2023
GATA3 expression in primary lung carcinomas: correlation with histopathologic features and TTF-1, napsin A, and p40 expression
Wang M, Chen P, Cai G. GATA3 expression in primary lung carcinomas: correlation with histopathologic features and TTF-1, napsin A, and p40 expression. Human Pathology 2023, 135: 93-98. PMID: 36702357, DOI: 10.1016/j.humpath.2023.01.007.Peer-Reviewed Original ResearchConceptsLarge cell carcinomaPrimary lung carcinomaSarcomatoid carcinomaCell carcinomaNapsin ALung carcinomaGATA3 expressionTTF-1Non-small cell carcinomaNon-small cell lung carcinomaPrimary non-small cell lung carcinomasPrimary lung cancerSquamous cell carcinomaPanel of immunostainsCell lung carcinomaExpression of GATA3Whole-slide sectionsTMA casesAdenosquamous carcinomaTumor histologyHistopathologic featuresGATA3 stainingLung cancerP40 expressionTumor origin
2016
TTF-1 Expression in Rectal Adenocarcinoma: A Case Report and Review of the Literature
Belalcazar A, Krishnamurti U, Shaib W. TTF-1 Expression in Rectal Adenocarcinoma: A Case Report and Review of the Literature. Case Reports In Oncology 2016, 9: 747-751. PMID: 27990111, PMCID: PMC5156892, DOI: 10.1159/000450973.Peer-Reviewed Original ResearchRectal adenocarcinomaCase reportTTF-1Primary lung adenocarcinomaThyroid transcription factor-1Year retrospective studyTTF-1 expressionLung metastasesRetrospective studyTranscription factor 1Colorectal adenocarcinomaLung adenocarcinomaAdenocarcinomaColon adenocarcinomaMedical literatureTumor samplesSpecific markersFactor 1Mammary analog secretory carcinoma of the thyroid gland: A primary thyroid adenocarcinoma harboring ETV6–NTRK3 fusion
Dogan S, Wang L, Ptashkin R, Dawson R, Shah J, Sherman E, Tuttle R, Fagin J, Klimstra D, Katabi N, Ghossein R. Mammary analog secretory carcinoma of the thyroid gland: A primary thyroid adenocarcinoma harboring ETV6–NTRK3 fusion. Modern Pathology 2016, 29: 985-995. PMID: 27282352, PMCID: PMC5019170, DOI: 10.1038/modpathol.2016.115.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAgedBiomarkers, TumorDisease ProgressionDisease-Free SurvivalFemaleGene FusionGene RearrangementGenetic Predisposition to DiseaseHumansImmunohistochemistryIn Situ Hybridization, FluorescenceMaleMammary Analogue Secretory CarcinomaMiddle AgedNeoplasm GradingNeoplasm Recurrence, LocalNeoplasm StagingOncogene Proteins, FusionPhenotypeThyroid NeoplasmsTreatment OutcomeConceptsMammary analog secretory carcinomaFree of diseaseETV6-NTRK3 fusionPapillary thyroid carcinomaS-100 proteinFluorescence in situ hybridizationSecretory carcinomaETV6 rearrangementThyroid carcinomaGCDFP-15TTF-1Minority of papillary thyroid carcinomasWell-differentiated papillary thyroid carcinomaThyroid glandS-100Papillary thyroid carcinoma componentAssociated with long-term survivalETV6-NTRK3 gene fusionSalivary glandsThyroid carcinoma componentFollicular cell originLow-grade tumorsHigher T stageLocally aggressive tumorSalivary gland counterparts
2014
Spectrum of somatic EGFR, KRAS, BRAF, PTEN mutations and TTF-1 expression in Brazilian lung cancer patients
CARNEIRO JG, COUTO PG, BASTOS-RODRIGUES L, BICALHO MA, VIDIGAL PV, VILHENA A, AMARAL NF, BALE AE, FRIEDMAN E, DE MARCO L. Spectrum of somatic EGFR, KRAS, BRAF, PTEN mutations and TTF-1 expression in Brazilian lung cancer patients. Genetics Research 2014, 96: e002. PMID: 24594201, PMCID: PMC7045132, DOI: 10.1017/s0016672314000032.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAged, 80 and overBrazilCarcinoma, Non-Small-Cell LungCarcinoma, Squamous CellCase-Control StudiesDNA-Binding ProteinsErbB ReceptorsFemaleGenetic Predisposition to DiseaseHumansImmunoenzyme TechniquesLung NeoplasmsMaleMiddle AgedMutationNeoplasm StagingPolymerase Chain ReactionPrognosisProto-Oncogene ProteinsProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)PTEN Phosphohydrolaseras ProteinsTranscription FactorsConceptsNon-small cell lung cancerSquamous cell carcinomaTTF-1 expressionLung cancerTTF-1PTEN mutationsBrazilian lung cancer patientsCancer typesPI3K pathway inhibitorsCell lung cancerCancer-related mortalityLung cancer patientsSomatic mutationsCommon somatic mutationsNSCLC patientsInter-individual variabilityCancer patientsEGFR mutationsTherapeutic responseBrazilian patientsHigh prevalenceKRAS mutationsLung adenocarcinomaSomatic EGFRTreatment response
2001
Expression of Thyroid Transcription Factor-1, Surfactant Proteins, Type I Cell–associated Antigen, and Clara Cell Secretory Protein in Pulmonary Hypoplasia
Zhou H, Morotti R, Profitt S, Langston C, Wert S, Whitsett J, Greco M. Expression of Thyroid Transcription Factor-1, Surfactant Proteins, Type I Cell–associated Antigen, and Clara Cell Secretory Protein in Pulmonary Hypoplasia. Pediatric And Developmental Pathology 2001, 4: 364-371. PMID: 11441338, DOI: 10.1007/s10024001-0002-9.Peer-Reviewed Original ResearchConceptsClara cell secretory proteinPulmonary hypoplasiaWeeks gestational ageTranscription factor 1Thyroid transcription factor-1Cell-associated antigensSecretory proteinsTTF-1Surfactant proteinsHomeodomain transcription factorGestational ageFactor 1Distal lung developmentProximal-distal axisEpithelial gene expressionDistal lung parenchymaNormal fetal lungTranscription factorsFinal common pathwayLung organogenesisExpression patternsGene expressionImmunolocalization patternsProteinLung parenchyma
2000
Expression of Thyroid Transcription Factor-1, Surfactant Proteins, Type I Cell–associated Antigen, and Clara Cell Secretory Protein in Pulmonary Hypoplasia
Zhou H, Morotti R, Profitt S, Langston C, Wert S, Whitsett J, Greco M. Expression of Thyroid Transcription Factor-1, Surfactant Proteins, Type I Cell–associated Antigen, and Clara Cell Secretory Protein in Pulmonary Hypoplasia. Pediatric And Developmental Pathology 2000, 4: 364-371. DOI: 10.1007/s10024-001-0002-9.Peer-Reviewed Original ResearchClara cell secretory proteinTranscription factor 1Pulmonary hypoplasiaWeeks gestational ageThyroid transcription factor-1Cell-associated antigensSecretory proteinsTTF-1Surfactant proteinsHomeodomain transcription factorGestational ageFactor 1Distal lung developmentProximal-distal axisEpithelial gene expressionDistal lung parenchymaNormal fetal lungTranscription factorsFinal common pathwayLung organogenesisExpression patternsGene expressionNKx2 familyImmunolocalization patternsProteinExpression of Thyroid Transcription Factor-1 in Congenital Cystic Adenomatoid Malformation of the Lung
Morotti R, Gutierrez M, Askin F, Profitt S, Wert S, Whitsett J, Greco M. Expression of Thyroid Transcription Factor-1 in Congenital Cystic Adenomatoid Malformation of the Lung. Pediatric And Developmental Pathology 2000, 3: 455-461. PMID: 10890930, DOI: 10.1007/s100240010092.Peer-Reviewed Original ResearchConceptsCongenital cystic adenomatoid malformationCCAM type 1TTF-1 expressionCystic adenomatoid malformationThyroid transcription factor-1Gestational ageTTF-1Type 1Adenomatoid malformationTranscription factor 1Fetal lungAlveolar cell markersBasal cellsEpithelial cellsWeeks gestational ageTTF-1 stainingType 4Factor 1Bronchiolar basal cellsDistal air spacesAlveolar type II cellsType I cellsEarly lung developmentType II cellsCCAM cases
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