2022
Single-cell RNA-seq uncovers cellular heterogeneity and provides a signature for paediatric sleep apnoea.
Cortese R, Adams T, Cataldo K, Hummel J, Kaminski N, Kheirandish-Gozal L, Gozal D. Single-cell RNA-seq uncovers cellular heterogeneity and provides a signature for paediatric sleep apnoea. European Respiratory Journal 2022, 61: 2201465. PMID: 36356973, DOI: 10.1183/13993003.01465-2022.Peer-Reviewed Original ResearchConceptsObstructive sleep apnoeaSleep apnoeaImpact of OSASystemic immune functionMononuclear cell compositionMolecular signaturesCell-specific markersSystemic inflammationCardiovascular dysfunctionImmune cellsImmune functionSingle-cell transcriptomic analysisPaediatric sleep apnoeaUndescribed cell typePrevalent diseaseMajor causeCellular compositionApnoeaCell compositionRNA expression datasetsDiagnostic settingCell typesCell lineagesMolecular diagnostic settingScRNA-seq
2017
Polysomnographic phenotypes and their cardiovascular implications in obstructive sleep apnoea
Zinchuk AV, Jeon S, Koo BB, Yan X, Bravata DM, Qin L, Selim BJ, Strohl KP, Redeker NS, Concato J, Yaggi HK. Polysomnographic phenotypes and their cardiovascular implications in obstructive sleep apnoea. Thorax 2017, 73: 472. PMID: 28935698, PMCID: PMC6693344, DOI: 10.1136/thoraxjnl-2017-210431.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedCardiovascular DiseasesCluster AnalysisCross-Sectional StudiesFemaleHumansIschemic Attack, TransientLongitudinal StudiesMaleMiddle AgedMortalityPhenotypePolysomnographyProportional Hazards ModelsRisk AssessmentSeverity of Illness IndexSleep Apnea, ObstructiveStrokeConceptsObstructive sleep apnoeaCardiovascular outcomesPolysomnographic featuresSleep apnoeaPolysomnographic dataIncident transient ischemic attackUS Veteran cohortTransient ischemic attackAcute coronary syndromeAdverse cardiovascular outcomesPeriodic limb movementsOSA severity classificationPolysomnographic phenotypeCoronary syndromeIschemic attackCardiovascular implicationsOSA phenotypesOSA evaluationPathophysiological domainsPoor sleepMild/Patient clustersVeteran cohortSurvival analysisCombined outcome
2008
Selective effects of CPAP on sleep apnoea‐associated manifestations
Vgontzas A, Zoumakis E, Bixler E, Lin H, Collins B, Basta M, Pejovic S, Chrousos G. Selective effects of CPAP on sleep apnoea‐associated manifestations. European Journal Of Clinical Investigation 2008, 38: 585-595. PMID: 18627419, PMCID: PMC4528610, DOI: 10.1111/j.1365-2362.2008.01984.x.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressureObstructive sleep apnoeaMonths of continuous positive airway pressureNon-obese controlsTNF-R1 levelsInterleukin-6Visceral adiposityObese controlsInsulin resistanceTNF-R1TNF-alphaDaytime sleepinessVisceral fatObstructive sleep apnoea patientsBlood pressurePositive airway pressureTumor necrosis factor-alphaMeasurement of interleukin-6Interleukin-6 levelsNecrosis factor-alphaAssociated with insulin resistanceMeasures of daytime sleepinessFasting blood glucoseTNF receptor 1Predicting insulin resistance
2002
Cardiovascular medication use in patients with undiagnosed obstructive sleep apnoea
Otake K, Delaive K, Walld R, Manfreda J, Kryger M. Cardiovascular medication use in patients with undiagnosed obstructive sleep apnoea. Thorax 2002, 57: 417. PMID: 11978918, PMCID: PMC1746332, DOI: 10.1136/thorax.57.5.417.Peer-Reviewed Original ResearchConceptsMore daily dosesCardiovascular diseaseSystemic hypertensionMedication usePrescribed medicationsDaily dosesMore prescriptionsOdds ratioSleep apnoea/hypopnoea syndromeUndiagnosed obstructive sleep apnoeaObstructive sleep apnoeaCardiovascular medication useCongestive heart failureUse of medicationsGeneral population controlsOSAS casesMore medicationsSecondary preventionAngina pectorisHeart failureSleep apnoeaMedication costsSuch medicationsMyocardial infarctionOSAS diagnosis
2000
Fever and a rash in a 61 year old man
Federman D, Kirsner R. Fever and a rash in a 61 year old man. Postgraduate Medical Journal 2000, 76: 237-238. PMID: 10727572, PMCID: PMC1741540, DOI: 10.1136/pmj.76.894.237.Peer-Reviewed Original ResearchConceptsObstructive sleep apnoeaProximal lower extremity weaknessGastro-oesophageal reflux diseaseLower extremity weaknessWhite homosexual menYear old manProximal upper extremityShortness of breathWorsening rashSeronegative rheumatoid arthritisSleep apnoeaGenital ulcersTested HIVDry mouthPenile dischargeExtremity weaknessWrist painRaynaud's phenomenonMorning stiffnessReflux diseaseMedical historyBilateral handsHomosexual menRheumatoid arthritisOlder men
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