2023
Solitary Fibrous Tumor of the Pancreas
Yavas A, Tan J, Ozkan H, Yilmaz F, Reid M, Bagci P, Shi J, Shia J, Adsay V, Klimstra D, Basturk O. Solitary Fibrous Tumor of the Pancreas. The American Journal Of Surgical Pathology 2023, 47: 1230-1242. PMID: 37573546, PMCID: PMC10592360, DOI: 10.1097/pas.0000000000002108.Peer-Reviewed Original ResearchConceptsPancreatic solitary fibrous tumorSolitary fibrous tumorNuclear STAT6 expressionFibrous tumorTumor cellsDifferential diagnosis of mesenchymal neoplasmsSTAT6 expressionAtypical spindle cell tumorDiagnosis of mesenchymal neoplasmsLow-grade stromal tumorsMetastatic renal cell carcinomaSpindle tumor cellsFree of diseaseLow-grade sarcomaSpindle cell tumorsRenal cell carcinomaNAB2-STAT6 fusionFollow-up dataStromal tumorsHypervascular massNeuroendocrine tumorsCell carcinomaMesenchymal neoplasmsCell tumorsCystic areas
2020
Laparoscopic cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for limited peritoneal metastasis. The PSOGI international collaborative registry
Arjona-Sanchez A, Aziz O, Passot G, Salti G, Esquivel J, Van der Speeten K, Piso P, Nedelcut D, Sommariva A, Yonemura Y, Turaga K, Selvasekar C, Rodriguez-Ortiz L, Sanchez-Hidalgo J, Casado-Adam A, Rufian-Peña S, Briceño J, Glehen O. Laparoscopic cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for limited peritoneal metastasis. The PSOGI international collaborative registry. European Journal Of Surgical Oncology 2020, 47: 1420-1426. PMID: 33298341, DOI: 10.1016/j.ejso.2020.11.140.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntineoplastic Combined Chemotherapy ProtocolsCarboplatinCisplatinColonic NeoplasmsCytoreduction Surgical ProceduresDisease-Free SurvivalDoxorubicinFemaleFollow-Up StudiesHumansHyperthermic Intraperitoneal ChemotherapyLaparoscopyLength of StayMaleMesotheliomaMiddle AgedMitomycinNeoadjuvant TherapyNeoplasm, ResidualOvarian NeoplasmsOxaliplatinPaclitaxelPeritoneal NeoplasmsPseudomyxoma PeritoneiRegistriesSeverity of Illness IndexSurvival RateTumor BurdenConceptsPeritoneal Surface Oncology Group InternationalHyperthermic intraperitoneal chemotherapyLength of stayCytoreductive surgeryIntraperitoneal chemotherapyPeritoneal metastasisBenign multicystic mesotheliomaLaparoscopic cytoreductive surgeryLimited peritoneal metastasesPost-operative morbidityFree of diseaseMedian length of stayIndividual patient dataMedian PCIPeritoneal diseasePeritoneal disseminationMulticystic mesotheliomaOvarian carcinomaMidterm outcomesPseudomyxoma peritoneiLaparoscopic approachPostoperative outcomesFrequent indicationInvasive histologyColon carcinoma
2019
Sclerosing epithelioid mesenchymal neoplasm of the pancreas – a proposed new entity
Basturk O, Weigelt B, Adsay V, Benhamida J, Askan G, Wang L, Arcila M, Zamboni G, Fukushima N, Gularte-Mérida R, Da Cruz Paula A, Selenica P, Kumar R, Pareja F, Maher C, Scholes J, Oda Y, Santini D, Doyle L, Petersen I, Flucke U, Koelsche C, Reynolds S, Yavas A, von Deimling A, Reis-Filho J, Klimstra D. Sclerosing epithelioid mesenchymal neoplasm of the pancreas – a proposed new entity. Modern Pathology 2019, 33: 456-467. PMID: 31383964, PMCID: PMC7000300, DOI: 10.1038/s41379-019-0334-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiomarkers, TumorEpithelioid CellsEuropeFemaleGenetic Predisposition to DiseaseHumansImmunohistochemistryJapanMaleMiddle AgedMolecular Diagnostic TechniquesPancreatic NeoplasmsPhenotypeRetrospective StudiesSclerosisStromal CellsTerminology as TopicTreatment OutcomeUnited StatesConceptsEpithelioid mesenchymal neoplasmWhole-exome sequencingMesenchymal neoplasmsMonths of median follow-upNo lymph node metastasisRound-oval nucleiIndolent clinical courseMedian Follow-UpGastrointestinal stromal tumorsFree of diseaseSolid pseudopapillary neoplasmLymph node metastasisUnique histologic featuresPathogenic gene fusionsSpindle cell fasciclesTumor suppressor geneMethylation profilesSingle sample gene set enrichment analysisLack of abnormalitiesNeoadjuvant/adjuvant therapyStromal tumorsClinical coursePancreatic tumorsPseudopapillary neoplasmNode metastasis
2016
Mammary analog secretory carcinoma of the thyroid gland: A primary thyroid adenocarcinoma harboring ETV6–NTRK3 fusion
Dogan S, Wang L, Ptashkin R, Dawson R, Shah J, Sherman E, Tuttle R, Fagin J, Klimstra D, Katabi N, Ghossein R. Mammary analog secretory carcinoma of the thyroid gland: A primary thyroid adenocarcinoma harboring ETV6–NTRK3 fusion. Modern Pathology 2016, 29: 985-995. PMID: 27282352, PMCID: PMC5019170, DOI: 10.1038/modpathol.2016.115.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAgedBiomarkers, TumorDisease ProgressionDisease-Free SurvivalFemaleGene FusionGene RearrangementGenetic Predisposition to DiseaseHumansImmunohistochemistryIn Situ Hybridization, FluorescenceMaleMammary Analogue Secretory CarcinomaMiddle AgedNeoplasm GradingNeoplasm Recurrence, LocalNeoplasm StagingOncogene Proteins, FusionPhenotypeThyroid NeoplasmsTreatment OutcomeConceptsMammary analog secretory carcinomaFree of diseaseETV6-NTRK3 fusionPapillary thyroid carcinomaS-100 proteinFluorescence in situ hybridizationSecretory carcinomaETV6 rearrangementThyroid carcinomaGCDFP-15TTF-1Minority of papillary thyroid carcinomasWell-differentiated papillary thyroid carcinomaThyroid glandS-100Papillary thyroid carcinoma componentAssociated with long-term survivalETV6-NTRK3 gene fusionSalivary glandsThyroid carcinoma componentFollicular cell originLow-grade tumorsHigher T stageLocally aggressive tumorSalivary gland counterparts
2014
Choledochal cysts: a clinicopathologic study of 36 cases with emphasis on the morphologic and the immunohistochemical features of premalignant and malignant alterations
Katabi N, Pillarisetty V, DeMatteo R, Klimstra D. Choledochal cysts: a clinicopathologic study of 36 cases with emphasis on the morphologic and the immunohistochemical features of premalignant and malignant alterations. Human Pathology 2014, 45: 2107-2114. PMID: 25123074, DOI: 10.1016/j.humpath.2014.06.016.Peer-Reviewed Original ResearchConceptsCholedochal cystFree of diseasePyloric gland metaplasiaDevelopment of neoplasiaAssociated with metaplasiaBiliary intraepithelial neoplasiaPyloric glandsIntraepithelial neoplasiaKi-67Immunohistochemical featuresBilIN-2Clinicopathological analysisTumor progressionMalignant alterationCarcinomaIntestinal metaplasiaBilIN-1Clinicopathological studyMetaplasiaNeoplastic changesIncreased p53Risk factorsBilIN-3CystsNeoplasia
2011
Liver angiomyolipomas: A clinical, radiologic, and pathologic analysis of 22 patients from a single center
Butte J, K. R, Shia J, Gönen M, D’Angelica M, Getrajdman G, Allen P, Fong Y, DeMatteo R, Klimstra D, Jarnagin W. Liver angiomyolipomas: A clinical, radiologic, and pathologic analysis of 22 patients from a single center. Surgery 2011, 150: 557-567. PMID: 21621235, DOI: 10.1016/j.surg.2011.03.006.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAngiolipomaBiopsy, NeedleCohort StudiesCombined Modality TherapyContrast MediaDiagnostic ImagingFemaleFollow-Up StudiesHumansImmunohistochemistryLiver NeoplasmsMagnetic Resonance ImagingMaleMiddle AgedNeoplasm StagingRetrospective StudiesStatistics, NonparametricSurvival AnalysisTime FactorsTomography, X-Ray ComputedTreatment OutcomeConceptsClinical behaviorFollow-upPatients treated with R0 resectionMemorial Sloan-Kettering Cancer CenterLost to follow-upAssociated with disease-related mortalityIntra-arterial chemotherapyTreated with chemotherapyFree of diseaseSpectrum of presentationDisease-related mortalityLiver angiomyolipomasR0 resectionIndolent coursePatient diedConsecutive patientsRare neoplasmsAsymptomatic patientsHeterogeneous enhancementLiver involvementMedian ageUnrelated causeMesenchymal neoplasmsHistological featuresAngiomyolipoma
2005
Pleomorphic Pancreatic Endocrine Neoplasms
Zee S, Hochwald S, Conlon K, Brennan M, Klimstra D. Pleomorphic Pancreatic Endocrine Neoplasms. The American Journal Of Surgical Pathology 2005, 29: 1194-1200. PMID: 16096409, DOI: 10.1097/01.pas.0000164370.81132.25.Peer-Reviewed Original ResearchConceptsPancreatic endocrine neoplasmsNuclear pleomorphismFollow-upMemorial Sloan-Kettering Cancer CenterSolid pseudopapillary tumorFree of diseaseLow-grade tumorsNeedle aspiration cytologySignificant nuclear pleomorphismAbundant dense core granulesS-100 proteinMinority of casesCurative resectionUnresectable tumorsLiver metastasesAspiration cytologyPathology filesProgesterone receptorPrognostic significanceDense core granulesPleomorphic nucleiClinical featuresMitotic rateImmunohistochemical findingsEndocrine neoplasms
2003
Laparoscopic retroperitoneal lymph node dissection for clinical stage I nonseminomatous germ cell testicular cancer: a long-term update
Bhayani S, Ong A, Oh W, Kantoff P, Kavoussi L. Laparoscopic retroperitoneal lymph node dissection for clinical stage I nonseminomatous germ cell testicular cancer: a long-term update. Urology 2003, 62: 324-327. PMID: 12893344, DOI: 10.1016/s0090-4295(03)00324-8.Peer-Reviewed Original ResearchConceptsLaparoscopic retroperitoneal lymph node dissectionRetroperitoneal lymph node dissectionClinical Stage I nonseminomatous germ cell testicular tumorGerm cell testicular tumorsFree of diseaseYears of follow-upLymph node dissectionTesticular tumorsFollow-upNode dissectionLymph nodesTesticular cancerManagement of clinical stage I nonseminomatous germ cell testicular tumorsLong-term cancer controlModified follow-up scheduleGerm cell testicular cancerMinimally invasive treatment optionCancer controlModified template dissectionPathologically negative nodesMetastatic testicular cancerCycles of chemotherapyInvasive treatment optionFollow-up scheduleLong-term complications
1975
ADVANCED DIFFUSE HISTIOCYTIC LYMPHOMA, A POTENTIALLY CURABLE DISEASE RESULTS WITH COMBINATION CHEMOTHERAPY
Devita V, Canellos G, Chabner B, Schein P, Hubbard S, Young R. ADVANCED DIFFUSE HISTIOCYTIC LYMPHOMA, A POTENTIALLY CURABLE DISEASE RESULTS WITH COMBINATION CHEMOTHERAPY. The Lancet 1975, 305: 248-250. PMID: 46388, DOI: 10.1016/s0140-6736(75)91142-3.Peer-Reviewed Original ResearchConceptsAdvanced diffuse histiocytic lymphomaDiffuse histiocytic lymphomaCombination chemotherapyHistiocytic lymphomaPatients treated with radiotherapyTreated with combination chemotherapySurvival free of diseaseEvidence of tumorFree of diseaseRecurrence of tumorReticulum-cell sarcomaDefinition of cureModern drug treatmentComplete remissionPartial respondersNon-respondersDrug treatmentPatientsSurvival dataLymphomaRemissionChemotherapyNitrogen mustardTumorTreatment
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