2025
Treatment of Extraosseous Giant Cell Tumor of Bone and Calcitriol-Mediated Hypercalcemia With Denosumab in Paget Disease
Magvanjav O, Bergwitz C. Treatment of Extraosseous Giant Cell Tumor of Bone and Calcitriol-Mediated Hypercalcemia With Denosumab in Paget Disease. JCEM Case Reports 2025, 3: luaf031. PMID: 40110572, PMCID: PMC11920620, DOI: 10.1210/jcemcr/luaf031.Peer-Reviewed Original ResearchGiant cell tumor of boneBone-specific alkaline phosphataseGiant cell tumorOne-time doseTumor of boneCell tumorsPaget's diseaseCalcitriol-mediated hypercalcemiaOsteoclast-like giant cellsDose of denosumabTreated with bisphosphonatesReduced tumor sizeElevated calcitriolParathyroid autonomyPolyostotic PDBStromal mononuclear cellsPelvic massSymptomatic hypercalcemiaTumor regrowthTumor sizeParathyroid hormoneKidney injuryNormal calciumMononuclear cellsDenosumab
2019
Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas arising from an intraductal papillary mucinous neoplasm
Charifa A, Walther Z, Salem R, Jain D. Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas arising from an intraductal papillary mucinous neoplasm. Human Pathology Reports 2019, 15: 95-98. DOI: 10.1016/j.ehpc.2018.12.007.Peer-Reviewed Case Reports and Technical NotesOsteoclast-like giant cellsUndifferentiated carcinomaInvasive carcinomaGiant cellsMucinous neoplasmsEndoscopic ultrasoundIntraductal papillary mucinous neoplasmIntraductal mucinous neoplasmPapillary mucinous neoplasmRare pancreatic tumorPancreatic ductal carcinomaDuctal lesionsDuctal carcinomaPancreatic tumorsPancreatic adenocarcinomaCarcinoma subtypesHistological examinationPancreatic massCarcinomaEpithelial markersAmpullary massEpithelial originIPMNNeoplastic progressionNeoplasmsBisphosphonate-loaded Bone Cement as a Local Adjuvant Therapy for Giant Cell Tumor of Bone
Greenberg DD, Lee FY. Bisphosphonate-loaded Bone Cement as a Local Adjuvant Therapy for Giant Cell Tumor of Bone. American Journal Of Clinical Oncology 2019, 42: 231-237. PMID: 30811352, DOI: 10.1097/coc.0000000000000504.Peer-Reviewed Original ResearchConceptsGiant cell tumorAdjuvant therapyLocal adjuvant therapySystemic side effectsAvascular necrosisCell tumorsSide effectsMusculoskeletal Tumor Society scoreOsteoclast-like giant cellsAggressive bone resorptionTherapeutic Level IVHigh-speed burringLocal recurrence rateAtypical femur fracturesLevel of evidenceTraditional adjuvant therapyBone cementAtypical fracturesSystemic bisphosphonatesPulmonary metastasesSociety ScoreCurettage proceduresRecurrence rateFemur fracturesPolymethylmethacrylate bone cement
2015
Successful Intravascular Correction of Intratumoral Pseudoaneurysm by Erosion of the Aorta in a Patient with Thoracic Giant Cell Tumor of Bone Responding to Denosumab
Fraile N, Toloi D, Kurimori C, Matutino A, Codima A, Camargo V, Feher O, Munhoz R. Successful Intravascular Correction of Intratumoral Pseudoaneurysm by Erosion of the Aorta in a Patient with Thoracic Giant Cell Tumor of Bone Responding to Denosumab. Case Reports In Oncological Medicine 2015, 2015: 626741. PMID: 26600960, PMCID: PMC4639671, DOI: 10.1155/2015/626741.Peer-Reviewed Original ResearchGiant cell tumorCell tumorsGiant cellsOsteoclast-like giant cellsInitiation of denosumabNuclear factor-kB ligandUnequivocal clinical improvementTumor stromal cellsMonoclonal antibody denosumabAdvanced GCTMultiple resectionsUnremarkable recoveryClinical improvementFirst doseSurgical resectionEndovascular approachAggressive neoplasmTherapeutic optionsAntibody denosumabStent placementOsteoclast activityDenosumabReceptor activatorActionable targetsStromal cells
1998
K-ras Oncogene Mutations in Osteoclast-like Giant Cell Tumors of the Pancreas and Liver
Westra W, Sturm P, Drillenburg P, Choti M, Klimstra D, Albores-Saavedra J, Montag A, Offerhaus G, Hruban R. K-ras Oncogene Mutations in Osteoclast-like Giant Cell Tumors of the Pancreas and Liver. The American Journal Of Surgical Pathology 1998, 22: 1247-1254. PMID: 9777987, DOI: 10.1097/00000478-199810000-00010.Peer-Reviewed Original ResearchConceptsOsteoclast-like giant cell tumorOsteoclast-like giant cellsK-ras mutationsGiant cell tumorK-ras oncogeneK-rasGiant cellsCell tumorsEpithelial proliferationMononuclear cellsEpithelial markersAtypical intraductal epithelial proliferationEpithelial precursorsK-ras oncogene mutationsIntraductal epithelial proliferationMucinous cystic neoplasmsFinding of K-ras mutationsInfiltrating mononuclear cellsPhagocytize tumor cellsEnigmatic tumorsUndifferentiated carcinomaMesenchymal tumorsAbsent stainingEpithelial lesionsCystic neoplasms
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