2020
Discovery and Mediation Analysis of Cross-Phenotype Associations Between Asthma and Body Mass Index in 12q13.2
Salinas YD, Wang Z, DeWan AT. Discovery and Mediation Analysis of Cross-Phenotype Associations Between Asthma and Body Mass Index in 12q13.2. American Journal Of Epidemiology 2020, 190: 85-94. PMID: 32700739, PMCID: PMC7784522, DOI: 10.1093/aje/kwaa144.Peer-Reviewed Original ResearchConceptsBody mass indexMass indexComorbidity of asthmaWhite British subjectsCross-phenotype associationsAdult asthmaAsthma diagnosisAsthmaConfounder adjustmentAsthma associationsBMI associationsMediation analysisLimited evidenceCandidate gene studiesBMIObesityUK BiobankAssociationDiagnosisTwin studiesAgeFurther characterizationComorbiditiesConfoundersPhenotypic and Molecular Characterization of Risk Loci Associated With Asthma and Lung Function
Karaca M, Atceken N, Karaca Ş, Civelek E, Şekerel BE, Polimanti R. Phenotypic and Molecular Characterization of Risk Loci Associated With Asthma and Lung Function. Allergy Asthma And Immunology Research 2020, 12: 806-820. PMID: 32638561, PMCID: PMC7347000, DOI: 10.4168/aair.2020.12.5.806.Peer-Reviewed Original ResearchLung functionRespiratory diseaseFat massPulmonary function testsPhenome-wide association studyAllergic respiratory diseasesBody fat massPrevious genome-wide association studyGenome-wide association studiesAsthma comorbidityAdult asthmaAsthma pathogenesisFunction testsPediatric cohortBlood levelsImmune cellsAllergic reactionsMultifactorial etiologyAsthmaAssociation studiesIndividual susceptibilityRisk allelesDiseaseDiscovery Genome-Wide Association StudiesComorbidities
2018
Impaired type I interferon regulation in the blood transcriptome of recurrent asthma exacerbations
Gomez JL, Diaz MP, Nino G, Britto CJ. Impaired type I interferon regulation in the blood transcriptome of recurrent asthma exacerbations. BMC Medical Genomics 2018, 11: 21. PMID: 29486764, PMCID: PMC5830339, DOI: 10.1186/s12920-018-0340-3.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsAsthma exacerbationsInterferon-stimulated genesRespiratory infectionsIL-15Vivo cohortToll-like receptor 2STAT1 responseRecurrent asthma exacerbationsAcute asthma exacerbationPro-inflammatory moleculesType I interferon regulationBlood mononuclear cellsPro-inflammatory signatureTranscriptomic signaturesType I interferonFold changeAdult asthmaAcute phaseMononuclear cellsImmunologic genesExacerbationIndependent cohortReceptor 2I interferon
2016
Community-based Participatory Research Is Needed to Address Pulmonary Health Disparities
Harris DA, Pensa MA, Redlich CA, Pisani MA, Rosenthal MS. Community-based Participatory Research Is Needed to Address Pulmonary Health Disparities. Annals Of The American Thoracic Society 2016, 13: 1231-1238. PMID: 27249657, DOI: 10.1513/annalsats.201601-054ps.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCommunity-based participatory researchHealth disparitiesPulmonary diseaseHealth equityPediatric asthma outcomesOutcome of treatmentAmerican Thoracic SocietyAdult asthmaAsthma outcomesMedical managementLung diseaseThoracic SocietyPulmonary medicineHealth behaviorsSpecific interventionsRacial disparitiesParticipatory researchCommunity healthHealth careDiseaseNational InstituteOutcomesSustainable interventionsCommunity-based approachHealth
2001
Cost-effectiveness of inhaled corticosteroids in adults with mild-to-moderate asthma: Results from the Asthma Policy Model
Paltiel AD, Fuhlbrigge AL, Kitch BT, Liljas B, Weiss ST, Neumann PJ, Kuntz KM. Cost-effectiveness of inhaled corticosteroids in adults with mild-to-moderate asthma: Results from the Asthma Policy Model. Journal Of Allergy And Clinical Immunology 2001, 108: 39-in4. PMID: 11447380, DOI: 10.1067/mai.2001.116289.Peer-Reviewed Original ResearchConceptsSymptom-free daysCorticosteroid therapyAcute exacerbationModerate asthmaHealth-related qualityPopulation of patientsCost-effectiveness findingsHealth care costsCost-effectiveness analysisTotal health costsAdult asthmaObservational cohortRandomized trialsPatient preferencesPatient surveyClinical impactCorticosteroidsSide effectsCare costsDrug efficacyNatural historyAsthmaIncremental costTherapyMild
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