2024
SINE RNA of the imprinted miRNA clusters mediates constitutive type III interferon expression and antiviral protection in hemochorial placentas
Wickramage I, VanWye J, Max K, Lockhart J, Hortu I, Mong E, Canfield J, Lamabadu Warnakulasuriya Patabendige H, Guzeloglu-Kayisli O, Inoue K, Ogura A, Lockwood C, Akat K, Tuschl T, Kayisli U, Totary-Jain H. SINE RNA of the imprinted miRNA clusters mediates constitutive type III interferon expression and antiviral protection in hemochorial placentas. Cell Host & Microbe 2024, 32: 2035. PMID: 39396520, PMCID: PMC11620534, DOI: 10.1016/j.chom.2024.10.003.Peer-Reviewed Original ResearchCRISPR-based dissection of microRNA-23a ~ 27a ~ 24-2 cluster functionality in hepatocellular carcinoma
Cui M, Liu Z, Wang S, Bae S, Guo H, Zhou J, Liu R, Wang L. CRISPR-based dissection of microRNA-23a ~ 27a ~ 24-2 cluster functionality in hepatocellular carcinoma. Oncogene 2024, 43: 2708-2721. PMID: 39112518, PMCID: PMC11364504, DOI: 10.1038/s41388-024-03115-z.Peer-Reviewed Original ResearchConceptsMiR-23aMiR-27aCRISPR interferenceCRISPR activationHigh-throughput RNA-seqCell migrationCDK1/cyclin B activityReduced cell growth in vitroMiRNA target predictionCell cycle arrestMiRNA clusterHepatocellular carcinoma cellsCell growth in vitroRNA-seqGene networksTarget predictionCRISPR knockoutOncogenic roleGrowth in vitroCycle arrestMature miRNAsMiRNAsG2/M phaseSignaling pathwayOncogenic function
2018
Characterization of hepatocellular adenoma and carcinoma using microRNA profiling and targeted gene sequencing
Zheng J, Sadot E, Vigidal J, Klimstra D, Balachandran V, Kingham T, Allen P, D’Angelica M, DeMatteo R, Jarnagin W, Ventura A. Characterization of hepatocellular adenoma and carcinoma using microRNA profiling and targeted gene sequencing. PLOS ONE 2018, 13: e0200776. PMID: 30052636, PMCID: PMC6063411, DOI: 10.1371/journal.pone.0200776.Peer-Reviewed Original ResearchMeSH KeywordsAdenoma, Liver CellAdultAgedAged, 80 and overbeta CateninBiomarkers, TumorCarcinoma, HepatocellularCluster AnalysisDNA Mutational AnalysisFemaleGene Expression Regulation, NeoplasticHumansImmunohistochemistryInflammationLiver NeoplasmsMaleMicroRNAsMiddle AgedPilot ProjectsSequence Analysis, DNASequence Analysis, RNAConceptsMiR-490-3pMiR-520c-3pMiR-515-5pMicroRNA profilesMiR-490MiR-515MiR-1180MiR-766MiR-429MiR-518bMiR-200aMiR-452MiR-517aDrivers of hepatocarcinogenesisMiRNA clusterMicroRNAsMicroRNA expressionHepatocellular adenomaHepatocellular carcinomaMiRNAsNon-neoplastic liverTargeted gene sequencingNormal liverBenign liver tumorsNon-tumor liver tissues
2013
miR-17∼92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease
Patel V, Williams D, Hajarnis S, Hunter R, Pontoglio M, Somlo S, Igarashi P. miR-17∼92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 10765-10770. PMID: 23759744, PMCID: PMC3696812, DOI: 10.1073/pnas.1301693110.Peer-Reviewed Original ResearchConceptsMiRNA clusterKidney cyst growthPolycystic kidney diseasePosttranscriptional gene expressionCyst growthOncogenic miRNA clusterShort noncoding RNAsKidney-specific inactivationKidney cyst formationDysregulated miRNA expressionPosttranscriptional repressionNoncoding RNAsHyperproliferative epithelial cellsGene dosageGene expressionHepatocyte nuclear factor-1βGenes PKD1Common genetic causeMiRNA expressionMouse modelFluid-filled cystsMiRNAsKidney diseaseTransgenic overexpressionKidney cysts
2012
EBV and human microRNAs co‐target oncogenic and apoptotic viral and human genes during latency
Riley KJ, Rabinowitz GS, Yario TA, Luna JM, Darnell RB, Steitz JA. EBV and human microRNAs co‐target oncogenic and apoptotic viral and human genes during latency. The EMBO Journal 2012, 31: 2207-2221. PMID: 22473208, PMCID: PMC3343464, DOI: 10.1038/emboj.2012.63.Peer-Reviewed Original ResearchConceptsHuman microRNAsLatent membrane protein 1Viral miRNA functionHigh-throughput sequencingHuman miRNA targetsMiRNA-binding sitesMiRNA functionEBV BHRF1Human genesMiRNA targetsMRNA targetsCellular miRNAsMembrane protein 1MiRNA clusterHuman miRNAsGene expressionCell cycleReporter assaysDistinct binding sitesViral mRNAsMiRNAsLytic genesLytic switchProtein 1EBV latent membrane protein 1
2010
Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia
Mi S, Li Z, Chen P, He C, Cao D, Elkahloun A, Lu J, Pelloso LA, Wunderlich M, Huang H, Luo RT, Sun M, He M, Neilly MB, Zeleznik-Le NJ, Thirman MJ, Mulloy JC, Liu PP, Rowley JD, Chen J. Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 3710-3715. PMID: 20133587, PMCID: PMC2840429, DOI: 10.1073/pnas.0914900107.Peer-Reviewed Original ResearchConceptsMouse bone marrow progenitor cellsMiRNA clusterTarget genesMLL fusionsBone marrow progenitor cellsMiR-17Marrow progenitor cellsCell differentiationDNA copy number amplificationsWild-type MLLProgenitor cellsRelevant target genesHistone H3 acetylationPotential target genesMLL fusion genesCopy number amplificationDevelopment of MLLH3K4 trimethylationIndividual miRNAsH3 acetylationMixed lineage leukemiaCell cycleHuman cellsDirect bindingMiRNAs
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