2019
Syntaphilin Is a Novel Biphasic Biomarker of Aggressive Prostate Cancer and a Metastasis Predictor
Hwang MJ, Bryant KG, Seo JH, Liu Q, Humphrey PA, Melnick MAC, Altieri DC, Robert ME. Syntaphilin Is a Novel Biphasic Biomarker of Aggressive Prostate Cancer and a Metastasis Predictor. American Journal Of Pathology 2019, 189: 1180-1189. PMID: 31079810, PMCID: PMC6560381, DOI: 10.1016/j.ajpath.2019.02.009.Peer-Reviewed Original ResearchConceptsProstate cancerTumor bulkInvasive frontHigh Gleason grade prostate cancerLocalized prostate cancerGrade prostate cancerAggressive prostate cancerCell proliferationKi-67 labelingTumor cell proliferationMetastasis predictorMetastatic diseaseDistant metastasisGleason gradeAccessible biomarkersProstate tumorsMetastatic potentialNovel markerCancerBiphasic patternProliferative rateHigh expressionOxidative metabolismReduced levelsTumors
2013
Gastroenteropancreatic neuroendocrine neoplasms: Historical context and current issues
Yang Z, Tang L, Klimstra D. Gastroenteropancreatic neuroendocrine neoplasms: Historical context and current issues. Seminars In Diagnostic Pathology 2013, 30: 186-196. PMID: 24144288, DOI: 10.1053/j.semdp.2013.06.005.Peer-Reviewed Original ResearchConceptsNeuroendocrine tumorsProliferative rateDiverse group of tumorsWorld Health Organization classificationClassification of neuroendocrine tumorsGastroenteropancreatic neuroendocrine tumorsGroup of tumorsDigestive organsDiffuse neuroendocrine systemPrognostic parametersKi67 indexHistological gradeOrganization classificationPrognostic valueMitotic countClinical outcomesOptimal treatmentIntratumoral heterogeneityTNM stageTumorNeuroendocrine cellsGrading criteriaNeuroendocrine systemCut-pointsMultiple studiesPolycystin-1C terminus cleavage and its relation with polycystin-2, two proteins involved in polycystic kidney disease.
Bertuccio CA, Caplan MJ. Polycystin-1C terminus cleavage and its relation with polycystin-2, two proteins involved in polycystic kidney disease. Medicina 2013, 73: 155-62. PMID: 23570767.Peer-Reviewed Original ResearchConceptsPolycystin-1Polycystin-2Autosomal dominant polycystic kidney diseaseTerminal cytoplasmic tailProtein sortingNormal tubulogenesisPolycystic kidney diseaseProtein functionCytoplasmic tailTerminal tailCommon genetic causeCystogenic processExtracellular matrixDifferentiation mechanismsCellular proliferationGenetic causeMultiple cleavagesDominant polycystic kidney diseasePathwayHigh proliferative rateCleavageProliferative rateSecretory characteristicsGenesTubulogenesis
2012
Objective Quantification of the Ki67 Proliferative Index in Neuroendocrine Tumors of the Gastroenteropancreatic System
Tang L, Gonen M, Hedvat C, Modlin I, Klimstra D. Objective Quantification of the Ki67 Proliferative Index in Neuroendocrine Tumors of the Gastroenteropancreatic System. The American Journal Of Surgical Pathology 2012, 36: 1761-1770. PMID: 23026928, DOI: 10.1097/pas.0b013e318263207c.Peer-Reviewed Original ResearchMeSH KeywordsCell DifferentiationCell ProliferationClinical CompetenceClinical Laboratory TechniquesHumansImage Processing, Computer-AssistedImmunohistochemistryIntestinal NeoplasmsIntestine, SmallKi-67 AntigenNeoplasm GradingNeuroendocrine TumorsObserver VariationPancreatic NeoplasmsPredictive Value of TestsPrognosisRectal NeoplasmsReproducibility of ResultsConceptsNeuroendocrine tumorsKi67 assessmentWorld Health OrganizationGold standardProliferative rateTumor cell proliferative rateDetermination of therapeutic strategyGrade neuroendocrine tumorsKi67 labeling indexIntraclass correlationKi67 proliferative indexDetermination of prognosisDigital image analysisIntraobserver consistencyCell proliferative rateKi67 percentageGroup tumorsKi67 scoreTumor gradeKi67 indexPrognostic stratificationProliferative indexClinicopathological characteristicsKi67 labelingLabeling index
2010
The Pathologic Classification of Neuroendocrine Tumors
Klimstra D, Modlin I, Coppola D, Lloyd R, Suster S. The Pathologic Classification of Neuroendocrine Tumors. Pancreas 2010, 39: 707-712. PMID: 20664470, DOI: 10.1097/mpa.0b013e3181ec124e.Peer-Reviewed Original ResearchConceptsNeuroendocrine tumorsPathological classificationAssessment of neuroendocrine tumoursInformation relevant to prognosisStaging of neuroendocrine tumorsClassification of neuroendocrine tumorsStaging neuroendocrine tumorsRelevant to prognosisPathological dataPrognostic assessmentWell-differentiatedPathological assessmentHigh-gradePrimary siteProliferative ratePathological featuresOrgan-specific systemsTumorPathologySystem of nomenclatureGradePrognosis
2003
PECAM-1 promotes β-catenin accumulation and stimulates endothelial cell proliferation
Biswas P, Canosa S, Schoenfeld J, Schoenfeld D, Tucker A, Madri JA. PECAM-1 promotes β-catenin accumulation and stimulates endothelial cell proliferation. Biochemical And Biophysical Research Communications 2003, 303: 212-218. PMID: 12646189, DOI: 10.1016/s0006-291x(03)00313-9.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsbeta CateninBlotting, WesternCell AdhesionCell DivisionCytoplasmCytoskeletal ProteinsEndotheliumFlow CytometryHumansLungMiceMice, KnockoutMicroscopy, FluorescencePlatelet Endothelial Cell Adhesion Molecule-1Precipitin TestsSignal TransductionTrans-ActivatorsTranscription, GeneticTransfectionConceptsPECAM-1-positive endothelial cellsBeta-catenin proteinCell proliferationEndothelial cellsPECAM-1Beta-catenin localizationCytoplasmic domainΒ-catenin accumulationFull-length PECAM-1Functional consequencesEndothelial cell proliferationCell membraneKnockout animalsAdhesion moleculesLess accumulationCellsAccumulationProliferative rateProliferationMembraneProteinBinds
1997
Effect of strain on human keratinocytes in vitro
Takei T, Rivas‐Gotz C, Delling C, Koo J, Mills I, McCarthy T, Centrella M, Sumpio B. Effect of strain on human keratinocytes in vitro. Journal Of Cellular Physiology 1997, 173: 64-72. PMID: 9326450, DOI: 10.1002/(sici)1097-4652(199710)173:1<64::aid-jcp8>3.0.co;2-h.Peer-Reviewed Original Research
1996
Molecular Markers Help Characterize Neuroendocrine Lung Tumors
Rusch V, Klimstra D, Venkatraman E. Molecular Markers Help Characterize Neuroendocrine Lung Tumors. The Annals Of Thoracic Surgery 1996, 62: 798-810. PMID: 8784011, DOI: 10.1016/s0003-4975(96)00435-3.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, NeoplasmBiomarkers, TumorCarcinoid TumorCarcinoma, NeuroendocrineDiagnosis, DifferentialErbB ReceptorsHumansImmunohistochemistryKi-67 AntigenLung NeoplasmsNeoplasm ProteinsNeuroendocrine TumorsNuclear ProteinsRetinoblastoma ProteinRetrospective StudiesSurvival RateTumor Suppressor Protein p53ConceptsSmall cell lung cancerAtypical carcinoidLung cancerRb stainingAC tumorsNeuroendocrine tumorsLung tumorsEarly stage SCLCHigh-grade neuroendocrine lung tumorsStage small cell lung cancerProliferative rateHigh-grade neuroendocrine tumorsCell neuroendocrine carcinomaCell undifferentiated carcinomaSmall cell carcinomaPrimary lung tumorsKaplan-Meier methodCell lung cancerLog-rank testNeuroendocrine lung tumorsAntibody MIB-1Comparison of survival ratesLow proliferative rateOverexpression of EGFRAbsent p53
1995
IL-8 and angiogenesis: evidence that human endothelial cells lack receptors and do not respond to IL-8 in vitro
Petzelbauer P, Watson C, Watson C, Pfau S, Pober J. IL-8 and angiogenesis: evidence that human endothelial cells lack receptors and do not respond to IL-8 in vitro. Cytokine 1995, 7: 267-272. PMID: 7543779, DOI: 10.1006/cyto.1995.0031.Peer-Reviewed Original ResearchConceptsHuman umbilical vein endothelial cellsIL-8Cultured human umbilical vein endothelial cellsDermal microvascular endothelial cellsEndothelial cellsHuman endothelial cellsRecombinant human IL-8IL-8 treatmentMicrovascular human endothelial cellsReceptor mRNA expressionEndothelial cell growth factorHuman IL-8Human dermal microvascular endothelial cellsMicrovascular endothelial cellsCytoplasmic calcium concentrationUmbilical vein endothelial cellsCell growth factorVein endothelial cellsAngiogenic factorsMRNA expressionDirect actionGrowth factorCalcium concentrationIndirect actionProliferative rate
1986
Human Melanocytes Cultured from Nevi and Melanomas
Halaban R, Ghosh S, Duray P, Kirkwood J, Lerner A. Human Melanocytes Cultured from Nevi and Melanomas. Journal Of Investigative Dermatology 1986, 87: 95-101. PMID: 2425008, DOI: 10.1111/1523-1747.ep12523594.Peer-Reviewed Original ResearchConceptsPresence of mitogensHuman melanocytesNeonatal melanocytesRate of proliferationPrimary melanomaCongenital neviMalignant transformationTransformation of melanocytesCholera toxinIsobutylmethyl xanthineHuman placentaGrowth factorProliferative rateMelanomaNewborn foreskinUnidentified factorsCell linesMelanocytesMitogenNeviHuman neonatal melanocytesPopulation doublingsMonthsLate eventProliferation
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