2017
Predictive value of telomere length on outcome following acute myocardial infarction: evidence for contrasting effects of vascular vs. blood oxidative stress
Margaritis M, Sanna F, Lazaros G, Akoumianakis I, Patel S, Antonopoulos AS, Duke C, Herdman L, Psarros C, Oikonomou EK, Shirodaria C, Petrou M, Sayeed R, Krasopoulos G, Lee R, Tousoulis D, Channon KM, Antoniades C. Predictive value of telomere length on outcome following acute myocardial infarction: evidence for contrasting effects of vascular vs. blood oxidative stress. European Heart Journal 2017, 38: 3094-3104. PMID: 28444175, PMCID: PMC5837455, DOI: 10.1093/eurheartj/ehx177.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsAcute myocardial infarctionVascular smooth muscle cellsVascular oxidative stressSaphenous veinMyocardial infarctionOxidative stressPredictive valueRecent acute myocardial infarctionCoronary artery bypassBlood mononuclear cellsClinical predictive valueBlood oxidative stressSmooth muscle cellsFunctional genetic polymorphismsEffects of vascularTissue-specific biomarkersArtery bypassProspective cohortConsecutive patientsClinical outcomesVascular factorsPost-AMIMononuclear cellsArtery segments
2014
GSTA1*‐69C/T and GSTO2*N142D as asthma‐ and allergy‐related risk factors in Italian adult patients
Piacentini S, Polimanti R, Iorio A, Cortesi M, Papa F, Rongioletti M, Liumbruno GM, Manfellotto D, Fuciarelli M. GSTA1*‐69C/T and GSTO2*N142D as asthma‐ and allergy‐related risk factors in Italian adult patients. Clinical And Experimental Pharmacology And Physiology 2014, 41: 180-184. PMID: 24471578, DOI: 10.1111/1440-1681.12201.Peer-Reviewed Original ResearchConceptsRespiratory allergyNovel susceptibility lociImportant biochemical featuresGSTO2 gene polymorphismsRisk factorsSingle nucleotide polymorphismsGlutathione S-transferase enzymesGenomic DNAGST genesMolecular mechanismsCellular protectionItalian adult patientsSusceptibility lociRisk of asthmaPresence of inflammationAdult study populationCommon risk factorsNucleotide polymorphismsFunctional genetic polymorphismsBiochemical featuresAdult patientsAsthmatic childrenGenesLociSubjective symptoms
2004
Effects of a Functional COMT Polymorphism on Prefrontal Cognitive Function in Patients With 22q11.2 Deletion Syndrome
Bearden C, Jawad A, Lynch D, Sokol S, Kanes S, McDonald-McGinn D, Saitta S, Harris S, Moss E, Wang P, Zackai E, Emanuel B, Simon T. Effects of a Functional COMT Polymorphism on Prefrontal Cognitive Function in Patients With 22q11.2 Deletion Syndrome. American Journal Of Psychiatry 2004, 161: 1700-1702. PMID: 15337663, DOI: 10.1176/appi.ajp.161.9.1700.Peer-Reviewed Original ResearchConceptsPrefrontal cognitive functionCognitive functionFunctional COMT polymorphismCatechol-O-methyltransferase (COMT) geneAttentional problemsDeletion syndromeExecutive functionPrefrontal cognitionExecutive dysfunctionNeurocognitive testingBehavioral manifestationsCOMT genotypeCOMT polymorphismAnalysis of covarianceComposite measureFunctional genetic polymorphismsCognitionIndividualsPresent studySchizophreniaPrevious studiesPredictorsMeasuresO-methyltransferase geneNormal individuals
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