2024
Deficits in prefrontal metabotropic glutamate receptor 5 are associated with functional alterations during emotional processing in bipolar disorder
Asch R, Worhunsky P, Davis M, Holmes S, Cool R, Boster S, Carson R, Blumberg H, Esterlis I. Deficits in prefrontal metabotropic glutamate receptor 5 are associated with functional alterations during emotional processing in bipolar disorder. Journal Of Affective Disorders 2024, 361: 415-424. PMID: 38876317, PMCID: PMC11250898, DOI: 10.1016/j.jad.2024.06.025.Peer-Reviewed Original ResearchMetabotropic glutamate receptor 5Bipolar disorderGlutamate receptor 5Positron emission tomographyFear processingEmotional processingAssociated with greater activationEmotion processing taskAssociated with impulsivityFunctional brain differencesAssociated with functional alterationsParietal brain regionsPathology of BDIncreased cortical activityAssociated with difficultiesDepressive disorderHealthy comparisonReceptor availabilityBrain differencesPre/postcentral gyriAttention difficultiesGreater activationBrain regionsPsychomotor functionTreatment development
2011
The Neuroscience and Genetics of Childhood Maltreatment
McCrory E, De Brito S, Viding E. The Neuroscience and Genetics of Childhood Maltreatment. 2011, 121-125. DOI: 10.1002/9781119993971.ch20.Peer-Reviewed Original ResearchLater psychopathologyChildhood maltreatmentFunctional brain differencesIndividual differencesPsychological adaptationEmotional developmentNeurobiological circuitryAntisocial personality disorderEarly adversityNeurobiological mechanismsBrain differencesConduct disorderEnvironmental experiencesChildhood adversityChildren's riskPsychopathologyPersonality disorderAdversityMaltreatmentNeuroscienceDisordersAnxietyProtective genesDepressionChildrenThe Impact of Childhood Maltreatment: A Review of Neurobiological and Genetic Factors
McCrory E, De Brito S, Viding E. The Impact of Childhood Maltreatment: A Review of Neurobiological and Genetic Factors. Frontiers In Psychiatry 2011, 2: 48. PMID: 21847382, PMCID: PMC3148713, DOI: 10.3389/fpsyt.2011.00048.Peer-Reviewed Original ResearchChildhood maltreatmentFunctional brain differencesFunctional MRI studyAdrenal axis stress responseCare-giving experienceMagnetic resonance imaging studyResonance imaging studyAtypical developmentEmotional developmentAtypical activationNeurobiological correlatesAmygdala hyperactivityBrain differencesFrontal regionsPsychiatric vulnerabilityEnvironmental adversityBehavioral studiesChildhood historyInformation biasesMaltreatmentPreliminary evidenceSuch experiencesStructural MRINeuroendocrine findingsSignificant risk factors
2010
Research Review: The neurobiology and genetics of maltreatment and adversity
McCrory E, De Brito SA, Viding E. Research Review: The neurobiology and genetics of maltreatment and adversity. Journal Of Child Psychology And Psychiatry 2010, 51: 1079-1095. PMID: 20546078, DOI: 10.1111/j.1469-7610.2010.02271.x.Peer-Reviewed Original ResearchConceptsChildhood maltreatmentEarly adversityFunctional brain differencesIndividual's genetic makeAdrenal axis stress responseAtypical developmentEmotional developmentNeurobiological developmentAtypical activationNeurobiological mechanismsBrain differencesPrefrontal cortexPsychiatric vulnerabilityEnvironmental experiencesAdversityEnvironmental adversityBrain regionsEarly stressMaltreatmentNeuroendocrine findingsChildrenAdultsCorpus callosumGenetic makeHuman studies
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