2023
Second-Line Therapy Sequencing in Primary Warm Autoimmune Hemolytic Anemia: Splenectomy-Rituximab Versus Rituximab-Splenectomy
Waldron C, Ito S, Wang D, Viswanathan G, Butt A, Goshua G. Second-Line Therapy Sequencing in Primary Warm Autoimmune Hemolytic Anemia: Splenectomy-Rituximab Versus Rituximab-Splenectomy. Blood 2023, 142: 2317. DOI: 10.1182/blood-2023-189957.Peer-Reviewed Original ResearchWarm autoimmune hemolytic anemiaSecond-line therapyAutoimmune hemolytic anemiaAdult patientsHemolytic anemiaSecond-line treatmentFirst-line treatmentPrevention of thrombosisDegree of anemiaLaparoscopic surgical techniquesPatient's disease statusQuality-adjusted life expectancyRate of infectionProbabilistic sensitivity analysesNet monetary benefitRituximab cyclesTherapy sequencingComplete remissionPartial remissionPerioperative mortalityPrimary outcomeTherapeutic sequencingLaparoscopic techniquePreferred treatmentRelapse riskAdjuvant immunotherapy in renal cell carcinoma: A living systematic review and network meta-analysis (NMA).
Sipra Q, Bin Riaz I, Naqvi S, He H, Siddiqi R, Islam M, Asghar N, Ikram W, Xu W, Singh P, Ho T, Bilen M, Zakharia Y, Bryce A. Adjuvant immunotherapy in renal cell carcinoma: A living systematic review and network meta-analysis (NMA). Journal Of Clinical Oncology 2023, 41: 694-694. DOI: 10.1200/jco.2023.41.6_suppl.694.Peer-Reviewed Original ResearchRenal cell carcinomaDisease-free survivalAdjuvant immunotherapyBaseline riskCell carcinomaTreatment optionsImproved disease-free survivalLocalized Renal Cell CarcinomaRisk categoriesAdjuvant treatment optionsAbsolute risk differenceUnique treatment optionRisk stratification systemMixed treatment comparisonSignificant differencesRelative effect estimatesEvidence synthesis frameworkAdjuvant pembrolizumabNivolumab-ipilimumabOverall survivalTreatment landscapeAbsolute benefitPreferred treatmentRecent trialsDisease progressionTaking a chance: How likely am I to receive my preferred treatment in a clinical trial?
Walter S, Blaha O, Esserman D. Taking a chance: How likely am I to receive my preferred treatment in a clinical trial? Statistical Methods In Medical Research 2023, 32: 572-592. PMID: 36628522, PMCID: PMC9983058, DOI: 10.1177/09622802221146305.Peer-Reviewed Original ResearchConceptsPatient preference designConcordance ratePreferred treatmentClinical trialsDifferent treatment preferencesProportion of patientsParallel group designPreference designPatient's primary motivationTrial patientsPoor outcomeBlinded trialClinical equipoiseTreatment preferencesTwo-armZelen designAlternative treatmentStudy outcomesStudy designTrialsTreatmentPatientsPotential participantsOutcomesGroup design
2018
Multimodality Imaging Involving Magnetic Resonance Facilitates Giant Symptomatic Myxoma Resection
Hur DJ, Prescher LM, Meadows JL, Pfau SE, Homer RJ, Tellides G, Yun JJ. Multimodality Imaging Involving Magnetic Resonance Facilitates Giant Symptomatic Myxoma Resection. The Annals Of Thoracic Surgery 2018, 107: e15-e17. PMID: 30558736, DOI: 10.1016/j.athoracsur.2018.05.083.Peer-Reviewed Case Reports and Technical Notes
2016
A Mobile Extracorporeal Extremity Salvage System for Replantation and Transplantation
Kueckelhaus M, Fischer S, Sisk G, Kiwanuka H, Bueno E, Dermietzel A, Alhefzi M, Aycart M, Diehm Y, Pomahac B. A Mobile Extracorporeal Extremity Salvage System for Replantation and Transplantation. Annals Of Plastic Surgery 2016, 76: 355-360. PMID: 26808757, DOI: 10.1097/sap.0000000000000681.Peer-Reviewed Original ResearchConceptsMuscle damageLimb lossPerfusion deviceDeceased organ donorsIschemic muscle damageBilateral hind limbsPreferred treatmentBilateral limbsMuscle biopsyOrgan donorsTraumatic amputationHealthy limbPerfusion solutionReplantationArterial systemTransplantationHypoxic cellsPerfusate compositionHind limbPorcine limbsLimbSignificant differencesYorkshire pigsSalvage systemSimilar changes
2011
Management of Early Stage Non–Small Cell Lung Cancer in High-Risk Patients
Donington JS, Blasberg JD. Management of Early Stage Non–Small Cell Lung Cancer in High-Risk Patients. Thoracic Surgery Clinics 2011, 22: 55-65. PMID: 22108689, DOI: 10.1016/j.thorsurg.2011.08.018.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerEarly-stage non-small cell lung cancerHigh-risk patientsCell lung cancerLung cancerStage I non-small cell lung cancerStage non-small cell lung cancerPeri-procedural morbidityOperable lung cancerType of resectionRefinement of indicationsAnatomic resectionMediastinal lymphSublobar resectionOncologic efficacyTreatment optionsPreferred treatmentResectionPatientsCancerTreatmentLobectomyLymphMorbidityMortality
2010
Causes and Consequences of Inadequate Management of Acute Pain
Sinatra R. Causes and Consequences of Inadequate Management of Acute Pain. Pain Medicine 2010, 11: 1859-1871. PMID: 21040438, DOI: 10.1111/j.1526-4637.2010.00983.x.Peer-Reviewed Original ResearchConceptsInadequate pain managementAcute painPain managementTolerability balanceChronic painMultimodal therapyIntense acute painSingle-agent regimensAcute pain managementSevere acute painCurrent practice guidelinesMillions of patientsAgent regimensMultiple analgesicsAnalgesic therapyPain controlAvailable therapiesClinical effectivenessPreferred treatmentPractice guidelinesUndermanaged painEffective treatmentPainSide effectsPatient health
2008
Effect of 2 Stitches vs. 1 Stitch on the Prevention of Preterm Birth in Women With Singleton Pregnancies Who Undergo Cervical Cerclage
Woensdregt K, Norwitz E, Cackovic M, Paidas M, Illuzzi J. Effect of 2 Stitches vs. 1 Stitch on the Prevention of Preterm Birth in Women With Singleton Pregnancies Who Undergo Cervical Cerclage. Obstetrical & Gynecological Survey 2008, 63: 483-484. DOI: 10.1097/ogx.0b013e3181809023.Peer-Reviewed Original ResearchCerclage placementCervical cerclageCervical insufficiencyPreterm birthSingleton pregnanciesSignificant differencesCervical cerclage placementSonographic cervical lengthRetrospective cohort studyTime of deliveryLogistic regression analysisGestational age cutoffCervical lengthCohort studyComplication rateSurgical groupGestational ageConsecutive pregnanciesPreferred treatmentPregnancy lossRelative riskBaseline differencesAge cutoffCerclagePregnancy
2003
Outcome of liver transplantation for familial amyloidotic polyneuropathy
Sharma P, Perri RE, Sirven JE, Zeldenrust SR, Brandhagen DJ, Rosen CB, Douglas DD, Mulligan DC, Rakela J, Wiesner RH, Balan V. Outcome of liver transplantation for familial amyloidotic polyneuropathy. Liver Transplantation 2003, 9: 1273-1280. PMID: 14625827, DOI: 10.1016/j.lts.2003.09.016.Peer-Reviewed Original ResearchConceptsLiver transplantationOrthostatic hypotensionFamilial amyloidotic polyneuropathySeptal thicknessPosterior wallSurvival rateEarly liver transplantationSeverity of neuropathyOutcome of symptomsAmyloidotic polyneuropathyAutosomal dominant disorderMetS patientsCombined liverClinical featuresHeart transplantMetS groupDiarrheal symptomsAdverse outcomesPrimary amyloidosisPreferred treatmentHeart diseaseMedical recordsHypotensionPatientsDiarrhea
1988
Reversal of Experimental Parkinsonism in African Green Monkeys Following Fetal Dopamine Neuron Transplantation
Collier T, Redmond D, Roth R, Elsworth J, Sladek J. Reversal of Experimental Parkinsonism in African Green Monkeys Following Fetal Dopamine Neuron Transplantation. 1988, 211-218. DOI: 10.1007/978-1-4613-0759-4_27.Peer-Reviewed Original ResearchChronic L-DOPA administrationL-DOPA administrationAfrican green monkeysNeuron transplantationExperimental parkinsonismMotor symptomsNigrostriatal systemBrain dopamineMotor abnormalitiesPreferred treatmentParkinson's diseaseL-DOPAGreen monkeysDiseaseProgressive debilitationNeurotransmitter dopamineAdministrationDopamineParkinsonismTransplantationSymptomsAbnormalitiesBrainSupplementation
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