2021
Dissection of Barrier Dysfunction in Organoid-Derived Human Intestinal Epithelia Induced by Giardia duodenalis
Holthaus D, Kraft M, Krug S, Wolf S, Müller A, Delgado Betancourt E, Schorr M, Holland G, Knauf F, Schulzke J, Aebischer T, Klotz C. Dissection of Barrier Dysfunction in Organoid-Derived Human Intestinal Epithelia Induced by Giardia duodenalis. Gastroenterology 2021, 162: 844-858. PMID: 34822802, DOI: 10.1053/j.gastro.2021.11.022.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisCaco-2 CellsChloridesCyclic AMPCyclic AMP-Dependent Protein KinasesCystic Fibrosis Transmembrane Conductance RegulatorDuodenumElectric ImpedanceGiardia lambliaGiardiasisHumansInterleukin-1Intestinal MucosaIon TransportNF-kappa BOrganoidsParasite LoadSignal TransductionSolute Carrier Family 12, Member 2Tight JunctionsTranscriptomeTumor Necrosis Factor-alphaConceptsG. duodenalis infectionBarrier dysfunctionGiardia duodenalisHuman duodenal tissueIntestinal barrier dysfunctionHuman intestinal epitheliumResponse element-binding proteinTight junction compositionProtozoan Giardia duodenalisAdequate cellular modelsChronic casesMajor expression changesPathophysiological mechanismsBarrier breakdownDuodenal mucosaGastrointestinal illnessDuodenal tissueBarrier lossPathogenic eventsHuman organoid systemEpithelial barrierTranswell systemChloride secretionIntestinal epitheliumTight junction components
2010
Molecular characterization of the cis-prenyltransferase of Giardia lamblia
Grabińska K, Cui J, Chatterjee A, Guan Z, Raetz C, Robbins P, Samuelson J. Molecular characterization of the cis-prenyltransferase of Giardia lamblia. Glycobiology 2010, 20: 824-832. PMID: 20308470, PMCID: PMC2900897, DOI: 10.1093/glycob/cwq036.Peer-Reviewed Original ResearchConceptsIsoprene unitsDouble deletion mutantGPI anchor synthesisMost eukaryotesHigher eukaryotesAnchor synthesisN-glycosylationGlycosylphosphatidylinositol (GPI) anchorCis-prenyltransferaseKinase activityPolyprenyl pyrophosphateBacterial enzymesDolichol kinase activityDolichol kinaseMolecular characterizationImportant enzymeN-glycansEukaryotesProtistsPolyprenol lipidsNormal growthPyrophosphate linkageEnzymeGiardia lambliaDolichol
2009
snoRNAs in Giardia lamblia: a novel role in RNA silencing?
Kolev NG, Ullu E. snoRNAs in Giardia lamblia: a novel role in RNA silencing? Trends In Parasitology 2009, 25: 348-350. PMID: 19616476, DOI: 10.1016/j.pt.2009.05.001.Peer-Reviewed Original Research
2002
Poor intestinal permeability in mildly stunted Nepali children: associations with weaning practices and Giardia lamblia infection
Goto R, Panter-Brick C, Northrop-Clewes C, Manahdhar R, Tuladhar N. Poor intestinal permeability in mildly stunted Nepali children: associations with weaning practices and Giardia lamblia infection. British Journal Of Nutrition 2002, 88: 141-149. PMID: 12171055, DOI: 10.1079/bjn2002599.Peer-Reviewed Original ResearchConceptsIntestinal permeabilityPoor intestinal permeabilityMannitol ratioNepali childrenGiardia lamblia infectionIntestinal permeability testDuration of supplementationCross-sectional studyEarly growth retardationFood malabsorptionLamblia infectionMucosal damageStage of weaningMorbidity dataLactose maldigestionHelminth infectionsLate infancyImmune systemPoor heightGrowth retardationUK childrenInfectionParasite infectionChildrenSame age
2000
A dual-specificity aminoacyl-tRNA synthetase in the deep-rooted eukaryote Giardia lamblia
Bunjun S, Stathopoulos C, Graham D, Min B, Kitabatake M, Wang A, Wang C, Vivarès C, Weiss L, Söll D. A dual-specificity aminoacyl-tRNA synthetase in the deep-rooted eukaryote Giardia lamblia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 12997-13002. PMID: 11078517, PMCID: PMC27167, DOI: 10.1073/pnas.230444397.Peer-Reviewed Original ResearchConceptsCys-tRNAAminoacyl-tRNA synthetaseProlyl-tRNA synthetasePrimitive eukaryote Giardia lambliaPro geneEukaryote Giardia lambliaNumber of archaeaAlanyl-tRNA synthetasesCysteinyl-tRNA synthetaseE. coli tRNACysS genesM. jannaschiiMethanococcus jannaschiiMost organismsGenomic sequencesSaccharomyces cerevisiaeCysteinyl-tRNAGene productsPro-tRNATRNA synthetaseDual specificityMethanobacterium thermoautotrophicumProtein synthesisEscherichia coliAmino acids
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