2023
Rational engineering of lung alveolar epithelium
Leiby K, Yuan Y, Ng R, Raredon M, Adams T, Baevova P, Greaney A, Hirschi K, Campbell S, Kaminski N, Herzog E, Niklason L. Rational engineering of lung alveolar epithelium. Npj Regenerative Medicine 2023, 8: 22. PMID: 37117221, PMCID: PMC10147714, DOI: 10.1038/s41536-023-00295-2.Peer-Reviewed Original Research
2021
Lung injury in axolotl salamanders induces an organ‐wide proliferation response
Jensen TB, Giunta P, Schultz NG, Griffiths JM, Duerr TJ, Kyeremateng Y, Wong H, Adesina A, Monaghan JR. Lung injury in axolotl salamanders induces an organ‐wide proliferation response. Developmental Dynamics 2021, 250: 866-879. PMID: 33587313, DOI: 10.1002/dvdy.315.Peer-Reviewed Original ResearchConceptsLung regenerationLung massX cranial nervesLung injurySupplemental administrationCranial nervesProliferative responseProliferation responseInjury responseLungInjuryMultiple cell typesMesenchymal cellsNeuregulinAmputationMost tissuesPneumocytesProliferationCell typesResponseAxolotl salamanderCellsNerve
2017
Bioengineered lungs generated from human iPSCs‐derived epithelial cells on native extracellular matrix
Ghaedi M, Le AV, Hatachi G, Beloiartsev A, Rocco K, Sivarapatna A, Mendez JJ, Baevova P, Dyal RN, Leiby KL, White ES, Niklason LE. Bioengineered lungs generated from human iPSCs‐derived epithelial cells on native extracellular matrix. Journal Of Tissue Engineering And Regenerative Medicine 2017, 12: e1623-e1635. PMID: 29024475, PMCID: PMC5991621, DOI: 10.1002/term.2589.Peer-Reviewed Original ResearchConceptsEpithelial progenitor cellsProgenitor cellsStem cellsEpithelial cellsLung progenitor cellsLung epithelial cellsHuman lungHuman-derived cellsReliable cell sourceNative extracellular matrixEarly stepsExtracellular matrixRat lungImportant early stepHuman iPSCLung regenerationLung tissue regenerationHuman lung tissueIPSCsLung scaffoldsCell sourceCellsEpithelial markersLung transplantationTissue regenerationLung regeneration
Calle EA, Leiby KL, Raredon MB, Niklason LE. Lung regeneration. Current Opinion In Anaesthesiology 2017, 30: 23-29. PMID: 27922848, PMCID: PMC5283945, DOI: 10.1097/aco.0000000000000425.Peer-Reviewed Original Research
2016
Comparative biology of decellularized lung matrix: Implications of species mismatch in regenerative medicine
Balestrini JL, Gard AL, Gerhold KA, Wilcox EC, Liu A, Schwan J, Le AV, Baevova P, Dimitrievska S, Zhao L, Sundaram S, Sun H, Rittié L, Dyal R, Broekelmann TJ, Mecham RP, Schwartz MA, Niklason LE, White ES. Comparative biology of decellularized lung matrix: Implications of species mismatch in regenerative medicine. Biomaterials 2016, 102: 220-230. PMID: 27344365, PMCID: PMC4939101, DOI: 10.1016/j.biomaterials.2016.06.025.Peer-Reviewed Original ResearchConceptsHuman endothelial cellsCell-matrix interactionsLung regenerationEndothelial cellsKey matrix proteinsComparative biologyCell adhesion moleculeMatrix proteinsLung extracellular matrixCell healthExtracellular matrixResidual DNASpecies mismatchRat lung scaffoldsRegenerative medicineAdhesion moleculesLung scaffoldsPrimate tissuesCellsVascular cell adhesion moleculeLung engineeringLung matrixLess expressionPulmonary cellsProfound effect
2010
Tissue-Engineered Lungs for in Vivo Implantation
Petersen TH, Calle EA, Zhao L, Lee EJ, Gui L, Raredon MB, Gavrilov K, Yi T, Zhuang ZW, Breuer C, Herzog E, Niklason LE. Tissue-Engineered Lungs for in Vivo Implantation. Science 2010, 329: 538-541. PMID: 20576850, PMCID: PMC3640463, DOI: 10.1126/science.1189345.Peer-Reviewed Original ResearchConceptsLung tissueLung matrixAcellular lung matrixNative lung tissueTissue-engineered lungsLung transplantationPrimary therapyAdult lung tissueAdult ratsPulmonary epitheliumVascular endotheliumFunctional lungLung regenerationVascular compartmentLungSeeded endothelial cellsMechanical characteristicsEndothelial cellsVivo implantationRatsEpitheliumTissueCellular componentsExtracellular matrixGas exchange
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