2023
Effectiveness of a Quality Improvement Intervention on Reperfusion Treatment for Patients With Acute Ischemic Stroke
Wang C, Gu H, Zong L, Zhang X, Zhou Q, Jiang Y, Li H, Meng X, Yang X, Wang M, Huo X, Wangqin R, Bei Y, Qi X, Liu X, Hu S, Wang Z, Zhao X, Wang Y, Liu L, Ma X, Morgan L, Xian Y, Schwamm L, Wang Y, Li Z, Yang Q, Chen G, Ma Q, Li X, Chen J, Zhao X, Wang H, Niu X, Xu J, Zhao L, Wang Z, Huang D, Jin X, Chen S, Li J, Yu J, Liu P, Li G, Hao Y, Yang G, Huang X, Zhou C, Yang J, Gu J, Sun P, Guo Z, Ma G, Chen G, Tang M, Wang N, Chen L, Li J, Li A, Li S, Cao M, Guo J, Ren Y, Li T, Zhang L, Xie Z, Dong J, Kong X, Liang H, Zhang Y. Effectiveness of a Quality Improvement Intervention on Reperfusion Treatment for Patients With Acute Ischemic Stroke. JAMA Network Open 2023, 6: e2316465. PMID: 37266940, PMCID: PMC10238948, DOI: 10.1001/jamanetworkopen.2023.16465.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeQuality improvement interventionsTargeted quality improvement interventionsReperfusion therapy ratesProportion of patientsIschemic strokeEligible patientsStepped-wedge clusterSymptom onsetReperfusion therapyEndovascular thrombectomyImprovement interventionsTherapy ratesUsual careSecondary outcomesPrimary outcomeSecondary hospitalsClinical trialsIntravenous recombinant tissue plasminogen activatorModified Rankin Scale scoreRecombinant tissue plasminogen activatorRankin Scale scoreTissue plasminogen activatorEVT rateHospital mortalityA scoping review described diversity in methods of randomization and reporting of baseline balance in stepped-wedge cluster randomized trials
Nevins P, Davis-Plourde K, Pereira Macedo J, Ouyang Y, Ryan M, Tong G, Wang X, Meng C, Ortiz-Reyes L, Li F, Caille A, Taljaard M. A scoping review described diversity in methods of randomization and reporting of baseline balance in stepped-wedge cluster randomized trials. Journal Of Clinical Epidemiology 2023, 157: 134-145. PMID: 36931478, PMCID: PMC10546924, DOI: 10.1016/j.jclinepi.2023.03.010.Peer-Reviewed Original ResearchConceptsStepped-wedge clusterIndividual-level characteristicsMethod of randomizationCross-sectional designControl armBaseline imbalancesCohort designMedian numberElectronic searchPrimary analysisBaseline balanceStudy designPrimary reportsBaselineTrialsIntervention conditionSW-CRTsRandomizationReporting
2022
Effectiveness of a community health worker-delivered care intervention for hypertension control in Uganda: study protocol for a stepped wedge, cluster randomized control trial
Ingenhoff R, Nandawula J, Siddharthan T, Ssekitoleko I, Munana R, Bodnar B, Weswa I, Kirenga B, Mutungi G, van der Giet M, Kalyesubula R, Knauf F. Effectiveness of a community health worker-delivered care intervention for hypertension control in Uganda: study protocol for a stepped wedge, cluster randomized control trial. Trials 2022, 23: 440. PMID: 35610712, PMCID: PMC9128241, DOI: 10.1186/s13063-022-06403-9.Peer-Reviewed Original ResearchConceptsCommunity health workersNon-communicable diseasesUncontrolled hypertensionBlood pressureCardiovascular disease risk assessmentHealthy lifestyle counselingMonthly household visitsBlood pressure controlSub-Saharan African settingPatient-related factorsPrimary care levelStepped-wedge clusterMedical treatment outcomeMajority of LMICsMulti-component interventionDisease risk assessmentNCD clinicsHypertension controlHypertensive patientsLifestyle counselingAdult patientsHTN managementMiddle-income countriesMedication adherenceEntire cohortGatekeeper training for vendors to reduce pesticide self-poisoning in rural South Asia: a study protocol for a stepped-wedge cluster randomised controlled trial
Weerasinghe M, Pearson M, Turner N, Metcalfe C, Gunnell DJ, Agampodi S, Hawton K, Agampodi T, Miller M, Jayamanne S, Parker S, Sumith JA, Karunarathne A, Dissanayaka K, Rajapaksha S, Rodrigo D, Abeysinghe D, Piyasena C, Kanapathy R, Thedchanamoorthy S, Madsen LB, Konradsen F, Eddleston M. Gatekeeper training for vendors to reduce pesticide self-poisoning in rural South Asia: a study protocol for a stepped-wedge cluster randomised controlled trial. BMJ Open 2022, 12: e054061. PMID: 35379621, PMCID: PMC8981379, DOI: 10.1136/bmjopen-2021-054061.Peer-Reviewed Original ResearchConceptsSelf-poisoning casesStepped-wedge clusterGatekeeper interventionStudy protocolOriginal study protocolMedical Research Ethics CommitteeScientific peer-reviewed journalsSurveillance of hospitalEthical review committeePeer-reviewed journalsSecondary outcomesPrimary outcomeResearch Ethics CommitteePost-training periodsOutcome measuresHigh riskFaculty of MedicineGatekeeper trainingRural Sri LankaRandom orderEthics CommitteeIntervention effectivenessReview CommitteeInterventionCOVID-19
2020
Getting to implementation: a protocol for a Hybrid III stepped wedge cluster randomized evaluation of using data-driven implementation strategies to improve cirrhosis care for Veterans
Rogal SS, Yakovchenko V, Morgan T, Bajaj JS, Gonzalez R, Park A, Beste L, Miech EJ, Lamorte C, Neely B, Gibson S, Malone PS, Chartier M, Taddei T, Garcia-Tsao G, Powell BJ, Dominitz JA, Ross D, Chinman MJ. Getting to implementation: a protocol for a Hybrid III stepped wedge cluster randomized evaluation of using data-driven implementation strategies to improve cirrhosis care for Veterans. Implementation Science 2020, 15: 92. PMID: 33087156, PMCID: PMC7579930, DOI: 10.1186/s13012-020-01050-7.Peer-Reviewed Original ResearchConceptsVA Medical CenterCirrhosis careVeterans Health AdministrationEvidence-based practiceImplementation interventionsAim 1Stepped-wedge clusterBackground cirrhosisImplementation strategiesMedical CenterWedge clusterAim 3Health AdministrationEBP uptakeCirrhosisAim 2CareExpert recommendationsSuccessful implementation strategiesInterventionVeteransChange taxonomyImplementation support toolsProgram evaluationSemi-structured interviewsAssessing a WeChat-Based Integrative Family Intervention (WIFI) for Schizophrenia: Protocol for a Stepped-Wedge Cluster Randomized Trial
Yu Y, Li T, Xi S, Li Y, Xiao X, Yang M, Ge X, Xiao S, Tebes J. Assessing a WeChat-Based Integrative Family Intervention (WIFI) for Schizophrenia: Protocol for a Stepped-Wedge Cluster Randomized Trial. JMIR Research Protocols 2020, 9: e18538. PMID: 32687478, PMCID: PMC7479588, DOI: 10.2196/18538.Peer-Reviewed Original ResearchINTERNATIONAL REGISTERED REPORT IDENTIFIERFamily caregiversHealth care utilization costsIncremental cost-effectiveness ratioStepped-wedge clusterFamily interventionsCost-effectiveness ratioQuality of lifeBaseline data collectionImmersion-crystallization processInstitutional review boardCost-effectiveness analysisSupportive careCaregiver burdenIntervention periodMHealth interventionsPsychiatric hospitalMental illnessReview boardSocietal perspectiveSchizophreniaIntervention costsPsychological distressTreatment effectsIntervention
2018
Evaluating the impact of multilevel evidence-based implementation strategies to enhance provider recommendation on human papillomavirus vaccination rates among an empaneled primary care patient population: a study protocol for a stepped-wedge cluster randomized trial
Finney Rutten LJ, Radecki Breitkopf C, St. Sauver JL, Croghan IT, Jacobson DJ, Wilson PM, Herrin J, Jacobson RM. Evaluating the impact of multilevel evidence-based implementation strategies to enhance provider recommendation on human papillomavirus vaccination rates among an empaneled primary care patient population: a study protocol for a stepped-wedge cluster randomized trial. Implementation Science 2018, 13: 96. PMID: 30001723, PMCID: PMC6043954, DOI: 10.1186/s13012-018-0778-x.Peer-Reviewed Original ResearchConceptsHPV vaccination ratesEvidence-based implementation strategiesStepped-wedge clusterVaccination ratesIntervention 1Human papillomavirusIntervention 2Human papillomavirus (HPV) vaccination ratesPrimary care patient populationPrimary care sitesProvider-level interventionsPractice-level interventionProcess evaluationAdolescent vaccinesBackgroundEach yearHPV vaccineMale patientsPrimary outcomePediatric populationPatient numbersPatient populationProvider recommendationStudy protocolClinical trialsBlock randomization
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