2025
Profiling DNA damage response in ATM/BRCA2 carriers to inform hereditary cancer risk.
Dedousis D, Hasan A, Patel K, Czyzewicz P, Devarajan K, Hall M, Daly M, Arora S. Profiling DNA damage response in ATM/BRCA2 carriers to inform hereditary cancer risk. Journal Of Clinical Oncology 2025, 43: 10574-10574. DOI: 10.1200/jco.2025.43.16_suppl.10574.Peer-Reviewed Original ResearchGermline pathogenic variantsCancer-free controlsPeripheral blood monocytesSignificant cut-pointsCRC casesDNA damage responseCut-pointsHereditary cancer riskBenjamini-Hochberg false discovery rate methodTwo-sided Mann-Whitney testHigh-risk familiesSporadic colorectal cancerPreliminary analysis of patientsDiagnosis of cancerAnalysis of patientsHigh-risk populationFalse discovery rate methodCancer riskHigh-risk groupNegative regulator of p53Age-matched controlsDNA repair genesDamage responseMann-Whitney testNon-carrier controls1145 Higher Proceduralist Stroke Thrombectomy Volume is Associated With Reduced Inpatient Mortality
Koo A, Renedo D, Ney J, Amllay A, Kanzler M, Stogniy S, Alawieh A, Sujijantarat N, Antonios J, Al Kasab S, Malhotra A, Hebert R, Matouk C, de Havenon A. 1145 Higher Proceduralist Stroke Thrombectomy Volume is Associated With Reduced Inpatient Mortality. Neurosurgery 2025, 71: 177-178. DOI: 10.1227/neu.0000000000003360_1145.Peer-Reviewed Original ResearchCut-pointsAbsolute risk of deathAssociated with lower oddsState Inpatient DatabasesFlorida State Inpatient DatabaseIn-hospital moralityRates of in-hospital mortalityPrimary study outcomeCare certificationRisk of deathOptimal cut-pointAssociated with reduced inpatient mortalityThrombectomy-capable stroke centersOverall careRetrospective cohort studyAIS patientsIn-Hospital DeathLow-volume cohortLower oddsIn-Hospital MortalityPotential confoundersAbsolute riskVolume cohortsInpatient mortalityCohort studyPerformance Evaluation of Algorithms to Estimate Daily Sedentary Time Using Wrist-Worn Sensors in Free-Living Adults
Matthews C, Saint-Maurice P, Freeman J, Hayes H, Shreves A, Doherty A, Hyde E, Ylarregui K, Jones R, Keadle S. Performance Evaluation of Algorithms to Estimate Daily Sedentary Time Using Wrist-Worn Sensors in Free-Living Adults. Journal For The Measurement Of Physical Behaviour 2025, 8 DOI: 10.1123/jmpb.2024-0051.Peer-Reviewed Original ResearchEstimate sedentary timeSedentary timeFree-living adultsCut-pointsEstimates of sedentary timeDaily sedentary timeFree-Living SettingsWrist-worn sensorLinear regressionValid daysActivPALAdultsMachine-learning algorithmsClassification algorithmsMachine-learning methodsPerformance evaluationMachine-learningAlgorithmGENEActivEquivalence testingDevelopment studiesRegressionAlgorithm estimationSensorAccurate performance
2024
Higher proceduralist stroke thrombectomy volume is associated with reduced inpatient mortality
Koo A, Renedo D, Ney J, Amllay A, Kanzler M, Stogniy S, Alawieh A, Sujijantarat N, Antonios J, Al Kasab S, Malhotra A, Hebert R, Matouk C, de Havenon A. Higher proceduralist stroke thrombectomy volume is associated with reduced inpatient mortality. Journal Of NeuroInterventional Surgery 2024, jnis-2024-022021. PMID: 39214687, DOI: 10.1136/jnis-2024-022021.Peer-Reviewed Original ResearchIn-Hospital DeathIn-Hospital MortalityAcute ischemic strokeCut-pointsAbsolute risk of deathAssociated with lower oddsState Inpatient DatabasesFlorida State Inpatient DatabaseIn-hospital moralityRates of in-hospital mortalityDiagnosis of acute ischemic strokePrimary study outcomeRisk of deathStroke careOptimal cut-pointAssociated with reduced inpatient mortalityEndovascular thrombectomyRetrospective cohort studyLower oddsPotential confoundersAbsolute riskAcute ischemic stroke patientsInpatient mortalityCohort studyInpatient DatabasePrediction of Large Vessel Occlusion Stroke Using Clinical Registries for Research.
de Havenon A, Ayodele I, Alhanti B, Mac Grory B, Xian Y, Fonarow G, Smith E, Worrall B. Prediction of Large Vessel Occlusion Stroke Using Clinical Registries for Research. Neurology 2024, 102: e209424. PMID: 38759133, PMCID: PMC11175650, DOI: 10.1212/wnl.0000000000209424.Peer-Reviewed Original ResearchConceptsLarge vessel occlusionNIH Stroke ScaleConsistent with previous studiesAdult acute ischemic stroke patientsCross-sectional cohort analysisAcute ischemic stroke patientsLarge vessel occlusion strokePosterior circulation strokeDiagnosis of ischemic strokeReceiver operating curveNeuroimagingGWTG-StrokeIschemic stroke patientsVascular neuroimagingAdult patientsAtrial fibrillationCirculation strokeCohort analysisClinical covariatesStroke patientsOcclusion strokeVessel occlusionPrevious studiesCut-pointsStroke ScaleDiffusion‐Weighted Imaging Fluid‐Attenuated Inversion Recovery Mismatch on Portable, Low‐Field Magnetic Resonance Imaging Among Acute Stroke Patients
Sorby‐Adams A, Guo J, de Havenon A, Payabvash S, Sze G, Pinter N, Jaikumar V, Siddiqui A, Baldassano S, Garcia‐Guarniz A, Zabinska J, Lalwani D, Peasley E, Goldstein J, Nelson O, Schaefer P, Wira C, Pitts J, Lee V, Muir K, Nimjee S, Kirsch J, Iglesias J, Rosen M, Sheth K, Kimberly W. Diffusion‐Weighted Imaging Fluid‐Attenuated Inversion Recovery Mismatch on Portable, Low‐Field Magnetic Resonance Imaging Among Acute Stroke Patients. Annals Of Neurology 2024, 96: 321-331. PMID: 38738750, PMCID: PMC11293843, DOI: 10.1002/ana.26954.Peer-Reviewed Original ResearchStroke patientsAcute ischemic strokeCut-pointsIschemic strokeStroke patients <Diagnosis of acute ischemic strokeSignal intensity ratioFluid-attenuated inversion recoveryAcute stroke patientsOptimal cut-pointMagnetic resonance imagingDiffusion-weighted imagingDWI-FLAIR mismatchStroke onsetTrained assessorsNational InstituteStrokeThrombolytic interventionNegative predictive valueFLAIR hyperintensitiesPatientsInterobserver agreementHyperacute strokeDiffusion-weightedPredictive value
2019
Measuring Treatment Response in Pediatric Trichotillomania: A Meta-Analysis of Clinical Trials
Farhat LC, Olfson E, Levine JLS, Li F, Franklin ME, Lee HJ, Lewin AB, McGuire JF, Rahman O, Storch EA, Tolin DF, Zickgraf HF, Bloch MH. Measuring Treatment Response in Pediatric Trichotillomania: A Meta-Analysis of Clinical Trials. Journal Of Child And Adolescent Psychopharmacology 2019, 30: 306-315. PMID: 31794677, PMCID: PMC7476376, DOI: 10.1089/cap.2019.0103.Peer-Reviewed Original ResearchConceptsCut-pointsOptimal cut-pointMeta-analysisTreatment responseData-driven cut-pointsClinical trialsMGH-HPSMassachusetts General Hospital Hair Pulling ScaleDefinitions of treatment responseMeta-analysis of clinical trialsMeta-DiSc softwareParent versionObjectives:</i></b>Measure treatment responseChild versionSeverity ScalePooled accuracy measuresClinical responseMeta-DiscPediatric trichotillomaniaNational InstitutePediatric populationYouden indexOlder childrenYoung children
2013
Gastroenteropancreatic neuroendocrine neoplasms: Historical context and current issues
Yang Z, Tang L, Klimstra D. Gastroenteropancreatic neuroendocrine neoplasms: Historical context and current issues. Seminars In Diagnostic Pathology 2013, 30: 186-196. PMID: 24144288, DOI: 10.1053/j.semdp.2013.06.005.Peer-Reviewed Original ResearchConceptsNeuroendocrine tumorsProliferative rateDiverse group of tumorsWorld Health Organization classificationClassification of neuroendocrine tumorsGastroenteropancreatic neuroendocrine tumorsGroup of tumorsDigestive organsDiffuse neuroendocrine systemPrognostic parametersKi67 indexHistological gradeOrganization classificationPrognostic valueMitotic countClinical outcomesOptimal treatmentIntratumoral heterogeneityTNM stageTumorNeuroendocrine cellsGrading criteriaNeuroendocrine systemCut-pointsMultiple studies
2011
Large Prospective Study of Ovarian Cancer Screening in High-Risk Women: CA125 Cut-Point Defined by Menopausal Status
Skates S, Mai P, Horick N, Piedmonte M, Drescher C, Isaacs C, Armstrong D, Buys S, Rodriguez G, Horowitz I, Berchuck A, Daly M, Domchek S, Cohn D, Van Le L, Schorge J, Newland W, Davidson S, Barnes M, Brewster W, Azodi M, Nerenstone S, Kauff N, Fabian C, Sluss P, Nayfield S, Kasten C, Finkelstein D, Greene M, Lu K. Large Prospective Study of Ovarian Cancer Screening in High-Risk Women: CA125 Cut-Point Defined by Menopausal Status. Cancer Prevention Research 2011, 4: 1401-1408. PMID: 21893500, PMCID: PMC3172691, DOI: 10.1158/1940-6207.capr-10-0402.Peer-Reviewed Original ResearchConceptsHigh-risk womenCut-pointsMenopausal statusScreening TrialOvarian Cancer Screening TrialOvarian cancer screening studiesPopulation of high-risk womenOvarian cancer screeningPremenopausal womenStandard cut-pointCancer Screening TrialCancer screening studyEffect of menopausal statusPostmenopausal subjectsClinical factorsScreening studiesOral contraceptivesCancer screeningEarly detection of ovarian cancerCA125 testDetection of ovarian cancerGynecologic Oncology GroupEligibility criteriaScreening protocolDemographic data
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply