Kupffer cell function
Lee C, Loureiro‐Silva M, Abraldes JG, Iwakiri Y, Haq O, Groszmann RJ. Decreased intrahepatic response to α1‐adrenergic agonists in lipopolysaccharide‐treated rats is located in the sinusoidal area and depends on Kupffer cell function. Journal Of Gastroenterology And Hepatology 2007, 22: 893-900. PMID: 17498219, DOI: 10.1111/j.1440-1746.2007.04922.x.Peer-Reviewed Original ResearchConceptsLipopolysaccharide-treated ratsKupffer cell functionVascular responsesAdrenergic agonistsKupffer cellsNormal liverSinusoidal areaNitric oxide synthase inhibitorCell functionOxide synthase inhibitorRole of KupfferVascular tone controlNitric oxide overproductionKrebs-Henseleit solutionNitric oxide productionΑ1-adrenergic agonistDose-response curveIntrahepatic responseMicrovascular abnormalitiesSecond doseEndotoxemic ratsLiver perfusionSynthase inhibitorMethoxamineGadolinium chlorideThe effect of methylprednisolone on warm ischemia-reperfusion injury in the liver
Saidi RF, Chang J, Verb S, Brooks S, Nalbantoglu I, Adsay V, Jacobs MJ. The effect of methylprednisolone on warm ischemia-reperfusion injury in the liver. The American Journal Of Surgery 2007, 193: 345-348. PMID: 17320532, DOI: 10.1016/j.amjsurg.2006.09.017.Peer-Reviewed Original ResearchConceptsIschemia-reperfusion injuryR injuryInterleukin-6Continuous clampingIschemic preconditioningSteatotic liversInflammatory responseNormal liverAspartate aminotransferaseLiver ischemia-reperfusion injuryWarm ischemia-reperfusion injuryMale Sprague-Dawley ratsSerum IL-6Serum interleukin-6Hours of reperfusionEffect of methylprednisoloneCause of morbiditySprague-Dawley ratsIntravenous methylprednisoloneHepatic ischemiaIschemia inductionSerum levelsIschemic controlsIschemic periodLiver ischemia
2006
Increased phosphodiesterase-5 expression is involved in the decreased vasodilator response to nitric oxide in cirrhotic rat livers
Loureiro-Silva MR, Iwakiri Y, Abraldes JG, Haq O, Groszmann RJ. Increased phosphodiesterase-5 expression is involved in the decreased vasodilator response to nitric oxide in cirrhotic rat livers. Journal Of Hepatology 2006, 44: 886-893. PMID: 16545481, DOI: 10.1016/j.jhep.2006.01.032.Peer-Reviewed Original ResearchMeSH Keywords3',5'-Cyclic-GMP PhosphodiesterasesAnimalsCyclic Nucleotide Phosphodiesterases, Type 5Enzyme InhibitorsLiver CirculationLiver CirrhosisMaleNitric OxideNitric Oxide Synthaseomega-N-MethylargininePhosphodiesterase InhibitorsPhosphoric Diester HydrolasesPiperazinesPurinesRatsRats, Sprague-DawleySildenafil CitrateSulfonesVasodilationConceptsPDE-5 expressionPhosphodiesterase-5 expressionCirrhotic liverCirrhotic rat liverPresence of sildenafilNitric oxideVasodilator responseDeficient responseNormal liverAscitic cirrhotic ratsDecreased vascular responseDecreased vasodilator responseConcentration-response curvesRat liverCyclic guanosine 3Second messenger cyclic guanosine 3Vasodilator effectCirrhotic ratsVascular responsesBACKGROUND/Liver perfusionDecreased responseSpontaneous NO donorSildenafil citrateNO donor
2004
Ectonucleotidase NTPDase2 is Selectively Down-Regulated in Biliary Cirrhosis
Dranoff J, Kruglov E, Toure J, Braun N, Zimmermann H, Jain D, Knowles A, Sévigny J. Ectonucleotidase NTPDase2 is Selectively Down-Regulated in Biliary Cirrhosis. Journal Of Investigative Medicine 2004, 52: 475-482. DOI: 10.1177/108155890405200741.Peer-Reviewed Original ResearchBile duct ligationNTPDase2 expressionPrimary biliary cirrhosisBiliary cirrhosisPortal fibroblastsReal-time polymerase chain reactionPolymerase chain reactionBiopsy specimensPortal areasExperimental ratsFibrous bandsNormal liverConfocal immunofluorescenceExpression of NTPDase2Fibrogenic liver cellsHepatitis C cirrhosisLiver biopsy specimensFibrotic liver diseaseChain reactionHuman liver biopsy specimensHepatic stellate cellsNew therapeutic approachesSmooth muscle actinCarbon tetrachloride administrationTriphosphate diphosphohydrolase 2Ectonucleotidase NTPDase2 Is Selectively Down-Regulated in Biliary Cirrhosis
Dranoff JA, Kruglov EA, Toure J, Braun N, Zimmermann H, Jain D, Knowles AF, Sévigny J. Ectonucleotidase NTPDase2 Is Selectively Down-Regulated in Biliary Cirrhosis. Journal Of Investigative Medicine 2004, 52: 475. PMID: 15651265, DOI: 10.1136/jim-52-07-42.Peer-Reviewed Original ResearchConceptsBile duct ligationNTPDase2 expressionPrimary biliary cirrhosisBiliary cirrhosisPortal fibroblastsReal-time polymerase chain reactionCCl4 administrationPolymerase chain reactionBiopsy specimensPortal areasExperimental ratsFibrous bandsNormal liverConfocal immunofluorescenceAlpha-smooth muscle actinExpression of NTPDase2Fibrogenic liver cellsHepatitis C cirrhosisLiver biopsy specimensFibrotic liver diseaseHuman liver biopsy specimensChain reactionNew therapeutic approachesHepatic stellate cellsCarbon tetrachloride administrationEctonucleotidase NTPDase2 Is Selectively Down-Regulated in Biliary Cirrhosis.
Dranoff J, Kruglov E, Toure J, Braun N, Zimmermann H, Jain D, Knowles A, Sévigny J. Ectonucleotidase NTPDase2 Is Selectively Down-Regulated in Biliary Cirrhosis. Journal Of Investigative Medicine 2004, 52: 475. DOI: 10.1097/00042871-200411000-00042.Peer-Reviewed Original ResearchBile duct ligationNTPDase2 expressionPrimary biliary cirrhosisBiliary cirrhosisPortal fibroblastsReal-time polymerase chain reactionCCl4 administrationPolymerase chain reactionBiopsy specimensPortal areasExperimental ratsFibrous bandsNormal liverConfocal immunofluorescenceExpression of NTPDase2Fibrogenic liver cellsHepatitis C. ConclusionsHepatitis C cirrhosisLiver biopsy specimensFibrotic liver diseaseChain reactionHuman liver biopsy specimensHepatic stellate cellsNew therapeutic approachesSmooth muscle actinA null mutation of Hhex results in abnormal cardiac development,defective vasculogenesis and elevated Vegfa levels
Hallaq H, Pinter E, Enciso J, McGrath J, Zeiss C, Brueckner M, Madri J, Jacobs HC, Wilson CM, Vasavada H, Jiang X, Bogue CW. A null mutation of Hhex results in abnormal cardiac development,defective vasculogenesis and elevated Vegfa levels. Development 2004, 131: 5197-5209. PMID: 15459110, DOI: 10.1242/dev.01393.Peer-Reviewed Original ResearchConceptsEpithelial-mesenchymal transformationVEGFA levelsVentricular septal defectVascular endothelial growth factorDefective vasculogenesisEndothelial growth factorEndocardial cushionsInhibitor of VEGFVascular developmentTract abnormalitiesSeptal defectSFlt-1Right ventricleNormal liverVentral foregut endodermNormal cardiovascular developmentReceptor 1Abnormal cardiac developmentGrowth factorNull mutationVentral foregutAberrant developmentCompact myocardiumAV explantsE8.5-9.0
2001
Cellular localization and up‐regulation of multidrug resistance–associated protein 3 in hepatocytes and cholangiocytes during obstructive cholestasis in rat liver
Soroka C, Lee J, Azzaroli F, Boyer J. Cellular localization and up‐regulation of multidrug resistance–associated protein 3 in hepatocytes and cholangiocytes during obstructive cholestasis in rat liver. Hepatology 2001, 33: 783-791. PMID: 11283840, DOI: 10.1053/jhep.2001.23501.Peer-Reviewed Original ResearchConceptsObstructive cholestasisMultidrug resistance-associated protein 3Bile duct-ligated animalsMultidrug resistanceToxic bile acidsModel of cholestasisDuct-ligated animalsExpression of MRP3Intensity of stainingHepatocytes of liverWestern blot analysisBile ductHepatic expressionCentral veinCholestasisMRP3 expressionNormal liverBile acidsPericentral regionsIndirect immunofluorescenceProtein 3Days postligationMRP3Mrp2 proteinLiver
1999
Selective retention of activated CD8+ T cells by the normal liver.
Mehal W, Juedes A, Crispe I. Selective retention of activated CD8+ T cells by the normal liver. The Journal Of Immunology 1999, 163: 3202-10. PMID: 10477588, DOI: 10.4049/jimmunol.163.6.3202.Peer-Reviewed Original Research
1986
Quantitative US attenuation in normal liver and in patients with diffuse liver disease: importance of fat.
Taylor K, Riely C, Hammers L, Flax S, Weltin G, Garcia-Tsao G, Conn H, Kuc R, Barwick K. Quantitative US attenuation in normal liver and in patients with diffuse liver disease: importance of fat. Radiology 1986, 160: 65-71. PMID: 3520657, DOI: 10.1148/radiology.160.1.3520657.Peer-Reviewed Original Research
1977
The clinical and physiological implications of hepatoma B12-binding proteins.
Waxman S, Liu C, Schreiber C, Helson L. The clinical and physiological implications of hepatoma B12-binding proteins. Cancer Research 1977, 37: 1908-14. PMID: 66988.Peer-Reviewed Original ResearchConceptsCell linesElevated sialyltransferase activityB12 binding capacitySerum B12Hepatocellular carcinomaHepatoma seraSialic acid contentNormal liverHepatoma cell lineB12Previous casesPatientsHepatomaPerfusateSialyltransferase activityLiverSerumPhysiological implicationsChemotherapyCarcinomaNeoplasiaProteinTumorsDisease
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