2024
The amalgam of naive CD4+ T cell transcriptional states is reconfigured by helminth infection to dampen the amplitude of the immune response
Even Z, Meli A, Tyagi A, Vidyarthi A, Briggs N, de Kouchkovsky D, Kong Y, Wang Y, Waizman D, Rice T, De Kumar B, Wang X, Palm N, Craft J, Basu M, Ghosh S, Rothlin C. The amalgam of naive CD4+ T cell transcriptional states is reconfigured by helminth infection to dampen the amplitude of the immune response. Immunity 2024, 57: 1893-1907.e6. PMID: 39096910, PMCID: PMC11421571, DOI: 10.1016/j.immuni.2024.07.006.Peer-Reviewed Original ResearchT cell receptorImmune responseNaive CD4<sup>+</sup> T cellsCD4<sup>+</sup> T cellsIFN-IHelminth infectionsNippostrongylus brasiliensis infectionDecreased immune responseType I interferonNaive TT cellsMemory-likeUnrelated antigensTranscriptional changesExtracellular matrixSPF miceCell receptorsI interferonGerm-freeResponse to certain environmental cuesInfectionMiceFunctional changesCell transcriptional statesTranscriptional heterogeneity
2023
Effector response to necroptotic cell death: an ensemble of immune and stromal cells
Hughes L, Altun O, Nevin J, Wang M, Kluger Y, Pelorosso F, Leighton J, Rothlin C, Ghosh S. Effector response to necroptotic cell death: an ensemble of immune and stromal cells. The Journal Of Immunology 2023, 210: 72.39-72.39. DOI: 10.4049/jimmunol.210.supp.72.39.Peer-Reviewed Original ResearchApoptotic cell deathCell deathGene expression programsEffector responsesNecroptotic cell deathSingle-cell levelMyofibroblast transitionExpression programsStromal cellsTissue renewalTranscriptomic changesCellular corpsesInflammatory bowel diseaseExcessive inflammatory responseInfluence of TGFChemo-genetic approachNon-resolving inflammationMolecular pathwaysResolution of inflammationEssential roleMajor stromal cellsBowel diseaseInflammatory responseInjury modelHelminth infections
2019
Soil‐transmitted helminth infection and intestinal inflammation among the Shuar of Amazonian Ecuador
Cepon‐Robins T, Gildner T, Schrock J, Eick G, Bedbury A, Liebert M, Urlacher S, Madimenos F, Harrington C, Amir D, Bribiescas R, Sugiyama L, Snodgrass J. Soil‐transmitted helminth infection and intestinal inflammation among the Shuar of Amazonian Ecuador. American Journal Of Biological Anthropology 2019, 170: 65-74. PMID: 31260090, DOI: 10.1002/ajpa.23897.Peer-Reviewed Original ResearchConceptsSoil-Transmitted HelminthsIntestinal inflammationImmune system developmentSTH exposureSTH infectionsSpecies of STHFC levelsSoil-transmitted helminth infectionsElevated intestinal inflammationIntestinal inflammatory responseAnti-inflammatory pathwayLow FC levelsInfection intensityHuman immune systemUninfected childrenFecal calprotectinRole of exposureInflammatory responseStool samplesTrichuris trichiuraT. trichiuraHelminth infectionsLifestyle changesInflammationImmune system
2017
Yeast-expressed recombinant As16 protects mice against Ascaris suum infection through induction of a Th2-skewed immune response
Wei J, Versteeg L, Liu Z, Keegan B, Gazzinelli-Guimarães AC, Fujiwara RT, Briggs N, Jones KM, Strych U, Beaumier CM, Bottazzi ME, Hotez PJ, Zhan B. Yeast-expressed recombinant As16 protects mice against Ascaris suum infection through induction of a Th2-skewed immune response. PLOS Neglected Tropical Diseases 2017, 11: e0005769. PMID: 28708895, PMCID: PMC5529013, DOI: 10.1371/journal.pntd.0005769.Peer-Reviewed Original ResearchConceptsTh2-skewed immune responseTh2-type responseCholera toxin B subunitImmune responseEgg challengeProtective immunitySignificant protectionPredominant Th2-type responseTh2-type immune responseFeasible vaccine candidateTh1-type responseCommon helminth infectionA. suum infectionAscaris suum infectionExact protective mechanismHost immune systemToxin B subunitA. suumRestimulated splenocytesA. suum eggsChallenge infectionIL-4IL-5Trichuris infectionHelminth infectionsMacrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells
Bosurgi L, Cao YG, Cabeza-Cabrerizo M, Tucci A, Hughes LD, Kong Y, Weinstein JS, Licona-Limon P, Schmid ET, Pelorosso F, Gagliani N, Craft JE, Flavell RA, Ghosh S, Rothlin CV. Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells. Science 2017, 356: 1072-1076. PMID: 28495875, PMCID: PMC5556699, DOI: 10.1126/science.aai8132.Peer-Reviewed Original ResearchConceptsApoptotic cellsTissue repair programChemotaxis genesTissue-resident macrophagesIL-4IL-13Tissue repairPattern recognition receptorsTissue repair genesCell adhesionRepair genesGenetic ablationCytokine-dependent inductionHelminth infectionsRecognition receptorsInduction of colitisGenesBroad repertoireSoluble cytokinesMacrophage functionCellsInductionHost responseEctopic activityInterleukin-4
2016
Effectiveness of Albendazole for Hookworm Varies Widely by Community and Correlates with Nutritional Factors: A Cross-Sectional Study of School-Age Children in Ghana.
Humphries D, Nguyen S, Kumar S, Quagraine JE, Otchere J, Harrison LM, Wilson M, Cappello M. Effectiveness of Albendazole for Hookworm Varies Widely by Community and Correlates with Nutritional Factors: A Cross-Sectional Study of School-Age Children in Ghana. American Journal Of Tropical Medicine And Hygiene 2016, 96: 347-354. PMID: 27895280, PMCID: PMC5303035, DOI: 10.4269/ajtmh.16-0682.Peer-Reviewed Original ResearchConceptsEgg reduction rateCross-sectional studyMass drug administrationSchool-aged childrenEffectiveness of albendazoleCure rateDrug AdministrationMid-upper arm circumferenceSoil-transmitted helminth infectionsHost factorsNutritional factorsSingle-dose albendazoleOverall cure rateBlood hemoglobin levelsKintampo North MunicipalitySignificant community-level variationIndividual host factorsWorld Health OrganizationCommon STHHemoglobin levelsArm circumferenceHookworm infectionHelminth infectionsDeworming programsHookworm prevalenceThe Hygiene Hypothesis and Its Inconvenient Truths about Helminth Infections
Briggs N, Weatherhead J, Sastry KJ, Hotez PJ. The Hygiene Hypothesis and Its Inconvenient Truths about Helminth Infections. PLOS Neglected Tropical Diseases 2016, 10: e0004944. PMID: 27632204, PMCID: PMC5025185, DOI: 10.1371/journal.pntd.0004944.Peer-Reviewed Original Research
2012
The promise and pitfalls of mass drug administration to control intestinal helminth infections
Humphries D, Nguyen S, Boakye D, Wilson M, Cappello M. The promise and pitfalls of mass drug administration to control intestinal helminth infections. Current Opinion In Infectious Diseases 2012, 25: 584-589. PMID: 22903231, DOI: 10.1097/qco.0b013e328357e4cf.Peer-Reviewed Original ResearchConceptsMass drug administrationIntestinal helminth infectionsHelminth infectionsDrug AdministrationSoil-transmitted nematode infectionsIntensity of schistosomiasisHigh-risk groupResource-limited settingsLong-term controlSignificant morbidityPregnant womenLong-term benefitsNew drug developmentIntensity of infectionIntestinal helminthsEndemic areasConsistent benefitInfectionChemotherapeutic interventionCertain populationsDrug developmentBenzimidazole anthelminthicsIntensive monitoringPrevalenceAdministration
2011
Effectiveness of a School-Based Deworming Campaign in Rural Kenya
Peterson LS, Ondiek M, Oludhe DO, Naul BA, Vermund SH. Effectiveness of a School-Based Deworming Campaign in Rural Kenya. Journal Of Tropical Pediatrics 2011, 57: 461-463. PMID: 21212131, PMCID: PMC12129568, DOI: 10.1093/tropej/fmq118.Peer-Reviewed Original ResearchConceptsDeworming campaignsIntestinal helminth infectionsSingle stool sampleRe-infection rateDirect stool smearDirect smear examinationHeavy environmental contaminationPrimary school-aged childrenSchool-aged childrenStool samplesStool surveyHelminth infectionsSmear examinationStool smearsHeavy infectionsSchool childrenInfectionRural KenyaChildrenParasite prevalenceCommunity educationSanitation improvementTrue rateDefinitive impactPrevalencePoly-helminth infection in east guatemalan school children
Sorensen WC, Cappello M, Bell D, DiFedele LM, Brown MA. Poly-helminth infection in east guatemalan school children. Journal Of Global Infectious Diseases 2011, 3: 25-31. PMID: 21572605, PMCID: PMC3068574, DOI: 10.4103/0974-777x.77292.Peer-Reviewed Original ResearchGuatemalan school childrenBivariate analysisSchool childrenGlobal public health concernPrevalence of hookwormMultiple logistic regressionPublic health concernLow-intensity infectionsBaseline prevalenceSTH infectionsKato-KatzHelminth infectionsAnthropometric measuresAssociated epidemiologyInfectionLogistic regressionGuatemalan childrenHealth concernAnemiaChi-squareSignificant decreaseHemoglobinChildrenT-testInfection intensity
2009
High Prevalence of Soil-transmitted Helminths in Western Kenya: Failure to Implement Deworming Guidelines in Rural Nyanza Province
Riesel JN, Ochieng’ F, Wright P, Vermund SH, Davidson M. High Prevalence of Soil-transmitted Helminths in Western Kenya: Failure to Implement Deworming Guidelines in Rural Nyanza Province. Journal Of Tropical Pediatrics 2009, 56: 60-62. PMID: 19502602, PMCID: PMC12129559, DOI: 10.1093/tropej/fmp043.Peer-Reviewed Original ResearchConceptsSTH infectionsSoil-transmitted helminth infectionsRural Nyanza ProvinceNyanza ProvinceSingle stool sampleRegular deworming programmeSoil-Transmitted HelminthsGreater morbidityRegular dewormingPrimary school-aged childrenSchool-aged childrenHigh prevalenceStool samplesHelminth infectionsDeworming programsSignificant burdenInfectionWorm infectionPrevalencePeople worldTwo-thirdsRural Kenyan villagesWestern KenyaChildrenKenyan villages
2008
Orthologs of macrophage migration inhibitory factor from parasitic nematodes
Vermeire JJ, Cho Y, Lolis E, Bucala R, Cappello M. Orthologs of macrophage migration inhibitory factor from parasitic nematodes. Trends In Parasitology 2008, 24: 355-363. PMID: 18603473, PMCID: PMC3615561, DOI: 10.1016/j.pt.2008.04.007.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMacrophage migration inhibitory factorParasitic nematodesMigration inhibitory factorHost-parasite interfaceSpecies-specific activityDevelopmental biologyThree-dimensional structureMammalian hostsInhibitory factorHost cellular immune responseParasite survivalChronic helminth infectionsVaccine-based strategiesCellular immune responsesOrthologsMIF moleculeParasite moleculesNematodesHost cytokinesImmune responseHelminth infectionsDisease controlIdeal targetRecent progressMolecules
2005
Prevalence and predictors of intestinal helminth infections among human immunodeficiency virus type 1-infected adults in an urban African setting.
Modjarrad K, Zulu I, REDDEN DT, Njobvu L, FREEDMAN DO, VERMUND SH. Prevalence and predictors of intestinal helminth infections among human immunodeficiency virus type 1-infected adults in an urban African setting. American Journal Of Tropical Medicine And Hygiene 2005, 73: 777-82. PMID: 16222025, PMCID: PMC2749260, DOI: 10.4269/ajtmh.2005.73.777.Peer-Reviewed Original ResearchConceptsHIV-1-infected adultsIntestinal helminth infectionsHelminth infectionsUrban African settingIntestinal helminthsHuman immunodeficiency virus type 1Immunodeficiency virus type 1Detrimental immunologic effectsRoutine HIV careAfrican settingHuman immunodeficiency virusLight-intensity infectionsHIV infection ratesVirus type 1HIV careImmunologic effectsConcomitant infectionImmunodeficiency virusPrior historyHelminth diagnosisAscaris lumbricoidesHelminth statusParasitologic dataInfection rateInfectionTreatment of Intestinal Helminths Does Not Reduce Plasma Concentrations of HIV-1 RNA in Coinfected Zambian Adults
Modjarrad K, Zulu I, Redden DT, Njobvu L, Lane HC, Bentwich Z, Vermund SH. Treatment of Intestinal Helminths Does Not Reduce Plasma Concentrations of HIV-1 RNA in Coinfected Zambian Adults. The Journal Of Infectious Diseases 2005, 192: 1277-1283. PMID: 16136473, PMCID: PMC2730764, DOI: 10.1086/444543.Peer-Reviewed Original ResearchConceptsHIV-1 RNAViral loadPlasma concentrationsAntihelminthic treatmentCopies/Helminth infectionsIntestinal helminthsHigh pretreatment viral loadMedian baseline viral loadPretreatment viral loadBaseline viral loadDysfunctional immune responseIntestinal helminth infectionsHuman immunodeficiency virusMean viral loadCopies/mLHigher helminth burdensPosttreatment visitAsymptomatic adultsImmunodeficiency virusProspective studyZambian adultsUninfected groupHIV-1Immune response
2002
Poor intestinal permeability in mildly stunted Nepali children: associations with weaning practices and Giardia lamblia infection
Goto R, Panter-Brick C, Northrop-Clewes C, Manahdhar R, Tuladhar N. Poor intestinal permeability in mildly stunted Nepali children: associations with weaning practices and Giardia lamblia infection. British Journal Of Nutrition 2002, 88: 141-149. PMID: 12171055, DOI: 10.1079/bjn2002599.Peer-Reviewed Original ResearchConceptsIntestinal permeabilityPoor intestinal permeabilityMannitol ratioNepali childrenGiardia lamblia infectionIntestinal permeability testDuration of supplementationCross-sectional studyEarly growth retardationFood malabsorptionLamblia infectionMucosal damageStage of weaningMorbidity dataLactose maldigestionHelminth infectionsLate infancyImmune systemPoor heightGrowth retardationUK childrenInfectionParasite infectionChildrenSame age
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