2025
FapR regulates HssRS-mediated heme homeostasis in Bacillus anthracis
Pi H, Burroughs O, Carlin S, Beavers W, Hillebrand G, Krystofiak E, Stauff D, Skaar E. FapR regulates HssRS-mediated heme homeostasis in Bacillus anthracis. MBio 2025, 16: e02057-24. PMID: 40407322, PMCID: PMC12153329, DOI: 10.1128/mbio.02057-24.Peer-Reviewed Original ResearchConceptsHeme homeostasisKnowledge of bacterial physiologyTwo-component signaling systemRegulation of fatty acid biosynthesisMembrane integrityFatty acid biosynthesisHeme toxicityCausative agent of anthraxHeme stressGram-positive pathogensAgent of anthraxGram-positive bacteriaBacterial physiologyHeme sensingTranscriptional regulationAcid biosynthesisTranscription factorsFapRFacultative anaerobesHeme biosynthesisRegulatory pathwaysHssRSVertebrate bloodMolecular adaptationsMolecular mechanisms
2023
Human Gene Age Dating Reveals an Early and Rapid Evolutionary Construction of the Adaptive Immune System
Zhang L, Park J, Dong M, Arsala D, Xia S, Chen J, Sosa D, Atlas J, Long M, Chen S. Human Gene Age Dating Reveals an Early and Rapid Evolutionary Construction of the Adaptive Immune System. Genome Biology And Evolution 2023, 15: evad081. PMID: 37170918, PMCID: PMC10210621, DOI: 10.1093/gbe/evad081.Peer-Reviewed Original ResearchT cell adaptive immunityNew genesPositive selectionRapid gene duplicationEvolution of longevityStrong positive selectionVertebrate immune systemAdaptive immunityAmino acid substitutionsVertebrate lineageGene ageGene duplicationEutherian radiationGene annotationGenome assemblyRapid originationVertebrate speciesPlacental mammalsHuman genesImmunity genesMolecular adaptationsNucleotide sequenceGenetic constructionNegative regulatorInteraction pathway
2020
Adaptive Regulation of Hepatocyte Transporters in Cholestasis
Boyer J. Adaptive Regulation of Hepatocyte Transporters in Cholestasis. 2020, 378-389. DOI: 10.1002/9781119436812.ch31.Peer-Reviewed Original ResearchSignal transduction pathwaysAdaptive responseOrganic solute transporterSecretory polarityTranscription factorsTransduction pathwaysMolecular adaptationsSolute transportersCytoskeleton structureIntracellular vesiclesTarget genesMembrane transportersCellular eventsJunctional proteinsNuclear receptorsCanalicular domainCholestatic phenotypeTransportersTight junctionsVital functionsRegulationAdaptive regulationImportant ligandsEnzymatic reactionsBile salt synthesis
2017
Molecular Prerequisites for Diminished Cold Sensitivity in Ground Squirrels and Hamsters
Matos-Cruz V, Schneider ER, Mastrotto M, Merriman DK, Bagriantsev SN, Gracheva EO. Molecular Prerequisites for Diminished Cold Sensitivity in Ground Squirrels and Hamsters. Cell Reports 2017, 21: 3329-3337. PMID: 29262313, PMCID: PMC5741102, DOI: 10.1016/j.celrep.2017.11.083.Peer-Reviewed Original ResearchConceptsTransmembrane domainCold toleranceCold sensitivityGround squirrelsRat orthologMolecular adaptationsMammalian hibernatorsReciprocal mutationsAmino acidsFunctional significanceOrthologsSquirrelsMolecular prerequisitesActive stateHibernatorsTRPM8Somatosensory neuronsTolerancePoor activationSpeciesDomainMutationsResiduesHibernationCells
2003
Adaptation of Borrelia burgdorferi in the vector and vertebrate host
Pal U, Fikrig E. Adaptation of Borrelia burgdorferi in the vector and vertebrate host. Microbes And Infection 2003, 5: 659-666. PMID: 12787742, DOI: 10.1016/s1286-4579(03)00097-2.Peer-Reviewed Original ResearchConceptsComplex enzootic cycleUnique adaptive featuresDifferent host environmentsAdaptation of BorreliaMolecular adaptationsRegulatory mechanismsB. burgdorferiHost environmentSensu latoEnzootic cycleExtracellular pathogensDomestic animalsAdaptive featuresBorrelia burgdorferi sensu latoHostBurgdorferi sensu latoCausative agentDiverse rangeArthropodsAdaptationLatoBurgdorferiPathogensLyme diseaseBorrelia
2002
Molecular Adaptation of Borrelia burgdorferi in the Murine Host
Liang FT, Nelson FK, Fikrig E. Molecular Adaptation of Borrelia burgdorferi in the Murine Host. Journal Of Experimental Medicine 2002, 196: 275-280. PMID: 12119353, PMCID: PMC2193918, DOI: 10.1084/jem.20020770.Peer-Reviewed Original ResearchConceptsLipoprotein geneMolecular adaptationsHost immune selection pressureAnalysis of expressionNovel adaptation mechanismSteps of adaptationSelection pressureLyme disease spirocheteB. burgdorferiMurine hostGenesHost tissuesImmune selection pressureAdaptation mechanismsChronic infectionMurine infectionCritical stepHostBorrelia burgdorferiInfectionAdaptationSpirochetesBurgdorferiInitial inoculumPathogens
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