2008
Mapping DNA Adducts of Mitomycin C and Decarbamoyl Mitomycin C in Cell Lines Using Liquid Chromatography/Electrospray Tandem Mass Spectrometry
Paz MM, Ladwa S, Champeil E, Liu Y, Rockwell S, Boamah EK, Bargonetti J, Callahan J, Roach J, Tomasz M. Mapping DNA Adducts of Mitomycin C and Decarbamoyl Mitomycin C in Cell Lines Using Liquid Chromatography/Electrospray Tandem Mass Spectrometry. Chemical Research In Toxicology 2008, 21: 2370-2378. PMID: 19053323, PMCID: PMC2630229, DOI: 10.1021/tx8002615.Peer-Reviewed Original ResearchConceptsBreast cancer cellsMitomycin CCancer cellsMCF-7 human breast cancer cellsEMT6 cellsEMT6 mouse mammary tumor cellsHuman breast cancer cellsMCF-7 breast cancer cellsMouse mammary tumor cellsMammary tumor cellsMCF-7 cellsHuman fibroblastsMitomycin C treatmentTumor cellsReductive metabolitesDecarbamoyl mitomycin CNormal human fibroblasts
2001
Bioreductive metabolism of mitomycin C in EMT6 mouse mammary tumor cells: cytotoxic and non-cytotoxic pathways, leading to different types of DNA adducts. The effect of dicumarol44Abbreviations: MC, mitomycin C; DIC, dicumarol; 2,7-DAM, 2,7-diaminomitosene; and XDH, xanthine dehydrogenase.
Palom Y, Belcourt M, Tang L, Mehta S, Sartorelli A, Pritsos C, Pritsos K, Rockwell S, Tomasz M. Bioreductive metabolism of mitomycin C in EMT6 mouse mammary tumor cells: cytotoxic and non-cytotoxic pathways, leading to different types of DNA adducts. The effect of dicumarol44Abbreviations: MC, mitomycin C; DIC, dicumarol; 2,7-DAM, 2,7-diaminomitosene; and XDH, xanthine dehydrogenase. Biochemical Pharmacology 2001, 61: 1517-1529. PMID: 11377381, DOI: 10.1016/s0006-2952(01)00609-8.Peer-Reviewed Original Research
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