2024
De-Escalated Therapy and Early Treatment of Recurrences in HPV-Associated Head and Neck Cancer: The Potential for Biomarkers to Revolutionize Personalized Therapy
Yarbrough W, Schrank T, Burtness B, Issaeva N. De-Escalated Therapy and Early Treatment of Recurrences in HPV-Associated Head and Neck Cancer: The Potential for Biomarkers to Revolutionize Personalized Therapy. Viruses 2024, 16: 536. PMID: 38675879, PMCID: PMC11053602, DOI: 10.3390/v16040536.Peer-Reviewed Original ResearchConceptsHPV+ HNSCCHPV-associated head and neck cancerHead and neck cancerHuman papillomavirus-associatedDe-escalation therapyDetect recurrent diseaseTreatment of recurrenceHPV-associated cancersHead and neckEarly treatment of recurrencePapillomavirus-associatedDevelopment of biomarkersResponsive tumorsRecurrent diseaseStandard therapyCompanion biomarkersHPV carcinogenesisHPV vaccinationNeck cancerPoor prognosisDecrease morbidityHNSCCEarly treatmentMolecular vulnerabilitiesPersonalized therapyEstablished and Emerging Biomarkers of Immunotherapy in Renal Cell Carcinoma
Jani Y, Jansen C, Gerke M, Bilen M. Established and Emerging Biomarkers of Immunotherapy in Renal Cell Carcinoma. Immunotherapy 2024, 16: 405-426. PMID: 38264827, PMCID: PMC11913054, DOI: 10.2217/imt-2023-0267.Peer-Reviewed Original ResearchConceptsRenal cell carcinomaCell carcinomaImmune checkpoint inhibitorsBiomarker of immunotherapyRisk of adverse eventsSignificant side effectsCheckpoint inhibitorsDevelopment of biomarkersAdverse eventsImmunotherapyTherapeutic efficacySide effectsPatientsClinical biomarkersPatient's diseaseTherapeutic biomarkersClinician's abilityBiomarkersCarcinomaPatient careImproving clinicians' abilityEfficacy
2022
Toward Precision Phenotyping of Multiple Sclerosis
Pitt D, Lo CH, Gauthier SA, Hickman RA, Longbrake E, Airas LM, Mao-Draayer Y, Riley C, De Jager PL, Wesley S, Boster A, Topalli I, Bagnato F, Mansoor M, Stuve O, Kister I, Pelletier D, Stathopoulos P, Dutta R, Lincoln MR. Toward Precision Phenotyping of Multiple Sclerosis. Neurology Neuroimmunology & Neuroinflammation 2022, 9: e200025. PMID: 36041861, PMCID: PMC9427000, DOI: 10.1212/nxi.0000000000200025.Peer-Reviewed Original ResearchConceptsMultiple sclerosisSecondary progressive multiple sclerosisPathological processesProgressive multiple sclerosisKey pathological processClinical trial designDevelopment of biomarkersPerilesional inflammationNeuroaxonal degenerationMS phenotypeTrial designClinical importancePersonalized careM phenotypeSclerosisPhenotypeRemyelinationInflammationSyndromePrognosticationDegenerationProgressionBiomarkersCare
2021
Immunotherapy Treatment for Triple Negative Breast Cancer
Berger ER, Park T, Saridakis A, Golshan M, Greenup RA, Ahuja N. Immunotherapy Treatment for Triple Negative Breast Cancer. Pharmaceuticals 2021, 14: 763. PMID: 34451860, PMCID: PMC8401402, DOI: 10.3390/ph14080763.Peer-Reviewed Original ResearchTriple-negative breast cancerImmune related adverse eventsBreast cancerMetastatic settingMetastatic triple-negative breast cancerEarly breast cancer settingImmune checkpoint inhibitor therapyBreast cancer settingCheckpoint inhibitor therapyRelated adverse eventsLocal recurrence rateHigh-risk subtypesNegative breast cancerDevelopment of biomarkersTypes of cancerImmunotherapy useAdverse eventsCheckpoint therapyOverall survivalStandard therapySystemic treatmentInhibitor therapyDismal prognosisImmunotherapy treatmentRecurrence rateCumulus cells of euploid versus whole chromosome 21 aneuploid embryos reveal differentially expressed genes
Tiegs AW, Titus S, Mehta S, Garcia-Milian R, Seli E, Scott RT. Cumulus cells of euploid versus whole chromosome 21 aneuploid embryos reveal differentially expressed genes. Reproductive BioMedicine Online 2021, 43: 614-626. PMID: 34417138, DOI: 10.1016/j.rbmo.2021.06.015.Peer-Reviewed Original ResearchConceptsSerum response factorCumulus cellsDifferential gene expressionRNA sequencing analysisGene expression analysisIngenuity Pathway AnalysisCellular communication network factor 1Embryo developmental competenceExpression analysisPreimplantation embryo qualityGene expressionPathway analysisSegment polarity protein 2Sequencing analysisGenesProtein 2Response factorTrisomy 21Factor 1Developmental competenceAneuploid embryosReal-time polymerase chain reaction assaysDevelopment of biomarkersEmbryosCellsCirculating Donor Lung-specific Exosome Profiles Enable Noninvasive Monitoring of Acute Rejection in a Rodent Orthotopic Lung Transplantation Model
Habertheuer A, Ram C, Schmierer M, Chatterjee S, Hu R, Freas A, Zielinski P, Rogers W, Silvestro EM, McGrane M, Moore JS, Korutla L, Siddiqui S, Xin Y, Rizi R, Tao J, Kreisel D, Naji A, Ochiya T, Vallabhajosyula P. Circulating Donor Lung-specific Exosome Profiles Enable Noninvasive Monitoring of Acute Rejection in a Rodent Orthotopic Lung Transplantation Model. Transplantation 2021, 106: 754-766. PMID: 33993180, DOI: 10.1097/tp.0000000000003820.Peer-Reviewed Original ResearchConceptsAcute rejectionDonor exosomesExosome profileSyngeneic controlsRat orthotopic lung transplant modelChronic lung allograft dysfunctionOrthotopic lung transplantation modelLung transplant modelPosttransplant time pointsAcute rejection episodesLung allograft dysfunctionLung transplant patientsLung transplant rejectionLung transplantation modelEarly therapeutic interventionMajor risk factorTime-sensitive diagnosisDevelopment of biomarkersAllograft dysfunctionRejection episodesLewis recipientsTransplant patientsPulmonary allograftsRecipient bloodAllogeneic grafts
2018
Donor tissue-specific exosome profiling enables noninvasive monitoring of acute rejection in mouse allogeneic heart transplantation
Habertheuer A, Korutla L, Rostami S, Reddy S, Lal P, Naji A, Vallabhajosyula P. Donor tissue-specific exosome profiling enables noninvasive monitoring of acute rejection in mouse allogeneic heart transplantation. Journal Of Thoracic And Cardiovascular Surgery 2018, 155: 2479-2489. PMID: 29499866, DOI: 10.1016/j.jtcvs.2017.12.125.Peer-Reviewed Original ResearchConceptsEarly acute rejectionDonor heartsAcute rejectionHeart transplantationStudy armsImmunologic rejectionMaintenance armHeterotopic heart transplantation modelAllogeneic heart transplantationTime pointsHeart transplantation modelHeterotopic heart transplantationAbsence of rejectionNovel biomarker platformDevelopment of biomarkersNoninvasive monitoringTransplant heartCardiac allograftsImmunocompetent recipientsAllograft monitoringImmunodeficient recipientsRecipient circulationTransplantation modelDay 1Total plasma
2017
Magnetoencephalography as a Tool in Psychiatric Research: Current Status and Perspective
Uhlhaas P, Liddle P, Linden D, Nobre A, Singh K, Gross J. Magnetoencephalography as a Tool in Psychiatric Research: Current Status and Perspective. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2017, 2: 235-244. PMID: 28424797, PMCID: PMC5387180, DOI: 10.1016/j.bpsc.2017.01.005.Peer-Reviewed Original ResearchPsychiatric researchAberrant rhythmic activityAbnormal brain dynamicsAutism spectrum disorderNeurobiological mechanismsPsychiatric conditionsCircuit dysfunctionNeuropsychiatric disordersNeuropsychiatric conditionsSpectrum disorderApplication of magnetoencephalographyNeural oscillationsBrain dynamicsMagnetoencephalographyNeuronal eventsPreclinical researchDisordersMEG signalsMillisecond resolutionDevelopment of biomarkersSchizophreniaPathophysiological mechanismsPsychiatricAutismTranslational research
2016
Subcortical volumetric abnormalities in bipolar disorder
Hibar DP, Westlye LT, van Erp TG, Rasmussen J, Leonardo CD, Faskowitz J, Haukvik UK, Hartberg CB, Doan NT, Agartz I, Dale AM, Gruber O, Krämer B, Trost S, Liberg B, Abé C, Ekman CJ, Ingvar M, Landén M, Fears SC, Freimer NB, Bearden CE, Sprooten E, Glahn D, Pearlson G, Emsell L, Kenney J, Scanlon C, McDonald C, Cannon D, Almeida J, Versace A, Caseras X, Lawrence N, Phillips M, Dima D, Delvecchio G, Frangou S, Satterthwaite T, Wolf D, Houenou J, Henry C, Malt U, Bøen E, Elvsåshagen T, Young A, Lloyd A, Goodwin G, Mackay C, Bourne C, Bilderbeck A, Abramovic L, Boks M, van Haren N, Ophoff R, Kahn R, Bauer M, Pfennig A, Alda M, Hajek T, Mwangi B, Soares J, Nickson T, Dimitrova R, Sussmann J, Hagenaars S, Whalley H, McIntosh A, Thompson P, Andreassen O. Subcortical volumetric abnormalities in bipolar disorder. Molecular Psychiatry 2016, 21: 1710-1716. PMID: 26857596, PMCID: PMC5116479, DOI: 10.1038/mp.2015.227.Peer-Reviewed Original ResearchConceptsLateral ventricleBipolar disorderBDII patientsBD patientsIntracranial volumeLarger thalamic volumesSubcortical volumetric abnormalitiesLarger lateral ventriclesSignificant differencesSubcortical brain measuresCase-control differencesDevelopment of biomarkersMean hippocampusVolumetric abnormalitiesIllness onsetThalamic volumeBDI patientsGlobus pallidusSmaller hippocampiClinical subtypesDisease progressionHealthy controlsBrain changesNucleus accumbensPatients
2014
A review of the relationship between proinflammatory cytokines and major depressive disorder
Young J, Bruno D, Pomara N. A review of the relationship between proinflammatory cytokines and major depressive disorder. Journal Of Affective Disorders 2014, 169: 15-20. PMID: 25128861, DOI: 10.1016/j.jad.2014.07.032.Peer-Reviewed Original ResearchConceptsMajor depressive disorderProinflammatory cytokinesDepressive disorderCytokine profileSerum levelsIL-6IL-8 serum levelsHeterogeneity of MDDAnti-inflammatory treatmentPathogenesis of depressionAnti-inflammatory therapyElevated proinflammatory cytokinesElevated serum levelsProgression of MDDDevelopment of biomarkersInflammatory hypothesisMDD treatmentCSF levelsDepression medicationsMCP-1Inflammatory processMDD pathogenesisDepressed patientsPossible diagnostic toolAdjuvant properties
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