Prothrombin complex concentrates in cardiac surgery: where are we?
Santana J, Brovman E. Prothrombin complex concentrates in cardiac surgery: where are we? Current Opinion In Anaesthesiology 2021, 35: 36-41. PMID: 34669612, DOI: 10.1097/aco.0000000000001074.Peer-Reviewed Original ResearchConceptsProthrombin complex concentrateFresh frozen plasmaCardiac surgeryRBC transfusionRed blood cellsRate of RBC transfusionProthrombin complex concentrate administrationReducing RBC transfusionsConcentrations of coagulation factorsOff-label useAssociated with reduced ratesFrozen plasmaSafety profileProthrombin complexSurgeryCoagulation factorsHemostatic agentsTransfusionComplex concentrateBlood cellsMeta-analysisCochrane reviewAdministration timeProthrombinShort acquisition
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