2015
Catecholamine mechanisms in the prefrontal cortex: proven strategies for enhancing higher cognitive function
Berridge C, Arnsten A. Catecholamine mechanisms in the prefrontal cortex: proven strategies for enhancing higher cognitive function. Current Opinion In Behavioral Sciences 2015, 4: 33-40. DOI: 10.1016/j.cobeha.2015.01.002.Peer-Reviewed Original ResearchAttention deficit hyperactivity disorderPharmacological treatmentCognitive dysfunctionPrefrontal cognitive dysfunctionCognition-enhancing effectsMultiple psychiatric disordersSpecific intracellular pathwaysDeficit hyperactivity disorderPrefrontal catecholaminesClinical efficacyCatecholamine mechanismsADHD medicationNovel medicationsReceptor mechanismsPrefrontal cognitionPsychiatric disordersCatecholamine receptorsCatecholamine modulationHigher cognitive functionsCognitive functionPrefrontal cortexHyperactivity disorderImproved treatmentIntracellular pathwaysKey modulator
2004
Effects of a Functional COMT Polymorphism on Prefrontal Cognitive Function in Patients With 22q11.2 Deletion Syndrome
Bearden C, Jawad A, Lynch D, Sokol S, Kanes S, McDonald-McGinn D, Saitta S, Harris S, Moss E, Wang P, Zackai E, Emanuel B, Simon T. Effects of a Functional COMT Polymorphism on Prefrontal Cognitive Function in Patients With 22q11.2 Deletion Syndrome. American Journal Of Psychiatry 2004, 161: 1700-1702. PMID: 15337663, DOI: 10.1176/appi.ajp.161.9.1700.Peer-Reviewed Original ResearchConceptsPrefrontal cognitive functionCognitive functionFunctional COMT polymorphismCatechol-O-methyltransferase (COMT) geneAttentional problemsDeletion syndromeExecutive functionPrefrontal cognitionExecutive dysfunctionNeurocognitive testingBehavioral manifestationsCOMT genotypeCOMT polymorphismAnalysis of covarianceComposite measureFunctional genetic polymorphismsCognitionIndividualsPresent studySchizophreniaPrevious studiesPredictorsMeasuresO-methyltransferase geneNormal individuals
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