2025
VEGF-D, unlike VEGF-A, improves vascular integrity in the lung and exerts a protective effect during acute lung injury
Yuan Y, Sharma L, Tang W, Yoon Y, Kirk S, Birukov K, Kaminski N. VEGF-D, unlike VEGF-A, improves vascular integrity in the lung and exerts a protective effect during acute lung injury. Physiology 2025, 40: 0734. DOI: 10.1152/physiol.2025.40.s1.0734.Peer-Reviewed Original ResearchAcute lung injuryAcute respiratory distress syndromeImmune cell infiltrationVEGF-DIdiopathic pulmonary fibrosisChronic obstructive pulmonary diseaseVEGF-AVascular integrityMicrovascular nicheAnti-inflammatory propertiesLung injuryCell infiltrationTNF-aLung tissueParacrine signalingPulmonary vascular integrityBarrier functionLung injury indexLevels of pro-inflammatory markersRespiratory distress syndromeTherapeutic targetTumor necrosis factor-aEffects of VEGF-ABronchoalveolar lavage fluidImproving vascular integrityAdrenomedullin Enhances Vascular Integrity and Endothelial Cell Maturation in Bioengineered Lung Models
YOON Y, Kirk S, Promnares K, Karki P, Birukov K, Yuan Y. Adrenomedullin Enhances Vascular Integrity and Endothelial Cell Maturation in Bioengineered Lung Models. Physiology 2025, 40: 1257. DOI: 10.1152/physiol.2025.40.s1.1257.Peer-Reviewed Original ResearchVascular barrier functionEndothelial cell maturationShear stressElectric cell impedance sensingCell maturationBarrier functionMicrovascular nicheAngiopoietin-1Single-cell RNA sequencingParacrine signalingVascular modelLung modelEndothelial cell barrier functionVascular integrityEndothelial cell markersCell barrier functionEndothelial cell integrityAdjacent cell typesAnti-inflammatory responseRNA sequencingNative vasculatureCellular phenotypesFluid flowIn vitro modelGene expression
2024
Endometrial stromal cell signaling and microRNA exosome content in women with adenomyosis
Zipponi M, Cacciottola L, Camboni A, Stratopoulou C, Taylor H, Dolmans M. Endometrial stromal cell signaling and microRNA exosome content in women with adenomyosis. Molecular Human Reproduction 2024, 31: gaae044. PMID: 39673794, DOI: 10.1093/molehr/gaae044.Peer-Reviewed Original ResearchStromal cell signalsMenstrual phaseHealthy subjectsPresence of endometrial glandsPathogenesis of adenomyosisCompared to controlsEndometrial biopsyEndometrial glandsEutopic endometriumStromal compartmentAdenomyosisAdenomyosis developmentMolecular mechanismsCell signalingLesion establishmentStromal cellsNanoparticle tracking analysisFlow cytometryEpithelial glandsParacrine signalingQuality of lifeSecreted exosomesIntercellular communicationExosomal contentsReproductive healthStructure, interaction and nervous connectivity of beta cell primary cilia
Müller A, Klena N, Pang S, Garcia L, Topcheva O, Aurrecoechea Duran S, Sulaymankhil D, Seliskar M, Mziaut H, Schöniger E, Friedland D, Kipke N, Kretschmar S, Münster C, Weitz J, Distler M, Kurth T, Schmidt D, Hess H, Xu C, Pigino G, Solimena M. Structure, interaction and nervous connectivity of beta cell primary cilia. Nature Communications 2024, 15: 9168. PMID: 39448638, PMCID: PMC11502866, DOI: 10.1038/s41467-024-53348-5.Peer-Reviewed Original ResearchConceptsPrimary ciliaCell's primary ciliumNon-islet cellsPancreatic beta cellsCiliary pocketSensory organellesAxonemal organizationMotility componentsExtrinsic signalsStructural basisBeta cellsCiliaCell typesExpansion microscopyParacrine signalingIslet innervationCellsIsletsBetaAxonemeOrganellesSignalThree-dimensional reconstructionInteractionComplementary and Inducible creERT2 Mouse Models for Functional Evaluation of Endothelial Cell Subtypes in the Bone Marrow
Poulos M, Ramalingam P, Winiarski A, Gutkin M, Katsnelson L, Carter C, Pibouin-Fragner L, Eichmann A, Thomas J, Miquerol L, Butler J. Complementary and Inducible creERT2 Mouse Models for Functional Evaluation of Endothelial Cell Subtypes in the Bone Marrow. Stem Cell Reviews And Reports 2024, 20: 1135-1149. PMID: 38438768, PMCID: PMC11087254, DOI: 10.1007/s12015-024-10703-9.Peer-Reviewed Original ResearchBone marrowEndothelial cellsMouse modelAdult bone marrowArteriole endothelial cellsAdult BMOff-target activityHematopoietic dysfunctionAdult marrowHematopoietic homeostasisEndothelial cell subtypesVascular subtypeCre-expressing lineEndothelial subtypesEndothelial-specificMouse linesHSC activationCell subtypesEC subtypesParacrine signalingPerivascular cellsModulate HSC activationMarrowSubtypesAdult endothelium
2020
ENDOMETRIOSIS STROMAL CELLS INDUCE BONE MARROW MESENCHYMAL STEM CELLS DIFFERENTIATION AND PD-1 EXPRESSION THROUGH PARACRINE SIGNALING
Mamillapalli R, Peng C, Habata S, Taylor H. ENDOMETRIOSIS STROMAL CELLS INDUCE BONE MARROW MESENCHYMAL STEM CELLS DIFFERENTIATION AND PD-1 EXPRESSION THROUGH PARACRINE SIGNALING. Fertility And Sterility 2020, 114: e78. DOI: 10.1016/j.fertnstert.2020.08.240.Peer-Reviewed Original Research
2016
IL‐17‐ & TNFa‐Activation Induces Pro‐Inflammatory Paracrine Signaling and Basement Membrane Remodeling by Human Pericytes
Lauridsen H, Liu R, Pober J, Gonzalez A. IL‐17‐ & TNFa‐Activation Induces Pro‐Inflammatory Paracrine Signaling and Basement Membrane Remodeling by Human Pericytes. The FASEB Journal 2016, 30 DOI: 10.1096/fasebj.30.1_supplement.951.1.Peer-Reviewed Original Research
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