p63 and p73 repress CXCR5 chemokine receptor gene expression in p53-deficient MCF-7 breast cancer cells during genotoxic stress
Mitkin N, Muratova A, Sharonov G, Korneev K, Sviriaeva E, Mazurov D, Schwartz A, Kuprash D. p63 and p73 repress CXCR5 chemokine receptor gene expression in p53-deficient MCF-7 breast cancer cells during genotoxic stress. Biochimica Et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 2017, 1860: 1169-1178. PMID: 29107083, DOI: 10.1016/j.bbagrm.2017.10.003.Peer-Reviewed Original ResearchConceptsMCF-7 breast cancer cellsBreast cancer cellsP53 family membersCXCR5 expressionMCF-7 cellsGenotoxic stressChemokine receptor gene expressionTumor response to chemotherapyCancer cellsNFkB activationParental MCF-7 cellsResponse to chemotherapyReceptor gene expressionDNA alkylating agent methyl methanesulfonateAssociated with elevated expressionChemokine receptor genesGene expressionActivation of p53 tumor suppressorMCF-7P53 tumor suppressorSite-directed mutagenesisP53 family genesCRISPR/Cas9-mediated inactivationEffects of genotoxic stressP53 gene
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