2023
The serotype-specific prevalence of pneumococci in hospitalized pneumonia patients with COPD: a prospective, multi-center, cohort study
Kim J, Jung J, Kang M, Kim D, Choi H, Cho Y, Jang S, Lee C, Oh Y, Park J. The serotype-specific prevalence of pneumococci in hospitalized pneumonia patients with COPD: a prospective, multi-center, cohort study. The Korean Journal Of Internal Medicine 2023, 38: 714-724. PMID: 37586811, PMCID: PMC10493435, DOI: 10.3904/kjim.2023.152.Peer-Reviewed Original ResearchConceptsCommunity-acquired pneumoniaSerotype-specific prevalencePneumococcal pneumoniaCohort studyS. pneumoniaeChronic obstructive pulmonary disease patientsPneumococcal polysaccharide vaccine 23Obstructive pulmonary disease patientsPCV-13 vaccinationUrine antigen detectionPulmonary disease patientsCommon pneumococcal serotypesPost-vaccination eraPneumococcal vaccinationSerotype 22FCOPD patientsInfluenza vaccinationPCV-13Clinical characteristicsVaccination statusOverall incidencePneumonia patientsPPV-23Pneumococcal serotypesVaccination rates
2021
Decline in Pneumococcal Disease in Young Children During the Coronavirus Disease 2019 (COVID-19) Pandemic in Israel Associated With Suppression of Seasonal Respiratory Viruses, Despite Persistent Pneumococcal Carriage: A Prospective Cohort Study
Danino D, Ben-Shimol S, Van Der Beek BA, Givon-Lavi N, Avni YS, Greenberg D, Weinberger DM, Dagan R. Decline in Pneumococcal Disease in Young Children During the Coronavirus Disease 2019 (COVID-19) Pandemic in Israel Associated With Suppression of Seasonal Respiratory Viruses, Despite Persistent Pneumococcal Carriage: A Prospective Cohort Study. Clinical Infectious Diseases 2021, 75: e1154-e1164. PMID: 34904635, PMCID: PMC8754767, DOI: 10.1093/cid/ciab1014.Peer-Reviewed Original ResearchConceptsCommunity-acquired alveolar pneumoniaInvasive pneumococcal diseasePneumococcal carriagePneumococcal diseaseRespiratory virusesSurveillance projectCOVID-19 pandemicBacteremic pneumococcal pneumoniaNasopharyngeal pneumococcal carriageSpecific respiratory virusesSARS-CoV-2 casesFirst SARS-CoV-2 caseLower respiratory infectionsProspective cohort studyPneumococcal carriage prevalencePneumococcal serotype distributionRespiratory syncytial virusSeasonal respiratory virusesRespiratory virus detectionChest X-rayDensity of colonizationAlveolar pneumoniaPneumococcal pneumoniaCohort studyRespiratory infectionsRIPK3 Activates MLKL-mediated Necroptosis and Inflammasome Signaling during Streptococcus Infection.
Huang HR, Cho SJ, Harris RM, Yang J, Bermejo S, Sharma L, Dela Cruz CS, Xu JF, Stout-Delgado HW. RIPK3 Activates MLKL-mediated Necroptosis and Inflammasome Signaling during Streptococcus Infection. American Journal Of Respiratory Cell And Molecular Biology 2021, 64: 579-591. PMID: 33625952, PMCID: PMC8086037, DOI: 10.1165/rcmb.2020-0312oc.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnimalsCalcium ChannelsCase-Control StudiesDisease Models, AnimalFemaleGene Expression RegulationHumansInflammasomesMacrophages, AlveolarMaleMiceMice, Inbred C57BLMice, KnockoutMiddle AgedMitochondriaMitochondrial Permeability Transition PoreNecroptosisNLR Family, Pyrin Domain-Containing 3 ProteinPneumonia, PneumococcalProtein KinasesProto-Oncogene Proteins c-aktReactive Oxygen SpeciesReceptor-Interacting Protein Serine-Threonine KinasesSignal TransductionStreptococcus pneumoniaeConceptsCommunity-acquired pneumoniaPneumococcal pneumoniaSevere pathological damageHealthy control subjectsPotential plasma markerNLRP3 inflammasome activationCommon bacterial pathogensMitochondrial permeability transition pore openingStreptococcal pneumoniaPlasma markersStreptococcus infectionBacterial clearanceControl subjectsPathological damageLeading causeMitochondrial reactive oxygenInflammasome activationMurine modelMitochondrial calcium uptakePneumoniaPermeability transition pore openingHuman studiesHigh mortalityInflammasome signalingTransition pore opening
2020
Who is at risk of 13-valent conjugated pneumococcal vaccine failure?
Yildirim M, Keskinocak P, Pelton S, Pickering L, Yildirim I. Who is at risk of 13-valent conjugated pneumococcal vaccine failure? Vaccine 2020, 38: 1671-1677. PMID: 31974018, DOI: 10.1016/j.vaccine.2019.12.060.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseaseVaccine failureIPD casesVaccine serotypesDiagnosis of IPDHigh vaccine coverage ratesPneumococcal conjugate vaccineVaccine coverage ratesUnderlying risk factorsYears of ageMonths of agePneumococcal pneumoniaImmunization PracticesVaccine scheduleConjugate vaccinePneumococcal diseasePrimary dosesClinical presentationImmunization scheduleSerotype 19ACourse of immunisationRisk factorsComorbiditiesStudy periodPassive surveillance
2018
2555. Predicting Risk of Breakthrough Invasive Pneumococcal Disease in Children After 13-Valent Pneumococcal Conjugate Vaccination
Yildirim M, Pelton S, Keskinocak P, Yildirim I. 2555. Predicting Risk of Breakthrough Invasive Pneumococcal Disease in Children After 13-Valent Pneumococcal Conjugate Vaccination. Open Forum Infectious Diseases 2018, 5: s68-s69. PMCID: PMC6252819, DOI: 10.1093/ofid/ofy209.163.Peer-Reviewed Original ResearchPCV13 vaccinationNonvaccine serotypesIncomplete vaccinationThirteen-valent pneumococcal conjugate vaccineDose of PCV7Pneumococcal conjugate vaccinationInvasive pneumococcal diseaseChildhood immunization scheduleCases of IPDStreptococcus pneumoniae isolatesYears of ageEnhanced surveillance systemConjugate vaccinationPCV13 immunizationVT-IPDPneumococcal pneumoniaIPD casesConjugate vaccineIncomplete immunizationPneumococcal diseasePneumococcal infectionComorbid conditionsImmunization scheduleComplete immunizationClinical data
2016
Pneumococcal Vaccination Strategies. An Update and Perspective
Berical AC, Harris D, Dela Cruz CS, Possick JD. Pneumococcal Vaccination Strategies. An Update and Perspective. Annals Of The American Thoracic Society 2016, 13: 933-944. PMID: 27088424, PMCID: PMC5461988, DOI: 10.1513/annalsats.201511-778fr.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsInvasive pneumococcal diseasePneumococcal diseasePneumococcal vaccineNext-generation pneumococcal vaccinesPneumococcal vaccine recommendationsVaccination of infantsPneumococcal polysaccharide vaccineNasal carriage ratePneumococcal conjugate vaccineChronic pulmonary diseaseProtein-conjugate vaccineImplementation of vaccinesMucosal immunity responseBasis of agePneumococcal vaccinationImportant global pathogenPneumococcal pneumoniaPneumococcal infectionPolysaccharide vaccineVaccine recommendationsCommon presentationConjugate vaccinePulmonary diseaseVaccine indicationsCarriage rate
2015
Association between Respiratory Syncytial Virus Activity and Pneumococcal Disease in Infants: A Time Series Analysis of US Hospitalization Data
Weinberger DM, Klugman KP, Steiner CA, Simonsen L, Viboud C. Association between Respiratory Syncytial Virus Activity and Pneumococcal Disease in Infants: A Time Series Analysis of US Hospitalization Data. PLOS Medicine 2015, 12: e1001776. PMID: 25562317, PMCID: PMC4285401, DOI: 10.1371/journal.pmed.1001776.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusPneumococcal pneumoniaRate of hospitalizationPneumococcal diseaseHospitalization dataSeven-valent pneumococcal conjugate vaccineBacterial infectionsRespiratory syncytial virus activityLaboratory-confirmed dataPneumococcal pneumonia hospitalizationsPneumococcal conjugate vaccineIntroduction of PCV7Secondary bacterial infectionState Inpatient DatabasesPoisson regression modelsRSV hospitalizationPCV7 introductionPneumonia hospitalizationsConjugate vaccineInpatient DatabaseSyncytial virusPneumococcal septicemiaPneumonia casesEpidemic timingHospitalization
2013
Effect of the 2009 Influenza A(H1N1) Pandemic on Invasive Pneumococcal Pneumonia
Fleming-Dutra KE, Taylor T, Link-Gelles R, Garg S, Jhung MA, Finelli L, Jain S, Shay D, Chaves SS, Baumbach J, Hancock EB, Beall B, Bennett N, Zansky S, Petit S, Yousey-Hindes K, Farley MM, Gershman K, Harrison LH, Ryan P, Lexau C, Lynfield R, Reingold A, Schaffner W, Thomas A, Moore MR. Effect of the 2009 Influenza A(H1N1) Pandemic on Invasive Pneumococcal Pneumonia. The Journal Of Infectious Diseases 2013, 207: 1135-1143. PMID: 23303809, DOI: 10.1093/infdis/jit008.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedChildChild, PreschoolConfidence IntervalsDatabases, FactualFemaleHospitalizationHumansInfluenza A Virus, H1N1 SubtypeInfluenza, HumanMaleMiddle AgedOdds RatioPandemicsPneumonia, PneumococcalPoisson DistributionPopulation SurveillanceRisk FactorsSeasonsSeverity of Illness IndexStreptococcus pneumoniaeUnited StatesYoung Adult
2010
Association of Serotype with Risk of Death Due to Pneumococcal Pneumonia: A Meta-Analysis
Weinberger DM, Harboe ZB, Sanders EA, Ndiritu M, Klugman KP, Rückinger S, Dagan R, Adegbola R, Cutts F, Johnson HL, O'Brien KL, Scott JA, Lipsitch M. Association of Serotype with Risk of Death Due to Pneumococcal Pneumonia: A Meta-Analysis. Clinical Infectious Diseases 2010, 51: 692-699. PMID: 20715907, PMCID: PMC2927802, DOI: 10.1086/655828.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseaseRisk of deathCarriage prevalenceHost factorsAssociation of serotypesLower comorbidity scorePooled effect estimatesStudy-specific estimatesNasopharyngeal carriage prevalenceCase fatality ratioSerotype-specific dataHigher carriage prevalenceRandom-effects methodBacteremic pneumoniaPooled RRComorbidity scorePneumococcal pneumoniaPneumococcal diseaseMeningitis patientsDisease outcomePotential confoundingPneumoniaSerotype 14Epidemiologic measuresMeta-analysis
2005
Intrathoracic Lymphadenopathy in Hospitalized Patients With Pneumococcal Pneumonia
Stein D, Haramati L, Spindola-Franco H, Friedman J, Klapper P. Intrathoracic Lymphadenopathy in Hospitalized Patients With Pneumococcal Pneumonia. CHEST Journal 2005, 127: 1271-1275. DOI: 10.1016/s0012-3692(15)34476-7.Peer-Reviewed Original ResearchConceptsPrevalence of lymphadenopathyCharacteristics of pneumoniaPneumococcal pneumoniaCT scanIntrathoracic lymphadenopathyHospitalized patientsPleural effusionCT scan featuresDegree of lymphadenopathyCauses of lymphadenopathyCommunity-acquired pneumoniaChest CT scanStudy exclusion criteriaStudy inclusion criteriaContralateral lymphadenopathyHepatitis CInvolved lobeSmoking historyDifferent comorbiditiesHIV infectionLymph nodesCommon etiologyHIV statusMean ageBlood culturesIntrathoracic lymphadenopathy in hospitalized patients with pneumococcal pneumonia.
Stein D, Haramati L, Spindola-Franco H, Friedman J, Klapper P. Intrathoracic lymphadenopathy in hospitalized patients with pneumococcal pneumonia. CHEST Journal 2005, 127: 1271-5. PMID: 15821204, DOI: 10.1378/chest.127.4.1271.Peer-Reviewed Original ResearchConceptsPrevalence of lymphadenopathyCharacteristics of pneumoniaCT scanPneumococcal pneumoniaIntrathoracic lymphadenopathyHospitalized patientsPleural effusionClinical diagnosis of pneumoniaPresence of pleural effusionCommunity-acquired pneumoniaCT scan featuresEnlarged lymph nodesChest CT scanStudy exclusion criteriaDegree of lymphadenopathyDiagnosis of pneumoniaStudy inclusion criteriaContralateral lymphadenopathyBlood culturesHIV infectionHepatitis CLymph nodesLymphadenopathySmoking historyHIV status
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