2023
Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis
Shi X, DeCiucis M, Grabinska K, Kanyo J, Liu A, Lam T, Shen H. Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis. Molecular Cell 2023, 84: 802-810.e6. PMID: 38157846, PMCID: PMC10922821, DOI: 10.1016/j.molcel.2023.12.008.Peer-Reviewed Original ResearchProtein quality controlMitochondrial protein quality controlDual regulationMetabolic compartmentalizationIron homeostasisMitochondrial iron-sulfur clustersIron-sulfur clustersMitochondrial transportersProtein regulationMammalian cellsCRISPR knockoutCysteine residuesTransporter regulationLoop 1SLC25A39Glutathione homeostasisMetabolic sensingGlutathione uptakeMature neuronsProtein levelsHomeostasisRegulationAFG3L2Biochemical featuresMitochondrial glutathione levels
2017
Drosophila CG3303 is an essential endoribonuclease linked to TDP-43-mediated neurodegeneration
Laneve P, Piacentini L, Casale AM, Capauto D, Gioia U, Cappucci U, Di Carlo V, Bozzoni I, Di Micco P, Morea V, Di Franco CA, Caffarelli E. Drosophila CG3303 is an essential endoribonuclease linked to TDP-43-mediated neurodegeneration. Scientific Reports 2017, 7: 41559. PMID: 28139767, PMCID: PMC5282483, DOI: 10.1038/srep41559.Peer-Reviewed Original ResearchConceptsEukaryotic RNA metabolismDrosophila nervous systemTDP-43-mediated neurodegenerationImportant biological processesNovel family memberUnique biochemical featuresEssential endoribonucleaseRibosome biogenesisDrosophila viabilityRNA metabolismPositive regulatorFunctional characterisationBiosynthetic enzymesRibonuclease familyGene productsBiological processesMolecular levelNervous system activityBiochemical featuresCholinergic circuitsPhenotypeViral replicationNervous systemImmature phenotypeFamily members
2014
GSTA1*‐69C/T and GSTO2*N142D as asthma‐ and allergy‐related risk factors in Italian adult patients
Piacentini S, Polimanti R, Iorio A, Cortesi M, Papa F, Rongioletti M, Liumbruno GM, Manfellotto D, Fuciarelli M. GSTA1*‐69C/T and GSTO2*N142D as asthma‐ and allergy‐related risk factors in Italian adult patients. Clinical And Experimental Pharmacology And Physiology 2014, 41: 180-184. PMID: 24471578, DOI: 10.1111/1440-1681.12201.Peer-Reviewed Original ResearchConceptsRespiratory allergyNovel susceptibility lociImportant biochemical featuresGSTO2 gene polymorphismsRisk factorsSingle nucleotide polymorphismsGlutathione S-transferase enzymesGenomic DNAGST genesMolecular mechanismsCellular protectionItalian adult patientsSusceptibility lociRisk of asthmaPresence of inflammationAdult study populationCommon risk factorsNucleotide polymorphismsFunctional genetic polymorphismsBiochemical featuresAdult patientsAsthmatic childrenGenesLociSubjective symptoms
2011
Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012
Galluzzi L, Vitale I, Abrams J, Alnemri E, Baehrecke E, Blagosklonny M, Dawson T, Dawson V, El-Deiry W, Fulda S, Gottlieb E, Green D, Hengartner M, Kepp O, Knight R, Kumar S, Lipton S, Lu X, Madeo F, Malorni W, Mehlen P, Nuñez G, Peter M, Piacentini M, Rubinsztein D, Shi Y, Simon H, Vandenabeele P, White E, Yuan J, Zhivotovsky B, Melino G, Kroemer G. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death & Differentiation 2011, 19: 107-120. PMID: 21760595, PMCID: PMC3252826, DOI: 10.1038/cdd.2011.96.Peer-Reviewed Original ResearchConceptsCell death subroutinesCell death modalitiesCell deathDeath modalitiesMitotic catastropheMolecular definitionCell death morphologyAutophagic cell deathUtility of expressionNomenclature CommitteeExtrinsic apoptosisDeath morphologyRegulated necrosisIntrinsic apoptosisGenetic explorationFunctional classificationApoptosisBiochemical featuresVivo settingsSubstantial progressExpressionDeath
2006
Developing novel nonnucleoside HIV-1 reverse transcriptase inhibitors: beyond the butterfly.
Basavapathruni A, Anderson K. Developing novel nonnucleoside HIV-1 reverse transcriptase inhibitors: beyond the butterfly. Current Pharmaceutical Design 2006, 12: 1857-65. PMID: 16724952, DOI: 10.2174/138161206776873617.Peer-Reviewed Original ResearchConceptsNonnucleoside reverse transcriptase inhibitorsReverse transcriptase inhibitorsTranscriptase inhibitorsHuman immunodeficiency virus type 1 infectionResistance to nonnucleoside reverse transcriptase inhibitorsTreatment of human immunodeficiency virus type 1 infectionType 1 infectionFood and Drug AdministrationU.S. Food and Drug AdministrationCombination therapyDevelopment of resistanceMechanism of actionHIV-1 Reverse Transcriptase InhibitorsDrug AdministrationNonnucleosideNonnucleoside HIV-1 reverse transcriptase inhibitorNonnucleoside inhibitorsFeatures of inhibitionPotential new inhibitorsInhibitorsAmino acid substitutionsBiochemical featuresMolecular mechanismsNew inhibitorsAcid substitutions
2003
The Apoptosis-Necrosis Continuum: Insights from Genetically Altered Mice
Zeiss CJ. The Apoptosis-Necrosis Continuum: Insights from Genetically Altered Mice. Veterinary Pathology 2003, 40: 481-495. PMID: 12949404, DOI: 10.1354/vp.40-5-481.Peer-Reviewed Original ResearchConceptsCell death programApoptosis-inducing factorTissue-specific rolesCaspase-dependent mechanismCaspase-dependent apoptosisApoptosis-necrosis continuumAnimal developmentDeath programKey genesApoptotic effectorsApoptotic phenotypeRegulated processCaspase activationIntimate crosstalkApoptotic cascadeDependent effectorsHomeostatic pathwaysCell deathNecrotic onesBiochemical networksApoptosisPathologic stimuliBiochemical featuresMutant miceGenes
1991
Biochemical characterization of the protective membrane glycoprotein GP46/M-2 of Leishmania amazonensis
Rivas L, Kahl L, Manson K, McMahon-Pratt D. Biochemical characterization of the protective membrane glycoprotein GP46/M-2 of Leishmania amazonensis. Molecular And Biochemical Parasitology 1991, 47: 235-243. PMID: 1719417, DOI: 10.1016/0166-6851(91)90183-7.Peer-Reviewed Original ResearchConceptsGP46/MCarbohydrate side chainsDNA-derived protein sequenceLipid anchorSpecies-specific epitopesProtein sequencesSide chainsBiochemical characterizationLeishmania amazonensisProteinBiochemical featuresPolypeptide portionSurface membraneMonoclonal antibodiesPolypeptideAmazonensisMoleculesEpitopesAnchorsSequenceMembraneDigestionAntibodiesChainPromastigotes
1987
Hypercalcemia of Malignancy
Insogna KL, Broadus AE. Hypercalcemia of Malignancy. Annual Review Of Medicine 1987, 38: 241-256. PMID: 3555293, DOI: 10.1146/annurev.me.38.020187.001325.Books
1978
A father and son with cholestasis and peripheral pulmonic stenosis A distinct form of intrahepatic cholestasis
Riely C, LaBrecque D, Ghent C, Horwich A, Klatskin G. A father and son with cholestasis and peripheral pulmonic stenosis A distinct form of intrahepatic cholestasis. The Journal Of Pediatrics 1978, 92: 406-411. PMID: 632979, DOI: 10.1016/s0022-3476(78)80428-4.Peer-Reviewed Original ResearchConceptsPeripheral pulmonic stenosisIntrahepatic cholestasisPulmonic stenosisBile acidsSerum bile acid levelsSyndrome of cholestasisBile acid levelsAbnormal bile acidsIndividual bile acidsBenign courseCholestasisProgressive formVertical transmissionAcid levelsGenetic etiologyStenosisSyndromeBiochemical featuresPrevious reportsDistinctive patternsPatientsEtiologyDisease
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