2017
Targeting EZH2 in acral lentiginous melanoma (ALM).
Izsak A, Giles K, Lui K, Weiss S, Moran U, Vega-Saenz de Miera E, Stein J, Lee A, Darvishian F, Shapiro R, Berman R, Pavlick A, Wilson M, Osman I. Targeting EZH2 in acral lentiginous melanoma (ALM). Journal Of Clinical Oncology 2017, 35: 9534-9534. DOI: 10.1200/jco.2017.35.15_suppl.9534.Peer-Reviewed Original ResearchAcral lentiginous melanomaCM cell linesCutaneous melanomaALM casesCell linesMetastatic progressionEZH2 expressionMetastatic acral lentiginous melanomaEZH2 inhibitionEZH2 inhibitorsEffects of GSK126Mean IHC scoreColony formationEZH2 protein expressionClinicopathological dataPrimary tumorLentiginous melanomaMetastatic tumorsClinical trialsHistone methyltransferase EZH2Treatment outcomesIHC scoreLow dosesTherapeutic potentialTumors
2010
In Utero Exposure to Diethylstilbestrol (DES) or Bisphenol-A (BPA) Increases EZH2 Expression in the Mammary Gland: An Epigenetic Mechanism Linking Endocrine Disruptors to Breast Cancer
Doherty LF, Bromer JG, Zhou Y, Aldad TS, Taylor HS. In Utero Exposure to Diethylstilbestrol (DES) or Bisphenol-A (BPA) Increases EZH2 Expression in the Mammary Gland: An Epigenetic Mechanism Linking Endocrine Disruptors to Breast Cancer. Discover Oncology 2010, 1: 146-155. PMID: 21761357, PMCID: PMC3140020, DOI: 10.1007/s12672-010-0015-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzhydryl CompoundsBlotting, WesternCarcinogensCell Line, TumorDiethylstilbestrolEndocrine DisruptorsEnhancer of Zeste Homolog 2 ProteinEpigenesis, GeneticFemaleGene ExpressionHistone-Lysine N-MethyltransferaseHumansMammary Neoplasms, ExperimentalMicePhenolsPolycomb Repressive Complex 2PregnancyPrenatal Exposure Delayed EffectsReverse Transcriptase Polymerase Chain ReactionConceptsUtero exposureMCF-7 cellsEZH2 expressionMammary tissueMammary glandBreast cancerBreast cancer riskEffects of BPAAdult mammary tissueEZH2 protein expressionPersistent epigenetic changesZeste homolog 2DES exposureFetal exposureEZH2 mRNA expressionBreast neoplasiaNeoplastic changesCancer riskBPA treatmentEndocrine-disrupting chemicalsAdult womenDevelopmental programmingMRNA expressionUteroMice
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