2021
Krüppel-like factor 5 regulates wound repair and the innate immune response in human airway epithelial cells
Paranjapye A, NandyMazumdar M, Browne JA, Leir SH, Harris A. Krüppel-like factor 5 regulates wound repair and the innate immune response in human airway epithelial cells. Journal Of Biological Chemistry 2021, 297: 100932. PMID: 34217701, PMCID: PMC8353497, DOI: 10.1016/j.jbc.2021.100932.Peer-Reviewed Original ResearchConceptsKrüppel-like factor 5Lung epithelial cell lineEpithelial cell lineHistone modification H3K27acEpithelial cell identityDirect gene targetsSiRNA-mediated depletionHuman airway epithelial cellsCCAAT enhancer-binding protein betaEnhancer-binding protein betaCell linesSecretion of cytokinesAirway epithelial cellsHuman lung diseasesInnate immune responseHuman airway epitheliumPseudomonas aeruginosa lipopolysaccharideFactor 5Cell identityCalu-3 cellsChIP-seqTranscription factorsRNA-seqGene targetsIL-1βThe Bromodomain Containing 8 (BRD8) transcriptional network in human lung epithelial cells
Browne JA, NandyMazumdar M, Paranjapye A, Leir SH, Harris A. The Bromodomain Containing 8 (BRD8) transcriptional network in human lung epithelial cells. Molecular And Cellular Endocrinology 2021, 524: 111169. PMID: 33476703, PMCID: PMC8035426, DOI: 10.1016/j.mce.2021.111169.Peer-Reviewed Original ResearchConceptsCCCTC-binding factorTranscription factorsChIP-seq peaksProcess enrichment analysisArchitectural proteinsChromatin modificationsChromatin accessibilityTranscriptional networksProtein functionLung epithelial cell lineRepressive signalsHuman lung epithelial cellsEpithelial cell lineHuman lung epithelial cell lineEnrichment analysisGene expressionLung epithelial cellsCell cycleInnate immune responseLung epithelial functionCell proliferationAntimicrobial peptidesCell linesEpithelial functionEpithelial cells
2005
Cytokines differentially regulate the synthesis of prostanoid and nitric oxide mediators in tumorigenic versus non-tumorigenic mouse lung epithelial cell lines
Dwyer-Nield L, Srebernak M, Barrett B, Ahn J, Cosper P, Meyer A, Kisley L, Bauer A, Thompson D, Malkinson A. Cytokines differentially regulate the synthesis of prostanoid and nitric oxide mediators in tumorigenic versus non-tumorigenic mouse lung epithelial cell lines. Carcinogenesis 2005, 26: 1196-1206. PMID: 15746162, DOI: 10.1093/carcin/bgi061.Peer-Reviewed Original ResearchConceptsMouse lung epithelial cell lineLung epithelial cell lineInducible NO synthaseBiosynthetic enzymesEpithelial cell lineCell linesProstaglandin E2Lung tumor-derived cell linesTumor-derived cell linesNon-tumorigenic linesNitric oxidePG biosynthetic enzymesCytokine exposureInhibition of iNOSNormal lung cellsCyclooxygenase-2 activityPhysiological relevanceLung tumor formationLung tumor growthMouse lung tumorsSpontaneous transformantsTumor formationCritical mediatorControl lungsEpithelial cells
2001
Effects of the Serine/Threonine Kinase SGK1 on the Epithelial Na+ Channel (ENaC) and CFTR: Implications for Cystic Fibrosis
Wagner C, Ott M, Klingel K, Beck S, Melzig J, Friedrich B, Wild K, Bröer S, Moschen I, Albers A, Waldegger S, Tümmler B, Egan M, Geibel J, Kandolf R, Lang F. Effects of the Serine/Threonine Kinase SGK1 on the Epithelial Na+ Channel (ENaC) and CFTR: Implications for Cystic Fibrosis. Cellular Physiology And Biochemistry 2001, 11: 209-218. PMID: 11509829, DOI: 10.1159/000051935.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-3-isobutylxanthineAmino Acid SubstitutionAnimalsBronchiCell LineCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorEpithelial CellsEpithelial Sodium ChannelsHumansIn Situ HybridizationLungMacrophages, AlveolarMutationOocytesPatch-Clamp TechniquesProtein Serine-Threonine KinasesPulmonary AlveoliRNA, ComplementaryRNA, MessengerSodiumSodium ChannelsXenopus laevisConceptsSerine/threonine kinase SGK1Lung tissueCystic fibrosisCF patientsKinase SGK1CF lung tissueXenopus oocytesLoss of CFTRLung epithelial cell lineCoexpression of CFTREffect of SGK1Pathophysiological factorsEpithelial cell lineRespiratory epitheliumLung phenotypeVariety of stimuliCl(-) secretionSGK1 expressionInhibitor amilorideInhibitory effectEpithelial cellsEnhanced expressionChannel ENaC.CFTR mutationsChannel activity
1999
Isocyanate-conjugated human lung epithelial cell proteins: A link between exposure and asthma?
Wisnewski A, Lemus R, Karol M, Redlich C. Isocyanate-conjugated human lung epithelial cell proteins: A link between exposure and asthma? Journal Of Allergy And Clinical Immunology 1999, 104: 341-347. PMID: 10452755, DOI: 10.1016/s0091-6749(99)70377-5.Peer-Reviewed Original ResearchConceptsIsocyanate-induced asthmaHuman lung epithelial cell lineEpithelial cell proteinsLung epithelial cell lineEpithelial cell lineLymphocyte proliferationProliferation of PBMCCell linesAirway inflammationAtopic subjectsNonasthmatic individualsHDI exposureAirway epitheliumImmunostimulatory potentialAsthmaCell proteinsWestern blottingPotential roleProliferationExposureHDI concentrationCross-linking chemicalsCell polypeptidesConjugation patternSubjects
1998
Cytokine-induced nitric oxide formation in normal but not in neoplastic murine lung epithelial cell lines
Thompson D, Porter S, Bauer A, Das K, Ou B, Dwyer-Nield L, White C, Malkinson A. Cytokine-induced nitric oxide formation in normal but not in neoplastic murine lung epithelial cell lines. American Journal Of Physiology 1998, 274: l922-l932. PMID: 9609731, DOI: 10.1152/ajplung.1998.274.6.l922.Peer-Reviewed Original ResearchConceptsLung epithelial cell lineEpithelial cell lineLung epithelial cellsNontumorigenic cellsCell linesMurine lung epithelial cell lineEpithelial cellsMurine lung epithelial cellsTumorigenic counterpartsMRNA stabilityE10 cellsTumorigenic cellsWestern blot analysisProtein synthesisNormal progenitor cellsCell's abilityINOS regulationNuclear factor-kappaB activationProgenitor cellsCytokine-induced NO synthesisSpontaneous transformantsBlot analysisInducible NO synthaseMurine linesTransformation alters
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