2025
Spreading depolarization triggers pro- and anti-inflammatory signalling: a potential link to headache
Kaya Z, Belder N, Sever-Bahçekapılı M, Erdener Ş, Dönmez-Demir B, Bağcı C, Köroğlu M, Bilguvar K, Dalkara T. Spreading depolarization triggers pro- and anti-inflammatory signalling: a potential link to headache. Brain 2025, awaf015. PMID: 39823578, DOI: 10.1093/brain/awaf015.Peer-Reviewed Original ResearchCortical spreading depolarizationCaspase-1 activationPost-CSDInflammatory signalingCell-specific transcriptomic dataMigraine headacheHMGB1 releaseCell-specific transcriptomesCaspase-1Inflammatory responseCell-specific activityUpregulation of genesPro-inflammatory transcriptsTranscriptome dataPro-inflammatory stimuliResolution of inflammationCo-ImmunoprecipitationTranscriptome analysisTranscriptomic responseFRET analysisCNS cell typesAnti-inflammatory responseAnti-inflammatory signalsAnti-inflammatory profileTranscriptional changes
2016
Implications of Cellular Senescence on Aging and Disease in the Brain
Crowe E, Tuzer S, Cohen J, Yetkin E, D’Agostino L, Sell C, Torres C. Implications of Cellular Senescence on Aging and Disease in the Brain. Healthy Ageing And Longevity 2016, 263-286. DOI: 10.1007/978-3-319-26239-0_14.Peer-Reviewed Original ResearchSenescence in vitroDisease in vivoAccumulation of senescent astrocytesHIV-associated dementiaIrreversible mitotic arrestSignificant neuronal lossResistance to apoptosisLow regenerative capacityPro-inflammatory signalingCNS cell typesResponse to insultsSenescence-like phenotypeProgenitor cellsAging BrainStress in vitroLoss of astrocyte functionMouse modelNeuroinflammatory functionsSynaptic plasticityInflammatory stressNeural stemNeurodegenerative diseasesGrowth factorRegenerative capacityReactive astrogliosis
2001
Multiple sclerosis: Altered glutamate homeostasis in lesions correlates with oligodendrocyte and axonal damage
Werner P, Pitt D, Raine C. Multiple sclerosis: Altered glutamate homeostasis in lesions correlates with oligodendrocyte and axonal damage. Annals Of Neurology 2001, 50: 169-180. PMID: 11506399, DOI: 10.1002/ana.1077.Peer-Reviewed Original ResearchConceptsMultiple sclerosisAxonal damageWhite matterGlutamate excitotoxicityGlutamate homeostasisMS lesionsGlutaminase expressionMS white matterInflammatory neurologic diseasesActive MS lesionsCNS cell typesOligodendroglial pathologyNoninflammatory conditionsDystrophic axonsNeurologic diseaseGLT-1Low-level expressionAnimal modelsGlutamate transportersHomeostasis contributesLesion correlatesGlutamate transportLesionsOligodendrocytesTherapeutic import
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