2021
Insulin sensitivity and pancreatic β-cell function in patients with primary aldosteronism
Grewal S, Fosam A, Chalk L, Deven A, Suzuki M, Correa R, Blau J, Demidowich A, Stratakis C, Muniyappa R. Insulin sensitivity and pancreatic β-cell function in patients with primary aldosteronism. Endocrine 2021, 72: 96-103. PMID: 33462741, PMCID: PMC8087621, DOI: 10.1007/s12020-020-02576-y.Peer-Reviewed Original ResearchConceptsΒ-cell functionHepatic insulin resistance indexOral glucose tolerance testPancreatic β-cell functionInsulin sensitivityInsulinogenic indexDisposition indexEffects of hyperaldosteronismCross-sectional study designInsulin resistance indexGlucose tolerance testOral disposition indexSimilar glucose toleranceBackgroundPrimary aldosteronismExcess aldosteronePA cohortArterial pressurePrimary aldosteronismGlucose toleranceControl subjectsTolerance testLess insulinResistance indexPA subjectsInsulin action
2020
Intrahepatic fat, irrespective of ethnicity, is associated with reduced endogenous insulin clearance and hepatic insulin resistance in obese youths: A cross‐sectional and longitudinal study from the Yale Pediatric NAFLD cohort
Tricò D, Galderisi A, Mari A, Polidori D, Galuppo B, Pierpont B, Samuels S, Santoro N, Caprio S. Intrahepatic fat, irrespective of ethnicity, is associated with reduced endogenous insulin clearance and hepatic insulin resistance in obese youths: A cross‐sectional and longitudinal study from the Yale Pediatric NAFLD cohort. Diabetes Obesity And Metabolism 2020, 22: 1628-1638. PMID: 32363679, PMCID: PMC8174801, DOI: 10.1111/dom.14076.Peer-Reviewed Original ResearchConceptsHepatic insulin resistance indexNon-alcoholic fatty liver diseaseEndogenous insulin clearanceInsulin secretion rateInsulin clearanceHepatic insulin resistanceObese youthInsulin resistanceOral glucose tolerance testIntrahepatic fat accumulationIntrahepatic fat contentReduced insulin clearanceInsulin resistance indexFatty liver diseaseGlucose tolerance testWaist-hip ratioIntrahepatic lipid accumulationHepatic insulin sensitivityPlasma glucose levelsMulti-ethnic cohortC-peptide dataNAFLD cohortIntrahepatic fatLiver diseaseInsulin levels
2019
OR31-6 Insulin Sensitivity and Pancreatic Beta-Cell Function in Patients with Primary Aldosteronism
Grewal S, Fosam A, Chalk L, Deven A, Suzuki M, Demidowich A, Correa R, Blau J, Stratakis C, Muniyappa R. OR31-6 Insulin Sensitivity and Pancreatic Beta-Cell Function in Patients with Primary Aldosteronism. Journal Of The Endocrine Society 2019, 3: or31-6. PMCID: PMC6554914, DOI: 10.1210/js.2019-or31-6.Peer-Reviewed Original ResearchOral glucose tolerance testΒ-cell functionBeta-cell functionHepatic insulin resistance indexPancreatic beta-cell functionPrimary aldosteronismHepatic insulin sensitivityInsulin sensitivityInsulinogenic indexDisposition indexGlucose tolerancePA groupPancreatic β-cell functionIslet β-cell functionInsulin resistance indexMean arterial pressureGlucose tolerance testOral disposition indexType 2 diabetesSimilar glucose toleranceMinimal model analysisExcess aldosteronePA cohortElevated aldosteroneRenin levels
2016
Pioglitazone after Ischemic Stroke or Transient Ischemic Attack
Kernan WN, Viscoli CM, Furie KL, Young LH, Inzucchi SE, Gorman M, Guarino PD, Lovejoy AM, Peduzzi PN, Conwit R, Brass LM, Schwartz GG, Adams HP, Berger L, Carolei A, Clark W, Coull B, Ford GA, Kleindorfer D, O'Leary JR, Parsons MW, Ringleb P, Sen S, Spence JD, Tanne D, Wang D, Winder TR. Pioglitazone after Ischemic Stroke or Transient Ischemic Attack. New England Journal Of Medicine 2016, 374: 1321-1331. PMID: 26886418, PMCID: PMC4887756, DOI: 10.1056/nejmoa1506930.Peer-Reviewed Original ResearchConceptsTransient ischemic attackIschemic strokeInsulin resistanceMyocardial infarctionIschemic attackPrimary outcomeRecent ischemic strokeDouble-blind trialFuture cardiovascular eventsHomeostasis model assessmentInsulin resistance indexRisk of strokeEligible patientsNonfatal strokePioglitazone groupCardiovascular eventsCause mortalityPlacebo groupPreventive therapyCerebrovascular diseaseInsulin sensitivityRisk factorsResistance indexHigh riskLower risk
2011
Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease
Kumashiro N, Erion DM, Zhang D, Kahn M, Beddow SA, Chu X, Still CD, Gerhard GS, Han X, Dziura J, Petersen KF, Samuel VT, Shulman GI. Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 16381-16385. PMID: 21930939, PMCID: PMC3182681, DOI: 10.1073/pnas.1113359108.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseFatty liver diseaseHepatic DAG contentInsulin resistanceHepatic insulin resistanceLiver diseaseHepatic steatosisCellular mechanismsHomeostatic model assessmentInsulin resistance indexMarkers of inflammationType 2 diabetesER stress markersLipid dropletsHepatic diacylglycerol contentEndoplasmic reticulum stressActivation of PKCεLiver biopsyNondiabetic individualsHepatocellular lipidsInsulin sensitivityCytoplasmic lipid dropletsDAG contentResistance indexAnimal models
2006
Plasma interleukin 6 levels are elevated in polycystic ovary syndrome independently of obesity or sleep apnea
Vgontzas A, Trakada G, Bixler E, Lin H, Pejovic S, Zoumakis E, Chrousos G, Legro R. Plasma interleukin 6 levels are elevated in polycystic ovary syndrome independently of obesity or sleep apnea. Metabolism 2006, 55: 1076-1082. PMID: 16839844, DOI: 10.1016/j.metabol.2006.04.002.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromePolycystic ovary syndrome groupNormal-weight controlsIL-6 levelsTNF-alphaObese controlsIL-6Sleep apneaInsulin resistanceObese womenPlasma concentrationsTumor necrosis factor-alpha valuesPlasma concentrations of IL-6Plasma interleukin-6 levelsTumor necrosis factor-alphaCytokine plasma concentrationsConcentrations of IL-6Indices of insulin resistanceInterleukin-6 levelsExcessive daytime sleepinessNecrosis factor-alphaBody mass indexInsulin resistance indexPremenopausal womenNighttime polysomnography
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply