2025
Lung adenocarcinoma-derived IFN-γ promotes growth by modulating CD8+ T cell production of CCR5 chemokines
Kratzmeier C, Taheri M, Mei Z, Lim I, Khalil M, Carter-Cooper B, Fanaroff R, Ong C, Schneider E, Chang S, Leyder E, Li D, Luzina I, Banerjee A, Krupnick A. Lung adenocarcinoma-derived IFN-γ promotes growth by modulating CD8+ T cell production of CCR5 chemokines. Journal Of Clinical Investigation 2025 PMID: 40553564, DOI: 10.1172/jci191070.Peer-Reviewed Original ResearchCD8+ T cellsIFN-gCCR5 chemokinesT cellsCD4+Foxp3+ T regulatory cellsCD8+ T-cell productionCancer cellsHuman lung cancer patientsLevels of IFN-gT regulatory cellsMurine lung adenocarcinomaLung adenocarcinoma modelLung cancer patientsMechanisms of immunoregulationCell line modelsLung cancer cellsTumor bedAdenocarcinoma modelTh1 cytokinesTumor microenvironmentImmunological environmentImmunoregulatory pathwaysCarcinogen-inducedTumor growthLung cancer
2024
Immunosenescence-related T cell phenotypes and white matter in schizophrenia patients with tardive dyskinesia
Li N, Li Y, Yu T, Gou M, Chen W, Wang X, Tong J, Chen S, Tan S, Wang Z, Tian B, Li C, Tan Y. Immunosenescence-related T cell phenotypes and white matter in schizophrenia patients with tardive dyskinesia. Schizophrenia Research 2024, 269: 36-47. PMID: 38723519, DOI: 10.1016/j.schres.2024.04.017.Peer-Reviewed Original ResearchCD95+ T cellsTardive dyskinesiaT-cell phenotypeT cell subpopulationsBrain structural abnormalitiesT cellsSchizophrenia patientsFractional anisotropyCD95+Distribution of T cell phenotypesStructural abnormalitiesAssociated with brain structural abnormalitiesMemory T-cell subpopulationsCD8+ T cellsLevels of IFN-gInferior fronto-occipital fasciculusLevels of cytokinesSuperior longitudinal fasciculusFronto-occipital fasciculusChoroid plexus volumeIntracellular levelsWhite matter tractsOrofacial TDPallidum volumesPublished routines
2012
Syntaxin 11 is required for NK and CD8+ T‐cell cytotoxicity and neutrophil degranulation
D'Orlando O, Zhao F, Kasper B, Orinska Z, Müller J, Hermans‐Borgmeyer I, Griffiths G, Stadt U, Bulfone‐Paus S. Syntaxin 11 is required for NK and CD8+ T‐cell cytotoxicity and neutrophil degranulation. European Journal Of Immunology 2012, 43: 194-208. PMID: 23042080, PMCID: PMC5405866, DOI: 10.1002/eji.201142343.Peer-Reviewed Original ResearchConceptsVesicular traffickingSyntaxin-11NK cellsLymphocyte cytotoxicityT cellsIFN-gActivated CD8(+) T cellsCD8+ T cell cytotoxicityCD8(+) T cellsLevels of IFN-gT cell cytotoxicityImmune cell populationsMacrophage phagocytic functionMast cell activationDefective phenotypesImmune cellsSTX11 mutationsAntigen presentationCytokine productionCytokine secretionImpaired degranulationSTX11Cell activationPhagocytic functionFunctional reconstitution
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