2025
Hybrid granular cell tumor/perineurioma: a report of two rare cases with PIK3CA mutations
Toklu A, Panse G, Jour G, Linos K, Cloutier J, Dehner C. Hybrid granular cell tumor/perineurioma: a report of two rare cases with PIK3CA mutations. Virchows Archiv 2025, 1-8. PMID: 40159563, DOI: 10.1007/s00428-025-04089-3.Peer-Reviewed Original ResearchPeripheral nerve sheath tumorsHybrid peripheral nerve sheath tumorsRare mesenchymal neoplasmNerve sheath tumorsWell-circumscribed lesionGLUT1 stainingPIK3CA mutationsUnusual neoplasmsSheath tumorsMesenchymal neoplasmsRare caseDual differentiationDifferential diagnosisPathological spectrumMolecular testingGranular cell componentPathogenic mutationsTumorPerineurial cellsPIK3CANeoplasmsPerineuriomaMolecular featuresGranular cellsMolecular analysis
2023
Solitary Fibrous Tumor of the Pancreas
Yavas A, Tan J, Ozkan H, Yilmaz F, Reid M, Bagci P, Shi J, Shia J, Adsay V, Klimstra D, Basturk O. Solitary Fibrous Tumor of the Pancreas. The American Journal Of Surgical Pathology 2023, 47: 1230-1242. PMID: 37573546, PMCID: PMC10592360, DOI: 10.1097/pas.0000000000002108.Peer-Reviewed Original ResearchConceptsPancreatic solitary fibrous tumorSolitary fibrous tumorNuclear STAT6 expressionFibrous tumorTumor cellsDifferential diagnosis of mesenchymal neoplasmsSTAT6 expressionAtypical spindle cell tumorDiagnosis of mesenchymal neoplasmsLow-grade stromal tumorsMetastatic renal cell carcinomaSpindle tumor cellsFree of diseaseLow-grade sarcomaSpindle cell tumorsRenal cell carcinomaNAB2-STAT6 fusionFollow-up dataStromal tumorsHypervascular massNeuroendocrine tumorsCell carcinomaMesenchymal neoplasmsCell tumorsCystic areas
2021
The 2021 WHO Classification of Tumors of the Thymus and Mediastinum: What Is New in Thymic Epithelial, Germ Cell, and Mesenchymal Tumors?
Marx A, Chan JKC, Chalabreysse L, Dacic S, Detterbeck F, French CA, Hornick JL, Inagaki H, Jain D, Lazar AJ, Marino M, Marom EM, Moreira AL, Nicholson AG, Noguchi M, Nonaka D, Papotti MG, Porubsky S, Sholl LM, Tateyama H, Thomas de Montpréville V, Travis WD, Rajan A, Roden AC, Ströbel P. The 2021 WHO Classification of Tumors of the Thymus and Mediastinum: What Is New in Thymic Epithelial, Germ Cell, and Mesenchymal Tumors? Journal Of Thoracic Oncology 2021, 17: 200-213. PMID: 34695605, DOI: 10.1016/j.jtho.2021.10.010.Peer-Reviewed Original ResearchConceptsThymic epithelial tumorsGerm cell tumorsCell tumorsMesenchymal neoplasmsWHO classificationEpithelial tumorsMediastinal germ cell tumorsLow tumor mutational burdenTumor mutational burdenNew tumor entityClear cell carcinomaPositron emission tomographyClassification of tumorsThymic EpithelialThymic carcinomaFifth editionB3 thymomaTargetable mutationsCell carcinomaMesenchymal tumorsMetaplastic thymomaImmunohistochemical characterizationClinical informationMutational burdenDiagnostic advances
2020
Calcifying fibrous tumor of the gastrointestinal tract: A clinicopathologic review and update
Turbiville D, Zhang X. Calcifying fibrous tumor of the gastrointestinal tract: A clinicopathologic review and update. World Journal Of Gastroenterology 2020, 26: 5597-5605. PMID: 33071524, PMCID: PMC7545394, DOI: 10.3748/wjg.v26.i37.5597.Peer-Reviewed Original ResearchConceptsFibrous tumorGastrointestinal tractVascular type Castleman's diseaseRare mesenchymal lesionsType Castleman's diseaseInflammatory myofibroblastic tumorAngiomatoid nodular transformationGastrointestinal stromal tumorsSpindle cell proliferationSolitary fibrous tumorBenign mesenchymal neoplasmNodular fibrous pseudotumorLymphoplasmacytic inflammationLocal resectionMyofibroblastic tumorPlexiform fibromyxomaClinicopathologic reviewNodular transformationStromal tumorsCastleman's diseaseMesenchymal lesionsMesenchymal neoplasmsDifferential diagnosisLower riskLarge intestine
2019
Sclerosing epithelioid mesenchymal neoplasm of the pancreas – a proposed new entity
Basturk O, Weigelt B, Adsay V, Benhamida J, Askan G, Wang L, Arcila M, Zamboni G, Fukushima N, Gularte-Mérida R, Da Cruz Paula A, Selenica P, Kumar R, Pareja F, Maher C, Scholes J, Oda Y, Santini D, Doyle L, Petersen I, Flucke U, Koelsche C, Reynolds S, Yavas A, von Deimling A, Reis-Filho J, Klimstra D. Sclerosing epithelioid mesenchymal neoplasm of the pancreas – a proposed new entity. Modern Pathology 2019, 33: 456-467. PMID: 31383964, PMCID: PMC7000300, DOI: 10.1038/s41379-019-0334-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiomarkers, TumorEpithelioid CellsEuropeFemaleGenetic Predisposition to DiseaseHumansImmunohistochemistryJapanMaleMiddle AgedMolecular Diagnostic TechniquesPancreatic NeoplasmsPhenotypeRetrospective StudiesSclerosisStromal CellsTerminology as TopicTreatment OutcomeUnited StatesConceptsEpithelioid mesenchymal neoplasmWhole-exome sequencingMesenchymal neoplasmsMonths of median follow-upNo lymph node metastasisRound-oval nucleiIndolent clinical courseMedian Follow-UpGastrointestinal stromal tumorsFree of diseaseSolid pseudopapillary neoplasmLymph node metastasisUnique histologic featuresPathogenic gene fusionsSpindle cell fasciclesTumor suppressor geneMethylation profilesSingle sample gene set enrichment analysisLack of abnormalitiesNeoadjuvant/adjuvant therapyStromal tumorsClinical coursePancreatic tumorsPseudopapillary neoplasmNode metastasisA Case Study Evaluating the Diagnosis and Treatment of a Rare Mesenchymal Tumor
Shinder B, Sack J, Sadimin E, Tunuguntla H. A Case Study Evaluating the Diagnosis and Treatment of a Rare Mesenchymal Tumor. Urology 2019, 131: e1-e2. PMID: 31247212, DOI: 10.1016/j.urology.2019.06.019.Peer-Reviewed Case Reports and Technical NotesConceptsCellular angiofibromaPainless right inguinal massRare mesenchymal tumorRight inguinal massBenign mesenchymal neoplasmLimited treatment optionsOval-shaped massSurgical excisionInguinal massMesenchymal tumorsMesenchymal neoplasmsCT scanTreatment optionsSpermatic cordImmunohistochemical analysisRadiographic featuresImaging modalitiesAngiofibromaDiagnostic casesCD34NeoplasmsTumorExcisionDesminCord
2018
Treatment with epigenetic agents profoundly inhibits tumor growth in leiomyosarcoma
De Carvalho Fischer C, Hu Y, Morreale M, Lin WY, Wali A, Thakar M, Karunasena E, Sen R, Cai Y, Murphy L, Zahnow CA, Keer H, Thakar M, Ahuja N. Treatment with epigenetic agents profoundly inhibits tumor growth in leiomyosarcoma. Oncotarget 2018, 9: 19379-19395. PMID: 29721210, PMCID: PMC5922404, DOI: 10.18632/oncotarget.25056.Peer-Reviewed Original ResearchDNA methyltransferase inhibitorEpigenetic modulatorsLMS cell linesCell linesMES-SAApoptotic pathwayCell cycleMethyltransferase inhibitorCell survivalDifferentiation patternsEpigenetic agentsNovel chemotherapeutic regimensPotential therapeutic applicationsLeiomyosarcoma cell lineRare mesenchymal neoplasmSpectrum of sensitivityChemotherapeutic regimensPoor prognosisMesenchymal neoplasmsSensitive linesTumor growthGuadecitabineTherapeutic applicationsAdditional studiesModulator
2011
Liver angiomyolipomas: A clinical, radiologic, and pathologic analysis of 22 patients from a single center
Butte J, K. R, Shia J, Gönen M, D’Angelica M, Getrajdman G, Allen P, Fong Y, DeMatteo R, Klimstra D, Jarnagin W. Liver angiomyolipomas: A clinical, radiologic, and pathologic analysis of 22 patients from a single center. Surgery 2011, 150: 557-567. PMID: 21621235, DOI: 10.1016/j.surg.2011.03.006.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAngiolipomaBiopsy, NeedleCohort StudiesCombined Modality TherapyContrast MediaDiagnostic ImagingFemaleFollow-Up StudiesHumansImmunohistochemistryLiver NeoplasmsMagnetic Resonance ImagingMaleMiddle AgedNeoplasm StagingRetrospective StudiesStatistics, NonparametricSurvival AnalysisTime FactorsTomography, X-Ray ComputedTreatment OutcomeConceptsClinical behaviorFollow-upPatients treated with R0 resectionMemorial Sloan-Kettering Cancer CenterLost to follow-upAssociated with disease-related mortalityIntra-arterial chemotherapyTreated with chemotherapyFree of diseaseSpectrum of presentationDisease-related mortalityLiver angiomyolipomasR0 resectionIndolent coursePatient diedConsecutive patientsRare neoplasmsAsymptomatic patientsHeterogeneous enhancementLiver involvementMedian ageUnrelated causeMesenchymal neoplasmsHistological featuresAngiomyolipoma
2007
Low-grade Fibromyxoid Sarcoma Presenting Clinically as a Primary Ovarian Neoplasm
Winfield HL, De Las Casas LE, Greenfield WW, Santin AD, McKenney JK. Low-grade Fibromyxoid Sarcoma Presenting Clinically as a Primary Ovarian Neoplasm. International Journal Of Gynecological Pathology 2007, 26: 173-176. PMID: 17413985, DOI: 10.1097/01.pgp.0000228145.36807.43.Peer-Reviewed Original ResearchConceptsLow-grade fibromyxoid sarcomaFibromyxoid sarcomaMesenchymal neoplasmsLeft-sided pelvic massDisease 11 monthsLeft ovarian massPrimary ovarian neoplasmsSecondary ovarian involvementMiddle-aged patientsBland spindle cell proliferationLeft hypogastric arteryMalignant mesenchymal neoplasmDeep soft tissuesSpindle cell proliferationRetroperitoneal sarcomaAbdominal painUrinary frequencyHypogastric arteryOvarian involvementSurgical resectionOvarian neoplasmsLeft ureterOvarian massesPelvic massFleshy mass
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