2024
Bacterial flagella hijack type IV pili proteins to control motility
Liu X, Tachiyama S, Zhou X, Mathias R, Bonny S, Khan M, Xin Y, Roujeinikova A, Liu J, Ottemann K. Bacterial flagella hijack type IV pili proteins to control motility. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2317452121. PMID: 38236729, PMCID: PMC10823254, DOI: 10.1073/pnas.2317452121.Peer-Reviewed Original Research
2021
Structure of Geobacter pili reveals secretory rather than nanowire behaviour
Gu Y, Srikanth V, Salazar-Morales AI, Jain R, O’Brien J, Yi SM, Soni RK, Samatey FA, Yalcin SE, Malvankar NS. Structure of Geobacter pili reveals secretory rather than nanowire behaviour. Nature 2021, 597: 430-434. PMID: 34471289, PMCID: PMC9127704, DOI: 10.1038/s41586-021-03857-w.Peer-Reviewed Original ResearchConceptsExtracellular electron transferType 4 piliElectron transferProtein nanowiresCryo-electron microscopyNanowiresNanowire behaviorGeobacter piliC-terminal residuesTranslocation machineryAssembly architectureLoss of secretionMajor phylaGeobacter speciesPrevious structural analysisSurface appendagesGeobacter sulfurreducensAromatic side chainsPiliPilAΠ stackingWidespread effectsBioelectronicsMicroorganismsFilaments
2017
Structural basis of host recognition and biofilm formation by Salmonella Saf pili
Zeng L, Zhang L, Wang P, Meng G. Structural basis of host recognition and biofilm formation by Salmonella Saf pili. ELife 2017, 6: e28619. PMID: 29125121, PMCID: PMC5700814, DOI: 10.7554/elife.28619.Peer-Reviewed Original ResearchConceptsHost recognitionBiofilm formationNovel functionStructure-based mutantsSelf-association activityFunctional characterizationBiofilm formation assaysStructural basisBacterial aggregationFormation assaysCell aggregationPiliAdherence assaysColonizationSAXS characterizationAssaysMutantsSAFABacterial infectionsSAFDOligomerizationCrystal structureAggregationMechanismFormation
2016
Biogenesis of the Gram-positive bacterial cell envelope
Siegel S, Liu J, Ton-That H. Biogenesis of the Gram-positive bacterial cell envelope. Current Opinion In Microbiology 2016, 34: 31-37. PMID: 27497053, PMCID: PMC5164837, DOI: 10.1016/j.mib.2016.07.015.Peer-Reviewed Original ResearchConceptsWall teichoic acidGram-positive cell envelopeCell envelopeLipoteichoic acidLytR-CpsA-Psr family proteinsPhylum of Gram-positive bacteriaSortase-assembled piliCell envelope biogenesisBacterial cell envelopeGram-negative counterpartsGram-positive bacterial cell envelopeGram-positive bacteriaEnvelope biogenesisFamily proteinsTeichoic acidGram-negative organismsSurface displaySurface proteinsFolding mechanismOxidized proteinsGram-positiveCapsular polysaccharideDivergent functionsPiliBiogenesis
2006
Analysis of FimX, a phosphodiesterase that governs twitching motility in Pseudomonas aeruginosa
Kazmierczak BI, Lebron MB, Murray TS. Analysis of FimX, a phosphodiesterase that governs twitching motility in Pseudomonas aeruginosa. Molecular Microbiology 2006, 60: 1026-1043. PMID: 16677312, PMCID: PMC3609419, DOI: 10.1111/j.1365-2958.2006.05156.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBacterial ProteinsCell MovementCyclic GMPEscherichia coli ProteinsFemaleFimbriae, BacterialHeLa CellsHumansMiceMice, Inbred C57BLPhosphoric Diester HydrolasesPhosphorus-Oxygen LyasesPneumonia, BacterialPoint MutationProtein Structure, TertiaryPseudomonas aeruginosaSequence DeletionVirulenceConceptsEAL domainBacterial poleGGDEF-EAL proteinsCyclic dimeric guanosine monophosphateDiguanylate cyclase activityPolar surface structuresType IV piliWild-type strainGGDEF domainDiguanylate cyclasesREC domainLocalization signalPilus assemblyGGDEFNon-polar sitesFimXSurface piliPseudomonas aeruginosaPhosphodiesterase activityBiofilm formationProteinMutantsPiliMotilityDomain
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