2018
Induction of a Senescence-Like Phenotype in Cultured Human Fetal Microglia During HIV-1 Infection
Chen N, Partridge A, Tuzer F, Cohen J, Nacarelli T, Navas-Martín S, Sell C, Torres C, Martín-García J. Induction of a Senescence-Like Phenotype in Cultured Human Fetal Microglia During HIV-1 Infection. The Journals Of Gerontology Series A 2018, 73: 1187-1196. PMID: 29415134, PMCID: PMC6093403, DOI: 10.1093/gerona/gly022.Peer-Reviewed Original ResearchConceptsHIV-Associated Neurocognitive DisordersHIV-1 infectionHuman fetal microgliaHIV-1Fetal microgliaSenescence-like phenotypeIL-8Effective anti-retroviral therapyHIV-1 pseudotypedAnti-retroviral therapyChronically infected patientsReactive oxygen speciesProduction of cytokinesSenescence-associated secretory phenotypeCaveolin-1 levelsMarkers of cellular senescenceIL-8 productionMarkers of senescenceElevated markersSupernatant transferInfected patientsATP-linked respirationPost-infectionIL-6Mitochondrial reactive oxygen species
2016
Implications of Cellular Senescence on Aging and Disease in the Brain
Crowe E, Tuzer S, Cohen J, Yetkin E, D’Agostino L, Sell C, Torres C. Implications of Cellular Senescence on Aging and Disease in the Brain. Healthy Ageing And Longevity 2016, 263-286. DOI: 10.1007/978-3-319-26239-0_14.Peer-Reviewed Original ResearchSenescence in vitroDisease in vivoAccumulation of senescent astrocytesHIV-associated dementiaIrreversible mitotic arrestSignificant neuronal lossResistance to apoptosisLow regenerative capacityPro-inflammatory signalingCNS cell typesResponse to insultsSenescence-like phenotypeProgenitor cellsAging BrainStress in vitroLoss of astrocyte functionMouse modelNeuroinflammatory functionsSynaptic plasticityInflammatory stressNeural stemNeurodegenerative diseasesGrowth factorRegenerative capacityReactive astrogliosis
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