2024
Childhood maltreatment and health in the UK Biobank: triangulation of outcome-wide and polygenic risk score analyses
Espinosa Dice A, Lawn R, Ratanatharathorn A, Roberts A, Denckla C, Kim A, de la Rosa P, Zhu Y, VanderWeele T, Koenen K. Childhood maltreatment and health in the UK Biobank: triangulation of outcome-wide and polygenic risk score analyses. BMC Medicine 2024, 22: 135. PMID: 38523269, PMCID: PMC10962116, DOI: 10.1186/s12916-024-03360-9.Peer-Reviewed Original ResearchConceptsOutcome-wide analysisUK BiobankBias due to unmeasured confoundingPolygenic risk score analysisPolygenic risk scoresPhysical health outcomesLower household incomeDirection of associationImprove causal inferenceRisk score analysisHearing difficultiesHealth behaviorsHealth outcomesHealth themesUnmeasured confoundersSocioeconomic statusDiastolic blood pressureAnalytic sampleTriangulation studySources of biasHousehold incomeRisk scoreTriangulation designChildhood maltreatmentGeneralized linear modelSex differences in the pleiotropy of hearing difficulty with imaging-derived phenotypes: a brain-wide investigation
He J, Cabrera-Mendoza B, De Angelis F, Pathak G, Koller D, Curhan S, Curhan G, Mecca A, van Dyck C, Polimanti R. Sex differences in the pleiotropy of hearing difficulty with imaging-derived phenotypes: a brain-wide investigation. Brain 2024, 147: 3395-3408. PMID: 38454550, PMCID: PMC11449129, DOI: 10.1093/brain/awae077.Peer-Reviewed Original ResearchImaging-derived phenotypesHearing difficultiesBrain imaging-derived phenotypesSex-combined analysisLatent causal variable analysesMendelian randomization approachGeneralized linear regression analysisLocal genetic correlation analysisMultivariate generalized linear regression analysisGenome-wide association studiesLatent causal variableGenetic correlation analysisGenetic correlationsLocal genetic correlationMendelian randomizationPeripheral auditory systemOlder adultsGWAS dataLinear regression analysisHealth burdenGenomic regionsAssociation studiesPleiotropic regionsSex differencesTranscriptome regulation
2021
Medicare Beneficiaries With Self-Reported Functional Hearing Difficulty Have Unmet Health Care Needs
Reed NS, Assi L, Horiuchi W, Hoover-Fong JE, Lin FR, Ferrante LE, Inouye SK, Miller Iii ER, Boss EF, Oh ES, Willink A. Medicare Beneficiaries With Self-Reported Functional Hearing Difficulty Have Unmet Health Care Needs. Health Affairs 2021, 40: 786-794. PMID: 33939509, PMCID: PMC8323057, DOI: 10.1377/hlthaff.2020.02371.Peer-Reviewed Original Research
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