2024
Implementation, intervention, and downstream costs for implementation of a multidisciplinary complex pain clinic in the Veterans Health Administration
Daniels S, Cave S, Wagner T, Perez T, Edmond S, Becker W, Midboe A. Implementation, intervention, and downstream costs for implementation of a multidisciplinary complex pain clinic in the Veterans Health Administration. Health Services Research 2024, 59: e14345. PMID: 38956400, PMCID: PMC11540574, DOI: 10.1111/1475-6773.14345.Peer-Reviewed Original ResearchVeterans Health AdministrationIntervention sitesIntervention costsHealth AdministrationPain clinicDownstream costsQuasi-experimental study designChronic painVA administrative dataAverage intervention costComplex chronic painRoutes of careActivity-based cost dataHealthcare utilization costsVA Medical CenterHistory of chronic painMicro-costing methodImplementation facilitatorsHospice patientsCost of treating patientsControl groupAdministrative dataInpatient costsIntervention cohortClinically similar characteristicsImpact of large scale, multicomponent intervention to reduce proton pump inhibitor overuse in integrated healthcare system: difference-in-difference study
Kurlander J, Laine L, Kim H, Roberts C, Saffar D, Myers A, Holleman R, Gao Y, Shank M, Nelson R, Forman J, Helfrich C, Krein S, Saini S, Yang Y. Impact of large scale, multicomponent intervention to reduce proton pump inhibitor overuse in integrated healthcare system: difference-in-difference study. The BMJ 2024, 385: e076484. PMID: 38604668, PMCID: PMC11007585, DOI: 10.1136/bmj-2023-076484.Peer-Reviewed Original ResearchConceptsPrimary care visitsProton pump inhibitors prescriptionUpper gastrointestinal diagnosesMulticomponent interventionCare visitsHealthcare systemHospital admissionUS Veterans Affairs Healthcare SystemVeterans Affairs Healthcare SystemAbsolute reductionGastrointestinal diagnosesIntegrated healthcare systemProton pump inhibitor overuseReducing proton-pump inhibitorDifference-in-differences studyProton pump inhibitorsPercentage of patientsProton pump inhibitor useAcid peptic diseaseElectronic prescribingPrimary careHealthcare utilizationIntervention sitesPPI prescriptionsOlder adultsLast-mile delivery increases vaccine uptake in Sierra Leone
Meriggi N, Voors M, Levine M, Ramakrishna V, Kangbai D, Rozelle M, Tyler E, Kallon S, Nabieu J, Cundy S, Mobarak A. Last-mile delivery increases vaccine uptake in Sierra Leone. Nature 2024, 627: 612-619. PMID: 38480877, PMCID: PMC10954551, DOI: 10.1038/s41586-024-07158-w.Peer-Reviewed Original ResearchConceptsChild health interventionsMobile vaccination teamsRural areas of Sierra LeoneRandomized Controlled TrialsHealth professionalsIntervention sitesHealth interventionsIntervention costsCommunity mobilizationImmunization ratesRemote populationsSierra LeoneControlled TrialsRural areasDelivery of doseInterventionVaccine uptakeAccess difficultiesVaccination teamsBehavioral issuesVaccination pointsVaccine deliveryRemote villagesCommunityCOVID-19 vaccine
2022
Preliminary analysis of self-reported quality health indicators of patients on opioid agonist therapy at specialty and primary care clinics in Ukraine: A randomized control trial
Pashchenko O, Bromberg D, Dumchev K, LaMonaca K, Pykalo I, Filippovych M, Esserman D, Polonsky M, de Leon S, Morozova O, Dvoriak S, Altice F. Preliminary analysis of self-reported quality health indicators of patients on opioid agonist therapy at specialty and primary care clinics in Ukraine: A randomized control trial. PLOS Global Public Health 2022, 2: e0000344. PMID: 36962514, PMCID: PMC10021202, DOI: 10.1371/journal.pgph.0000344.Peer-Reviewed Original ResearchPrimary care clinicsOpioid use disorderOpioid agonist therapyPrimary careComplete self-reported dataPatient medical record dataMedical record dataComprehensive health outcomesAddiction treatment clinicsAdult PWIDAgonist therapySecondary outcomesParent trialPrimary outcomeRandomized participantsCare clinicsTreatment clinicsIntervention sitesUse disordersHealth outcomesAddiction treatmentRecord dataSelf-reported dataHealth indicatorsClinic
2020
Sankofa pediatric HIV disclosure intervention did not worsen depression scores in children living with HIV and their caregivers in Ghana
Radcliffe C, Sam A, Matos Q, Antwi S, Amissah K, Alhassan A, Ofori IP, Xu Y, Deng Y, Reynolds NR, Paintsil E. Sankofa pediatric HIV disclosure intervention did not worsen depression scores in children living with HIV and their caregivers in Ghana. BMC Public Health 2020, 20: 1578. PMID: 33081739, PMCID: PMC7576749, DOI: 10.1186/s12889-020-09678-2.Peer-Reviewed Original ResearchConceptsBeck Depression InventoryBDI scoresChildren's Depression InventoryCDI scoresDepression InventoryHIV disclosure interventionsCross-sectional studyHIV statusPresent studyCaregiver-child dyadsLow prevalenceIntervention sitesDepression scoresSignificant associationDisclosure statusConclusionsOur findingsDisclosure interventionCaregiversScoresInterventionChildrenOriginal dyadStatusHIVPrevalenceEffectiveness of enhanced cognitive behavior therapy for bulimia nervosa in Japan: a randomized controlled trial protocol
Ohara C, Sekiguchi A, Takakura S, Endo Y, Tamura N, Kikuchi H, Maruo K, Sugawara N, Hatano K, Kawanishi H, Funaba M, Sugawara A, Nohara N, Kawai K, Fukudo S, Sudo N, Cooper Z, Yoshiuchi K, Ando T. Effectiveness of enhanced cognitive behavior therapy for bulimia nervosa in Japan: a randomized controlled trial protocol. BioPsychoSocial Medicine 2020, 14: 2. PMID: 32123540, PMCID: PMC7041176, DOI: 10.1186/s13030-020-0174-z.Peer-Reviewed Original ResearchCognitive behavior therapyBody mass indexStart of treatmentBulimia nervosaBehavior therapyEffectiveness of CBTTreatment of BNDiagnosis of BNFifth Edition diagnosisWeeks of treatmentEnd of treatmentYears of ageDSM-5 criteriaSecondary outcomesMulticenter RCTPrimary outcomeMass indexFirst RCTRoutine treatmentTAU groupTrial protocolAdult outpatientsEdition diagnosisHigh prevalenceIntervention sites
2019
SEQUENTIAL IMPLEMENTATION AS A LEARNING HEALTH ORGANIZATION: THE EQUIPPED GERIATRIC MEDICATION SAFETY MODEL
Vandenberg A, Kegler M, Hastings S, Hwang U, Vaughan C. SEQUENTIAL IMPLEMENTATION AS A LEARNING HEALTH ORGANIZATION: THE EQUIPPED GERIATRIC MEDICATION SAFETY MODEL. Innovation In Aging 2019, 3: s945-s945. PMCID: PMC6846564, DOI: 10.1093/geroni/igz038.3434.Peer-Reviewed Original ResearchEmergency departmentOlder adultsHealth OrganizationImportant public health issueSame electronic health recordEffective Programs frameworkHospital emergency departmentPublic health issueEvidence-based interventionsElectronic health recordsResearch NetworkInappropriate medicationsAdverse eventsClinical decision supportIntervention sitesHealth issuesHealth recordsIntervention packageProcess evaluationCollaborative research networksHealthcare practiceWidespread disseminationAdultsFocus groupsSafety programThe Implementation of a National Multifaceted Emergency Medicine Resident Wellness Curriculum Is Not Associated With Changes in Burnout
Williamson K, Lank P, Hartman N, Lu D, Wheaton N, Cash J, Branzetti J, Lovell E, Alliance T. The Implementation of a National Multifaceted Emergency Medicine Resident Wellness Curriculum Is Not Associated With Changes in Burnout. AEM Education And Training 2019, 4: 103-110. PMID: 32313856, PMCID: PMC7163197, DOI: 10.1002/aet2.10391.Peer-Reviewed Original ResearchMaslach Burnout InventoryCommon Program RequirementsWellness curriculumSurvey administrationIntervention sitesEmergency medicineAccreditation Council for Graduate Medical Education Common Program RequirementsBurnout scoresMaslach Burnout Inventory scoresGlobal burnout scoresEducational intervention trialPersonal accomplishment scoresResident wellness curriculumAssociated with changesProgram requirementsAccomplishment scoresWellness initiativesEM residentsBurnout InventoryResident burnoutResident competencyIntervention trialsSponsoring institutionNational studyBurnout
2016
Cellular prion protein as a receptor for amyloid-β oligomers in Alzheimer's disease
Salazar SV, Strittmatter SM. Cellular prion protein as a receptor for amyloid-β oligomers in Alzheimer's disease. Biochemical And Biophysical Research Communications 2016, 483: 1143-1147. PMID: 27639648, PMCID: PMC5303667, DOI: 10.1016/j.bbrc.2016.09.062.Peer-Reviewed Original ResearchConceptsCellular prion proteinPrion proteinSignal transduction downstreamDisease pathophysiologyNeuronal surfaceMetabotropic glutamate receptor 5Neuronal cell surface moleculesGlutamate receptor 5Disease-associated stateAlzheimer's disease pathophysiologyAltered signal transductionTransduction downstreamSignal transductionGenetic evidenceSpecificity of bindingPyk2 kinaseCell surface moleculesFyn kinaseSynaptic dysfunctionAβO toxicitySynaptic transmissionMouse modelIntervention sitesReceptor 5Alzheimer's diseasePatient and Provider Satisfaction With a Comprehensive Strategy to Improve Prevention of Mother-to-Child HIV Transmission Services in Rural Nigeria
Boehmer A, Audet CM, Blevins M, Gebi UI, Wester CW, Vermund SH, Aliyu MH. Patient and Provider Satisfaction With a Comprehensive Strategy to Improve Prevention of Mother-to-Child HIV Transmission Services in Rural Nigeria. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2016, 72: s117-s123. PMID: 27355498, PMCID: PMC5113240, DOI: 10.1097/qai.0000000000001058.Peer-Reviewed Original ResearchConceptsPrevention of motherProvider satisfactionPatient satisfactionWeeks postpartumControl armIntervention sitesChild HIV transmission servicesChild HIV transmission rateMother-infant careCD4 cell countHIV transmission ratesCluster-randomized trialTotal patient satisfactionAntiretroviral therapyHIV careChild transmissionPrescribed treatmentClinician satisfactionHealth personnelLower cadre workersCell countHealth problemsMale involvementProvider rolesProviders' abilityChapter 8 Targeting Aβ Receptors to Modify Alzheimer’s Disease Progression
Haas L, Strittmatter S. Chapter 8 Targeting Aβ Receptors to Modify Alzheimer’s Disease Progression. 2016, 227-250. DOI: 10.1016/b978-0-12-802173-6.00008-3.Peer-Reviewed Original ResearchAlzheimer's diseaseDisease progressionIntervention sitesCourse of ADMetabotropic glutamate receptor 5Glutamate receptor 5Receptor-mediated mechanismAlzheimer's disease progressionHigh-affinity natureAD pathophysiologyReceptor mechanismsReceptor 5Preclinical successMGluR5 pathwayAβ receptorsCellular prion proteinSuch receptorsPathological processesDiseasePathophysiological signalsReceptorsPrion proteinSpecific pathwaysPathwayHigh affinity
2015
Assisted partner notification services to augment HIV testing and linkage to care in Kenya: study protocol for a cluster randomized trial
Wamuti B, Erdman L, Cherutich P, Golden M, Dunbar M, Bukusi D, Richardson B, Ng’ang’a A, Barnabas R, Mutiti P, Macharia P, Jerop M, Otieno F, Poole D, Farquhar C. Assisted partner notification services to augment HIV testing and linkage to care in Kenya: study protocol for a cluster randomized trial. Implementation Science 2015, 10: 23. PMID: 25884936, PMCID: PMC4342094, DOI: 10.1186/s13012-015-0212-6.Peer-Reviewed Original ResearchConceptsAssisted partner notification servicesPartner notification servicesAssisted partner notificationHIV testingPartner notificationHIV partner notification servicesCluster Randomized Controlled TrialHIV testing programsHIV testing sitesCluster randomized trialHealth-care settingsPublic health strategiesSexual partnersSexual exposure to HIVExposure to HIVControl of HIV transmissionHealth facilitiesIncremental cost-effectivenessIntervention sitesHealth strategiesStudy staffPartner referralNational guidelinesHIV transmissionCase finding
2007
Partners in Caregiving in a Special Care Environment: Cooperative Communication Between Staff and Families on Dementia Units
Robison J, Curry L, Gruman C, Porter M, Henderson CR, Pillemer K. Partners in Caregiving in a Special Care Environment: Cooperative Communication Between Staff and Families on Dementia Units. The Gerontologist 2007, 47: 504-515. PMID: 17766671, DOI: 10.1093/geront/47.4.504.Peer-Reviewed Original ResearchConceptsEvaluation of partnersEvidence-based interventionsFamilies of residentsResidents' family membersFamily-focused programsReduced depressionEffective staffConflict resolution techniquesPositive outcomesBehavioral symptomsControl conditionStaff behaviorCare environmentFamily membersTraining sessionsNursing staff membersCaregivingReduced conflictIntervention facilitiesTreatment groupsIntervention sitesNursing homesCare involvementControl groupDementia unit
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